Ultrafiltration system

Abstract

The utility model discloses an ultrafiltration system which comprises a concentration bag and a filtering assembly, the concentration bag is provided with a first bag inlet and a bag outlet, the filtering assembly is provided with a filtering liquid inlet end and a filtering liquid outlet end, the filtering liquid inlet end is used for introducing a mixture to be filtered, and the filtering liquid outlet end is connected with the first bag inlet. A filtering piece is arranged between the filtering liquid inlet end and the filtering liquid outlet end; the ultrafiltration assembly is provided with an ultrafiltration liquid inlet end and a permeation end, the ultrafiltration liquid inlet end is connected with the bag outlet, and the permeation end is used for outputting permeate after the mixture to be filtered is filtered by the filter part and the ultrafiltration assembly. According to the ultrafiltration system disclosed by the embodiment of the utility model, the filtering component and the ultrafiltration component are directly connected, and a mixture to be filtered is positioned in a closed environment separated from the outside in a filtering operation process and an ultrafiltration operation process, so that sterile operation is favorably realized, a product is unlikely to be polluted by impurities in the outside environment in an operation process, and the product quality is relatively high.

Description

Technical Field

[0001] The utility model relates to the field of biotechnology, and more specifically, to an ultrafiltration system. Background Art

[0002] In the field of biotechnology, ultrafiltration technology is a separation and purification method that is widely used in the biopharmaceutical field. In the processing fields of biological products, health products, chemicals, etc., ultrafiltration equipment is required to concentrate certain products.

[0003] In the related art, the operation process of the ultrafiltration equipment is open to the outside world, which makes it difficult to ensure aseptic operation, easily causing product contamination and having an adverse effect on product quality. Utility Model Content

[0004] The utility model aims to solve at least one of the technical problems existing in the prior art. To this end, one purpose of the utility model is to provide an ultrafiltration system, the operation process of which is closed, has good airtightness, is conducive to aseptic operation, is not easy to cause product contamination, and has good product quality.

[0005] The ultrafiltration system according to the embodiment of the utility model comprises: a concentration bag, the concentration bag having a first bag inlet and a bag outlet, a filter assembly, the filter assembly having a filter liquid inlet end and a filter liquid outlet end, the filter liquid inlet end is used to pass the mixture to be filtered, the filter liquid outlet end is connected to the first bag inlet, and a filter element is provided between the filter liquid inlet end and the filter liquid outlet end; an ultrafiltration assembly, the ultrafiltration assembly having an ultrafiltration liquid inlet end and a permeate end, the ultrafiltration liquid inlet end is connected to the bag outlet, and the permeate end is used to output permeate after the mixture to be filtered passes through the filter element and the ultrafiltration assembly.

[0006] According to the ultrafiltration system of the embodiment of the utility model, the filtration component and the ultrafiltration component are directly connected, and the mixture to be filtered during the filtration operation and the ultrafiltration operation is in a closed environment separated from the outside world, which is conducive to aseptic operation, makes the product less susceptible to contamination by impurities in the external environment during the operation, and the product quality is higher.

[0007] In addition, the ultrafiltration system according to the above embodiment of the utility model may also have the following additional technical features:

[0008] According to some embodiments of the present invention, the concentration bag further includes a second bag inlet, the ultrafiltration component has a reflux end, the reflux end is connected to the second bag inlet via a reflux branch and is used for the non-permeated material in the ultrafiltration component to reflux to the concentration bag.

[0009] According to some embodiments of the utility model, the reflux branch is connected in series with a pressure valve and a pressure gauge, the pressure valve is used to control the pressure of the reflux branch to be less than or equal to 0.1 MPa, and the pressure gauge is used to display the pressure of the reflux branch.

[0010] According to some embodiments of the utility model, the ultrafiltration system further comprises a liquid storage bag, wherein the liquid storage bag is connected to the reflux end via a liquid storage branch, the liquid storage branch is provided with a first opening and closing valve, and the reflux branch is provided with a second opening and closing valve.

