L-prolinamide purity detection device

Abstract

The utility model discloses an L-prolinamide purity detection device, and relates to the technical field of L-prolinamide. The device comprises a control box, a control top cover and a material changing drawer, a mixing tank and a reagent storage tank are clamped and fixed to the inner side of the control box, a first material passing pipe is arranged on one side of the peripheral face of the control box, a second material passing pipe penetrates through the bottom of the peripheral face of the reagent storage tank in a clamped mode, and the control top cover is clamped and fixed to the top of the control box; a heating plate and an air pump are clamped and fixed to the bottom of the control top cover, a material changing drawer is clamped to one end of the control box in a sliding mode, a plurality of pressure sensing assemblies are clamped and fixed in the material changing drawer, and a detection test tube is arranged on the top of each pressure sensing assembly. According to the L-prolinamide purity detection device, the control box, the control top cover and the material changing drawer are arranged, so that the problems that although the L-prolinamide purity detection device is simple in structure and convenient to operate, the single titration amount is often difficult to control, and the detection result is influenced by the environment to a certain extent are solved.

Description

Technical Field

[0001] The utility model belongs to the technical field of L-prolineamide, and particularly relates to a purity detection device for L-prolineamide. Background Art

[0002] L-prolineamide is a chemical substance, mainly a white powdery solid, easy to absorb moisture, easily soluble in water, methanol, ethanol and other solvents, and solubility in ethyl acetate. It dissolves at high temperatures and slightly dissolves at low temperatures. As an important optically active pyrrole derivative, it can directly catalyze asymmetric Robinson cyclization reactions, Aldol reactions, etc. It can also be used as a chiral intermediate to synthesize certain chiral drugs. In the process of L-prolineamide processing, it is usually necessary to detect the purity of L-prolineamide to ensure the quality of the finished product produced subsequently. Usually, when L-prolineamide is detected by a purity detection device, a pH indicator is added to a solution containing L-prolineamide, and then titrated with a standard sodium hydroxide solution. The pH value is controlled to determine the endpoint and calculate the purity. The detection device has a simple structure and is easy to operate, but it still has the following disadvantages in actual use:

[0003] 1. When the device detects the purity of L-prolineamide, due to the difference in the purity of L-prolineamide in the solution, the titration amount is usually difficult to control, and the detection results are usually not accurate enough, resulting in large differences in the quality of the final product;

[0004] 2. When the device detects the purity of L-prolineamide, it is often necessary to dissolve L-prolineamide in a solvent to facilitate the subsequent observation of the test results. However, the solubility of L-prolineamide is affected by the environment, which may cause deviations between the test results and the actual situation. Utility Model Content

[0005] The utility model aims to provide an L-prolineamide purity detection device, which solves the problems that although the L-prolineamide purity detection device has a simple structure and is easy to operate, the amount of a single titration is often difficult to control, the detection result is not accurate enough, and the detection result is affected by the environment to a certain extent.

[0006] In order to solve the above technical problems, the utility model is realized by the following technical solutions:

[0007] The utility model discloses an L-prolineamide purity detection device, comprising a control box, a control top cover and a material change drawer, wherein a mixing tank and a reagent storage tank are fixedly connected to the inner side of the control box, a first material passing pipe is arranged on one side of the outer peripheral surface of the control box, a second material passing pipe is penetrated and connected to the bottom of the outer peripheral surface of the reagent storage tank, a control top cover is fixedly connected to the top of the control box, a heating plate and an air pump are fixedly connected to the bottom of the control top cover, a material change drawer is slidably connected to one end of the control box, a plurality of pressure sensing components are fixedly connected to the inside of the material change drawer, and a detection test tube is arranged on the top of each pressure sensing component;

