Kit for detecting hereditary cerebrovascular diseases

Abstract

The utility model relates to a kit for detecting hereditary cerebrovascular diseases, and belongs to the technical field of medical detection. The kit comprises: a plate, the surface of which is provided with a positioning hole; the first supporting piece is arranged at the bottom of the plate piece, and the plane where the first supporting piece is located is perpendicular to the plane where the plate piece is located; the fine adjustment assembly is arranged on the first supporting piece, and the fine adjustment assembly is adaptive to the thickness of the workbench; when the first supporting part and the plate part abut against the workbench, the fine adjustment assembly, the first supporting part and the plate part are combined to form a clamping groove. According to the kit, the plate is placed on the working table, the first supporting piece abuts against the working table, the fine adjustment assembly is controlled to enable the working table to be just clamped in the clamping groove, then the position of the plate is fixed, the situation that the plate is shaken due to mistaken touch can be effectively avoided, the accuracy of a detection result is improved, and meanwhile the detection efficiency is improved. Various liquid agents can be added into a plurality of reagent tubes at one time, and the working efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of medical detection, in particular to a kit for detecting hereditary cerebrovascular diseases. Background Art

[0002] Cerebrovascular disease is a multifactorial disease caused by the interaction of genetic and environmental factors, including CADASIL, CARASIL, Fabry, etc. Among them, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an autosomal dominant genetic disease combined with subcortical infarcts and leukoencephalopathy. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy is an inherited small artery disease caused by mutations in the Notch3 (CADASIL defect gene) gene on chromosome 19. It manifests as subcortical ischemia and leads to progressive dementia with pseudobulbar palsy. Currently, Notch 3 protein ELISA kits are commonly used to detect inherited cerebrovascular diseases. ELISA (Enzyme Linked ImmunoSorbent Assay) kits are enzyme-linked immunosorbent assay kits. When using ELISA kits to detect inherited cerebrovascular diseases, equal amounts of reagent tubes need to be placed in corresponding compartments according to the number of samples to be tested. Then, various liquids are accurately dripped into the corresponding reagent tubes. During this process, the reagent tubes may be accidentally touched by the reagent kit equipment or the experimenter, causing shaking, which may cause the liquid in the reagent tubes to spill, affecting the accuracy of the test results. Utility Model Content

[0003] Based on this, it is necessary to provide a kit for detecting hereditary cerebrovascular diseases, which is a problem that in the process of using ELISA detection kits to detect hereditary cerebrovascular diseases, various liquids need to be accurately dropped into the corresponding compartments. During this process, it is inevitable that the kit equipment or experimenters will accidentally touch it and cause it to shake, thereby causing the liquid inside to spill, affecting the accuracy of the test results.

[0004] The utility model provides a kit for detecting hereditary cerebrovascular diseases, comprising:

[0005] A plate having a positioning hole on its surface;

[0006] A first support member is provided at the bottom of the plate, wherein the plane where the first support member is located is perpendicular to the plane where the plate is located;

[0007] a fine-tuning assembly, disposed on the first support member, wherein the fine-tuning assembly is self-adaptive to the thickness of the workbench;

[0008] When both the first support member and the plate member come into contact with the workbench, the fine-tuning assembly, the first support member and the plate member are combined to form a clamping groove.

[0009] In one embodiment, the fine-tuning assembly includes a first threaded rod, a first clamping member and a first guide rod, the first guide rod is fixed to the bottom of the first support member, the first threaded rod is rotatably connected to the bottom of the first support member, the first clamping member is threadedly connected to the outer wall of the first threaded rod, and the first guide rod passes through the first clamping member.

[0010] In one embodiment, a first knob is fixedly connected to the bottom of the first threaded rod, a plane where the first support member is located is parallel to a plane where the plate member is located, and the first clamping member and the plate member are located on the same side of the first support member.

[0011] In one embodiment, the fine-tuning assembly includes a second support member, a second threaded rod and a second clamping member, the second support member is fixedly connected to the first support member, a threaded hole is provided on the second support member for interference fit with the second threaded rod, and the second clamping member is fixedly connected to the second threaded rod.

[0012] In one embodiment, the plane where the second clamping member is located is parallel to the plane where the plate member is located, and the bottom of the second threaded rod is fixedly connected to a second knob.

[0013] In one embodiment, the first support member is detachably connected to the plate member via a connecting assembly.

