Mobile phase containing device for liquid chromatography

Abstract

The mobile phase containing device comprises a base, a bottle body is vertically clamped on one side of the upper end of the base, the top of the bottle body is provided with a bottle neck, the outer side and the upper end of the bottle neck are sleeved with a transfer sleeve in a sealed mode, a limiting step is arranged in the middle of the inner side of the transfer sleeve, a filtering piece is erected, clamped and supported on the upper portion of the limiting step, and the filtering piece is connected with the bottle neck in a sealed mode. A detachable cover plate is arranged at the upper end of the transfer sleeve in a matched mode, a liquid guide pipe valve capable of being opened and closed is arranged in the middle of the upper end of the cover plate, the lower end of the liquid guide pipe valve is communicated with an inner cavity of the transfer sleeve, and a connecting pipe nozzle is arranged on one side of the transfer sleeve. The liquid input end can be directly led into the transfer sleeve and the bottle body through the liquid inlet pipe, and the electromagnetic valve can be closed immediately after completion, so that the interior of the bottle body can be vacuumized at negative pressure subsequently, the defect that an existing solvent bottle containing a mobile phase is communicated with air and is generally open is overcome, and convenience is brought to liquid chromatography testing.

Description

Technical Field

[0001] The utility model relates to the technical field of experimental instruments, in particular to a mobile phase containing device for liquid chromatography. Background Art

[0002] The substance that carries the components to be tested forward in chromatography is called the mobile phase, and common mobile phases include gas, liquid, and supercritical fluid. Taking liquid mobile phase as an example, the existing solvent bottle containing the mobile phase is connected to the air and is generally open. The open mobile phase holding device has little effect on the commonly used non-volatile neutral mobile phase, but it has great limitations for the mobile phase that easily absorbs carbon dioxide or oxygen in the air and then destroys the mobile phase components; and the existing mobile phase is easily mixed with impurities during use, which may affect the smooth progress of the experiment. Utility Model Content

[0003] The purpose of this section is to summarize some aspects of the embodiments of the utility model and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the abstract of the specification and the name of the utility model of this application to avoid blurring the purpose of this section, the abstract of the specification and the name of the utility model, and such simplifications or omissions cannot be used to limit the scope of the utility model.

[0004] Therefore, the purpose of the utility model is to provide a mobile phase holding device for liquid chromatography, so as to solve the problems proposed in the above-mentioned background technology that the mobile phase holding device for liquid chromatography is prone to absorb carbon dioxide or oxygen in the air during use, thereby destroying the mobile phase components, and that the existing mobile phase holding device is prone to mixing with impurities during use, which may affect the smooth progress of the experiment.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a mobile phase containing device for liquid chromatography, comprising a base, a bottle body is vertically clamped on one side of the upper end of the base, the top of the bottle body is provided with a bottle mouth, the outer side and the upper end of the bottle mouth are sealed with a transfer sleeve, the middle part of the inner side of the transfer sleeve is provided with a limiting step, a filter is mounted on the upper part of the limiting step, a detachable cover is matched at the upper end of the transfer sleeve, a liquid guide tube valve that can be opened and closed is arranged in the center of the upper end of the cover plate, and the lower end of the liquid guide tube valve is connected to the inner cavity of the transfer sleeve, a connecting nozzle is arranged on one side of the transfer sleeve, and a vacuum device connected to the connecting nozzle and used for sucking the inner cavity of the transfer sleeve and the inner cavity of the bottle body is arranged on the other side of the upper end of the base.

[0006] As a preferred solution of the mobile phase containing device for liquid chromatography described in the utility model, a placement groove matching the bottle body is also provided on the upper part and the inner side of the base.

[0007] As a preferred solution of the mobile phase containing device for liquid chromatography described in the utility model, the liquid guide tube valve includes a liquid inlet tube fixedly passing through the cover plate, and a solenoid valve arranged on the liquid inlet tube.

