Sealing device for DNA nucleic acid extraction

Abstract

The utility model relates to the technical field of nucleic acid extraction, and discloses a sealing device for DNA (deoxyribonucleic acid) nucleic acid extraction, which comprises an injector and a liquid guide tube, liquid guide holes are arranged on two opposite side walls of the bottom of the liquid guide tube, a sealing sleeve is sleeved on the outer side of the bottom of the liquid guide tube, through holes are arranged on two opposite side walls of the sealing sleeve, and the sealing sleeve is sleeved on the sealing sleeve. Connecting rods are fixedly connected to the outer walls of the two opposite sides of the top of the sealing sleeve, adjusting assemblies are arranged at the top ends of the two connecting rods, liquid needed for nucleic acid extraction is sucked through cooperation of the injector and the liquid guide pipe, the liquid guide hole is used for outflow or inflow of the liquid, and the through hole in the sealing sleeve and the liquid guide hole are in a staggered state initially. And the connecting rod serves as a connecting part between the sealing sleeve and the adjusting assembly, the rotating sleeve is manually rotated so that the connecting rod can drive the sealing sleeve to rotate synchronously, and therefore the through hole and the liquid guide hole can be aligned or staggered, and liquid entering and exiting are controlled.

Description

Technical Field

[0001] The utility model relates to the technical field of nucleic acid extraction, and specifically to a sealing device for DNA nucleic acid extraction. Background Art

[0002] The sealing device for DNA nucleic acid extraction is mainly used to prevent liquid exposure during the nucleic acid extraction process to avoid occupational infection of medical staff. The protection requirements for hospitals in the process of DNA nucleic acid extraction are high. If effective protection cannot be achieved, it will lead to occupational exposure of medical staff and cause occupational infection of medical staff. Therefore, when extracting DNA nucleic acid, medical staff are generally required to wear protective clothing to avoid infection.

[0003] Existing devices have some disadvantages during use. For example, most of the nucleic acid extraction devices in the prior art are not equipped with sealing devices. During operation, they may come into contact with external equipment or air, such as microorganisms, dust in the air, or aerosols generated during other experiments. These pollutants may cross-react with the nucleic acid in the sample, resulting in false positive or false negative results, making it difficult to ensure the accuracy of the test results. Utility Model Content

[0004] The utility model aims to provide a sealing device for DNA nucleic acid extraction, so as to solve the problem that most nucleic acid extraction devices are not provided with sealing devices, and may come into contact with external equipment or air during operation, making it difficult to ensure the accuracy of the detection results.

[0005] The utility model provides the following technical solution: a sealing device for DNA nucleic acid extraction, comprising a syringe and a liquid guide tube, wherein liquid guide holes are provided on two opposite side walls of the bottom of the liquid guide tube, a sealing sleeve is sleeved on the outer side of the bottom of the liquid guide tube, through holes are provided on two opposite side walls of the sealing sleeve, connecting rods are fixedly connected to the two opposite side outer walls of the top of the sealing sleeve, and adjustment components are provided on the tops of the two connecting rods.

[0006] In the above scheme, the liquid required for nucleic acid extraction is sucked by the cooperation of the syringe and the liquid guide tube. The liquid guide hole is used for the outflow or inflow of the liquid. The through hole on the sealing sleeve and the liquid guide hole are initially in a misaligned state.

[0007] As a preferred embodiment of the above technical solution, the adjustment component includes a movable sleeve slidably sleeved on the outer wall of the syringe, a rotating sleeve is sleeved on the outer wall of the movable sleeve, the rotating sleeve is rotatably connected to the movable sleeve, the top ends of the two connecting rods are fixed to the lower end surface of the rotating sleeve, a plurality of telescopic rods are fixed in an array on the upper end surface of the movable sleeve, the top ends of the plurality of telescopic rods are fixedly connected to a fixing ring, and the fixing ring is fixedly sleeved on the outer wall of the syringe.

[0008] In the above solution, the connecting rod drives the sealing sleeve to rotate synchronously by manually rotating the rotating sleeve, so that the through hole and the liquid guide hole are aligned or misaligned.

[0009] As a preferred embodiment of the above technical solution, sealing gaskets are bonded and fixed to the inner walls on both sides of the sealing sleeve, the outer wall of the sealing gasket is in contact with the inner wall of the sealing sleeve, and the inner wall of the sealing gasket is in contact with the outer wall of the catheter.

[0010] In the above solution, the liquid guiding hole is blocked by a sealing gasket, thereby improving the sealing performance of the bottom of the liquid guiding tube.

[0011] As a preferred embodiment of the above technical solution, a plurality of auxiliary rotating rods are fixed in a circular array on the outer wall of the rotating sleeve.

[0012] In the above solution, the auxiliary rotating rod is provided to provide a force point for the user, so as to facilitate the rotating operation of the rotating sleeve.

