Fosaprepitant intermediate trifluoromethyl acid ester device

Abstract

The utility model provides a fosaprepitant intermediate trifluoromethyl acid ester device, and belongs to the technical field of medicine production. Comprising a reaction kettle body; the stirring part is positioned in the reaction kettle body and is used for stirring reaction materials in the reaction kettle body; the driving part is positioned on the reaction kettle body and is used for driving the stirring part to stir; the inhibiting part is positioned on the stirring part and is used for releasing an additive or an inhibitor into the reaction kettle body. Through the arrangement of the rotating rod and the storage barrel, when the shielding part closes the opening of the storage tank, the storage barrel is vertically arranged, an additive or an inhibitor is stored in the storage barrel, the electric push rod pushes the storage plate, so that the storage plate leaves the sliding chute, the shielding part is automatically opened, and a solution in the reaction kettle body passes through the storage tank; therefore, an additive or an inhibitor in the material storage barrel enters a solution, and useless by-products generated by the solution are reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical production, in particular to a fosaprepitant intermediate trifluoromethyl ester device. Background Art

[0002] Fosaprepitant is a drug used to prevent chemotherapy-induced nausea and vomiting. Its synthesis process requires precise control to ensure product quality and safety. Regarding the device for the trifluoromethyl ester of the intermediate of fosaprepitant, it usually involves a special equipment in the chemical synthesis process. This device is used to produce the intermediate of fosaprepitant, especially when performing trifluoromethylation reaction.

[0003] In the prior art, when the fosaprepitant intermediate undergoes trifluoromethylation reaction, due to the presence of a small amount of impurities in the raw materials, some side reactions will occur simultaneously with the main reaction, resulting in the production of unwanted by-products, thereby reducing the purity of the target product and interfering with subsequent reaction steps. Therefore, the present application provides a fosaprepitant intermediate trifluoromethyl ester device to meet the needs. Utility Model Content

[0004] The technical problem to be solved by the utility model is to provide a fosaprepitant intermediate trifluoromethyl ester device to solve the problem that when the existing fosaprepitant intermediate undergoes trifluoromethylation reaction, due to the presence of a small amount of impurities in the raw materials, some side reactions will be carried out simultaneously with the main reaction, resulting in the production of unwanted by-products, thereby reducing the purity of the target product and causing interference to subsequent reaction steps.

[0005] In order to solve the above technical problems, the utility model provides the following technical solutions: a fosaprepitant intermediate trifluoromethyl ester device, comprising: a reactor body; a stirring part, located in the reactor body, used to stir the reaction materials in the reactor body; a driving part, located on the reactor body, used to drive the stirring part to stir; an inhibition part, located on the stirring part, used to release additives or inhibitors into the reactor body.

[0006] Preferably, the pH sensor is located on the reactor body and is used to detect the pH value of the solution in the reactor body.

[0007] Preferably, the stirring part comprises: a stirring rod, which is located in the reactor body and one end of which is connected to the driving part; and a plurality of groups of stirring blades, which are installed on the stirring rod.

[0008] Preferably, it also includes: a slide groove, which is opened at the bottom end of the stirring blade and is used for installing the suppression part.

[0009] Preferably, the suppression part includes: a material storage plate installed in the slide groove; two groups of grooves, respectively opened on both sides of the top of the material storage plate; two groups of electric push rods, one group of electric push rods is installed in each group of grooves, one end of the electric push rod is connected to the stirring blade, and the other end is connected to the material storage plate, and it is configured that when the electric push rod is extended, the material storage plate slides out of the slide groove from the inside of the stirring blade; a material storage trough, opened on the material storage plate; multiple groups of partitions, evenly installed in the material storage trough, for dividing the material storage trough into multiple areas; multiple groups of storage pieces, located in the material storage trough, and a group of storage pieces is installed in the upper and lower areas of each group of partitions.

[0010] Preferably, several groups of shielding parts are all located on the material storage plate, used to open or close the opening of the material storage trough, and are arranged so that each group of shielding parts shields the opening above or below a group of partitions respectively.

[0011] Preferably, the material storage member includes: a central column installed in the material storage trough; two groups of rotating rods, both installed in the material storage trough, and one group of rotating rods is rotatably connected to the material storage plate, and the other group of rotating rods is rotatably connected to the central column; a material storage cylinder body is installed between the two groups of rotating rods, and is configured so that when the shielding part closes the opening of the material storage trough, the material storage cylinder body is vertically arranged for storing inhibitors or additives.

