Automatic sampling device adopting immersion tank method

Abstract

The utility model discloses an automatic sampling device adopting an immersion tank method. The automatic sampling device comprises a dissolution cup, an integrated dissolution cup cover arranged on the dissolution cup, a fixed needle seat, a sampling needle and a liquid supplementing needle, the dissolution cup is used for accommodating a solution to be detected; a needle seat fixing hole is formed in the integrated dissolution cup cover; the fixed needle seat is inserted into the needle seat fixing hole and is used for fixing the sampling needle and the fluid infusion needle; the sampling needle is used for sampling from the dissolution cup; the liquid supplementing needle is used for supplementing liquid into the dissolution cup; the lower end part of the sampling needle and the lower end part of the liquid supplementing needle are arranged in the dissolution cup after penetrating through the fixed needle seat, and are a certain distance away from the cup wall of the dissolution cup. According to the automatic sampling and liquid supplementing device, automatic sampling and liquid supplementing operation can be achieved, manual intervention is reduced, personal errors are reduced, due to automatic sampling and liquid supplementing, an operator does not need to wait beside the dissolution rate instrument and wait for instrument reminding to conduct manual operation, and therefore operation time is saved, and experiment efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of dissolution instruments, in particular to an automatic sampling device using an immersion tank method. Background Art

[0002] According to the Technical Guidelines for the Study of Generic Chemical Drugs for External Use on Skin issued by the Center for Drug Evaluation of the State Drug Administration and the United States Pharmacopoeia <1724> The chapter has relevant regulatory requirements for in vitro release testing of semi-solid preparations. Semi-solid preparations need to undergo in vitro release testing. Although diffusion cell dissolution devices are commonly used for such studies, in the United States Pharmacopoeia <1724> The immersion tank test device that can be used on ordinary dissolution apparatus is also included. However, due to the limitations of the mechanical design and operating logic of ordinary dissolution apparatus (combined with automatic sampling workstation), in normal operation, the operator can only complete the sampling and rehydration work manually. This operation is too complicated and it is easy to introduce errors in the results due to manual operation errors. Utility Model Content

[0003] In view of the problems existing in the prior art, the utility model provides an automatic sampling device using an immersion tank method.

[0004] In order to achieve the above purpose, the technical solution of the utility model is as follows:

[0005] The utility model provides an immersion tank method automatic sampling device, comprising: a dissolution cup, an integrated dissolution cup cover placed on the dissolution cup, a fixed needle seat, a sampling needle, and a fluid replenishment needle;

[0006] The dissolution cup is used to contain the solution to be tested;

[0007] The integrated dissolution cup cover is provided with a needle seat fixing hole;

[0008] The fixed needle seat is inserted into the needle seat fixing hole and is used to fix the sampling needle and the fluid infusion needle;

[0009] The sampling needle is used to take samples from the dissolution cup; the rehydration needle is used to add liquid to the dissolution cup; the lower ends of the sampling needle and the rehydration needle are both placed in the dissolution cup after passing through the fixed needle seat and are a distance away from the wall of the dissolution cup.

[0010] Preferably, the automatic sampling workstation is connected to the upper end of the sampling needle through a sampling line and a sampling line connector, and the automatic sampling workstation is connected to the upper end of the infusion needle through a fluid infusion line and a fluid infusion line connector.

[0011] Preferably, the upper end of the sampling needle and the upper end of the fluid infusion needle are bent at 90° to facilitate connection with an external automatic sampling workstation.

[0012] Preferably, the lower end of the sampling needle and the lower end of the rehydration needle are both 6 mm away from the wall of the dissolution cup.

[0013] Preferably, the number of the fixed needle seats is 2, and correspondingly, the number of the needle seat fixing holes is 2, and the sampling needle and the fluid infusion needle are both fixed on a fixed needle seat.

[0014] Preferably, the integrated dissolution cup cover is further provided with a paddle shaft hole, and the paddle shaft hole is placed between the two needle seat fixing holes.

[0015] Preferably, a paddle is further provided in the dissolution cup; a paddle shaft is further mounted on the paddle; and the paddle shaft passes through the paddle shaft hole.