[0008] The solvent and a certain amount of L-prolineamide can be mixed and stirred by the mixing tank to dissolve the L-prolineamide in the solvent, thereby improving the degree of automation of the device; the uniformly mixed L-prolineamide can be poured into multiple test tubes by the first feeding pipe, thereby facilitating the control of variables and improving the accuracy of the test results; the sodium hydroxide standard solution is stored in the reagent storage tank, and the sodium hydroxide standard solution can be dripped into multiple test tubes by the second feeding pipe, thereby facilitating the simultaneous detection of multiple L-prolineamide solutions; when the pH value of one portion of the solvent reaches a specified value, the titration is stopped, and the pH value of the solution in the multiple test tubes is calculated. To calculate the purity of L-prolineamide, since the amount of sodium hydroxide standard solution poured into multiple test tubes at the same time is nearly equal, the test results that do not meet the requirements can be eliminated with a slight difference, and the purity of the solution reaching the specified pH value can be calculated and the average value can be obtained to ensure the accuracy of the result without increasing the operating difficulty and structural complexity of the detection device. The control box can be heated by the heating plate, and the control box can be inflated or evacuated by the air pump to avoid deviations in the test results due to environmental factors. The pressure sensor can monitor the amount of solvent and the amount of sodium hydroxide standard solution in each test tube to facilitate subsequent calculations.

[0009] Furthermore, a first hopper is welded through the top of the mixing tank, a water inlet pipe is welded through the top of the outer circumference of the mixing tank, and a water outlet pipe is welded through the bottom of the outer circumference of the mixing tank. The water inlet pipe and the water outlet pipe are inserted and connected to one side of the control box, and the first hopper is connected to the top of the control cover;

[0010] Pour the solvent, L-prolineamide powder and pH indicator into the mixing tank, and mix the raw materials through the mixing tank. After the test is completed, pour clean water into the mixing tank through the water inlet pipe to clean the mixing tank to avoid affecting the next test.

[0011] Furthermore, a rotating motor is fixedly connected at the center of the top of the mixing tank, a stirring rod is fixedly connected at the bottom of the rotating motor, a stirring blade is fixedly welded on the outer peripheral surface of the stirring rod, the stirring rod is inserted through the top of the mixing tank, a liquid pump is connected through the bottom of the outer peripheral surface of the mixing tank, the first feeding pipe is connected through the top of the outer peripheral surface of the liquid pump, a plurality of first droppers are connected through the top of the first feeding pipe, and the plurality of first droppers are respectively suspended on the tops of a plurality of inspection test tubes;

[0012] The stirring blade can be driven to rotate by rotating the motor, and the solvent, L-prolineamide powder and pH indicator poured into the mixing tank are mixed and stirred, so that the L-prolineamide powder is dissolved in the solvent, and no manual operation is required, thereby improving the automation degree of the device. The solution can be slowly pumped into multiple first droppers by a liquid pump, and the solution is divided into multiple portions and poured into multiple detection test tubes for detection, thereby ensuring that the L-prolineamide concentrations of the solutions in the multiple detection test tubes are equal, facilitating the control of variables, and facilitating the subsequent judgment of the timing of stopping the titration of the sodium hydroxide standard solution, thereby ensuring the accuracy of the experimental results.

[0013] Furthermore, a second hopper is welded through the top of the reagent storage tank, a cylinder is clamped through the top of the reagent storage tank, a sealing plate is slidably clamped at the bottom of the cylinder, the sealing plate is attached to the inner wall of the reagent storage tank, a plurality of second droppers are clamped through the top of the second feed pipe, the second hopper is clamped through the top of the control top cover, and the plurality of second droppers are respectively suspended on the top of a plurality of test tubes;

[0014] The cylinder can drive the sealing pressing plate to move up and down, so that the sodium hydroxide standard solution inside the reagent storage tank is divided into multiple portions through the second feeding pipe and dripped into multiple detection test tubes, which is convenient for simultaneously testing multiple portions of L-prolineamide solution. When the pH value of one portion of the solvent reaches the specified value, the titration is stopped, and the operation is simple and convenient.

[0015] Furthermore, a control assembly is clamped and fixed on the top of the control cover, a ventilation pipe is clamped through the top of the air pump, and the ventilation pipe is inserted through the bottom of the control cover;

[0016] The control box can be heated by the heating plate, and the control box can be inflated or evacuated by the air pump, so as to avoid deviation of the test results due to environmental factors and ensure the accuracy of the test results.

