Brivaracetam intermediate synthesis temperature control reaction kettle

Abstract

The utility model relates to the technical field of medicine preparation, in particular to a brivaracetam intermediate synthesis temperature control reaction kettle, which not only enables raw materials to be heated more uniformly and ensures the synthesis effect of a brivaracetam intermediate, but also accelerates the cooling of the intermediate after synthesis, facilitates the subsequent reaction and improves the working efficiency. Through double heating of the heating plate and water circulation, the heating rate is increased; comprising a reaction kettle; the device further comprises a feeding mechanism, a driving mechanism, a stirring mechanism, a water circulation mechanism and an air exhaust mechanism, the feeding mechanism is installed on the reaction kettle and facilitates feeding of raw materials, the driving mechanism is installed on the reaction kettle and provides power for the stirring mechanism and the water circulation mechanism, and the stirring mechanism is installed on the reaction kettle and heats and stirs the raw materials. The water circulation mechanism is mounted on the reaction kettle and is used for conveniently heating and cooling raw materials, and the air extraction mechanism is mounted on the reaction kettle and is used for extracting air in the reaction kettle.

Description

Technical Field

[0001] The utility model relates to the technical field of drug preparation, in particular to a temperature-controlled reaction kettle for synthesizing a brivaracetam intermediate. Background Art

[0002] Brivaracetam is an anti-epileptic drug developed by UCB Pharmaceuticals of Belgium. In the central nervous system, SV2A plays a key role in maintaining the function of the central nervous system and is also related to the pathophysiology of epilepsy. Brivaracetam can serve as a selective and high-affinity ligand for SV2A and can therefore be used to inhibit the onset of epilepsy.

[0003] The existing Bu Wa Xi Tam intermediate synthesis temperature-controlled reactor, for example, a high-yield preparation method of Bu Wa Xi Tam disclosed in the invention patent with application number 202111677150.2, has a main structure including a constant temperature reactor including a reactor body, a temperature sensor is provided in the reactor body, a heating tube is spirally coiled on the reactor body, a water tank is provided on one side of the reactor body, the water tank is divided into a hot water area and a cold water area, the heating tube is connected with a water inlet pipe, the water tank is provided with a hot water pipe connected to the hot water area and a cold water pipe connected to the cold water area, the hot water pipe and the cold water pipe are both connected to the water inlet pipe, a rotatable rotating shaft is provided in the water inlet pipe, a sealing plate for blocking the hot water pipe or the cold water pipe is provided on the rotating shaft, and a rotating assembly for driving the rotating shaft to rotate is provided on the water inlet pipe; when in use, the raw materials are put into the constant temperature reactor, heated to 60 ° C, reacted for 4 hours, after the reaction is completed, the temperature is reduced to room temperature, 50g of water is added to the constant temperature reactor, stirred and allowed to stand for 30 minutes, the organic phase and the aqueous phase are separated, and the organic phase is concentrated under reduced pressure to obtain the Bu Wa Xi Tam intermediate.

[0004] However, most of the existing temperature-controlled reactors are heated unevenly, so that the raw materials are heated unevenly, affecting the reaction effect, and the heating efficiency is slow, wasting a lot of time. Utility Model Content

[0005] In order to solve the above technical problems, the utility model provides a Bu Wa racetam intermediate synthesis temperature control reactor which not only makes the raw materials heated more evenly and ensures the synthesis effect of the Bu Wa racetam intermediate, but also accelerates the cooling of the intermediate after synthesis, facilitates subsequent reactions, improves work efficiency, and improves the heating rate through dual heating of a heating plate and water circulation.

[0006] The utility model discloses a Bu Waxitan intermediate synthesis temperature control reactor, comprising a reactor; further comprising a feeding mechanism, a driving mechanism, a stirring mechanism, a water circulation mechanism and an exhaust mechanism, wherein the feeding mechanism is installed on the reactor and is convenient for feeding raw materials, the driving mechanism is installed on the reactor and provides power for the stirring mechanism and the water circulation mechanism, the stirring mechanism is installed on the reactor and heats and stirs the raw materials, the water circulation mechanism is installed on the reactor and is convenient for heating and cooling the raw materials, and the exhaust mechanism is installed on the reactor and extracts the air in the reactor; a worker feeds the raw materials into the reactor through the feeding mechanism and then closes the feeding mechanism to make the reactor in a sealed state, the reactor heats the raw materials, and at the same time the driving mechanism drives the stirring mechanism to rotate and stir the raw materials, and at the same time the water circulation mechanism transports hot water into the stirring mechanism to enhance the heating effect on the raw materials, and at the same time the exhaust mechanism extracts the air in the reactor, and after the reaction is finished, the water circulation mechanism transports cold water into the stirring mechanism again to accelerate the cooling of the raw materials.