[0012] Compared with the prior art, the utility model has at least the following beneficial effects: 1. In the above scheme, by setting the rotating rod and the storage cylinder, when the shielding part closes the opening of the storage tank, the storage cylinder is vertically arranged to store the additives or inhibitors in the storage cylinder, and the electric push rod pushes the storage plate to make the storage plate leave the slide slot, and the shielding part automatically opens to make the solution in the reactor body pass through the storage tank, thereby driving the storage cylinder to rotate, so that the additives or inhibitors therein enter the solution, thereby reducing the generation of useless by-products by the solution.

[0013] 2. By setting a material storage plate, when additives or inhibitors need to be added to the reactor body, the material storage plate slides out of the slide slot, thereby increasing the length of the stirring blade, thereby enhancing the stirring effect of the stirring blade.

[0014] 3. By setting up multiple groups of stirring blades, different additives or inhibitors can be added to multiple groups of storage plates. When a certain additive or inhibitor is needed, the electric push rod in the group of stirring blades can be controlled to allow the additive or inhibitor to enter the solution, thereby reducing the generation of useless by-products in the solution.

[0015] 4. By setting the electric push rod, the length of the storage tank away from the chute can be controlled, thereby controlling the amount of additives or inhibitors released to prevent excessive additives or inhibitors from causing more impact on the solution. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The accompanying drawings, which constitute a part of the specification, illustrate embodiments of the present disclosure and, together with the description, further serve to explain the principles of the present disclosure and enable those skilled in the relevant art to make and use the present disclosure.

[0017] Figure 1 It is a schematic diagram of the structure of the utility model;

[0018] Figure 2 It is a schematic diagram of the structure inside the reactor body of the utility model;

[0019] Figure 3 It is a structural schematic diagram of the stirring part in the utility model;

[0020] Figure 4 This is a schematic diagram of the structure of the stirring blade in the utility model;

[0021] Figure 5 It is a structural schematic diagram of the suppression part in the utility model.

[0022] [Reference Signs]

[0023] 1. Reactor body; 2. Driving unit; 3. pH sensor; 4. Stirring rod; 5. Stirring blade; 6. Slide; 7. Storage plate; 8. Groove; 9. Electric push rod; 10. Storage trough; 11. Partition; 12. Shielding unit; 13. Center column; 14. Rotating rod; 15. Storage cylinder.

[0024] As shown in the figure, in order to clearly implement the structure of the embodiment of the utility model, specific structures and devices are marked in the figure, but this is only for illustrative purposes and is not intended to limit the utility model to the specific structure, device and environment. According to specific needs, ordinary technicians in this field can adjust or modify these devices and environments, and the adjustments or modifications made are still included in the scope of the attached claims. DETAILED DESCRIPTION

[0025] The following is a detailed description of a fosaprepitant intermediate trifluoromethyl ester device provided by the utility model in combination with the accompanying drawings and specific embodiments. At the same time, it is explained here that in order to make the embodiments more detailed, the following embodiments are the best and preferred embodiments, and those skilled in the art may also adopt other alternatives to implement some known technologies; and the accompanying drawings are only for a more specific description of the embodiments, and are not intended to specifically limit the utility model.

[0026] Embodiment 1: Figures 1 to 5As shown, an embodiment of the utility model provides a fosaprepitant intermediate trifluoromethyl ester device, comprising: a reactor body 1; a stirring part, located in the reactor body 1, for stirring the reaction material in the reactor body 1; a driving part 2, located on the reactor body 1, for driving the stirring part for stirring; an inhibition part, located on the stirring part, for releasing additives or inhibitors into the reactor body 1; the driving part 2 adopts a driving motor or a plug-in motor to drive the rotation of the stirring rod 4.

[0027] like Figure 1 and Figure 2 As shown, the pH sensor 3 is located on the reactor body 1 and is used to detect the pH value of the solution in the reactor body 1. The pH sensor 3 is a prior art and will not be described in detail here.

[0028] like Figures 2 to 5 As shown, the stirring part includes: a stirring rod 4, which is located in the reactor body 1 and one end of which is connected to the driving part 2; and a plurality of stirring blades 5, which are installed on the stirring rod 4.

[0029] Embodiment 2: Figure 4 As shown, it also includes: a slide groove 6, which is opened at the bottom end of the stirring blade 5 and is used to install the suppression part.

[0030] like Figures 3 to 5 As shown, the suppression part includes: a material storage plate 7, which is installed in the slide groove 6; two groups of grooves 8, which are respectively opened on both sides of the top of the material storage plate 7; two groups of electric push rods 9, one group of electric push rods 9 is installed in each group of grooves 8, one end of the electric push rod 9 is connected to the stirring blade 5, and the other end is connected to the material storage plate 7, and it is configured that when the electric push rod 9 is extended, the material storage plate 7 slides out of the slide groove 6 from the stirring blade 5; a material storage trough 10, which is opened on the material storage plate 7; a plurality of groups of partitions 11, which are evenly installed in the material storage trough 10, and are used to divide the material storage trough 10 into a plurality of areas; a plurality of groups of storage parts, which are located in the material storage trough 10, and a group of storage parts is installed in the upper and lower areas of each group of partitions 11.