[0017] Furthermore, a transparent acrylic plate is passed through one side of the material exchange drawer, a test tube rack is clamped and fixed on the top of each pressure sensor assembly, an anti-slip ring is clamped through the top of each test tube rack, and the test tube is inserted through the top of the anti-slip ring;

[0018] The transparent acrylic plate can be used to judge the state of the solutions in multiple test tubes. When the pH value of a solvent reaches the specified value, the titration is stopped. Since the amount of sodium hydroxide standard solution poured into multiple test tubes at the same time is almost equal, the test results that do not meet the requirements can be eliminated with a slight difference. The amount of solvent and the amount of sodium hydroxide standard solution in multiple test tubes can be obtained based on the pressure sensing component, and the purity of the solution that reaches the specified pH value can be calculated and the average value can be obtained, thereby improving the accuracy of the test results without increasing the difficulty of operation and the complexity of the device.

[0019] The utility model has the following beneficial effects:

[0020] 1. The utility model solves the problem that when the device detects the purity of L-prolineamide, the amount of titration is usually difficult to control due to the difference in the purity of L-prolineamide in the solution, and the detected result is usually not accurate enough, resulting in the problem that the quality of the final product may be greatly different. The liquid pump divides the solution in the mixing tank into multiple portions through the first feeding pipe and pours them into multiple detection test tubes, and divides the sodium hydroxide standard solution in the reagent storage tank into multiple portions through the second feeding pipe and slowly drips them into the multiple detection test tubes. When the pH value of one portion of the solvent reaches a specified value, the titration is stopped. Since the amount of the sodium hydroxide standard solution poured into the multiple detection test tubes at the same time is nearly equal, the detection results that do not meet the requirements can be eliminated with a slight difference, and the amount of the solvent in the multiple detection test tubes and the amount of the sodium hydroxide standard solution are obtained according to the pressure sensing component, and the purity of the solution reaching the specified pH value is calculated and the average value is obtained, thereby improving the accuracy of the detection result without increasing the difficulty of operation and the complexity of the device.

[0021] 2. The utility model solves the problem that when the device detects the purity of L-prolineamide, it is often necessary to dissolve L-prolineamide in a solvent to facilitate the subsequent observation of the test results, but the solubility of L-prolineamide is affected by the environment, which may lead to deviations between the test results and the actual situation. Before the purity of L-prolineamide is detected, when the ambient temperature is low, the control heating plate is controlled to heat the control box so that the solvent is at a suitable temperature for monitoring, and the air pump is used to evacuate or inflate the control box so that the control box is at a standard atmospheric pressure, thereby avoiding deviations in the test results due to environmental factors and ensuring the accuracy of the test results. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the structure of the utility model;

[0023] Figure 2 It is a structural effect diagram of the utility model;

[0024] Figure 3This is a structural diagram of the control box, mixing tank and reagent storage tank of the utility model;

[0025] Figure 4 It is a cross-sectional view of the mixing tank of the utility model;

[0026] Figure 5 It is a cross-sectional view of the reagent storage tank of the utility model;

[0027] Figure 6 This is a structural diagram of the control top cover of the utility model;

[0028] Figure 7 This is a bottom view of the control cover of the utility model;

[0029] Figure 8 This is a structural diagram of the material changing drawer of the utility model;

[0030] Fig. 9 This is a structural diagram of the test tube and pressure sensor assembly of the utility model.

[0031] Reference numerals:

[0032] 1. Control box; 101. Mixing tank; 102. Reagent storage tank; 103. First material pipe; 104. Second material pipe; 105. Water inlet pipe; 106. Water outlet pipe; 107. Rotating motor; 108. First hopper; 109. First dropper; 110. Liquid pump; 111. Stirring rod; 112. Stirring blade; 113. Second dropper; 114. Second hopper; 115. Cylinder; 116. Sealing plate; 2. Control top cover; 201. Control component; 202. Ventilation pipe; 203. Heating plate; 204. Air pump; 3. Material change drawer; 301. Inspection test tube; 302. Test tube rack; 303. Transparent acrylic plate; 304. Anti-slip ring; 305. Pressure sensor component. DETAILED DESCRIPTION

