Rapid reaction flow antibody detection kit

Abstract

The utility model provides a rapid reaction flow type antibody detection box, which relates to the technical field of antibody detection and comprises a kit body, a drawing type storage box is slidably connected in the kit body, a kit cover is rotatably connected to the top of the kit body, and a torsion spring is arranged at the joint of the kit cover and the kit body. According to the kit, the kit cover capable of being rapidly opened and the drawing type antibody storage box are adopted, when the reagent bottles are taken out, only the kit cover needs to be pulled upwards, after the reagent bottles are taken out, the kit cover is automatically closed under the action of the torsional spring, and when the reagent bottles need to be cleaned or taken out at the same time, the drawing type storage box is drawn out, so that the reagent bottles are taken out. After the operation is finished, the pull-out type storage box is pushed into the kit body, the limiting strip extrudes the limiting bulge until the storage box completely enters the kit body, the limiting bulge is clamped with the arc-shaped grooves in the two sides of the limiting strip, and the limiting spring not only ensures the stability between the storage box and the kit body, but also does not affect the pull-out of the storage box.

Description

Technical Field

[0001] The utility model relates to the technical field of antibody detection, in particular to a rapid reaction flow antibody detection box. Background Art

[0002] Flow cytometry is a modern cell analysis method developed in the 1970s. It integrates computer technology, laser technology, fluid mechanics, cell chemistry and immunology, and has the function of analyzing and sorting cells. It can separate cells with different sizes and intracellular granularity by collecting forward scattered light and side scattered light, and can quickly measure cell surface antigens, cytokines and other cell biological indicators by identifying specific fluorescent markers on the cell surface and inside the cell.

[0003] Flow antibodies are a specific type of antibody used in flow cytometry. They are usually conjugated to fluorescein or other detectable markers and are used to recognize and quantify specific antigens on the cell surface or within cells.

[0004] A flow cytometry antibody test kit is a test kit for flow cytometry, which contains the flow antibodies required for the detection of specific cell surface or intracellular markers. Existing test kits are usually of an integrated design. In order to ensure stability during transportation, the test kit cover is fixedly connected to the test kit, resulting in a considerable amount of time spent on removing the reagent bottles. Furthermore, when different reagent bottles need to be removed multiple times, this operation needs to be repeated, resulting in the inability of the flow antibodies to react quickly with the cells being detected, affecting the detection efficiency. Utility Model Content

[0005] The utility model aims to solve the shortcomings in the prior art and proposes a rapid reaction flow antibody detection kit.

[0006] In order to achieve the above-mentioned purpose, the utility model adopts the following technical scheme: a rapid reaction flow antibody detection box, including a test kit box body, a pull-out storage box is slidably connected inside the test kit box body, and both sides of the pull-out storage box are provided with limit bars, the side walls of the test kit box body are provided with limit grooves, and the limit bars are arranged in the limit grooves, the side walls of the limit grooves are provided with limit slides, the limit slides are slidably connected inside the limit protrusions, and the side surfaces of the limit protrusions and the side walls of the limit slides are fixed with limit springs, the side surfaces of the limit strips are provided with arc grooves, the top of the test kit box body is rotatably connected with a test kit cover, and a torsion spring is provided at the connection between the test kit cover and the test kit box body.

[0007] Preferably, the top array of the pull-out storage box is provided with a reagent bottle storage slot, a compression spring is fixed at the bottom of the reagent bottle storage slot, a base is fixed at the other end of the compression spring, both sides of the base are provided with a snap-fit ​​protrusion, and a snap-fit ​​slot is provided on the inner wall of the reagent bottle storage slot. When the existing antibody reagent bottle is taken out, the reagent bottle enters the reagent bottle storage slot deeply, so that the staff can only grab the top of the reagent bottle, making it difficult to take out the reagent bottle. In view of such problems, the utility model adopts an automatic pop-up structure. When the reagent bottle is placed in the storage slot, the base is squeezed downward until the snap-fit ​​protrusions on both sides of the base are snap-fitted with the slot in the storage slot, and the compression spring is in a slightly compressed state at this time, and the elastic force of the spring is less than the friction between the snap-fit ​​protrusion and the slot. When the reagent bottle needs to be taken out, the reagent bottle is continued to be pressed downward to increase the compression amount of the compression spring, so that the rebound force of the compression spring is greater than the friction between the snap-fit ​​protrusion and the slot, and the base is popped out to half the depth of the storage slot, which is convenient for taking out the reagent bottle and improving the detection efficiency.