[0008] As a preferred solution of the mobile phase containing device for liquid chromatography described in the utility model, the filter element includes an annular holder with an outer diameter smaller than the outer diameter of the limiting step, and a filter screen fixed to the inner side of the annular holder.

[0009] As a preferred solution of the mobile phase containing device for liquid chromatography described in the utility model, the inner side of the bottom of the transfer sleeve has an annular clamping position adapted to the bottle mouth, and a sealing ring is also embedded and installed inside the annular clamping position.

[0010] As a preferred embodiment of the mobile phase holding device for liquid chromatography described in the utility model, the vacuum device includes a micro air pump arranged on the upper part of the base, and an air pipe with one end connected to the air inlet end of the micro air pump and the other end connected to the connecting nozzle.

[0011] As a preferred solution of a mobile phase holding device for liquid chromatography described in the utility model, a pressure sensor with a probe extending into the inner cavity of the transfer sleeve is also provided on the upper end of the cover plate, and a master control unit, i.e. a controller, of the holding device is also provided on the upper end of the base.

[0012] Compared with the prior art, the beneficial effects of the utility model are:

[0013] (I) This mobile phase holding device for liquid chromatography, with the cooperation of the bottle body, the transfer sleeve, the cover plate, the liquid guide tube valve, the sealing ring, the connecting nozzle and the exhaust device, after the liquid medium is injected into the bottle body, the liquid guide tube valve is first closed by the controller, and then the micro air pump is started to exhaust the air inside the transfer sleeve connected to the inner cavity of the bottle body through the air pipe and the connecting nozzle until the carbon dioxide or oxygen accumulated in the bottle body is exhausted, which effectively solves the test limitation caused by the easy entry of carbon dioxide or oxygen in the existing mobile phase holding device for liquid chromatography, and brings convenience to the experimental operation.

[0014] (ii) In this type of mobile phase holding device for liquid chromatography, when liquid is introduced into the bottle for storage, the filter located on the inner side of the transfer sleeve can filter out impurities from the runoff liquid, thereby preventing impurities from mixing into the bottle with the liquid, which is conducive to the smooth progress of the experiment. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a schematic diagram of the overall external structure of the utility model;

[0016] Figure 2 This is a schematic diagram of the external structure of the transfer sleeve of the utility model;

[0017] Figure 3 This is a schematic diagram of the internal structure of the transfer sleeve of the utility model;

[0018] Figure 4 This is a schematic diagram of the structure of the filter element of the utility model.

[0019] In the figure: 100, base; 110, placement groove; 200, bottle body; 210, bottle mouth; 300, transfer sleeve; 3001, limit step; 3002, annular clamp; 310, cover plate; 320, liquid guide tube valve; 3201, liquid inlet pipe; 3202, solenoid valve; 330, filter element; 3301, annular clamp; 3302, filter screen; 340, sealing ring; 350, connecting nozzle; 400, vacuum device; 410, micro air pump; 420, air pipe; 500, pressure sensor; 600, controller. DETAILED DESCRIPTION

[0020] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below with reference to the accompanying drawings.

[0021] Secondly, the present invention is described in detail with reference to the schematic diagram. When describing the implementation of the present invention, for the sake of convenience, the cross-sectional diagram showing the device structure will not be partially enlarged according to the general proportion, and the schematic diagram is only an example, which should not limit the scope of protection of the present invention. In addition, in actual production, the three-dimensional dimensions of length, width and depth should be included.

[0022] In order to make the purpose, technical solution and advantages of the present invention more clear, the implementation mode of the present invention will be further described in detail below with reference to the accompanying drawings.