[0031] like Figure 4 and Figure 5 As shown, several groups of shielding parts 12 are all located on the material storage plate 7 and are used to open or close the opening of the material storage trough 10, and are arranged so that each group of shielding parts 12 respectively shields the opening above or below a group of partitions 11.

[0032] like Figure 4 and Figure 5As shown, the material storage member includes: a central column 13, installed in the material storage trough 10; two groups of rotating rods 14, both installed in the material storage trough 10, and one group of rotating rods 14 is rotatably connected to the material storage plate 7, and the other group of rotating rods 14 is rotatably connected to the central column 13; a material storage cylinder 15, installed between the two groups of rotating rods 14, and is configured so that when the shielding portion 12 closes the opening of the material storage trough 10, the material storage cylinder 15 is vertically arranged for storing inhibitors or additives.

[0033] The technical solution provided by the utility model is that when the fosaprepitant intermediate is added to the reactor for trifluoromethylation reaction, the pH sensor 3 is used to judge the acidity or alkalinity of the solution in the reactor body 1, thereby judging whether useless byproducts are generated in the solution, and then adding a suitable additive or inhibitor thereto; when it is judged that the additive or inhibitor needs to be added, the electric push rod 9 in a certain group of stirring blades 5 is controlled to extend the electric push rod 9, thereby driving the storage plate 7 to leave the chute 6, and at this time, the shielding part 12 rotates in a direction away from the storage tank 10 after losing the obstruction of the storage plate 7, and automatically opens the opening of the storage tank 10, and the storage cylinder 15 begins to tilt from the original vertical state under the impact of the solution, so that the additive or inhibitor in the storage cylinder 15 enters the solution and reacts with the solution.

[0034] The present invention covers any substitution, modification, equivalent method and scheme made on the essence and scope of the present invention. In order to make the public have a thorough understanding of the present invention, specific details are described in detail in the above preferred embodiments of the present invention, and those skilled in the art can fully understand the present invention without the description of these details. In addition, in order to avoid unnecessary confusion about the essence of the present invention, well-known methods, processes, procedures, components and circuits are not described in detail.

[0035] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A fosaprepitant intermediate trifluoromethyl ester device, characterized in that: include: Reactor body (1); A stirring part, located in the reactor body (1), used for stirring the reaction materials in the reactor body (1); A driving part (2), located on the reactor body (1), and used to drive the stirring part to stir; An inhibitor, located on the stirring part, for releasing additives or inhibitors into the reactor body (1); A pH sensor (3) is located on the reactor body (1) and is used to detect the pH value of the solution in the reactor body (1); The stirring part comprises: A stirring rod (4) is located in the reactor body (1), and one end of the stirring rod is connected to the driving part (2); A plurality of groups of stirring blades (5) are mounted on the stirring rod (4); A chute (6) is provided at the bottom end of the stirring blade (5) and is used for installing the suppression part; The suppression unit comprises: A material storage plate (7) installed in the slide groove (6); Two groups of grooves (8) are respectively provided on both sides of the top of the material storage plate (7); Two groups of electric push rods (9), one group of electric push rods (9) is installed in each group of grooves (8), one end of the electric push rod (9) is connected to the stirring blade (5), and the other end is connected to the material storage plate (7), and is configured so that when the electric push rod (9) is extended, the material storage plate (7) slides out of the sliding groove (6) into the stirring blade (5); A material storage trough (10) is provided on the material storage plate (7); A plurality of groups of partitions (11) are evenly installed in the material storage tank (10) and are used to divide the material storage tank (10) into a plurality of areas; A plurality of groups of material storage members are located in the material storage trough (10), and a group of material storage members is installed in the upper and lower regions of each group of partitions (11); A plurality of groups of shielding portions (12), all located on the material storage plate (7), are used to open or close the opening of the material storage trough (10), and are arranged so that each group of shielding portions (12) shields the opening above or below a group of partitions (11); The material storage part comprises: A central column (13) installed in the material storage tank (10); Two groups of rotating rods (14) are both installed in the material storage trough (10), and one group of rotating rods (14) is rotatably connected to the material storage plate (7), and the other group of rotating rods (14) is rotatably connected to the central column (13); The material storage cylinder (15) is installed between the two groups of rotating rods (14) and is arranged so that when the shielding portion (12) closes the opening of the material storage tank (10), the material storage cylinder (15) is arranged vertically for storing inhibitors or additives.

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