[0033] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0034] See also Figure 1-9As shown, the utility model is a L-prolineamide purity detection device, comprising a control box 1, a control top cover 2 and a material exchange drawer 3, a mixing tank 101 and a reagent storage tank 102 are fixedly connected to the inner side of the control box 1, a first material passing pipe 103 is arranged on one side of the outer peripheral surface of the control box 1, a second material passing pipe 104 is penetrated and connected to the bottom of the outer peripheral surface of the reagent storage tank 102, a control top cover 2 is fixedly connected to the top of the control box 1, a heating plate 203 and an air pump 204 are fixedly connected to the bottom of the control top cover 2, a material exchange drawer 3 is slidably connected to one end of the control box 1, a plurality of pressure sensing components 305 are fixedly connected to the inside of the material exchange drawer 3, and a detection test tube 301 is arranged on the top of each pressure sensing component 305;

[0035] Insert multiple test tubes 301 into the test tube rack 302 and close the material exchange drawer 3, pour the solvent, L-prolineamide powder, and pH indicator into the mixing tank 101 and stir and mix them through the mixing tank 101, and control the air pump 204 to inflate or evacuate air according to the ambient temperature and air pressure, so that the control box 1 is at a standard atmospheric pressure. When the ambient temperature is low, control the heating plate 203 to heat the control box 1 to a suitable temperature, start the liquid pump 110 to slowly pump the solution into the first feeding pipe 103, divide a certain amount of solution evenly, and drop multiple portions of solution into multiple test tubes 3 through multiple first droppers 109. 01, control the reagent storage tank 102 to press the sodium hydroxide standard solution into the second feeding pipe 104, divide a certain amount of the sodium hydroxide standard solution equally, and slowly drop multiple portions of the sodium hydroxide standard solution into multiple detection test tubes 301 through multiple second droppers 113, observe the state of the solution in the detection test tube 301, and stop titrating when the pH value of one portion of the solvent reaches a specified value. According to the pressure sensing component 305, the amount of the solvent in the multiple detection test tubes 301 and the amount of the sodium hydroxide standard solution are obtained, and the detection results whose pH value does not reach the specified value are eliminated, and the purity of the solution that reaches the specified pH value is calculated and the average value is obtained.

[0036] Among them Figure 1-5As shown, a first hopper 108 is welded through the top of the mixing tank 101, a water inlet pipe 105 is welded through the top of the outer circumference of the mixing tank 101, a water outlet pipe 106 is welded through the bottom of the outer circumference of the mixing tank 101, the water inlet pipe 105 and the water outlet pipe 106 are inserted through one side of the control box 1, the first hopper 108 is inserted through the top of the control cover 2, a rotating motor 107 is fixed to the center of the top of the mixing tank 101, a stirring rod 111 is fixed to the bottom of the rotating motor 107, a stirring blade 112 is welded and fixed to the outer circumference of the stirring rod 111, the stirring rod 111 is inserted through the top of the mixing tank 101, a liquid pump 110 is inserted through the bottom of the outer circumference of the mixing tank 101, the first feeding pipe 103 is inserted through the top of the outer circumference of the liquid pump 110, a plurality of first droppers 109 are inserted through the top of the first feeding pipe 103, and the plurality of first droppers 109 are respectively suspended on the top of a plurality of detection test tubes 301;

[0037] A second hopper 114 is welded through the top of the reagent storage tank 102, a cylinder 115 is clamped through the top of the reagent storage tank 102, a sealing plate 116 is slidably clamped at the bottom of the cylinder 115, and the sealing plate 116 is attached to the inner wall of the reagent storage tank 102. A plurality of second droppers 113 are clamped through the top of the second feed pipe 104, and the second hopper 114 is clamped through the top of the control top cover 2, and the plurality of second droppers 113 are respectively suspended on the top of the plurality of test tubes 301.