[0007] Preferably, the reactor comprises a bracket, a reactor body, a heating plate, a discharge pipe and a valve. The bracket is installed on the ground, the bottom end of the reactor body is connected to the top end of the bracket, a cavity is arranged inside the reactor body, a feed port is provided at the top end of the reactor body and is connected to the cavity of the reactor body, a discharge port is provided at the bottom end of the reactor body and is connected to the cavity of the reactor body, the heating plate is wrapped and installed on the outer wall of the reactor body, the top end of the discharge pipe is connected to the bottom end of the reactor body and is connected to the inside of the discharge port of the reactor body, and the valve is installed on the discharge pipe; after the raw materials are delivered into the cavity of the reactor body, the heating plate heats the reactor body, thereby increasing the temperature in the cavity of the reactor body, so that the raw materials reach the required reaction temperature, and after the reaction is completed, the valve is opened, and the intermediate is discharged from the reactor through the discharge pipe.

[0008] Preferably, the feeding mechanism includes a feed pipe, a feed barrel, a hinge, a sealing cover and a handle. The bottom end of the feed pipe is connected to the top of the kettle body and communicated with the inside of the feed port of the kettle body. The bottom end of the feed barrel is communicated with the inside of the top of the feed pipe. The hinge is rotatably installed on the feed barrel, the sealing cover is installed on the hinge, and the handle is installed on the sealing cover. The worker operates the handle to open the sealing cover and feed the raw materials into the feed barrel. The raw materials enter the cavity of the kettle body through the feed barrel and the feed pipe. Then the worker operates the handle to close and lock the sealing cover to prevent the cavity of the bracket from exchanging gas with the outside world.

[0009] Preferably, the driving mechanism includes a support frame, an electric motor, a reducer, a transmission shaft 1 and a gear 1, the bottom end of the support frame is connected to the top of the kettle body, the bottom end of the electric motor is connected to the top of the support frame, the bottom end of the reducer is connected to the top of the support frame, the transmission shaft 1 is rotatably mounted on the support frame and longitudinally connected to the reducer, and the gear 1 is mounted on the transmission shaft 1; start the electric motor, the electric motor drives the transmission shaft 1 to rotate through the reducer, the transmission shaft 1 drives the gear 1 to rotate, the gear 1 is meshed with the stirring mechanism to provide power for the stirring mechanism, and the reducer provides power for the water circulation mechanism and the air extraction mechanism.

[0010] Preferably, the stirring mechanism includes a sleeve, gear 2, a heat pipe, a partition, a stirring rod and a water distributor. The sleeve is rotatably mounted on the top of the kettle body, gear 2 is mounted on the sleeve, the heat pipe is mounted on gear 2 and is located in the cavity of the kettle body, the partition is mounted inside gear 2 and divides the inside of the heat pipe into two parts, multiple groups of stirring rods are mounted on the heat pipe and connected to the inside of the heat pipe, the bottom end of the water distributor is connected to the top of the sleeve and connected to the inside of the sleeve and gear 2; gear 1 and gear 2 are meshed for transmission, gear 2 drives the sleeve and the heat pipe to rotate, the heat pipe drives the stirring rod to rotate to stir the raw materials, hot water enters the heat pipe through the water distributor and is transported to multiple groups of stirring rods, and then the hot water is transported out through the heat pipe and the water distributor, and the partition is provided to facilitate the circulation of water in the heat pipe, the stirring rod and the water distributor.

