Transdermal pool assembly for transdermal diffusion instrument

Abstract

The transdermal pool assembly comprises a hollow transdermal pool, a liquid inlet pipe and a waste liquid pipe, and is characterized in that the bottom of the transdermal pool is detachably and hermetically connected with the top of a lower base, an opening is formed in the upper side of the lower base, the liquid inlet pipe is communicated with the lower base, the top of the transdermal pool is detachably and hermetically connected with the bottom of an upper base, and the waste liquid pipe is communicated with the upper base. The upper base is hollow, the waste liquid pipe is communicated with the upper base, the upper side of the upper base is covered with a layer of silica gel gasket, the silica gel gasket is used for fixing the simulated skin and pressed by a pressing block, and the pressing block is hollow. The transdermal pool assembly is compact in structure and good in sealing effect, air in the transdermal pool can be effectively exhausted, cavities in the lower base, the transdermal pool and the upper base are completely filled with a solution, the accuracy of the volume of the extracted solution is guaranteed, and the accuracy of experimental data is guaranteed. Meanwhile, the transdermal pool assembly is convenient to disassemble and assemble, an operator can conveniently and manually disassemble the transdermal pool for cleaning, solution residues are avoided, and the accuracy of subsequent experimental data is guaranteed.

Description

Technical Field

[0001] The utility model belongs to the technical field of transdermal diffusion instruments, and in particular relates to a transdermal pool component for a transdermal diffusion instrument. Background Art

[0002] The purpose of the transdermal diffusion instrument is to study the rate at which plaster drugs and cream-like cosmetics penetrate the skin. During the experiment, the simulated skin required for the experiment is placed at the detection position on the transdermal pool. After the experiment, the solution in the transdermal pool is regularly extracted to analyze the amount of plaster or cosmetics that penetrate the skin and record the data. The test is repeated multiple times to obtain the average data. After each experiment, the transdermal pool needs to be removed and cleaned to prevent the residual solution from the previous experiment from affecting the next experimental data.

[0003] CN207528593U discloses a transdermal diffusion cell, comprising a base (4), a hollow cylindrical fixing member (2) and a hollow cylindrical gasket (3); the base (4) is provided with a diffusion cell (5) with an upper opening, the lower diameter of the diffusion cell (5) being smaller than the upper diameter, the bottom of the outer wall of the fixing member (2) being matched with the upper side wall of the diffusion cell (5) and being detachably connected, the gasket (3) being located at the bottom of the fixing member (2) and having an outer diameter matching the upper diameter of the diffusion cell (5), the inner diameter of the fixing member (2) and the inner diameter of the gasket (3) being matched with the diameter of the upper part of the diffusion cell (5), and the inner diameter of the gasket (3) and the inner diameter of the diffusion cell (5) being matched with the inner diameter of the gasket (3). The diameter of the lower part of the diffusion pool (5) matches that of the lower part of the diffusion pool (5), and further comprises a cover body (1) for covering the fixing part (2) from top to bottom to seal the internal space of the fixing part (2), the cover body (1) is provided with at least one one-way valve (6) for allowing gas to flow from the outside of the cover body (1) to the internal space of the fixing part (2) and at least one one-way valve (6) for allowing gas to flow from the internal space of the fixing part (2) to the outside of the cover body (1), and further comprises a liquid input pipe (8) for guiding liquid to the lower part of the diffusion pool (5) and a liquid output pipe (9) for guiding liquid from the lower part of the diffusion pool (5). The diffusion pool (5) is only open at the upper part, and the interfaces of the liquid input pipe (8) and the liquid output pipe (9) are directly arranged on the diffusion pool (5), so that the diffusion pool (5) is inconvenient to clean, and there is a cleaning dead corner, which will have an adverse effect on the accuracy of subsequent experimental data. Utility Model Content

[0004] The technical problem to be solved by the utility model is to provide a transdermal cell assembly for a transdermal diffusion instrument with a compact structure, good sealing effect and convenient assembly and disassembly, so as to ensure the accuracy of the volume of the extracted solution and the accuracy of the experimental data.

[0005] The technical solution adopted by the utility model to solve the above technical problems is: a transdermal pool component for a transdermal diffusion instrument, including a hollow transdermal pool, a liquid inlet pipe and a waste liquid pipe, the bottom of the transdermal pool is detachably sealed and connected to the top of the lower base, the upper side of the lower base is open, the liquid inlet pipe is communicated with the lower base, the top of the transdermal pool is detachably sealed and connected to the bottom of the upper base, the upper base is hollow, the waste liquid pipe is communicated with the upper base, the upper side of the upper base is covered with a layer of silicone gasket, the silicone gasket is used to fix the simulated skin, the silicone gasket is pressed by a pressing block, and the pressing block is hollow.