[0016] The technical solution of the utility model has the following beneficial effects:

[0017] The utility model can realize automatic sampling and fluid replenishment operations, reduces manual intervention, and reduces human errors. Due to the automatic sampling and fluid replenishment, the operator does not need to wait beside the dissolution instrument and wait for the instrument to remind to perform manual operations, thereby saving operation time and improving experimental efficiency. After the experiment is completed, the automatic sampling workstation can automatically complete the cleaning of the pipeline, avoiding the tedious steps of the operator manually cleaning the pipeline and improving the cleaning efficiency of the pipeline.

[0018] The utility model can reduce the number of operators: when conducting experiments with multiple cups (such as 8-12 cups), due to the realization of automatic operation, it is no longer necessary for multiple people to take samples at the same time, thereby reducing the number of operators.

[0019] The utility model can accurately take samples and replenish fluids: the lower ends of the sampling needle and the replenishment needle are designed to be 6 mm away from the wall of the dissolution cup, which ensures the accuracy of sampling and replenishment, avoids contact with the wall of the dissolution cup, and reduces the risk of contamination; the upper ends of the sampling needle and the replenishment needle are bent at 90°, which is convenient for connection with an external automatic sampling workstation and simplifies the operation process; the design of the fixed needle seat ensures the stability of the sampling needle and the replenishment needle during the experiment and improves the reliability of the experiment; the paddles and paddle shafts arranged in the dissolution cup are used to stir the solution, which ensures the uniformity of the solution, which is crucial to the accuracy of the dissolution test. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic diagram of the structure of the utility model;

[0021] Figure 2 This is a cross-sectional view of the structure of the utility model;

[0022] Figure 3 This is an exploded view of the utility model;

[0023] Figure 4This is a schematic diagram of the structure of the sampling needle and the fluid infusion needle of the utility model;

[0024] Figure 5 This is a schematic diagram of the connection between the sampling needle and the rehydration needle of the utility model and the automatic sampling workstation. DETAILED DESCRIPTION

[0025] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, and should not be construed as limiting the present invention.

[0026] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0027] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present utility model, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0028] In the present invention, unless otherwise clearly specified and limited, the terms "install", "connect", "connect", "fix" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0029] In the present invention, unless otherwise expressly specified or limited, a first feature is “on” or “below” a second feature.

[0030] “Under” may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, the first feature being “above”, “above”, and “above” the second feature includes the first feature being directly above and obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. The first feature being “under”, “below”, and “below” the second feature includes the first feature being directly below and obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0031] Reference Figures 1 to 5 The utility model provides an immersion tank method automatic sampling device, comprising: a dissolution cup 1, an integrated dissolution cup cover 2 placed on the dissolution cup 1, a fixed needle seat 3, a sampling needle 4, and a fluid replenishment needle 5;

[0032] The dissolution cup 1 is used to contain the solution to be tested;

[0033] The integrated dissolution cup cover 2 is provided with a needle holder fixing hole 201, wherein the integrated dissolution cup cover 2 covers the dissolution cup 1, providing a fixing structure to ensure the sealing and stability during the experiment;

[0034] The fixed needle seat 3 is inserted into the needle seat fixing hole 201 to fix the sampling needle 4 and the fluid replenishment needle 5 to ensure the stability and accuracy of the sampling needle 4 and the fluid replenishment needle 5 during the experiment;

[0035] The sampling needle 4 is used to take samples from the dissolution cup 1; the rehydration needle 5 is used to add liquid to the dissolution cup 1 to maintain a constant volume of the solution during the experiment; the lower end of the sampling needle 4 and the lower end of the rehydration needle 5 are both placed in the dissolution cup 1 after passing through the fixed needle seat 3, and are a certain distance away from the wall of the dissolution cup 1. The lower end of the sampling needle 4 and the lower end of the rehydration needle 5 are both 6mm D away from the wall of the dissolution cup to ensure the accuracy of sampling, avoid contact with the wall of the dissolution cup, and reduce the risk of contamination. The upper end of the sampling needle 4 and the upper end of the rehydration needle 5 are both bent at 90° to facilitate connection with an external automatic sampling workstation 8, which is also connected to the main unit of the dissolution instrument. The automatic sampling workstation 8 includes an automatic sampler; the automatic sampling workstation 8 provides an automated platform to realize automated sampling and rehydration processes.