[0011] According to some embodiments of the present invention, the first bag inlet is disposed at the bottom of the concentration bag, the bag outlet is disposed at the side of the concentration bag, and the second bag inlet is disposed at the top of the concentration bag.

[0012] According to some embodiments of the present invention, the ultrafiltration component further comprises a first pump body, and the first pump body is connected in series between the ultrafiltration liquid inlet end and the permeate end.

[0013] According to some embodiments of the present invention, there are multiple filter elements, and the multiple filter elements are connected in series between the filter liquid inlet end and the filter liquid outlet end, and the pore sizes of the multiple filter elements decrease along the filtering direction.

[0014] According to some embodiments of the present invention, the filter assembly further includes a second pump body, and the second pump body is connected in series with the filter element.

[0015] According to some embodiments of the present invention, the filter element is a capsule filter.

[0016] According to some embodiments of the utility model, the filtered liquid outlet is provided with a first joint, the first bag inlet is provided with a second joint, the first joint and the second joint are detachably connected, and a third opening and closing valve is provided at the second joint; and / or, the bag outlet is provided with a third joint, the ultrafiltration liquid inlet is provided with a fourth joint, and the third joint and the fourth joint are detachably connected.

[0017] Additional aspects and advantages of the present invention will be given in part in the following description, and in part will become apparent from the following description, or will be learned through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0019] Figure 1 It is a structural schematic diagram of an ultrafiltration system according to an embodiment of the utility model.

[0020] Reference numerals:

[0021] Ultrafiltration system 100;

[0022] Concentration bag 10; first bag inlet 11; bag outlet 12; second bag inlet 13;

[0023] Filter assembly 20; filter liquid inlet end 21; filter liquid outlet end 22; filter element 23; first filter element 231; second filter element 232; third filter element 233;

[0024] Ultrafiltration component 30; ultrafiltration liquid inlet end 31; permeate end 32; reflux end 33;

[0025] Pressure valve 41; pressure gauge 42; liquid storage bag 50; reflux branch 61; liquid storage branch 62;

[0026] A first pump body 71; a second pump body 72;

[0027] A first joint 81; a second joint 82; a third joint 83; a fourth joint 84; a fifth joint 85; a sixth joint 86; a seventh joint 87; an eighth joint 88;

[0028] A first on-off valve 91 ; a second on-off valve 92 ; a third on-off valve 93 ; and a three-way conversion head 94 . DETAILED DESCRIPTION

[0029] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0030] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0031] In the description of the present invention, "first feature" and "second feature" may include one or more such features, "plurality" means two or more, the first feature "above" or "below" the second feature may include the first and second features being in direct contact, or may include the first and second features not being in direct contact but being in contact through another feature between them, the first feature "above", "above" and "above" the second feature may include the first feature being directly above and diagonally above the second feature, or may simply mean that the first feature is at a higher level than the second feature.

[0032] An ultrafiltration system 100 according to an embodiment of the present invention will be described below with reference to the accompanying drawings.

[0033] Reference Figure 1 As shown, the ultrafiltration system 100 according to the embodiment of the present invention may include: a concentration bag 10 , a filter assembly 20 and an ultrafiltration assembly 30 .

[0034] Specifically, the concentration bag 10 has a first bag inlet 11 and a bag outlet 12. The filter assembly 20 has a filter inlet 21 and a filter outlet 22, the filter inlet 21 is used to pass the mixture to be filtered, the filter outlet 22 is connected to the first bag inlet 11, and a filter element 23 is provided between the filter inlet 21 and the filter outlet 22. The ultrafiltration assembly 30 has an ultrafiltration inlet 31 and a permeate end 32, the ultrafiltration inlet 31 is connected to the bag outlet 12, and the permeate end 32 is used to output the permeate after the mixture to be filtered passes through the filter element 23 and the ultrafiltration assembly 30.

[0035] The concentration bag 10 can be a 2D liquid storage bag, a 3D liquid storage bag, etc., which is non-toxic and has good sealing properties and is easy to obtain. The specifications of the concentration bag 10 can be 20ml, 30ml, etc., which can be determined according to the specific situation, for example, according to the amount of the mixture to be filtered. The mixture to be filtered can be a cell fluid including dead cells, cell fragments, macromolecular solutes, small molecular solutes and solvents. Macromolecular solutes can include cytokines, such as basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), cold blood enzyme protein, etc.