[0038] The solvent, L-prolineamide powder and pH indicator are poured into the mixing tank 101 through the first hopper 108, and the sodium hydroxide standard solution is poured into the reagent storage tank 102 through the second hopper 114. The rotating motor 107 is controlled to drive the stirring rod 111 and the stirring blade 112 to rotate, and the solvent, L-prolineamide powder and pH indicator are mixed and stirred to dissolve the L-prolineamide powder in the solvent. The liquid pump 110 is started to slowly pump the solution into the first feeding pipe 103, a certain amount of the solution is evenly divided, and multiple portions of the solution are dripped into multiple test tubes through multiple first droppers 109. In the tube 301, the start cylinder 115 drives the sealing pressure plate 116 to move downward, and the sodium hydroxide standard solution is pressed into the second feeding tube 104, a certain amount of the sodium hydroxide standard solution is evenly divided, and multiple portions of the sodium hydroxide standard solution are slowly dripped into multiple detection test tubes 301 through multiple second droppers 113, and the state of the solution in the detection test tube 301 is observed until the pH value of one portion of the solvent reaches a specified value. The titration is stopped. After the detection is completed, the water inlet pipe 105 is opened to pour clean water into the mixing tank 101, the mixing tank 101 is cleaned, and the waste water is discharged through the outlet pipe 106.

[0039] Among them Figure 1 , 2As shown in , 6 and 7, a control assembly 201 is fixedly connected to the top of the control cover 2, a vent pipe 202 is connected through the top of the air pump 204, and the vent pipe 202 is inserted through the bottom of the control cover 2;

[0040] The control component 201 records the structure monitored by the pressure sensor component 305. During the preparation work, the air pump 204 is controlled to inflate or evacuate air according to the ambient temperature and air pressure so that the control box 1 is at a standard atmospheric pressure. When the ambient temperature is low, the heating plate 203 is controlled to heat the control box 1 to a suitable temperature.

[0041] Among them Figure 1 , 2 As shown in , 8 and 9, a transparent acrylic plate 303 is passed through one side of the material exchange drawer 3, a test tube rack 302 is clamped and fixed on the top of each pressure sensor component 305, and an anti-slip ring 304 is clamped through the top of each test tube rack 302, and the detection test tube 301 is inserted into the top of the anti-slip ring 304;

[0042] Pull out the material exchange drawer 3 and insert multiple dry and uncontaminated test tubes 301 into multiple test tube racks 302, close the material exchange drawer 3 and judge the state of the solution in the multiple test tubes 301 through the transparent acrylic plate 303, stop titration when the pH value of a portion of the solvent reaches the specified value, obtain the amount of solvent in the multiple test tubes 301 and the amount of sodium hydroxide standard solution according to the pressure sensor component 305, eliminate the test results whose pH value does not reach the specified value, calculate the purity of the solution that reaches the specified pH value and find the average value, and take out the multiple test tubes 301 for cleaning after the test is completed.

[0043] The specific working principle of the utility model is as follows: when the purity of L-prolineamide needs to be tested, a certain amount of L-prolineamide powder, a certain amount of solvent and a pH indicator are weighed, a material exchange drawer 3 is pulled out and a plurality of dry and uncontaminated test tubes 301 are inserted into a plurality of test tube racks 302, the material exchange drawer 3 is closed and the air pump 204 is controlled to inflate or exhaust air according to the ambient temperature and air pressure, so that the control box 1 is at a standard atmospheric pressure. When the ambient temperature is low, the heating plate 203 is controlled to heat the control box 1. to a suitable temperature, pour the solvent, L-prolineamide powder and pH indicator into the mixing tank 101 through the first hopper 108, pour the sodium hydroxide standard solution into the reagent storage tank 102 through the second hopper 114, control the rotary motor 107 to drive the stirring rod 111 and the stirring blade 112 to rotate, mix and stir the solvent, L-prolineamide powder and pH indicator, dissolve the L-prolineamide powder in the solvent, start the liquid pump 110 to slowly pump the solution into the first feed pipe 103, and pump a certain amount of The solution is evenly divided, and multiple portions of the solution are dripped into multiple detection test tubes 301 through multiple first droppers 109, the cylinder 115 is started to drive the sealing plate 116 to move downward, and the sodium hydroxide standard solution is pressed into the second feeding pipe 104, a certain amount of sodium hydroxide standard solution is evenly divided, and multiple portions of the sodium hydroxide standard solution are slowly dripped into multiple detection test tubes 301 through multiple second droppers 113, and the state of the solution in the multiple detection test tubes 301 is judged by the transparent acrylic plate 303. When one portion When the pH value of the solvent reaches the specified value, the titration is stopped, and the amount of solvent in the multiple test tubes 301 and the amount of sodium hydroxide standard solution are obtained according to the pressure sensing component 305. The test results whose pH values ​​do not reach the specified values ​​are eliminated, and the purity of the solutions that reach the specified pH value is calculated and the average value is obtained. After the test is completed, the multiple test tubes 301 are taken out for cleaning, the water inlet pipe 105 is opened to pour clean water into the mixing tank 101, the mixing tank 101 is cleaned, and the waste water is discharged through the outlet pipe 106.