[0036] Furthermore, the automatic sampling workstation 8 is connected to the upper end of the sampling needle 4 through a sampling pipeline and a sampling pipeline connector, and the automatic sampling workstation 8 is connected to the upper end of the infusion needle 5 through a fluid infusion pipeline and a fluid infusion pipeline connector, thereby realizing automatic sampling and fluid infusion.

[0037] The number of the fixed needle seats 3 is 2, and the number of the needle seat fixing holes 201 is correspondingly 2, and the sampling needle 4 and the fluid infusion needle 5 are both fixed on a fixed needle seat 3. The integrated dissolution cup cover 2 is also provided with a paddle shaft hole 202, and the paddle shaft hole 202 is placed between the two needle seat fixing holes 201, and is used to install a paddle blade and a paddle shaft. The dissolution cup 1 is also provided with a paddle blade 6; a paddle shaft 7 is also installed on the paddle blade 6; the paddle shaft 7 passes through the paddle shaft hole 202, and is used to stir the solution during the experiment to ensure the uniformity of the solution.

[0038] Working principle of this utility model:

[0039] When the operator uses it, he selects "Immersion Tank Method" in the method interface of the dissolution apparatus host, and manually removes the pipeline between the original dissolution apparatus host and the automatic sampling workstation 8, and then replaces the immersion tank sampling needle 4 / rehydration needle 5 according to the pipeline number and connects it to the corresponding interface of the automatic sampling workstation 8. During the experiment, the original sampling rack of the dissolution apparatus host will no longer descend, and the sampling needle 4 / rehydration needle 5 in the immersion tank automatic sampling device will stay in the dissolution cup 1. After the experiment, the pipeline of the immersion tank automatic sampling device can be removed from the automatic sampling workstation 8 and installed back on the dissolution apparatus host.

[0040] The above description is only a preferred embodiment of the utility model, and does not limit the patent scope of the utility model. All equivalent structural changes made by using the contents of the utility model specification and drawings under the utility model concept, or directly / indirectly used in other related technical fields are included in the patent protection scope of the utility model.

Claims

1. An immersion tank automatic sampling device, characterized in that: include: Dissolution cup, an integrated dissolution cup cover placed on the dissolution cup, a fixed needle holder, a sampling needle, and a rehydration needle; The dissolution cup is used to contain the solution to be tested; The integrated dissolution cup cover is provided with a needle seat fixing hole; The fixed needle seat is inserted into the needle seat fixing hole and is used to fix the sampling needle and the fluid infusion needle; The sampling needle is used to take samples from the dissolution cup; the rehydration needle is used to add liquid to the dissolution cup; the lower ends of the sampling needle and the rehydration needle are both passed through the fixed needle seat and placed in the dissolution cup, and are a certain distance away from the wall of the dissolution cup.

2. The automatic sampling device of the immersion tank method according to claim 1, characterized in that: The external automatic sampling workstation is connected to the upper end of the sampling needle through a sampling pipeline and a sampling pipeline connector; the external automatic sampling workstation is connected to the upper end of the infusion needle through a fluid infusion pipeline and a fluid infusion pipeline connector.

3. The automatic sampling device of the immersion tank method according to claim 2 is characterized in that: The upper end of the sampling needle and the upper end of the fluid infusion needle are both bent at 90 degrees, so as to be easily connected to an external automatic sampling workstation.

4. The automatic sampling device using the immersion tank method according to any one of claims 1 to 3, characterized in that: The lower end of the sampling needle and the lower end of the rehydration needle are both 6 mm away from the wall of the dissolution cup.

5. The automatic sampling device using the immersion tank method according to claim 4, characterized in that: The number of the fixed needle seats is 2, and correspondingly, the number of the needle seat fixing holes is 2, and the sampling needle and the fluid infusion needle are both fixed on a fixed needle seat.

6. The automatic sampling device using the immersion tank method according to claim 5, characterized in that: The integrated dissolution cup cover is also provided with a paddle shaft hole, and the paddle shaft hole is placed between the two needle seat fixing holes.

7. The automatic sampling device using the immersion tank method according to claim 6, characterized in that: A paddle is also arranged in the dissolution cup; a paddle shaft is also installed on the paddle; and the paddle shaft passes through the paddle shaft hole.

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