[0036] Filtration refers to the operation of allowing relatively small macromolecular solutes, small molecular solutes and solvents in the mixture to be filtered to pass through the filtration component 20 by a certain pressure, and preventing relatively large cell debris, dead cells and the like in the mixture to be filtered from passing through the filtration component 20. The filter element 23 may be a capsule filter, a cartridge filter and the like to filter the mixture to be filtered. For example, in some embodiments, Figure 1 As shown, the filter element 23 is a capsule filter with a large filtering surface area, which is conducive to improving the filtering efficiency. The capsule filter does not contain adhesives and other chemicals, which is conducive to reducing possible contamination of the product. At the same time, the capsule filter is easy to install and has strong practicality.

[0037] Ultrafiltration is an operation that causes small molecular solutes and solvents with smaller sizes in the mixture to be filtered to pass through the ultrafiltration component 30 and flow out from the permeation end 32 by a certain pressure, and prevents large molecular solutes with sizes larger than small molecular solutes and solvents in the mixture to be filtered from passing through the ultrafiltration component 30. The ultrafiltration component 30 may include a housing, a membrane with holes, and other parts, and the mixture to be filtered is subjected to ultrafiltration operation through the membrane, and the size of the holes on the membrane may be 3 to 5 kd (kd, kilodaltons). The ultrafiltration liquid inlet end 31 may be located at the lower end of the ultrafiltration component 30, and the permeation end 32 may be located at the upper end of the ultrafiltration component 30. A closed waste liquid bag may be connected to the permeation end 32 to collect the waste liquid from the permeation end 32 for unified treatment of the waste liquid later.

[0038] The concentration bag 10, the filter assembly 20 and the ultrafiltration assembly 30 can be mainly disposable items, which can reduce product pollution and improve product quality. For example, the membrane and filter element 23 of the concentration bag 10 and the ultrafiltration assembly 30 are disposable items. The filter assembly 20 and the concentration bag 10, and the concentration bag 10 and the ultrafiltration assembly 30 can be connected by pipes, such as silicone tubes, which have strong pressure resistance and are not easy to fall off.

[0039] The filtering component 20 and the ultrafiltration component 30 can separate the macromolecular solutes in the mixture to be filtered, thereby achieving the purification and concentration of the product, namely the macromolecular solutes.

[0040] In some related technologies, the filtration operation and the ultrafiltration operation are usually performed separately. For example, there is no direct connection component between the filtration operation and the ultrafiltration operation, which results in low working efficiency. Moreover, the entire operation process including the filtration operation and the ultrafiltration operation is in an open state connected to the outside world, making the product susceptible to contamination by bacteria, microorganisms and other impurities in the external environment, resulting in low product quality. Alternatively, in some related technologies, the ultrafiltration system is placed in a biosafety cabinet. Although a sealed operation can be achieved, the biosafety cabinet has a high cost of use, occupies a large space, and needs to be opened for each operation, which is inconvenient to operate.

[0041] In the present application, after the mixture to be filtered is passed through the filter assembly 20 to complete the filtering operation, it enters the concentration bag 10 through the filter liquid outlet 22 and the first bag inlet 11, and the mixture to be filtered that enters the concentration bag 10 can enter the ultrafiltration assembly 30 through the bag outlet 12 and the ultrafiltration liquid inlet 31, so as to realize the ultrafiltration operation of the ultrafiltration assembly 30. The filter assembly 20 is directly connected to the ultrafiltration assembly 30, and the connecting structure is a closed environment separated from the outside world, so the working efficiency is high, and the interior of the filter assembly 20 and the ultrafiltration assembly 30 are separated from the outside world, so that the mixture to be filtered is in a closed environment separated from the outside world during the filtering operation and the ultrafiltration operation, which is conducive to the realization of aseptic operation, so that the product is not easily contaminated by bacteria, microorganisms and other impurities in the external environment during the operation, and the product quality is improved. In addition, the ultrafiltration system 100 contains fewer components and occupies less space. The ultrafiltration system 100 does not need to be placed in a biological safety cabinet, which is convenient to operate and conducive to reducing operating costs.