[0014] In one embodiment, the connecting assembly includes a clamping member, an elastic member and a limiting member, the clamping member is fixedly connected to the plate member, a through groove that is interference fit with the clamping member is provided on the first support member, the side wall of the plate member is symmetrically provided with grooves, the limiting member is fixedly connected to the clamping member through the elastic member, and the limiting member and the elastic member are both located in the groove.

[0015] In one embodiment, when the clamping member is clamped in the through slot, a portion of the limiting member is located in the groove, and another portion of the limiting member extends out of the clamping member, and this portion of the limiting member contacts the first support member.

[0016] The above-mentioned test kit for detecting hereditary cerebrovascular diseases is achieved by placing a plate on a workbench and making the first support member contact the workbench, adjusting the position of the fine-tuning component according to the thickness of the workbench, so that the workbench is just clamped in the clamping groove, and then fixing the position of the plate, and then placing a number of reagent tubes equal to the number of samples to be tested into the corresponding positioning holes, and then accurately dripping various liquids into the corresponding reagent tubes. In this process, since the plate is fixed on the workbench, it can effectively avoid shaking caused by accidentally touching the plate, thereby improving the accuracy of the test results. At the same time, it can be beneficial to add various liquids to multiple reagent tubes at one time, thereby improving work efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions of the present invention or the prior art, a brief introduction will be given below to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0018] Figure 1 This is a schematic structural diagram of a kit for detecting hereditary cerebrovascular diseases according to one embodiment of the present invention;

[0019] Figure 2 This is a schematic cross-sectional view of a fine-tuning assembly according to an embodiment of the present invention;

[0020] Figure 3 This is a schematic diagram of the three-dimensional structure of a fine-tuning component according to an embodiment of the present invention.

[0021] Reference numerals:

[0022] 110. Plate; 111. Positioning hole; 120. First support member; 130. Clamping groove; 140. Fine-tuning assembly; 141. First guide rod; 142. First threaded rod; 143. First clamping member; 144. First knob; 145. Second support member; 146. Second threaded rod; 147. Second clamping member; 148. Threaded hole; 149. Second knob; 150. Connecting assembly; 151. Clamp; 152. Groove; 153. Through slot; 154. Elastic member; 155. Limiting member. DETAILED DESCRIPTION

[0023] To make the purpose, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts shall fall within the scope of protection of the present invention.

[0024] It should be noted that when a component is referred to as being "fixed to" or "disposed on" another component, it may be directly on the other component or there may be a central component. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may be a central component at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in the specification of this utility model are for illustrative purposes only and do not represent the only implementation method.

[0025] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature specified as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of this utility model, "plurality" means at least two, for example, two, three, etc., unless otherwise specifically defined.

[0026] In the present invention, unless otherwise expressly specified or limited, when a first feature is "above" or "below" a second feature, it can mean that the first feature is directly in contact with the second feature, or the first feature and the second feature are indirectly in contact through an intermediary. Furthermore, when a first feature is "above," "above," or "above" a second feature, it can mean that the first feature is directly above or diagonally above the second feature, or simply means that the first feature is higher in level than the second feature. When a first feature is "below," "below," or "below" a second feature, it can mean that the first feature is directly below or diagonally below the second feature, or simply means that the first feature is lower in level than the second feature.

[0027] Unless otherwise defined, all technical and scientific terms used in the specification of this utility model have the same meanings as those commonly understood by those skilled in the art to which this utility model belongs. The terms used in the specification of this utility model are only for the purpose of describing specific embodiments and are not intended to limit the utility model. The term "and / or" used in the specification of this utility model includes any and all combinations of one or more of the relevant listed items.