[0006] After the transdermal cell assembly of the utility model is installed on the transdermal diffusion instrument, before use, the simulated skin is placed on the upper side of the upper base and covered with a silicone gasket, and then the silicone gasket is pressed tightly with a pressing block, and then the plaster or cream-like cosmetics are attached or placed on the upper side of the simulated skin. When the transdermal diffusion instrument is working, the solution enters the lower base through the liquid inlet pipe, and then enters the transdermal cell and the air in the transdermal cell is discharged into the waste liquid pipe until the solution fills the lower base, the transdermal cell and the upper base and contacts the simulated skin. As time goes by, the medicine on the plaster or the cream-like cosmetics slowly penetrates into the solution in the transdermal cell through the simulated skin, and the required volume of solution can be accurately extracted from the lower base using the existing sampling device and method for component analysis.

[0007] Preferably, a first O-type sealing ring is tightly arranged between the bottom of the transdermal pool and the top of the lower base, and a second O-type sealing ring is tightly arranged between the top of the transdermal pool and the bottom of the upper base. Further, the bottom of the transdermal pool is sleeved on the outside of the top of the lower base, and the outer circumference of the top of the lower base is integrally provided with a plurality of first sealing rings, the plurality of first sealing rings are arranged at intervals up and down, and a circle of first sealing grooves is arranged between two first sealing rings adjacent to each other, and one of the first O-type sealing rings is installed in each circle of the first sealing grooves, and the bottom of the upper base is sleeved on the outside of the top of the transdermal pool, and the inner circumference of the bottom of the upper base is integrally provided with a plurality of second sealing rings, the plurality of second sealing rings are arranged at intervals up and down, and a circle of second sealing grooves is arranged between two second sealing rings adjacent to each other, and one of the second O-type sealing rings is installed in each circle of the second sealing grooves. The first sealing ring, the first O-type sealing ring, the second sealing ring, and the second O-type sealing ring form a multi-channel sealing structure, which can realize reliable sealing of the interior of the transdermal pool assembly and ensure the sealing effect.

[0008] Preferably, one end of the liquid inlet pipe is connected to a first joint, the first joint is connected to the liquid inlet joint, the other end of the liquid inlet pipe is connected to a second joint, the side wall of the lower base is provided with a first threaded hole, and the second joint is threadedly connected to the first threaded hole.

[0009] Preferably, the waste liquid pipe is connected to a third joint, the third joint is connected to one end of the exhaust pipe, the other end of the exhaust pipe is connected to a fourth joint, the side wall of the upper base is provided with a second threaded hole and a mounting hole, the fourth joint is threadedly connected to the second threaded hole, and a temperature probe is installed in the mounting hole.

[0010] Furthermore, the second threaded hole is connected to the exhaust hole, the exhaust hole is opened on the inner side of the side wall of the upper base, the second threaded hole is opened on the outer side of the side wall of the upper base, and the exhaust hole is coaxial with the second threaded hole and is arranged obliquely downward.

[0011] Preferably, a circle of oblique conical surface is provided in the middle of the bottom end of the pressing block, and the oblique conical surface is inclined from top to bottom toward the center line of the pressing block. The oblique conical surface can be in close contact with the silicone gasket, and has a better pressing and fixing effect on the silicone gasket, thereby better fixing the simulated skin and sealing the upper end of the upper base, ensuring the overall sealing effect inside the transdermal cell assembly.

[0012] Preferably, a limiting groove is provided at the upper end of the upper base, and the silicone gasket is arranged in the limiting groove. The limiting groove can realize accurate positioning of the silicone gasket and prevent the silicone gasket from deflecting.

[0013] Compared with the prior art, the utility model has the following advantages: the transdermal pool assembly for the transdermal diffusion instrument of the utility model has a compact structure and good sealing effect, and can effectively discharge the air in the transdermal pool, so that the solution completely fills the cavity in the lower base, the transdermal pool and the upper base, ensuring the accuracy of the volume of the extracted solution and the accuracy of the experimental data. At the same time, the transdermal pool assembly is easy to disassemble and assemble, and the operator can conveniently manually disassemble the transdermal pool for cleaning to avoid solution residue and ensure the accuracy of subsequent experimental data. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 This is an appearance diagram of the transdermal cell assembly in the embodiment;

[0015] Figure 2 It is a partial cross-sectional schematic diagram of the transdermal cell assembly in the embodiment;

[0016] Figure 3 for Figure 2 Enlarged view of point A in the middle;

[0017] Figure 4 It is a schematic cross-sectional view of the structure of the lower base in the embodiment;