[0042] The mixture to be filtered is first filtered through the filter component 20, and then the filtered mixture to be filtered is ultrafiltered through the ultrafiltration component 30. This can filter out larger cell fragments, dead cells, etc. in the mixture to be filtered before the ultrafiltration operation, thereby reducing the possibility of cell fragments, dead cells, etc. entering the ultrafiltration component 30 and then blocking or even damaging the ultrafiltration component 30, which is beneficial to protecting the ultrafiltration component 30 and allowing the ultrafiltration operation to proceed smoothly.

[0043] According to the ultrafiltration system 100 of the embodiment of the utility model, the filtration component 20 and the ultrafiltration component 30 are directly connected, and the mixture to be filtered during the filtration operation and the ultrafiltration operation is in a closed environment separated from the outside world, which is conducive to aseptic operation, makes the product less susceptible to contamination by impurities in the external environment during the operation, and the product quality is higher.

[0044] In some embodiments of the present invention, Figure 1 As shown, the concentrate bag 10 further includes a second bag inlet 13, and the ultrafiltration assembly 30 has a reflux end 33, which is connected to the second bag inlet 13 via a reflux branch 61 and is used for the non-permeated material in the ultrafiltration assembly 30 to reflux to the concentrate bag 10. The reflux end 33 can be located at the side of the ultrafiltration assembly 30.

[0045] After the mixture to be filtered in the concentration bag 10 is passed to the ultrafiltration component 30 for an ultrafiltration operation, the material that has not passed through the ultrafiltration component 30 is left. The material that has not passed through can be refluxed to the concentration bag 10 through the reflux end 33 and the reflux branch 61, and then continue to pass through the ultrafiltration component 30 for a second ultrafiltration operation, and the cycle is repeated to achieve the circulation of the material between the concentration bag 10 and the ultrafiltration component 30, so that the mixture to be filtered can be subjected to multiple ultrafiltration operations, which has a better purification and concentration effect on the product, is conducive to improving the final product concentration, and meets the user's demand for product concentration. For example, in some specific embodiments, through filtering operations and multiple ultrafiltration operations, 30L of the mixture to be filtered is concentrated to 100ml of product.

[0046] In some embodiments, Figure 1 As shown, the reflux branch 61 is connected in series with a pressure valve 41 and a pressure gauge 42. The pressure valve 41 is used to control the pressure of the reflux branch 61 to be less than or equal to 0.1 MPa, and the pressure gauge 42 is used to display the pressure of the reflux branch 61. By controlling the pressure of the reflux branch 61 through the pressure valve 41, the pressure in the ultrafiltration assembly 30 connected to the reflux branch 61 can be controlled. If the pressure in the ultrafiltration assembly 30 exceeds 0.1 MPa, it is easy to damage the ultrafiltration assembly 30, for example, the membrane with holes in the ultrafiltration assembly 30 is damaged, affecting the normal operation of the ultrafiltration assembly 30. Therefore, by controlling the pressure of the pressure reflux branch 61 to be less than or equal to 0.1 MPa through the pressure valve 41, it is beneficial to protect the ultrafiltration assembly 30. And the pressure gauge 42 is convenient to observe the pressure value of the reflux branch 61 at any time during the operation process, so as to control the pressure of the reflux branch 61 to be always less than or equal to 0.1 MPa, which is convenient for the continuous normal operation of the ultrafiltration assembly 30. For example, the pressure of the return branch 61 is 0.07 MPa, 0.09 MPa, 0.1 MPa, etc.

[0047] In some embodiments, Figure 1 As shown, the ultrafiltration system 100 also includes a liquid storage bag 50, which is connected to the reflux end 33 through a liquid storage branch 62. The liquid storage branch 62 is provided with a first opening and closing valve 91, and the reflux branch 61 is provided with a second opening and closing valve 92. The liquid storage bag 50 can be a 2D liquid storage bag, a 3D liquid storage bag, etc., which is non-toxic and has good sealing performance and is easy to obtain. The opening and closing valve can be a thumb clip, etc., which is easy to operate.