[0011] Preferably, the water circulation mechanism includes a second transmission shaft, a water pump, a first water pipe, a first cold water pipe, a second valve, a second water pipe, a return pipe, a heating box, an electric heating wire, a water inlet pipe and a third valve. The second transmission shaft is rotatably mounted on the reducer, the bottom end of the water pump is connected to the top end of the support frame, one end of the first water pipe is connected to the water pump, the first cold water pipe is mounted on the first water pipe and communicates with the inside of the first water pipe, the second valve is mounted on the first cold water pipe, one end of the second water pipe is communicated with the inside of the water pump, the other end of the second water pipe is communicated with the water inlet of the water distributor, the return pipe is connected with the drain outlet of the water distributor, the bottom end of the heating box is connected to the top end of the kettle body, an inner cavity is provided inside the heating box, a plurality of groups of electric heating wires are mounted in the inner cavity of the heating box, the water inlet pipe is mounted on the side wall of the heating box and communicates with the inner cavity of the heating box , valve three is installed on the water inlet pipe, and the other end of the water delivery pipe one is connected to the inner cavity of the heating box; open valve three, the water inlet pipe is connected to the external water source, and water is delivered into the heating box through valve three, and then close valve three, and the electric heating wire heats it. After the heating is completed, the reducer drives the transmission shaft two to rotate, and the transmission shaft two starts the water pump. The water pump draws out the hot water in the heating box through the water delivery pipe one, and delivers it into the water distributor through the water delivery pipe two, and then the circulated water enters the return pipe through the water distributor, and the return pipe delivers the circulated water to the heating box again for heating. When the reaction is completed, the cold water pipe one is connected to the external water source, open valve three and valve two, and the water pump delivers cold water into the water distributor through the water delivery pipe one and the water delivery pipe two to accelerate the cooling of the intermediate after the reaction.

[0012] Preferably, the vacuum mechanism includes a transmission shaft three, an air pump, an vacuum pipe and a valve four, the transmission shaft three is rotatably mounted on the reducer, the bottom end of the air pump is connected to the top end of the support frame, one end of the vacuum pipe is mounted on the air pump, the other end of the air pump is connected to the interior of the cavity of the kettle body, and the valve four is mounted on the vacuum pipe; when the valve four is opened, the reducer drives the transmission shaft three to rotate, the transmission shaft three drives the air pump to work, and the air pump extracts the gas in the cavity of the kettle body through the vacuum pipe, so that the cavity of the kettle body is in a negative pressure state, thereby accelerating the reaction of the raw materials.

[0013] Compared with the prior art, the utility model has the following beneficial effects: workers feed the raw materials into the reactor through the feeding mechanism and then close the feeding mechanism to make the reactor in a sealed state, the reactor heats the raw materials, and at the same time the driving mechanism drives the stirring mechanism to rotate to stir the raw materials, and at the same time the water circulation mechanism transports hot water into the stirring mechanism to enhance the heating effect on the raw materials, and at the same time the exhaust mechanism extracts the air in the reactor, and after the reaction is completed, the water circulation mechanism again transports cold water into the stirring mechanism to accelerate the cooling of the raw materials. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a schematic diagram of the cross-section axonometric structure of the utility model;

[0015] Figure 2 It is a rear cross-sectional structural schematic diagram of the reaction kettle, feeding mechanism and stirring mechanism of the utility model;

[0016] Figure 3 It is a partially enlarged front view structural diagram of the driving mechanism and stirring mechanism of the utility model;

[0017] Figure 4 It is a top structural schematic diagram of the water circulation mechanism and the air extraction mechanism of the utility model;

[0018] Figure 5 It is a partially enlarged sectional axonometric structural schematic diagram of the water circulation mechanism of the utility model.

[0019] Markings in the attached drawings: 01, reactor; 11, bracket; 12, reactor body; 13, heating plate; 14, discharge pipe; 15, valve 1; 02, feeding mechanism; 21, feeding pipe; 22, feeding barrel; 23, hinge; 24, sealing cover; 25, handle; 03, driving mechanism; 31, support frame; 32, motor; 33, reducer; 34, transmission shaft 1; 35, gear 1; 04, stirring mechanism; 41, sleeve; 42, gear 2; 43. Heat transfer pipe; 44. Partition; 45. Stirring rod; 46. Water distributor; 05. Water circulation mechanism; 51. Transmission shaft two; 52. Water pump; 53. Water pipe one; 54. Cold water pipe one; 55. Valve two; 56. Water pipe two; 57. Return pipe; 58. Heating box; 59. Electric heating wire; 60. Water inlet pipe; 61. Valve three; 07. Exhaust mechanism; 71. Transmission shaft three; 72. Air pump; 73. Exhaust pipe; 74. Valve four. DETAILED DESCRIPTION

[0020] In order to facilitate the understanding of the utility model, the utility model will be described more comprehensively below with reference to the relevant drawings. The utility model can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the utility model more thorough and comprehensive.