[0023] Figure 1-Figure 4 The utility model is a schematic diagram of the entire structure of a mobile phase containing device for liquid chromatography, please refer to Figure 1-Figure 4The mobile phase containing device for liquid chromatography of the present embodiment comprises a base 100, a bottle body 200 is vertically clamped on one side of the upper end of the base 100, a bottle body 200 is provided at the top of the bottle body 200, a transfer sleeve 300 is sealedly sleeved on the outer side and the upper end of the bottle mouth 210, a limiting step 3001 is provided in the middle of the inner side of the transfer sleeve 300, a filter element 330 is mounted on the upper part of the limiting step 3001, a detachable cover plate 310 is matched at the upper end of the transfer sleeve 300, a liquid guide tube valve 320 which can be opened and closed is arranged in the middle of the upper end of the cover plate 310, and the lower end of the liquid guide tube valve 320 is connected to the inner cavity of the transfer sleeve 300, a connecting nozzle 350 is arranged on one side of the transfer sleeve 300, and a suction device 400 connected to the connecting nozzle 350 and used for suctioning the inner cavity of the transfer sleeve 300 and the inner cavity of the bottle body 200 is arranged on the other side of the upper end of the base 100.

[0024] The upper part and inner side of the base 100 are also provided with a placement groove 110 that matches the bottle body 200. When in use, the bottle body 200 for storing the mobile phase liquid can be directly placed in the placement groove 110, so that the bottle body 200 can be firmly placed on the base 100, and there is a through hole at the bottom of the base 100 with a diameter smaller than the placement groove 110 and vertically penetrating the placement groove 110. The through hole can facilitate the instrument to test the bottle body 200 and the mobile phase, which is simple and easy to use.

[0025] The liquid guide tube valve 320 includes a liquid inlet tube 3201 fixedly passed through the cover plate 310, and a solenoid valve 3202 arranged on the liquid inlet tube 3201. In the present embodiment, when liquid needs to be injected into the bottle body 200, after the solenoid valve 3202 is opened, the liquid input end can be directly introduced into the transfer sleeve 300 and the bottle body 200 through the liquid inlet tube 3201. After completion, the solenoid valve 3202 can be immediately closed so that the interior of the bottle body 200 can be evacuated under negative pressure, thereby avoiding the disadvantage that the existing solvent bottle containing the mobile phase is connected to the air and is generally open, which brings convenience to liquid chromatography testing.

[0026] It is understandable that the cover plate 310 and the transfer sleeve 300 can be connected by threaded connection, sealing top plug, etc., as long as the disassembly and assembly between the cover plate 310 and the transfer sleeve 300 are convenient and the sealing is guaranteed.

[0027] The filter element 330 includes an annular holder 3301 whose outer diameter is smaller than the outer diameter of the limiting step 3001, and a filter screen 3302 fixed on the inner side of the annular holder 3301. When the liquid is introduced into the bottle body 200 for storage, the filter screen 3302 located on the inner side of the transfer sleeve 300 can filter and remove impurities from the runoff liquid, thereby preventing impurities from mixing into the bottle with the liquid, which is conducive to the smooth progress of the experiment. When disassembling, the filter element 330 can be taken out by directly opening the cover plate 310.

[0028] The inner side of the bottom of the transfer sleeve 300 is provided with an annular clamping position 3002 that is compatible with the bottle mouth 210, and a sealing ring 340 is also embedded in the inner side of the annular clamping position 3002. In the present embodiment, when it is necessary to connect the transfer sleeve 300 and the bottle mouth 210, the annular clamping position 3002 at the bottom of the transfer sleeve 300 can be directly inserted into the outer side of the bottle mouth 210, and the installation and docking can be quickly completed with the cooperation of the sealing ring 340. When disassembling, it can be directly pulled out, which not only ensures the sealing of the bottle mouth 210, but also facilitates the disassembly and assembly operations, which is simple and efficient.

[0029] The vacuum device 400 includes a micro air pump 410 arranged on the upper part of the base 100, and an air pipe 420 connected to the air inlet end of the micro air pump 410 at one end and connected to the connecting nozzle 350 at the other end. When the liquid medium is injected into the bottle body 200, the liquid guide tube valve 320 is first closed, and then the micro air pump 410 is started to exhaust the air inside the transfer sleeve 300 connected to the inner cavity of the bottle body 200 through the air pipe 420 and the connecting nozzle 350 until the carbon dioxide or oxygen accumulated in the bottle body 200 is removed, which effectively solves the test limitations caused by the easy entry of carbon dioxide or oxygen in the existing mobile phase containing device for liquid chromatography, and brings convenience to experimental operation.