[0048] The second opening and closing valve 92 can be opened and the first opening and closing valve 91 can be closed, so that the material at the reflux end 33 can flow to the concentration bag 10 through the reflux branch 61 but cannot flow to the liquid storage bag 50 through the liquid storage branch 62, so that the mixture to be filtered circulates between the concentration bag 10 and the ultrafiltration assembly 30. The second opening and closing valve 92 can be closed and the first opening and closing valve 91 can be opened, so that the material at the reflux end 33 can flow to the liquid storage bag 50 through the liquid storage branch 62 but cannot flow to the concentration bag 10 through the reflux branch 61, so that the concentrated product can be collected in the liquid storage bag 50 instead of the product in the concentration bag 10, thereby reducing the influence of the mixture to be filtered that may exist in the concentration bag 10 and does not flow to the ultrafiltration assembly 30 on the purity of the product and improving the product quality.

[0049] The opening and closing states of the first opening and closing valve 91 and the second opening and closing valve 92 can be controlled according to user needs. For example, when the mixture to be filtered circulates between the concentration bag 10 and the ultrafiltration component 30, the opening and closing states of the first opening and closing valve 91 and the second opening and closing valve 92 are controlled according to whether the volume of the material in the concentration bag 10 meets the user needs.

[0050] In some embodiments, Figure 1 As shown, the reflux branch 61 is provided with a three-way conversion head 94, which is respectively connected to the reflux end 33, the liquid storage bag 50 and the second bag inlet 13, so that the material at the reflux end 33 can flow to the liquid storage bag 50 or the concentration bag 10 through the three-way conversion head 94, without having to set up two branches to distribute and connect the reflux end 33 and the liquid storage bag 50, the reflux end 33 and the second bag inlet 13, which is convenient to use and economical.

[0051] The positions of the first bag inlet 11, the bag outlet 12 and the second bag inlet 13 in the concentration bag 10 can be flexibly arranged. Figure 1 As shown, the first bag inlet 11 is arranged at the bottom of the concentration bag 10, the bag outlet 12 is arranged at the side of the concentration bag 10, and the second bag inlet 13 is arranged at the top of the concentration bag 10. The mixture to be filtered flowing into the concentration bag 10 through the first bag inlet 11 at the bottom can gradually fill the concentration bag 10 from bottom to top, which is conducive to fully utilizing the storage space of the concentration bag 10. The material flowing into the concentration bag 10 through the second bag inlet 13 at the top can flow into the concentration bag 10 from top to bottom, so as to utilize the self-weight of the material, so that the material flows into the concentration bag 10 at least under the action of gravity, thereby improving the reliability of the material flowing into the concentration bag 10.

[0052] The side bag outlet 12 allows the mixture to be filtered in the concentration bag 10 to flow toward the ultrafiltration assembly 30 more during the circulation between the concentration bag 10 and the ultrafiltration assembly 30, thereby reducing the mixture to be filtered that may exist in the concentration bag 10 and does not flow toward the ultrafiltration assembly 30, thereby improving the reliability of the circulation of the material between the concentration bag 10 and the ultrafiltration assembly 30.

[0053] In some embodiments of the present invention, Figure 1 As shown, the ultrafiltration component 30 also includes a first pump body 71, which is connected in series between the ultrafiltration liquid inlet end 31 and the permeation end 32, so as to apply a driving force to the mixture to be filtered through the first pump body 71, so as to drive the mixture to be filtered to enter the ultrafiltration component 30 from the ultrafiltration liquid inlet end 31 and flow toward the permeation end 32, so that the small molecule solutes and solvents in the mixture to be filtered flow out through the permeation end 32, and realize the ultrafiltration operation of the mixture to be filtered at the ultrafiltration component 30. And the flow rate of the mixture to be filtered can be controlled by the first pump body 71, so as to prevent the flow rate of the mixture to be filtered from being too fast and damaging the ultrafiltration component 30, such as the membrane in the ultrafiltration component 30, so as to make the ultrafiltration operation more reliable. The first pump body 71 can also reduce the possibility of material backflow, which is conducive to improving the ultrafiltration efficiency. The first pump body 71 can be a peristaltic pump, etc.