[0021] Example 1

[0022] The utility model discloses a temperature-controlled reactor for the synthesis of a Bu Waxitan intermediate, comprising a reactor 01; a feeding mechanism 02, a driving mechanism 03, a stirring mechanism 04, a water circulation mechanism 05 and an exhaust mechanism 07, wherein the feeding mechanism 02 is installed on the reactor 01 and is convenient for feeding raw materials, the driving mechanism 03 is installed on the reactor 01 and provides power for the stirring mechanism 04 and the water circulation mechanism 05, the stirring mechanism 04 is installed on the reactor 01 and heats and stirs the raw materials, the water circulation mechanism 05 is installed on the reactor 01 and is convenient for heating and cooling the raw materials, and the exhaust mechanism 07 is installed on the reactor 01 and extracts the air in the reactor 01; the reactor 01 comprises A bracket 11, a kettle body 12, a heating plate 13, a discharge pipe 14 and a valve 15, the bracket 11 is installed on the ground, the bottom end of the kettle body 12 is connected to the top end of the bracket 11, a cavity is arranged inside the kettle body 12, a feed port is opened at the top end of the kettle body 12 and communicates with the cavity of the kettle body 12, a discharge port is opened at the bottom end of the kettle body 12 and communicates with the cavity of the kettle body 12, the heating plate 13 is wrapped and installed on the outer wall of the kettle body 12, the top end of the discharge pipe 14 is connected to the bottom end of the kettle body 12 and communicates with the inside of the discharge port of the kettle body 12, and the valve 15 is installed on the discharge pipe 14; the feeding mechanism 02 includes a feed pipe 21, a feed barrel 22, a hinge 23, a sealing cover 24 and a handle 2 5, the bottom end of the feed pipe 21 is connected to the top of the kettle body 12 and communicated with the inside of the feed port of the kettle body 12, the bottom end of the feed barrel 22 is communicated with the inside of the top of the feed pipe 21, the hinge 23 is rotatably mounted on the feed barrel 22, the sealing cover 24 is mounted on the hinge 23, and the handle 25 is mounted on the sealing cover 24; the driving mechanism 03 includes a support frame 31, a motor 32, a reducer 33, a transmission shaft 34 and a gear 35, the bottom end of the support frame 31 is connected to the top of the kettle body 12, the bottom end of the motor 32 is connected to the top of the support frame 31, the bottom end of the reducer 33 is connected to the top of the support frame 31, the transmission shaft 34 is rotatably mounted on the support frame 31 and communicated with the reducer The machine 33 is connected longitudinally, and the gear 1 35 is installed on the transmission shaft 1 34; the stirring mechanism 04 includes a sleeve 41, a gear 2 42, a heat pipe 43, a partition 44, a stirring rod 45 and a water distributor 46. The sleeve 41 is rotatably installed on the top of the kettle body 12, the gear 2 42 is installed on the sleeve 41, the heat pipe 43 is installed on the gear 2 42 and is located in the cavity of the kettle body 12, the partition 44 is installed inside the gear 2 42 and divides the inside of the heat pipe 43 into two parts, multiple groups of stirring rods 45 are installed on the heat pipe 43 and communicate with the inside of the heat pipe 43, and the bottom end of the water distributor 46 is connected to the top of the sleeve 41 and communicates with the inside of the sleeve 41 and the gear 2 42;The water circulation mechanism 05 includes a transmission shaft 2 51, a water pump 52, a water pipe 1 53, a cold water pipe 1 54, a valve 2 55, a water pipe 2 56, a return pipe 57, a heating box 58, an electric heating wire 59, a water inlet pipe 60 and a valve 3 61. The transmission shaft 2 51 is rotatably mounted on the reducer 33, the bottom end of the water pump 52 is connected to the top end of the support frame 31, one end of the water pipe 1 53 is connected to the water pump 52, the cold water pipe 1 54 is mounted on the water pipe 1 53 and communicated with the inside of the water pipe 1 53, the valve 2 55 is mounted on the cold water pipe 1 54, and the water pipe One end of the second water pipe 56 is connected to the inside of the water pump 52, the other end of the water delivery pipe 56 is connected to the water inlet of the water distributor 46, the return pipe 57 is connected to the drain of the water distributor 46, the bottom end of the heating box 58 is connected to the top of the kettle body 12, the interior of the heating box 58 is provided with an inner cavity, a plurality of groups of electric heating wires 59 are installed in the inner cavity of the heating box 58, the water inlet pipe 60 is installed on the side wall of the heating box 58 and is connected to the inner cavity of the heating box 58, the valve three 61 is installed on the water inlet pipe 60, and the other end of the water delivery pipe 1 53 is connected to the inner cavity of the heating box 58;When it is working, first, the worker operates the handle 25 to open the sealing cover 24, and feeds the raw material into the feed barrel 22. The raw material enters the cavity of the kettle body 12 through the feed barrel 22 and the feed pipe 21. Then the worker operates the handle 25 to close and lock the sealing cover 24 to prevent the cavity of the bracket 11 from exchanging gas with the outside world, and starts the motor 32. The motor 32 drives the transmission shaft 1 34 to rotate through the reducer 33. The transmission shaft 1 34 drives the gear 1 35 to rotate. The gear 1 35 and the gear 2 42 meshes with the transmission, the second gear 42 drives the sleeve 41 and the heat pipe 43 to rotate, the heat pipe 43 drives the stirring rod 45 to rotate to stir the raw materials, and at the same time, the valve three 61 is opened, the water inlet pipe 60 is connected to the external water source, and the water is transported into the heating box 58 through the valve three 61, and then the valve three 61 is closed, and the electric heating wire 59 heats it. After the heating is completed, the reducer 33 drives the transmission shaft two 51 to rotate, the transmission shaft two 51 starts the water pump 52 to work, and the water pump 52 passes through the water pipe one 53 The hot water in the heating box 58 is extracted and transported into the water distributor 46 through the water delivery pipe 56. The hot water enters the heat pipe 43 through the water distributor 46 and is transported to the multiple groups of stirring rods 45. The hot water is then transported out through the heat pipe 43 and the water distributor 46. The partition 44 is provided to facilitate the circulation of water in the heat pipe 43, the stirring rod 45 and the water distributor 46. The circulated water then enters the return pipe 57 through the water distributor 46. The return pipe 57 transports the circulated water to the heating box 58 again. The heat box 58 is heated again, and the heating plate 13 heats the kettle body 12, thereby increasing the temperature in the cavity of the kettle body 12, so that the raw materials reach the required temperature for the reaction. When the reaction is completed, the cold water pipe 1 54 is connected to the external water source, and the valve 3 61 and the valve 2 55 are opened. The water pump 52 delivers cold water into the water distributor 46 through the water pipe 1 53 and the water pipe 2 56 to accelerate the cooling of the intermediate after the reaction. After the cooling is completed, the valve 15 is opened, and the intermediate is discharged from the reactor through the discharge pipe 14. ;