[0044] The above are only preferred embodiments of the present invention and do not limit the present invention. Any modification to the technical solutions recorded in the aforementioned embodiments and any equivalent replacement of some of the technical features therein, any modification, equivalent replacement, and improvement made are all within the protection scope of the present invention.

Claims

1. A L-prolineamide purity detection device, comprising a control box (1), a control top cover (2) and a material change drawer (3), characterized in that: A mixing tank (101) and a reagent storage tank (102) are snap-fitted and fixed on the inner side of the control box (1); a first material passage pipe (103) is arranged on one side of the outer peripheral surface of the control box (1); a second material passage pipe (104) is inserted and snap-fitted through the bottom of the outer peripheral surface of the reagent storage tank (102); a control top cover (2) is snap-fitted and fixed on the top of the control box (1); a heating plate (203) and an air pump (204) are snap-fitted and fixed on the bottom of the control top cover (2); a material exchange drawer (3) is slidably snap-fitted on one end of the control box (1); a plurality of pressure sensing components (305) are snap-fitted and fixed in the material exchange drawer (3); and a detection test tube (301) is arranged on the top of each of the pressure sensing components (305).

2. A L-prolineamide purity detection device according to claim 1, characterized in that: A first hopper (108) is welded through the top of the mixing tank (101), a water inlet pipe (105) is welded through the top of the outer peripheral surface of the mixing tank (101), and a water outlet pipe (106) is welded through the bottom of the outer peripheral surface of the mixing tank (101). The water inlet pipe (105) and the water outlet pipe (106) are inserted into one side of the control box (1), and the first hopper (108) is inserted into the top of the control cover (2).

3. A L-prolineamide purity detection device according to claim 1, characterized in that: A rotating motor (107) is fixedly connected at the center of the top of the mixing tank (101), a stirring rod (111) is fixedly connected to the bottom of the rotating motor (107), a stirring blade (112) is welded and fixedly connected to the outer peripheral surface of the stirring rod (111), the stirring rod (111) is inserted through the top of the mixing tank (101), a liquid pump (110) is inserted through the bottom of the outer peripheral surface of the mixing tank (101), the first material passage pipe (103) is inserted through the top of the outer peripheral surface of the liquid pump (110), a plurality of first droppers (109) are inserted through the top of the first material passage pipe (103), and the plurality of first droppers (109) are respectively suspended on the tops of a plurality of detection test tubes (301).

4. A L-prolineamide purity detection device according to claim 1, characterized in that: A second hopper (114) is welded through the top of the reagent storage tank (102), a cylinder (115) is clamped through the top of the reagent storage tank (102), a sealing plate (116) is slidably clamped at the bottom of the cylinder (115), and the sealing plate (116) is attached to the inner wall of the reagent storage tank (102), a plurality of second droppers (113) are clamped through the top of the second feed pipe (104), the second hopper (114) is clamped through the top of the control top cover (2), and the plurality of second droppers (113) are respectively suspended on the top of a plurality of detection test tubes (301).

5. A L-prolineamide purity detection device according to claim 1, characterized in that: A control assembly (201) is clamped and fixed on the top of the control top cover (2), a ventilation pipe (202) is clamped through the top of the air pump (204), and the ventilation pipe (202) is inserted through the bottom of the control top cover (2).

6. A L-prolineamide purity detection device according to claim 1, characterized in that: A transparent acrylic plate (303) is passed through one side of the material exchange drawer (3); a test tube rack (302) is clamped and fixed on the top of each pressure sensor assembly (305); an anti-slip ring (304) is clamped through the top of each test tube rack (302); and the detection test tube (301) is inserted into the top of the anti-slip ring (304).

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