[0028] Cerebrovascular disease is a multifactorial disease caused by the interaction of genetic and environmental factors, including CADASIL, CARASIL, Fabry, etc. Among them, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an autosomal dominant genetic disease combined with subcortical infarcts and leukoencephalopathy. Cerebral autosomal dominant arteriopathy with subcortical infarction and leukoencephalopathy is an inherited small artery disease, a hereditary cerebral small vessel disease caused by mutations in the Notch3 (CADASIL defect gene) gene on chromosome 19, manifesting as subcortical ischemic events and leading to progressive dementia with pseudobulbar palsy. Currently, Notch 3 protein ELISA kits are often used to detect inherited cerebrovascular diseases. ELISA (Enzyme Linked ImmunoSorbent Assay) kits are enzyme-linked immunosorbent assay kits. In the process of using ELISA kits to detect inherited cerebrovascular diseases, it is necessary to place equal amounts of reagent tubes into the corresponding compartments according to the number of samples to be tested, and then accurately drop various liquids into the corresponding reagent tubes. During this period, it is inevitable that the reagent kit equipment or the experimenter will accidentally touch it and cause shaking, which will cause the liquid in the reagent tube to spill, affecting the accuracy of the test results. Therefore, the following will be combined Figure 1-Figure 3 The utility model describes a kit for detecting hereditary cerebrovascular diseases.

[0029] like Figure 1 As shown, in one embodiment, a kit for detecting hereditary cerebrovascular diseases includes a plate 110 , a first support 120 and a fine-tuning component 140 .

[0030] The surface of the plate 110 has positioning holes 111, and the number of positioning holes 111 is 48 or 96, that is, 6*8 or 12*8. The first support member 120 is arranged at the bottom of the plate 110, and the plane where the first support member 120 is located is perpendicular to the plane where the plate 110 is located. The fine-tuning component 140 is arranged on the first support member 120, and the fine-tuning component 140 adapts to the thickness of the workbench.

[0031] When the first support member 120 and the plate member 110 both come into contact with the workbench, the fine-tuning assembly 140 , the first support member 120 , and the plate member 110 are combined to form a clamping groove 130 .

[0032] During use, the plate 110 is placed on the workbench, and the first support member 120 is in contact with the workbench. The position of the fine-tuning component 140 is adjusted according to the thickness of the workbench so that the workbench is just clamped in the clamping groove 130, thereby fixing the position of the plate 110. Then, the reagent tubes of the same number as the samples to be tested are placed in the corresponding positioning holes 111, and then various liquids are accurately dripped into the corresponding reagent tubes. In this process, since the plate 110 is fixed on the workbench, it can effectively avoid shaking caused by accidentally touching the plate 110, thereby improving the accuracy of the test results. At the same time, it can be beneficial to add various liquids to multiple reagent tubes at one time, thereby improving work efficiency.

[0033] like Figure 2 As shown, in one embodiment, the fine-tuning assembly 140 includes a first threaded rod 142, a first clamping member 143 and a first guide rod 141. The first guide rod 141 is fixed to the bottom of the first support member 120, the first threaded rod 142 is rotatably connected to the bottom of the first support member 120, the first clamping member 143 is threadedly connected to the outer wall of the first threaded rod 142, and the first guide rod 141 passes through the first clamping member 143.

[0034] In this embodiment, the bottom of the first threaded rod 142 is fixedly connected to the first knob 144, the plane of the first support member 120 is parallel to the plane of the plate 110, the first clamping member 143 and the plate 110 are located on the same side of the first support member 120, and the first clamping member 143, the first support member 120, and the plate 110 are combined to form a clamping groove 130.

[0035] When in use, place the plate 110 on the workbench and make the first support member 120 contact the workbench. Hold the first knob 144 to rotate the first threaded rod 142, so that the first clamping member 143 moves on the first guide rod 141 until the first clamping member 143 contacts the bottom of the workbench, thereby facilitating the fixing of the position of the plate 110.

[0036] like Figure 3 As shown, in one embodiment, the fine-tuning assembly 140 includes a second support member 145, a second threaded rod 146 and a second clamping member 147. The second support member 145 is fixedly connected to the first support member 120. A threaded hole 148 that is interference fit with the second threaded rod 146 is provided on the second support member 145. The second clamping member 147 is fixedly connected to the second threaded rod 146.

[0037] In this embodiment, the plane where the second clamping member 147 is located is parallel to the plane where the plate 110 is located, and the bottom of the second threaded rod 146 is fixedly connected to the second knob 149. The second clamping member 147, the first support member 120, and the plate 110 are combined to form a clamping groove 130.

[0038] When in use, place the plate 110 on the workbench and make the first support member 120 contact the workbench. Hold the second knob 149 to rotate the second threaded rod 146. The second threaded rod 146 drives the second clamping member 147 to move until the second clamping member 147 contacts the bottom of the workbench, thereby fixing the position of the plate 110.