[0023] Example 2

[0024] like Figures 1 to 5As shown, the utility model is a temperature-controlled reactor for the synthesis of Bu Waxitan intermediates, including a reactor 01; and also including a feeding mechanism 02, a driving mechanism 03, a stirring mechanism 04, a water circulation mechanism 05 and an exhaust mechanism 07. The feeding mechanism 02 is installed on the reactor 01 and is convenient for feeding raw materials. The driving mechanism 03 is installed on the reactor 01 and provides power for the stirring mechanism 04 and the water circulation mechanism 05. The stirring mechanism 04 is installed on the reactor 01 and heats and stirs the raw materials. The water circulation mechanism 05 is installed on the reactor 01 and is convenient for heating and cooling the raw materials. The exhaust mechanism 07 is installed on the reactor 01 and extracts the air in the reactor 01; the reactor 0 1 includes a bracket 11, a kettle body 12, a heating plate 13, a discharge pipe 14 and a valve 15, the bracket 11 is installed on the ground, the bottom end of the kettle body 12 is connected to the top end of the bracket 11, the kettle body 12 is provided with a cavity inside, the top end of the kettle body 12 is provided with a feed port and communicated with the cavity of the kettle body 12, the bottom end of the kettle body 12 is provided with a discharge port and communicated with the cavity of the kettle body 12, the heating plate 13 is wrapped and installed on the outer wall of the kettle body 12, the top end of the discharge pipe 14 is connected to the bottom end of the kettle body 12 and communicated with the discharge port of the kettle body 12, and the valve 15 is installed on the discharge pipe 14; the feeding mechanism 02 includes a feed pipe 21, a feed cylinder 22, a hinge 23, a sealing cover 24 and a handle The bottom end of the feed pipe 21 is connected to the top of the kettle body 12 and communicates with the inside of the feed port of the kettle body 12, the bottom end of the feed barrel 22 is connected to the inside of the top of the feed pipe 21, the hinge 23 is rotatably mounted on the feed barrel 22, the sealing cover 24 is mounted on the hinge 23, and the handle 25 is mounted on the sealing cover 24; the driving mechanism 03 includes a support frame 31, a motor 32, a reducer 33, a transmission shaft 34 and a gear 35, the bottom end of the support frame 31 is connected to the top of the kettle body 12, the bottom end of the motor 32 is connected to the top of the support frame 31, the bottom end of the reducer 33 is connected to the top of the support frame 31, the transmission shaft 34 is rotatably mounted on the support frame 31 and communicates with the reducer The speed machine 33 is longitudinally connected, and the gear 1 35 is installed on the transmission shaft 1 34; the stirring mechanism 04 includes a sleeve 41, a gear 2 42, a heat pipe 43, a partition 44, a stirring rod 45 and a water distributor 46, the sleeve 41 is rotatably installed on the top of the kettle body 12, the gear 2 42 is installed on the sleeve 41, the heat pipe 43 is installed on the gear 2 42 and is located in the cavity of the kettle body 12, the partition 44 is installed inside the gear 2 42 and divides the inside of the heat pipe 43 into two parts, multiple groups of stirring rods 45 are installed on the heat pipe 43 and communicate with the inside of the heat pipe 43, and the bottom end of the water distributor 46 is connected to the top of the sleeve 41 and communicates with the inside of the sleeve 41 and the gear 2 42;The water circulation mechanism 05 includes a transmission shaft 2 51, a water pump 52, a water pipe 1 53, a cold water pipe 1 54, a valve 2 55, a water pipe 2 56, a return pipe 57, a heating box 58, an electric heating wire 59, a water inlet pipe 60 and a valve 3 61. The transmission shaft 2 51 is rotatably mounted on the reducer 33. The bottom end of the water pump 52 is connected to the top end of the support frame 31. One end of the water pipe 1 53 is connected to the water pump 52. The cold water pipe 1 54 is mounted on the water pipe 1 53 and communicated with the inside of the water pipe 1 53. The valve 2 55 is mounted on the cold water pipe 1 54. One end of the water pipe 2 56 is communicated