[0018] Figure 5 It is a schematic cross-sectional view of the structure of the upper base in the embodiment;

[0019] Figure 6 It is a schematic cross-sectional view of the structure of the pressing block in the embodiment;

[0020] The specific reference numerals in the figure are as follows:

[0021] 1-transdermal pool, 2-liquid inlet pipe, 21-first joint, 22-liquid inlet joint, 23-second joint, 3-waste liquid pipe, 31-third joint, 32-exhaust pipe, 33-fourth joint, 4-lower base, 41-first O-type sealing ring, 42-first sealing ring, 43-first sealing groove, 44-first threaded hole, 5-upper base, 50-limiting groove, 51-second O-type sealing ring, 52-second sealing ring, 53-second sealing groove, 54-mounting hole, 55-exhaust hole, 56-second threaded hole, 57-temperature measuring probe, 6-silicone gasket, 7-pressing block, 71-oblique cone surface. DETAILED DESCRIPTION

[0022] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0023] The transdermal pool assembly for the transdermal diffusion instrument of the embodiment, as shown in the figure, includes a hollow transdermal pool 1, a liquid inlet tube 2 and a waste liquid tube 3. The transdermal pool 1 in this embodiment adopts a hollow quartz tube, the bottom of the transdermal pool 1 is detachably sealed and connected to the top of the lower base 4, the upper side of the lower base 4 is open, the liquid inlet tube 2 is communicated with the lower base 4, the top of the transdermal pool 1 is detachably sealed and connected to the bottom of the upper base 5, the upper base 5 is hollow, the waste liquid tube 3 is communicated with the upper base 5, the upper side of the upper base 5 is covered with a layer of silicone gasket 6, the upper end of the upper base 5 is provided with a limiting groove 50, the silicone gasket 6 is arranged in the limiting groove 50, the silicone gasket 6 is used to fix the simulated skin (not shown in the figure), the silicone gasket 6 is pressed by a pressing block 7, the pressing block 7 is hollow, and a circle of inclined conical surface 71 is provided in the middle of the bottom end of the pressing block 7, and the inclined conical surface 71 is inclined from top to bottom toward the center line of the pressing block 7.

[0024] In this embodiment, two first O-rings 41 are tightly arranged between the bottom of the transdermal pool 1 and the top of the lower base 4, and two second O-rings 51 are tightly arranged between the top of the transdermal pool 1 and the bottom of the upper base 5. Specifically, the bottom of the transdermal pool 1 is sleeved on the outer side of the top of the lower base 4, and three first sealing rings 42 are integrally arranged on the outer circumference of the top of the lower base 4. The three first sealing rings 42 are arranged at intervals up and down, and a circle of first sealing grooves 43 is provided between two upper and lower adjacent first sealing rings 42, and a first O-ring 41 is installed in each circle of first sealing grooves 43. The bottom of the upper base 5 is sleeved on the outer side of the top of the transdermal pool 1, and three second sealing rings 52 are integrally arranged on the inner circumference of the bottom of the upper base 5. The three second sealing rings 52 are arranged at intervals up and down, and a circle of second sealing grooves 53 is provided between two upper and lower adjacent second sealing rings 52, and a second O-ring 51 is installed in each circle of second sealing grooves 53.

[0025] In this embodiment, one end of the liquid inlet pipe 2 is connected to the first joint 21, the first joint 21 is connected to the liquid inlet joint 22, the other end of the liquid inlet pipe 2 is connected to the second joint 23, the side wall of the lower base 4 is provided with a first threaded hole 44, the second joint 23 is threadedly connected to the first threaded hole 44, the waste liquid pipe 3 is connected to the third joint 31, the third joint 31 is connected to one end of the exhaust pipe 32, the other end of the exhaust pipe 32 is connected to the fourth joint 33, the side wall of the upper base 5 is provided with a mounting hole 54, the inner side of the side wall of the upper base 5 is provided with an exhaust hole 55, the outer side of the side wall of the upper base 5 is provided with a second threaded hole 56, the second threaded hole 56 is communicated with the exhaust hole 55, and the exhaust hole 55 is coaxial with the second threaded hole 56 and is arranged obliquely downward, the fourth joint 33 is threadedly connected to the second threaded hole 56, and a temperature measuring probe 58 is installed in the mounting hole 54.