[0013] As a preferred embodiment of the above technical solution, a positioning protrusion is embedded on the outer wall of the syringe, and a positioning sticker is bonded and fixed on the outer wall of the rotating sleeve.

[0014] In the above solution, when the positioning sticker on the rotating sleeve rotates to the position directly below the positioning protrusion, the through hole and the liquid guide hole are aligned, so that the liquid can flow.

[0015] As a preferred embodiment of the above technical solution, the bottom port of the syringe is threadedly connected to the top end of the catheter.

[0016] In the above scheme, it is convenient to replace or clean the catheter.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] In the utility model, the liquid required for nucleic acid extraction is sucked by the cooperation of the syringe and the liquid guide tube, the liquid guide hole is used for the outflow or inflow of the liquid, the through hole on the sealing sleeve and the liquid guide hole are initially in a misaligned state, so as to prevent the liquid from flowing out, the connecting rod is used as a connecting component between the sealing sleeve and the adjustment component, and the connecting rod drives the sealing sleeve to rotate synchronously by manually rotating the rotating sleeve, so that the through hole and the liquid guide hole are aligned or misaligned, so as to control the inflow and outflow of the liquid, and when cleaning, the telescopic rod can be extended by pulling the movable sleeve, so that the movable sleeve is moved downward, so that the sealing sleeve is separated from the end of the liquid guide tube, and the structure is convenient for disassembling and assembling the liquid guide tube, which is convenient for replacement. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 A schematic diagram of the three-dimensional structure of a sealing device for DNA nucleic acid extraction;

[0020] Figure 2A schematic diagram of the explosion structure of a sealing device for DNA nucleic acid extraction;

[0021] Figure 3 It is a schematic diagram of the partial cross-sectional structure of a sealing device for DNA nucleic acid extraction.

[0022] In the figure: 10, syringe; 101, positioning protrusion; 11, liquid guide tube; 111, liquid guide hole; 12, sealing sleeve; 121, through hole; 122, sealing gasket; 13, connecting rod; 20, moving sleeve; 21, rotating sleeve; 211, auxiliary rotating rod; 212, positioning sticker; 22, telescopic rod; 23, fixing ring. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0024] Example 1

[0025] like Figure 1 As shown, the utility model provides a technical solution: a sealing device for DNA nucleic acid extraction, comprising a syringe 10 and a liquid guide tube 11, liquid guide holes 111 are opened on two opposite side walls of the bottom of the liquid guide tube 11, a sealing sleeve 12 is sleeved on the outer side of the bottom of the liquid guide tube 11, through holes 121 are opened on two opposite side walls of the sealing sleeve 12, connecting rods 13 are fixedly connected to the two opposite side outer walls of the top of the sealing sleeve 12, and adjustment components are arranged on the tops of the two connecting rods 13. During specific use, the liquid required for nucleic acid extraction is sucked by the cooperation of the syringe 10 and the liquid guide tube 11, and the liquid guide hole 111 is used for the outflow or inflow of liquid. The through hole 121 on the sealing sleeve 12 is initially in a misaligned state with the liquid guide hole 111 to prevent liquid from flowing out. The connecting rod 13 serves as a connecting component between the sealing sleeve 12 and the adjustment component, and the adjustment component is used to control the rotation and up and down movement of the sealing sleeve 12. The through hole 121 and the liquid guide hole 111 can be aligned or misaligned by the arranged adjustment component.

[0026] As an implementation method in this embodiment, Figure 1 and Figure 2As shown, the adjustment component includes a movable sleeve 20 slidably sleeved on the outer wall of the syringe 10, a rotating sleeve 21 is sleeved on the outer wall of the movable sleeve 20, the rotating sleeve 21 is rotatably connected to the movable sleeve 20, the top ends of the two connecting rods 13 are fixed to the lower end faces of the rotating sleeve 21, a plurality of telescopic rods 22 are fixedly arrayed on the upper end face of the movable sleeve 20, a plurality of telescopic rods 22 are fixedly connected to the top ends of the plurality of telescopic rods 22 with a fixing ring 23, and the fixing ring 23 is fixedly sleeved on the outer wall of the syringe 10. During specific use, the rotating sleeve 21 is manually rotated to make the connecting rod 13 drive the sealing sleeve 12 to rotate synchronously, so that the through hole 121 and the liquid guide hole 111 are aligned or misaligned, so as to control the inflow and outflow of the liquid, and during cleaning, the movable sleeve 20 can be pulled to extend the telescopic rod 22, so that the movable sleeve 20 moves downward, so that the sealing sleeve 12 is separated from the end of the liquid guide tube 11, and the structure is convenient for disassembly and assembly of the liquid guide tube 11, which is convenient for replacement.