with the inside of the water pump 52. The other end of the water pipe 2 56 is communicated with the water inlet of the water distributor 46. The return pipe 57 is communicated with the drain outlet of the water distributor 46. The heating box 5 The bottom end of the heating box 58 is connected to the top of the kettle body 12, the interior of the heating box 58 is provided with an inner cavity, a plurality of groups of electric heating wires 59 are installed in the inner cavity of the heating box 58, a water inlet pipe 60 is installed on the side wall of the heating box 58 and communicates with the inner cavity of the heating box 58, a valve three 61 is installed on the water inlet pipe 60, and the other end of the water delivery pipe one 53 is communicated with the inner cavity of the heating box 58; the exhaust mechanism 07 includes a transmission shaft three 71, an air pump 72, an exhaust pipe 73 and a valve four 74, the transmission shaft three 71 is rotatably installed on the reducer 33, the bottom end of the air pump 72 is connected to the top of the support frame 31, one end of the exhaust pipe 73 is installed on the air pump 72, the other end of the air pump 72 is communicated with the cavity of the kettle body 12, and the valve four 74 is installed on the exhaust pipe 73;When it is working, first, the worker operates the handle 25 to open the sealing cover 24, and feeds the raw material into the feed barrel 22. The raw material enters the cavity of the kettle body 12 through the feed barrel 22 and the feed pipe 21. Then the worker operates the handle 25 to close and lock the sealing cover 24 to prevent the cavity of the bracket 11 from exchanging gas with the outside world, and opens the valve four 74. The reducer 33 drives the transmission shaft three 71 to rotate, and the transmission shaft three 71 drives the air pump 72 to work. The air pump 72 extracts the gas in the cavity of the kettle body 12 through the exhaust pipe 73, so that the cavity of the kettle body 12 is in a negative pressure. state, accelerate the reaction of the raw materials, start the motor 32, the motor 32 drives the transmission shaft 1 34 to rotate through the reducer 33, the transmission shaft 1 34 drives the gear 1 35 to rotate, the gear 1 35 and the gear 2 42 are meshed for transmission, the gear 2 42 drives the sleeve 41 and the heat pipe 43 to rotate, the heat pipe 43 drives the stirring rod 45 to rotate to stir the raw materials, and at the same time, the valve 3 61 is opened, the water inlet pipe 60 is connected to the external water source, the water is transported into the heating box 58 through the valve 3 61, and then the valve 3 61 is closed, and the electric heating wire 59 heats it. After the heating is completed The reducer 33 drives the transmission shaft 2 51 to rotate, and the transmission shaft 2 51 starts the water pump 52 to work. The water pump 52 extracts the hot water in the heating box 58 through the water pipe 1 53, and transports it into the water distributor 46 through the water pipe 2 56. The hot water enters the heat pipe 43 through the water distributor 46, and is transported to the multiple groups of stirring rods 45, and then the hot water is transported out through the heat pipe 43 and the water distributor 46. By setting the partition 44, it is convenient for water to circulate in the heat pipe 43, the stirring rod 45 and the water distributor 46, and then the circulated water enters the return water through the water distributor 46. In the pipe 57, the return pipe 57 transports the circulated water to the heating box 58 for reheating. The heating plate 13 heats the kettle 12, thereby increasing the temperature in the cavity of the kettle 12, so that the raw materials reach the required temperature for the reaction. When the reaction is completed, the cold water pipe 1 54 is connected to the external water source, the valve 3 61 and the valve 2 55 are opened, and the water pump 52 transports the cold water into the water distributor 46 through the water pipe 1 53 and the water pipe 2 56 to accelerate the cooling of the intermediate after the reaction. After the cooling is completed, the valve 15 is opened, and the intermediate is discharged from the reactor through the discharge pipe 14. ;