[0026] After the above-mentioned transdermal pool assembly is installed on the transdermal diffusion instrument, before use, the simulated skin is placed in the limiting groove 50 at the upper end of the upper base 5, and then the silicone gasket 6 is pressed by the pressing block 7, and then the plaster or cream-like cosmetics are attached or placed on the upper side of the simulated skin. When the transdermal diffusion instrument is working, the solution enters the lower base 4 through the liquid inlet joint 22, the first joint 21, the liquid inlet pipe 2 and the second joint 23, and then enters the transdermal pool 1 and discharges the air in the transdermal pool 1 into the waste liquid pipe 3 through the fourth joint 33, the exhaust pipe 32 and the third joint 31, until the solution fills the lower base 4, the transdermal pool 1 and the upper base 5 and contacts the simulated skin. As time goes by, the medicine on the plaster or the cream-like cosmetics slowly penetrates into the solution in the transdermal pool 1 through the simulated skin, and the required volume of solution can be regularly and accurately extracted from the lower base 4 using the existing sampling device and method for component analysis.

[0027] When the transdermal pool 1 needs to be cleaned, the operator can manually pull out the upper base 5 and the lower base 4 with a little force, and quickly and conveniently clean the transdermal pool 1, the upper base 5 and the lower base 4, and reassemble them after cleaning.

[0028] The transdermal pool assembly has a compact structure and reliable sealing, which can ensure the accuracy of the extracted solution volume and the accuracy of the experimental data. The transdermal pool assembly is easy to assemble and disassemble, and the operator can easily manually disassemble the transdermal pool for cleaning to avoid solution residue and ensure the accuracy of subsequent experimental data.

Claims

1. A transdermal cell assembly for a transdermal diffusion instrument, comprising a hollow transdermal cell, a liquid inlet tube and a waste liquid tube, characterized in that: The bottom of the transdermal pool is detachably sealed and connected to the top of the lower base, the upper side of the lower base is open, the liquid inlet pipe is communicated with the lower base, the top of the transdermal pool is detachably sealed and connected to the bottom of the upper base, the upper base is hollow, the waste liquid pipe is communicated with the upper base, the upper side of the upper base is covered with a layer of silicone gasket, the silicone gasket is used to fix the simulated skin, the silicone gasket is pressed by a pressing block, and the pressing block is hollow.

2. A transdermal cell assembly for a transdermal diffusion instrument according to claim 1, characterized in that: A first O-type sealing ring is tightly arranged between the bottom of the transdermal pool and the top of the lower base, and a second O-type sealing ring is tightly arranged between the top of the transdermal pool and the bottom of the upper base.

3. A transdermal cell assembly for a transdermal diffusion instrument according to claim 2, characterized in that: The bottom of the transdermal pool is sleeved on the outer side of the top of the lower base, and a plurality of first sealing rings are integrally arranged on the outer circumference of the top of the lower base. The plurality of first sealing rings are arranged at intervals up and down, and a circle of first sealing grooves is provided between two adjacent first sealing rings up and down, and a first O-type sealing ring is installed in each circle of the first sealing grooves. The bottom of the upper base is sleeved on the outer side of the top of the transdermal pool, and a plurality of second sealing rings are integrally arranged on the inner circumference of the bottom of the upper base. The plurality of second sealing rings are arranged at intervals up and down, and a circle of second sealing grooves is provided between two adjacent second sealing rings up and down, and a second O-type sealing ring is installed in each circle of the second sealing grooves.

4. A transdermal cell assembly for a transdermal diffusion instrument according to claim 1, characterized in that: One end of the liquid inlet pipe is connected to a first joint, the first joint is connected to the liquid inlet joint, the other end of the liquid inlet pipe is connected to a second joint, the side wall of the lower base is provided with a first threaded hole, and the second joint is threadedly connected to the first threaded hole.

5. A transdermal cell assembly for a transdermal diffusion instrument according to claim 1, characterized in that: The waste liquid pipe is connected to a third joint, the third joint is connected to one end of the exhaust pipe, the other end of the exhaust pipe is connected to a fourth joint, the side wall of the upper base is provided with a second threaded hole and a mounting hole, the fourth joint is threadedly connected to the second threaded hole, and a temperature probe is installed in the mounting hole.

6. A transdermal cell assembly for a transdermal diffusion instrument according to claim 5, characterized in that: The second threaded hole is connected to the exhaust hole, the exhaust hole is opened on the inner side of the side wall of the upper base, the second threaded hole is opened on the outer side of the side wall of the upper base, and the exhaust hole is coaxial with the second threaded hole and is arranged obliquely downward.

7. A transdermal cell assembly for a transdermal diffusion instrument according to claim 1, characterized in that: A circle of inclined conical surface is arranged in the middle of the bottom end of the pressing block, and the inclined conical surface is inclined from top to bottom toward the center line of the pressing block.

8. A transdermal cell assembly for a transdermal diffusion instrument according to claim 1, characterized in that: A limiting groove is provided at the upper end of the upper base, and the silicone gasket is arranged in the limiting groove.

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