[0054] In some embodiments of the present invention, Figure 1 As shown, there are multiple filter elements 23, which are connected in series between the filter liquid inlet end 21 and the filter liquid outlet end 22, and the apertures of the multiple filter elements 23 decrease along the filtering direction. The mixture to be filtered introduced into the filter liquid inlet end 21 can be filtered multiple times by the multiple filter elements 23, and the filtering effect is better. The apertures of the multiple filter elements 23 decrease along the filtering direction, which can achieve graded filtration of the mixture to be filtered and improve the filtering effect.

[0055] For example, in some embodiments, Figure 1 As shown, the multiple filter elements 23 include a first filter element 231, a second filter element 232 and a third filter element 233 arranged along the filtering direction. The pore size of the first filter element 231 is 1 μm, the pore size of the second filter element 232 is 0.65 μm, and the pore size of the third filter element 233 is 0.22 μm. The first filter element 231, the second filter element 232 and the third filter element 233 can filter out cell fragments, dead cells, etc. with sizes greater than 1 μm, 0.65 μm, and 0.22 μm in the mixture to be filtered step by step, and bacteria (with a diameter of about 0.2 to 5 μm) that may exist in the mixture to be filtered can also be filtered out to a certain extent, and the effect of preventing cell fragments, dead cells, bacteria, etc. from passing through the filter component 20 is better.

[0056] In some embodiments of the present invention, Figure 1As shown, the filter assembly 20 also includes a second pump body 72, which is connected in series with the filter element 23, so as to apply a driving force to the mixture to be filtered through the second pump body 72, so as to drive the mixture to be filtered into the filter element 23, and realize the flow of the mixture to be filtered at the filter assembly 20. The flow rate of the mixture to be filtered can be controlled by the second pump body 72, and the possibility of material backflow can be reduced, which is conducive to improving the filtering efficiency. The second pump body 72 can be a peristaltic pump, etc.

[0057] In some embodiments of the present invention, Figure 1 As shown, the filtered liquid outlet 22 is provided with a first joint 81, the first bag inlet 11 is provided with a second joint 82, the first joint 81 and the second joint 82 are detachably connected, and a third opening and closing valve 93 is provided at the second joint 82. The joint can be a plug, for example, the first joint 81 is a male plug, and the second joint 82 is a female plug, which can realize the quick disassembly or connection of the first joint 81 and the second joint 82.

[0058] Through the detachable connection of the first joint 81 and the second joint 82, the detachable connection of the filter assembly 20 and the concentration bag 10 can be achieved, which is convenient for assembling the filter assembly 20 and the concentration bag 10 for filtering operation, and also convenient for disassembling the filter assembly 20 and the concentration bag 10, and the operation is convenient. The third on-off valve 93 can be opened when the filter assembly 20 passes the mixture to be filtered into the concentration bag 10, and can be closed after the mixture to be filtered is completely passed into the concentration bag 10, so that the filtering operation upstream of the concentration bag 10 and the ultrafiltration operation downstream of the concentration bag 10 are independently performed, reducing the mutual interference between the filtering operation and the ultrafiltration operation, and having better filtering and ultrafiltration effects on the mixture to be filtered.

[0059] For example, in some embodiments, Figure 1 As shown, the mixture to be filtered circulates between the concentration bag 10 and the ultrafiltration component 30 to perform multiple ultrafiltration operations. The third on-off valve 93 blocks the filter component 20 and the concentration bag 10, which can reduce the interference with the ultrafiltration operation of the mixture to be filtered and achieve a better ultrafiltration effect.

[0060] In some embodiments, Figure 1 As shown, the bag outlet 12 is provided with a third joint 83, and the ultrafiltration liquid inlet end 31 is provided with a fourth joint 84, and the third joint 83 and the fourth joint 84 are detachably connected. Through the detachable connection of the third joint 83 and the fourth joint 84, the detachable connection between the concentration bag 10 and the ultrafiltration component 30 can be achieved, which is convenient for assembling the concentration bag 10 and the ultrafiltration component 30 for ultrafiltration operation, and also convenient for disassembling the concentration bag 10 and the ultrafiltration component 30, and the operation is convenient.