[0025] The electric motor 32, reducer 33, water pump 52 and air pump 72 of the utility model are purchased on the market, and technicians in the industry only need to install and operate them according to the accompanying instruction manuals, without the need for creative work by technicians in this field.

[0026] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the technical principle of the present invention. These improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A temperature-controlled reactor for synthesizing a brivaracetam intermediate, comprising a reactor (01); characterized in that: The reactor (01) further comprises a feeding mechanism (02), a driving mechanism (03), a stirring mechanism (04), a water circulation mechanism (05) and an exhaust mechanism (07). The feeding mechanism (02) is mounted on the reactor (01) and is convenient for feeding raw materials. The driving mechanism (03) is mounted on the reactor (01) and provides power for the stirring mechanism (04) and the water circulation mechanism (05). The stirring mechanism (04) is mounted on the reactor (01) and is used to heat and stir the raw materials. The water circulation mechanism (05) is mounted on the reactor (01) and is convenient for heating and cooling the raw materials. The exhaust mechanism (07) is mounted on the reactor (01) and is used to extract the air in the reactor (01). The reactor (01) comprises a support (11), a reactor body (12), a heating plate (13), a discharge pipe (14) and a valve (15). The support (11) is mounted on the ground. The bottom end of the reactor body (12) is connected to the top end of the support (11). The interior of the reactor body (12) is provided with The kettle body (12) has a cavity, a feed port is formed at the top end of the kettle body (12) and is connected to the cavity of the kettle body (12), a discharge port is formed at the bottom end of the kettle body (12) and is connected to the cavity of the kettle body (12), a heating plate (13) is wrapped and installed on the outer wall of the kettle body (12), a discharge pipe (14) has a top end connected to the bottom end of the kettle body (12) and is connected to the inside of the discharge port of the kettle body (12), and a valve (15) is installed on the discharge pipe (14); the feeding mechanism (02) includes a feed pipe (21), a feeding barrel (22), a hinge (23), a sealing cover (24) and a handle (25), the bottom end of the feeding pipe (21) is connected to the top end of the kettle body (12) and communicates with the inside of the feeding port of the kettle body (12), the bottom end of the feeding barrel (22) is communicated with the inside of the top end of the feeding pipe (21), the hinge (23) is rotatably mounted on the feeding barrel (22), the sealing cover (24) is mounted on the hinge (23), and the handle (25) is mounted on the sealing cover (24).