[0027] As an implementation method in this embodiment, Figure 3 As shown, sealing gaskets 122 are bonded and fixed to the inner walls on both sides of the sealing sleeve 12. The outer wall of the sealing gasket 122 fits with the inner wall of the sealing sleeve 12, and the inner wall of the sealing gasket 122 fits with the outer wall of the liquid guiding tube 11. In order to ensure that the sealing sleeve 12 can prevent liquid from leaking, the sealing gasket 122 is provided to block the liquid guiding hole 111, thereby improving the sealing performance of the bottom of the liquid guiding tube 11.

[0028] As an implementation method in this embodiment, Figure 1 As shown, a plurality of auxiliary rotating rods 211 are fixed in a circular array on the outer wall of the rotating sleeve 21 . The auxiliary rotating rods 211 provide force points for the user, making it easy to rotate the rotating sleeve 21 .

[0029] As an implementation method in this embodiment, Figure 1 As shown, a positioning protrusion 101 is embedded on the outer wall of the syringe 10, and a positioning sticker 212 is bonded and fixed on the outer wall of the rotating sleeve 21. In order to quickly align or misalign the through hole 121 and the liquid guide hole 111, when the positioning sticker 212 on the rotating sleeve 21 rotates to the position directly below the positioning protrusion 101, the through hole 121 and the liquid guide hole 111 are aligned, and liquid can circulate.

[0030] As an implementation method in this embodiment, Figure 1 and Figure 2 As shown, the bottom end port of the syringe 10 is threadedly connected to the top end of the catheter 11, so as to facilitate the replacement or cleaning of the catheter 11.

[0031] Working principle: when liquid needs to be introduced into the syringe 10, the user operates the adjustment component to align the through hole 121 on the sealing sleeve 12 with the liquid guide hole 111. During the pulling and pulling process of the piston of the syringe 10, the liquid is sucked into the internal cavity. Then the user operates the adjustment component to stagger the through hole 121 on the sealing sleeve 12 with the liquid guide hole 111. When liquid needs to be discharged, the through hole 121 on the sealing sleeve 12 is aligned with the liquid guide hole 111 again. The liquid in the syringe 10 flows out through the liquid guide hole 111 and the through hole 121 under pressure. If it is necessary to stop the outflow of liquid or perform other operations (such as changing the sample, cleaning, etc.), the user operates the adjustment component again to misalign the through hole 121 with the liquid guide hole 111 to achieve sealing.

[0032] The above embodiments are only used to illustrate the technical solution of the present invention, but not to limit it.

Claims

1. A sealing device for DNA nucleic acid extraction, comprising a syringe (10) and a liquid guide tube (11), characterized in that: The bottom of the liquid guiding tube (11) is provided with liquid guiding holes (111) on two opposite side walls, the bottom of the liquid guiding tube (11) is sleeved with a sealing sleeve (12) on the outer side, the sealing sleeve (12) is provided with through holes (121) on two opposite side walls, the top of the sealing sleeve (12) is fixedly connected with connecting rods (13), and the tops of the two connecting rods (13) are provided with adjustment components.

2. A sealing device for DNA nucleic acid extraction according to claim 1, characterized in that: The adjustment assembly comprises a movable sleeve (20) slidably sleeved on the outer wall of the syringe (10); a rotating sleeve (21) is sleeved on the outer wall of the movable sleeve (20); the rotating sleeve (21) is rotatably connected to the movable sleeve (20); the top ends of the two connecting rods (13) are fixed to the lower end surface of the rotating sleeve (21); a plurality of telescopic rods (22) are fixedly arranged on the upper end surface of the movable sleeve (20); the top ends of the plurality of telescopic rods (22) are fixedly connected to a fixing ring (23); and the fixing ring (23) is fixedly sleeved on the outer wall of the syringe (10).

3. A sealing device for DNA nucleic acid extraction according to claim 1, characterized in that: Sealing pads (122) are bonded and fixed to the inner walls of the sealing sleeve (12) on both sides opposite to each other, the outer wall of the sealing pad (122) fits the inner wall of the sealing sleeve (12), and the inner wall of the sealing pad (122) fits the outer wall of the catheter (11).

4. A sealing device for DNA nucleic acid extraction according to claim 2, characterized in that: A plurality of auxiliary rotating rods (211) are fixed in an annular array on the outer wall of the rotating sleeve (21).

5. A sealing device for DNA nucleic acid extraction according to claim 2, characterized in that: A positioning protrusion (101) is embedded on the outer wall of the syringe (10), and a positioning sticker (212) is bonded and fixed on the outer wall of the rotating sleeve (21).

6. A sealing device for DNA nucleic acid extraction according to claim 1, characterized in that: The bottom end port of the syringe (10) is threadedly connected to the top end of the catheter (11).

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