[0061] In some embodiments, Figure 1As shown, the liquid storage branch 62 is provided with a fifth joint 85, and the liquid inlet end of the liquid storage bag 50 is provided with a sixth joint 86, and the fifth joint 85 and the sixth joint 86 are detachably connected. Through the detachable connection of the fifth joint 85 and the sixth joint 86, the detachable connection between the liquid storage branch 62 and the liquid storage bag 50 can be achieved, which is convenient for assembling the liquid storage branch 62 and the liquid storage bag 50 to collect the product, and also convenient for disassembling the liquid storage branch 62 and the liquid storage bag 50, and the operation is convenient.

[0062] In some embodiments, Figure 1 As shown, the second bag inlet 13 is provided with a seventh joint 87, and the reflux branch 61 is provided with an eighth joint 88, and the seventh joint 87 and the eighth joint 88 are detachably connected. Through the detachable connection of the seventh joint 87 and the eighth joint 88, the detachable connection between the concentration bag 10 and the reflux branch 61 can be achieved, which is convenient for assembling the concentration bag 10 and the reflux branch 61 so that the material circulates between the concentration bag 10 and the ultrafiltration assembly 30, and is also convenient for disassembling the concentration bag 10 and the reflux branch 61, which is easy to operate.

[0063] The connector, the on-off valve and the pipeline in the present application can be disposable, and the aseptic effect is better. The connector, the on-off valve and the pipeline in the present application can also be used multiple times, and the connector, the on-off valve and the pipeline are easy to disassemble and assemble, and are easy to clean and replace.

[0064] An ultrafiltration system 100 according to a specific embodiment of the present invention is described in detail below with reference to the accompanying drawings. It is worth noting that the following description is only an exemplary illustration and cannot be construed as a limitation to the present invention.

[0065] like Figure 1 As shown, the first joint 81 is connected to the second joint 82, the third joint 83 is connected to the fourth joint 84, the fifth joint 85 is connected to the sixth joint 86, and the eighth joint 88 is connected to the seventh joint 87, so as to assemble the filter assembly 20, the concentration bag 10, the ultrafiltration assembly 30, the pressure valve 41 and the liquid storage bag 50. The second pump body 72 and the third on-off valve 93 are opened, and the mixture to be filtered is passed through the first filter element 231, the second filter element 232 and the third filter element 233 through the second pump body 72 to achieve graded filtration of the mixture to be filtered. The mixture to be filtered after being filtered by the filter assembly 20 flows from the filtration liquid outlet end 22 to the first bag inlet 11 to flow into the concentration bag 10. After all the mixture to be filtered is passed into the concentration bag 10, the third on-off valve 93 is closed to block the filter assembly 20 and the concentration bag 10.

[0066] Close the first on-off valve 91 to block the liquid storage bag 50 and the reflux end 33. Open the first pump body 71 and the second on-off valve 92, open the pressure valve 41 and control the pressure displayed by the pressure gauge 42 to be less than or equal to 0.1Mpa, and drive the mixture to be filtered in the concentration bag 10 into the ultrafiltration component 30 through the first pump body 71. The small molecular solutes and solvents in the mixture to be filtered pass through the membrane of the ultrafiltration component 30 and flow out of the ultrafiltration component 30 from the permeation end 32. The large molecular solutes in the mixture to be filtered cannot pass through the membrane and flow into the concentration bag 10 from the reflux end 33. After the mixture to be filtered undergoes an ultrafiltration operation through the ultrafiltration component 30, its volume is reduced to form a material, which includes a large molecular solute, a small amount of small molecular solutes and solvents that have not passed through the membrane of the ultrafiltration component 30.