[0008] Preferably, a rubber sleeve is bonded to the inner wall of the base, which not only increases the friction between the inner wall of the base and the bottom of the reagent bottle, thus improving the stability of the reagent bottle, but also plays a protective role, preventing the bottom of the reagent bottle from breaking.

[0009] Preferably, one end of the limiting strip is provided as a pull-out protrusion to facilitate pulling out the storage box.

[0010] Preferably, the surface array of the pull-out protrusions is provided with anti-skid patterns, which increase the friction between the pull-out protrusions and the fingers of the staff, further facilitating the staff to move the pull-out storage box.

[0011] Preferably, one end of the reagent box cover is provided with an upward protrusion to facilitate staff to open the reagent box cover.

[0012] Preferably, gripping grooves are provided on both sides of the reagent box body to facilitate staff to carry the reagent box body.

[0013] Beneficial Effects

[0014] 1. A flow cytometry antibody test kit is a kit for flow cytometry, which contains the flow antibodies required for the detection of specific cell surface or intracellular markers. Existing test kits are usually designed in an integrated manner. In order to ensure stability during transportation, the test kit cover is fixedly connected to the test kit, which results in a considerable amount of time spent on removing the reagent bottles. Furthermore, when different reagent bottles need to be removed multiple times, this operation needs to be repeated, resulting in the inability of the flow antibodies to react quickly with the cells being detected, thus affecting the detection efficiency. The utility model adopts a quick-opening box cover and a pull-out antibody storage box. When removing the reagent bottles, you only need to pull up the box cover to remove them. After the reagent bottle is taken out, the box cover is automatically closed under the action of the torsion spring, which is not only highly stable but also easy to operate, saving time and effort, allowing the flow cytometry antibody to react quickly with the cells being tested during testing. When cleaning or taking out multiple reagent bottles at the same time, the pull-out storage box can be pulled out, and then the pull-out storage box can be pushed into the test kit box after completion. At the same time, to ensure stability during transportation, when the storage box enters the box body, the limit bar squeezes the limit protrusion until the storage box is completely entered into the box body, and the limit protrusion engages with the arc grooves on both sides of the limit bar. The limit spring not only ensures the stability between the storage box and the box body, but also does not affect the storage box being pulled out.

[0015] 2. When the existing antibody reagent bottle is taken out, since the reagent bottle is deep inside the reagent bottle storage slot, the staff can only grab the top of the reagent bottle, which makes it difficult to take out the reagent bottle. To address this problem, the utility model adopts an automatic pop-up structure. When the reagent bottle is placed in the storage slot, the base is squeezed downward until the engaging protrusions on both sides of the base engage with the engaging slots in the storage slot, and at this time the compression spring is in a slightly compressed state, and the elastic force of the spring is less than the friction between the engaging protrusion and the engaging slot. When the reagent bottle needs to be taken out, the reagent bottle continues to be pressed downward to increase the compression amount of the compression spring, so that the rebound force of the compression spring is greater than the friction between the engaging protrusion and the engaging slot, and the base is popped out to half the depth of the storage slot, which makes it convenient to take out the reagent bottle and improves the detection efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a three-dimensional structural schematic diagram of the utility model;

[0017] Figure 2 It is a three-dimensional structural schematic diagram of the reagent bottle storage box of the utility model;

[0018] Figure 3 It is a cross-sectional view of the reagent bottle storage box of the utility model;

[0019] Figure 4 It is a cross-sectional view of the reagent box body in the utility model;

[0020] Figure 5 It is a three-dimensional structural schematic diagram of the automatic pop-up structure in the utility model;

[0021] Figure 6 It is a three-dimensional structural schematic diagram of the limiting structure in the utility model.