[0039] Since the liquid in the reagent tube needs to be fully mixed in order to improve the accuracy of the results when using the kit to detect hereditary cerebrovascular diseases, the first support member 120 is detachably connected to the plate member 110 via the connecting assembly 150. Figure 2 .

[0040] Specifically, the connecting assembly 150 includes a clamping member 151, an elastic member 154 and a limiting member 155. The elastic member 154 is a spring. The clamping member 151 is fixedly connected to the plate 110. A through groove 153 that is interference fit with the clamping member 151 is provided on the first support member 120. The side wall of the plate 110 is symmetrically provided with grooves 152. The limiting member 155 is fixedly connected to the clamping member 151 through the elastic member 154. The limiting member 155 and the elastic member 154 are both located in the groove 152.

[0041] When the locking member 151 is locked in the through slot 153 , a portion of the limiting member 155 is located in the groove 152 , and another portion of the limiting member 155 extends out of the locking member 151 , and this portion of the limiting member 155 contacts the first supporting member 120 .

[0042] When the liquid in the reagent tube needs to be fully mixed, it is only necessary to press the limiter 155 into the groove 152, and then lift the plate 110 upwards to separate the plate 110 and the first support member 120. Then, the plate 110 can be placed on the vortex machine by holding the clamp 151 for full mixing, and vice versa. The connecting assembly 150 can be used to quickly disassemble and install the plate 110 and the first support member 120. The operation is simple and easy to use.

[0043] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above-mentioned embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0044] The above-described embodiments merely represent several implementations of the present invention. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that variations and improvements are possible within the scope of the present invention, as would be apparent to one skilled in the art. These variations and improvements fall within the scope of the present invention. Therefore, the scope of the present invention shall be determined by the appended claims.

Claims

1. A kit for detecting hereditary cerebrovascular diseases, characterized in that: include: A plate having a positioning hole on its surface; A first support member, arranged at the bottom of the plate, wherein the plane where the first support member is located is perpendicular to the plane where the plate is located; A fine-tuning component is arranged on the first supporting member, and the fine-tuning component is self-adjusting to the thickness of the workbench; Wherein, when both the first support member and the plate member are in conflict with the workbench, the fine-tuning component, the first support member and the plate member are combined to form a clamping groove.

2. The kit for detecting hereditary cerebrovascular disease according to claim 1, characterized in that: The fine-tuning assembly includes a first threaded rod, a first clamp and a first guide rod, the first guide rod is fixed to the bottom of the first support member, the first threaded rod is rotatably connected to the bottom of the first support member, the first clamp is threadedly connected to the outer wall of the first threaded rod, and the first guide rod passes through the first clamp.

3. The kit for detecting hereditary cerebrovascular disease according to claim 2, characterized in that: A first knob is fixedly connected to the bottom of the first threaded rod, a plane where the first support member is located is parallel to a plane where the plate member is located, and the first clamping member and the plate member are located on the same side of the first support member.

4. The kit for detecting hereditary cerebrovascular disease according to claim 1, characterized in that: The fine-tuning assembly includes a second support member, a second threaded rod and a second clamping member. The second support member is fixedly connected to the first support member. The second support member is provided with a threaded hole that is interference-fitted with the second threaded rod. The second clamping member is fixedly connected to the second threaded rod.

5. The kit for detecting hereditary cerebrovascular disease according to claim 4, characterized in that: The plane where the second clamping member is located is parallel to the plane where the plate member is located, and the bottom of the second threaded rod is fixedly connected with a second knob.

6. The kit for detecting hereditary cerebrovascular disease according to any one of claims 1 to 5, characterized in that: The first support member is detachably connected to the plate member via a connecting assembly.

7. The kit for detecting hereditary cerebrovascular disease according to claim 6, characterized in that: The connecting assembly includes a clamping member, an elastic member and a limiting member. The clamping member is fixedly connected to the plate member. A through groove that is interference fit with the clamping member is formed on the first supporting member. Grooves are symmetrically formed on the side walls of the plate member. The limiting member is fixedly connected to the clamping member via an elastic member. Both the limiting member and the elastic member are located in the groove.

8. The kit for detecting hereditary cerebrovascular disease according to claim 7, characterized in that: When the clamping member is clamped in the through slot, a portion of the limiting member is located in the groove, another portion of the limiting member extends out of the clamping member, and the limiting member contacts the first supporting member.

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