2. A temperature-controlled reactor for synthesizing a brivaracetam intermediate according to claim 1, characterized in that: The driving mechanism (03) comprises a support frame (31), a motor (32), a reducer (33), a transmission shaft (34) and a gear (35); the bottom end of the support frame (31) is connected to the top end of the kettle body (12); the bottom end of the motor (32) is connected to the top end of the support frame (31); the bottom end of the reducer (33) is connected to the top end of the support frame (31); the transmission shaft (34) is rotatably mounted on the support frame (31) and longitudinally connected to the reducer (33); and the gear (35) is mounted on the transmission shaft (34).

3. A temperature-controlled reactor for synthesizing a brivaracetam intermediate according to claim 1, characterized in that: The stirring mechanism (04) comprises a sleeve (41), a second gear (42), a heat conducting pipe (43), a partition (44), a stirring rod (45) and a water distributor (46). The sleeve (41) is rotatably mounted on the top of the kettle body (12). The second gear (42) is mounted on the sleeve (41). The heat conducting pipe (43) is mounted on the second gear (42) and is located in the cavity of the kettle body (12). The partition (44) is mounted inside the second gear (42) and divides the inside of the heat conducting pipe (43) into two parts. A plurality of stirring rods (45) are mounted on the heat conducting pipe (43) and are connected to the inside of the heat conducting pipe (43). The bottom end of the water distributor (46) is connected to the top of the sleeve (41) and is connected to the inside of the sleeve (41) and the second gear (42).

4. A temperature-controlled reactor for synthesizing a brivaracetam intermediate as claimed in claim 3, characterized in that: The water circulation mechanism (05) comprises a transmission shaft 2 (51), a water pump (52), a water pipe 1 (53), a cold water pipe 1 (54), a valve 2 (55), a water pipe 2 (56), a return pipe (57), a heating box (58), an electric heating wire (59), a water inlet pipe (60) and a valve 3 (61). The transmission shaft 2 (51) is rotatably mounted on the reducer (33). The bottom end of the water pump (52) is connected to the top end of the support frame (31). One end of the water pipe 1 (53) is connected to the water pump (52). The cold water pipe 1 (54) is mounted on the water pipe 1 (53) and communicated with the inside of the water pipe 1 (53). The valve 2 (55) is mounted on the cold water pipe 1 (54). One end of the water delivery pipe (56) is connected to the interior of the water pump (52), the other end of the water delivery pipe (56) is connected to the water inlet of the water distributor (46), the return pipe (57) is connected to the drain outlet of the water distributor (46), the bottom end of the heating box (58) is connected to the top end of the kettle body (12), the interior of the heating box (58) is provided with an inner cavity, a plurality of groups of electric heating wires (59) are installed in the inner cavity of the heating box (58), the water inlet pipe (60) is installed on the side wall of the heating box (58) and is connected to the inner cavity of the heating box (58), the valve (61) is installed on the water inlet pipe (60), and the other end of the water delivery pipe (53) is connected to the inner cavity of the heating box (58).

5. A temperature-controlled reactor for synthesizing a brivaracetam intermediate as claimed in claim 2, characterized in that: The air extraction mechanism (07) comprises a transmission shaft (71), an air pump (72), an air extraction pipe (73) and a valve (74). The transmission shaft (71) is rotatably mounted on the reducer (33). The bottom end of the air pump (72) is connected to the top end of the support frame (31). One end of the air extraction pipe (73) is mounted on the air pump (72). The other end of the air pump (72) is communicated with the inside of the cavity of the kettle body (12). The valve (74) is mounted on the air extraction pipe (73).

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