[0022] Legend:

[0023] 1. Reagent box body; 101. Grasping groove; 2. Pull-out storage box; 201. Limiting strip; 202. Pull-out protrusion; 3. Box cover; 301. Upward protrusion; 4. Reagent bottle storage slot; 401. Card slot; 5. Base; 501. Engaging protrusion; 6. Compression spring; 7. Limiting groove; 8. Limiting protrusion; 9. Limiting spring. DETAILED DESCRIPTION

[0024] In order to make the technical means, creative features, objectives and effects of the present invention easy to understand, the present invention is further described below in conjunction with specific embodiments and drawings, but the following embodiments are only preferred embodiments of the present invention, not all. Based on the embodiments in the implementation mode, other embodiments obtained by those skilled in the art without creative work are all within the protection scope of the present invention.

[0025] The specific embodiments of the present utility model are described below in conjunction with the accompanying drawings. Specific embodiment:

[0027] Reference Figure 1-6 , a rapid reaction flow antibody detection kit, comprising a reagent box body 1, and gripping grooves 101 are provided on both sides of the reagent box body 1, so that the staff can carry the reagent box body 1 conveniently. A pull-out storage box 2 is slidably connected inside the reagent box body 1, and both sides of the pull-out storage box 2 are provided with limit strips 201, and the side walls of the reagent box body 1 are provided with limit slots 7, and the limit strips 201 are provided in the limit slots 7, and the side walls of the limit slots 7 are provided with limit slides, and the limit slides are slidably connected with limit protrusions 8 inside the limit slides, and the side surfaces of the limit protrusions 8 and the side walls of the limit slides are fixed with limit springs 9, and the side surfaces of the limit strips 201 are provided with arc grooves, and the top of the reagent box body 1 is rotatably connected with a reagent box cover 3, and a torsion spring is provided at the connection between the reagent box cover 3 and the reagent box body 1. One end of the reagent box cover 3 is provided with an upturned protrusion 301, so that the staff can open the reagent box cover 3 conveniently. One end of the limit strip 201 is provided with a pull-out protrusion 202, so as to facilitate the pull-out storage box. The surface of the pull-out protrusion 202 is provided with an array of anti-skid patterns, which increase the friction between the pull-out protrusion 202 and the fingers of the staff, further facilitating the staff to move the pull-out storage box 2.

[0028] The top array of the pull-out storage box 2 is provided with a reagent bottle storage slot 4, a compression spring 6 is fixed at the bottom of the reagent bottle storage slot 4, a base 5 is fixed at the other end of the compression spring 6, and a rubber sleeve is bonded to the inner wall of the base 5. The rubber sleeve not only increases the friction between the inner wall of the base 5 and the bottom of the reagent bottle, improves the stability of the reagent bottle, but also plays a protective role to prevent the bottom of the reagent bottle from breaking. Both sides of the base 5 are set as engaging protrusions 501, and the inner wall of the reagent bottle storage slot 4 is provided with a card slot 401. When the existing antibody reagent bottle is taken out, since the reagent bottle is deeply inserted into the reagent bottle storage slot 4, the staff can only grab the top of the reagent bottle, which makes it difficult to take out the reagent bottle. To address this problem, the utility model adopts an automatic pop-up structure. When the reagent bottle is placed in the storage slot 4, the base 5 is squeezed downward until the engaging protrusions 501 on both sides of the base 5 are engaged with the engaging slots 401 in the storage slot, and at this time the compression spring 6 is in a slightly compressed state, and the elastic force of the spring is less than the friction between the engaging protrusion 501 and the engaging slot 401. When the reagent bottle needs to be taken out, the reagent bottle is continued to be pressed downward to increase the compression amount of the compression spring 6, so that the rebound force of the compression spring 6 is greater than the friction between the engaging protrusion 501 and the engaging slot 401, and the base 5 is popped out to half the depth of the storage slot 4, which is convenient for taking out the reagent bottle and improves the detection efficiency.

[0029] A flow cytometry antibody test kit is a kit for flow cytometry, which contains the flow antibodies required for the detection of specific cell surface or intracellular markers. Existing test kits are usually designed in an integrated manner. In order to ensure stability during transportation, the test kit cover is fixedly connected to the test kit, which results in taking out the reagent bottles taking a lot of time. Moreover, when different reagent bottles need to be taken out multiple times, this operation needs to be repeated, resulting in the inability of the flow antibodies to react quickly with the cells being tested, affecting the detection efficiency. The utility model adopts a quick-opening box cover and a pull-out antibody storage box. When taking out the reagent bottles, you only need to pull up the box cover. After taking out the reagent bottles, The box cover closes automatically under the action of the torsion spring, which is not only highly stable but also easy to operate, saving time and effort. During detection, the flow cytometry antibody can react quickly with the detected cells. When cleaning or taking out multiple reagent bottles at the same time, the pull-out storage box 2 can be pulled out, and then the pull-out storage box 2 can be pushed into the reagent box body 1. At the same time, to ensure stability during transportation, when the storage box enters the box body, the limit bar 201 squeezes the limit protrusion 8 until the storage box completely enters the box body. The limit protrusion 8 is engaged with the arc grooves on both sides of the limit bar 201. The limit spring 9 not only ensures the stability between the storage box and the box body, but also does not affect the storage box being pulled out.