[0067] The material circulates between the ultrafiltration assembly 30 and the concentration bag 10. When the volume of the material in the concentration bag 10 reaches the volume required by the user, the second opening and closing valve 92 is closed to block the reflux end 33 and the second bag inlet 13. The first opening and closing valve 91 is opened to connect the liquid storage bag 50 and the reflux end 33, so that the material in the concentration bag 10 flows into the ultrafiltration assembly 30 through the first pump body 71 and then flows into the liquid storage bag 50 through the reflux end 33 to obtain a concentrated product.

[0068] The ultrafiltration system 100 in this specific embodiment has a compact structure, few connecting pipes, and a small footprint. It is also a closed system. The filter element 23, the joint, the opening and closing valve, the concentration bag 10, the membrane of the ultrafiltration assembly 30, the liquid storage bag 50, and the silicone tube are all disposable items, which can reduce the possible contamination of the product and help improve the product quality. In addition, this specific embodiment first performs graded filtration on the mixture to be filtered through multiple filter elements 23 with different pore sizes, and then performs multiple ultrafiltration treatments on the graded filtered mixture to be filtered, so that the filtration and ultrafiltration efficiency is higher and the product quality is better.

[0069] Other structures and operations of the ultrafiltration system 100 according to the embodiment of the present invention are known to those skilled in the art and will not be described in detail here.

[0070] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0071] In the description of this specification, the description with reference to the terms "embodiment", "specific embodiment", "example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0072] Although the embodiments of the present invention have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. An ultrafiltration system, characterized in that: include: a concentrate bag having a first bag inlet and a bag outlet, A filter assembly, wherein the filter assembly has a filter liquid inlet end and a filter liquid outlet end, the filter liquid inlet end is used to pass the mixture to be filtered, the filter liquid outlet end is connected to the first bag inlet, and a filter element is provided between the filter liquid inlet end and the filter liquid outlet end; The ultrafiltration component comprises an ultrafiltration liquid inlet end and a permeate end, wherein the ultrafiltration liquid inlet end is connected to the bag outlet, and the permeate end is used for outputting permeate after the mixture to be filtered passes through the filter element and the ultrafiltration component.

2. The ultrafiltration system according to claim 1, characterized in that The concentration bag further comprises a second bag inlet, and the ultrafiltration component comprises a reflux end, which is connected to the second bag inlet via a reflux branch and is used for the non-permeated material in the ultrafiltration component to reflux to the concentration bag.

3. The ultrafiltration system according to claim 2, characterized in that: The reflux branch is connected in series with a pressure valve and a pressure gauge, the pressure valve is used to control the pressure of the reflux branch to be less than or equal to 0.1 MPa, and the pressure gauge is used to display the pressure of the reflux branch.

4. The ultrafiltration system according to claim 2, characterized in that: It also includes a liquid storage bag, which is connected to the reflux end through a liquid storage branch. The liquid storage branch is provided with a first opening and closing valve, and the reflux branch is provided with a second opening and closing valve.

5. The ultrafiltration system according to claim 2, characterized in that: The first bag inlet is arranged at the bottom of the concentration bag, the bag outlet is arranged at the side of the concentration bag, and the second bag inlet is arranged at the top of the concentration bag.

6. The ultrafiltration system according to claim 1, characterized in that: The ultrafiltration component further comprises a first pump body, which is connected in series between the ultrafiltration liquid inlet end and the permeate end.

7. The ultrafiltration system according to claim 1, characterized in that: There are multiple filter elements, and the multiple filter elements are connected in series between the filter liquid inlet end and the filter liquid outlet end, and the apertures of the multiple filter elements decrease along the filtering direction.

8. The ultrafiltration system according to claim 1, characterized in that: The filter assembly further comprises a second pump body, which is connected in series with the filter element.

9. The ultrafiltration system according to claim 1, characterized in that: The filter element is a capsule filter.

10. The ultrafiltration system according to any one of claims 1 to 9, characterized in that: The filtered liquid outlet is provided with a first joint, the first bag inlet is provided with a second joint, the first joint and the second joint are detachably connected, and a third opening and closing valve is provided at the second joint; and / or, The bag outlet is provided with a third joint, the ultrafiltration liquid inlet is provided with a fourth joint, and the third joint and the fourth joint are detachably connected.

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