[0030] Furthermore, a pressure sensor 500 is provided at the upper end of the cover plate 310 and the probe extends to the inner cavity of the transfer sleeve 300. A master control unit of the containing device, namely a controller 600, is also provided at the upper end of the base 100. It can be understood that in order to prevent the micro air pump 410 from excessively sucking the inside of the bottle body 200, the pressure sensor 500 will detect the negative pressure value inside the bottle body 200 in real time during suction. When the set value is reached, the controller 600 will immediately stop the operation of the micro air pump 410 after receiving the information feedback, so as to prevent the connector from being difficult to pull out or liquid from being sprayed due to excessive negative pressure. The controller 600 also makes it more convenient for the staff to use the device.

[0031] Although the present invention has been described above with reference to the embodiments, various modifications may be made thereto and parts thereof may be replaced with equivalents without departing from the scope of the present invention. In particular, as long as there is no structural conflict, the various features in the embodiments disclosed in the present invention may be used in combination with each other in any manner, and the fact that these combinations are not exhaustively described in this specification is only for the sake of omitting space and saving resources. Therefore, the present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A mobile phase holding device for liquid chromatography, characterized in that: The invention comprises a base (100), a bottle body (200) is vertically clamped on one side of the upper end of the base (100), the top of the bottle body (200) is provided with a bottle mouth (210), the outer side and the upper end of the bottle mouth (210) are sealed with a transfer sleeve (300), the middle part of the inner side of the transfer sleeve (300) is provided with a limiting step (3001), a filter element (330) is mounted on the upper part of the limiting step (3001), and the upper end of the transfer sleeve (300) is matched with a detachable cover plate (310), a liquid guide tube valve (320) that can be opened and closed is arranged in the center of the upper end of the cover plate (310), and the lower end of the liquid guide tube valve (320) is connected to the inner cavity of the transfer sleeve (300), a connecting nozzle (350) is arranged on one side of the transfer sleeve (300), and a vacuum device (400) connected to the connecting nozzle (350) and used for sucking the inner cavity of the transfer sleeve (300) and the inner cavity of the bottle body (200) is arranged on the other side of the upper end of the base (100).

2. A mobile phase containing device for liquid chromatography according to claim 1, characterized in that: The upper part and inner side of the base (100) are also provided with a placement groove (110) matching the bottle body (200).

3. A mobile phase containing device for liquid chromatography according to claim 1, characterized in that: The liquid guide pipe valve (320) comprises a liquid inlet pipe (3201) fixedly connected to and extending through the cover plate (310), and a solenoid valve (3202) arranged on the liquid inlet pipe (3201).

4. The mobile phase containing device for liquid chromatography according to claim 1, characterized in that: The filter element (330) comprises an annular holder (3301) whose outer diameter is smaller than the outer diameter of the limiting step (3001), and a filter screen (3302) fixed on the inner side of the annular holder (3301).

5. The mobile phase containing device for liquid chromatography according to claim 1, characterized in that: The inner side of the bottom of the transfer sleeve (300) is provided with an annular clamping position (3002) adapted to the bottle mouth (210), and a sealing ring (340) is also embedded and installed inside the annular clamping position (3002).

6. The mobile phase containing device for liquid chromatography according to claim 1, characterized in that: The air extraction device (400) comprises a micro air pump (410) disposed on the upper portion of the base (100), and an air pipe (420) having one end connected to the air inlet end of the micro air pump (410) and the other end connected to the connecting nozzle (350).

7. The mobile phase containing device for liquid chromatography according to claim 1, characterized in that: A pressure sensor (500) is also provided at the upper end of the cover plate (310), and the probe of the pressure sensor extends into the inner cavity of the transfer sleeve (300). A master control unit of the containing device, i.e., a controller (600), is also provided at the upper end of the base (100).

Images