[0030] The working principle of the utility model is as follows: the pull-out storage box 2 is pulled out, and the reagent bottles are sequentially placed in the corresponding reagent bottle storage slots 4. When the reagent bottles are placed in the storage slots 4, the base 5 is pressed downward until the engaging protrusions 501 on both sides of the base 5 engage with the engaging slots 401 in the storage slots, and at this time, the compression spring 6 is in a slightly compressed state, and the elastic force of the spring is less than the friction between the engaging protrusions 501 and the engaging slots 401. After the end, the pull-out storage box 2 is pushed into the reagent box body 1, and the storage box enters the box body. When the reagent bottle is taken out, the box cover is pulled up and the reagent bottle is pressed down continuously to increase the compression amount of the compression spring 6, so that the rebound force of the compression spring 6 is greater than the friction force between the engaging protrusion 501 and the engaging groove 401, and the base 5 is ejected to half the depth of the storage groove 4. Finally, the reagent bottle is taken out and the box cover is released, and the box cover is automatically closed under the action of the torsion spring.

[0031] In the present utility model, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0032] The above shows and describes the basic principle, main features and advantages of the utility model. Those skilled in the art should understand that the utility model is not limited by the above embodiments. The above embodiments and descriptions are only preferred examples of the utility model and are not used to limit the utility model. Without departing from the spirit and scope of the utility model, the utility model may have various changes and improvements, which fall within the scope of the utility model to be protected. The scope of protection of the utility model is defined by the attached claims and their equivalents.

Claims

1. A rapid reaction flow cytometry antibody detection kit, comprising a kit body (1), characterized in that: The reagent box body (1) is slidably connected to a pull-out storage box (2), and both sides of the pull-out storage box (2) are provided with limit strips (201). The side walls of the reagent box body (1) are provided with limit grooves (7), and the limit strips (201) are arranged in the limit grooves (7). The side walls of the limit grooves (7) are provided with limit slide grooves. The limit slide grooves are slidably connected to limit protrusions (8), and the side surfaces of the limit protrusions (8) and the side walls of the limit slide grooves are fixed with limit springs (9). The side surfaces of the limit strips (201) are provided with arc grooves. The top of the reagent box body (1) is rotatably connected to a reagent box cover (3), and a torsion spring is provided at the connection between the reagent box cover (3) and the reagent box body (1).

2. The rapid reaction flow cytometry antibody detection kit according to claim 1, characterized in that: The top array of the pull-out storage box (2) is provided with a reagent bottle storage slot (4), the bottom of the reagent bottle storage slot (4) is fixed with a compression spring (6), the other end of the compression spring (6) is fixed with a base (5), both sides of the base (5) are provided with a snap-fitting protrusion (501), and the inner wall of the reagent bottle storage slot (4) is provided with a snap-fitting slot (401).

3. The rapid reaction flow cytometry antibody detection kit according to claim 2, characterized in that: A rubber sleeve is bonded to the inner wall of the base (5).

4. The rapid reaction flow cytometry antibody detection kit according to claim 1, characterized in that: One end of the limiting strip (201) is provided as a pull-out protrusion (202).

5. The rapid reaction flow cytometry antibody detection kit according to claim 4, characterized in that: The surface of the pull-out protrusion (202) is provided with an array of anti-slip grooves.

6. The rapid reaction flow cytometry antibody detection kit according to claim 1, characterized in that: One end of the reagent box cover (3) is provided with an upward protrusion (301).

7. The rapid reaction flow cytometry antibody detection kit according to claim 1, characterized in that: The reagent kit body (1) is provided with gripping grooves (101) on both sides.

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