Mixed core temperature control plate for plasmid preparation

Abstract

The utility model belongs to the technical field of temperature control plates, and particularly relates to a mixed core temperature control plate for plasmid preparation, which comprises a first mixed core temperature control plate body, a second mixed core temperature control plate body and a third mixed core temperature control plate body, the first mixing core temperature control plate body, the second mixing core temperature control plate body and the third mixing core temperature control plate body are each provided with a mixing cavity, the mixing cavities are distinguished through handrails, and flow guide particles are distributed on the mixing cavities. According to the utility model, the mixed core temperature control plate is used for replacing a traditional reactor jacket or a bottom heating unit, so that the temperature control plate can be ensured to keep good performance during long-term operation, uncertain factors caused by a complex structure are reduced, and smooth production or experiment can be better ensured; meanwhile, for the condition that the temperature control plate needs to be frequently adjusted or replaced, the simple design can also improve the operation efficiency and reduce the cost and the time consumption.

Description

Technical Field

[0001] The utility model relates to the technical field of temperature control plates, in particular to a mixed core temperature control plate used for plasmid preparation. Background Art

[0002] The production process of mRNA (messenger ribonucleic acid) is a complex and delicate process, in which the use of plasmid preparation and mixing core temperature control plate technologies play a key role.

[0003] Typically, plasmids are designed to carry sequences encoding specific mRNAs. Through a series of molecular biology operations, such as amplification, extraction, and purification, high-quality plasmids containing the target sequence are obtained.

[0004] The Mixing Core Temperature Control Plate helps to precisely control the temperature during the reaction. In different production stages, specific temperature conditions are required to ensure efficient reaction and product quality. For example, during transcription, the appropriate temperature can promote enzyme activity and reaction rate.

[0005] The mixing core temperature control plate replaces the traditional reactor jacket or bottom heating unit. The coolant or heat medium flows through the temperature control plate and convects with the medium in the mixing core to achieve a full heat exchange effect. The flow channel is filled with irregular particles, which causes the passing fluid to form turbulence and increase the exchange area, so that the heat exchange effect is optimal.

[0006] To this end, we proposed a hybrid core temperature control plate for plasmid preparation to meet market demand. Utility Model Content

[0007] 1. Technical issues to be solved

[0008] In view of the deficiencies of the prior art, the utility model provides a mixed core temperature control plate for plasmid preparation, which solves the problems raised in the above background technology.

[0009] (II) Technical solution

[0010] In order to achieve the above-mentioned purpose, the utility model specifically adopts the following technical solutions:

[0011] A mixing core temperature control plate for plasmid preparation, comprising a first mixing core temperature control plate body, a second mixing core temperature control plate body and a third mixing core temperature control plate body, wherein the first mixing core temperature control plate body, the second mixing core temperature control plate body and the third mixing core temperature control plate body are all provided with mixing chambers, the mixing chambers are separated by railings, and flow-guiding particles are distributed on the mixing chambers, the first mixing core temperature control plate body, the second mixing core temperature control plate body and the third mixing core temperature control plate body are provided with flow channel openings, the sides of the second mixing core temperature control plate body and the third mixing core temperature control plate body are provided with wedge blocks, the side walls of the first mixing core temperature control plate body and the second mixing core temperature control plate body are provided with wedge grooves corresponding to the wedge blocks, and positioning holes are provided at the four corners of the first mixing core temperature control plate body, the second mixing core temperature control plate body and the third mixing core temperature control plate body.

[0012] Furthermore, the distribution directions of the flow-guiding particles are parallel, inclined, and symmetrical.

[0013] Furthermore, the flow channel opening is divided into an inlet and an outlet.

[0014] Furthermore, the height of the flow-guiding particles inside the mixing chamber is flush with the edge.

[0015] Furthermore, no wedge-shaped block is provided on the main body of the first hybrid core temperature control board, and no wedge-shaped groove is provided on the back side of the main body of the third hybrid core temperature control board.

[0016] (III) Beneficial effects

[0017] Compared with the prior art, the utility model provides a mixed core temperature control plate for plasmid preparation, which has the following beneficial effects:

[0018] The utility model replaces the traditional reactor jacket or bottom heating unit with a mixing core temperature control plate. Such a design can ensure that the temperature control plate maintains good performance in long-term operation, reduce uncertainty factors caused by complex structure, and thus better guarantee the smooth progress of production or experiments; at the same time, for situations where frequent adjustment or replacement of the temperature control plate is required, this simple design can also improve operating efficiency and reduce costs and time consumption. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the structure of the utility model;

[0020] Figure 2 It is the rear view of the structure of the utility model.

[0021] In the figure: 1. the first mixing core temperature control board body; 2. the second mixing core temperature control board body; 3. the third mixing core temperature control board body; 4. the mixing chamber; 5. the flow guide particles; 6. the flow channel opening; 7. the railing; 8. the wedge block; 9. the wedge groove; 10. the positioning hole. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0023] Example

[0024] like Figure 1 and 2 As shown, a hybrid core temperature control plate for plasmid preparation proposed in one embodiment of the utility model comprises a first hybrid core temperature control plate body 1, a second hybrid core temperature control plate body 2 and a third hybrid core temperature control plate body 3, wherein the first hybrid core temperature control plate body 1, the second hybrid core temperature control plate body 2 and the third hybrid core temperature control plate body 3 are all provided with a mixing chamber 4, the mixing chambers 4 are distinguished by a railing 7, and flow guide particles 5 are distributed on the mixing chamber 4, the first hybrid core temperature control plate body 1, the second hybrid core temperature control plate body 2 and the third hybrid core temperature control plate body 3 are provided with a flow channel opening 6, the second hybrid core temperature control plate body 2 and the third hybrid core temperature control plate body 3 are provided with a wedge block 8 on the side, the first hybrid core temperature control plate body 1 and the second hybrid core temperature control plate body 2 are provided with a wedge groove 9 corresponding to the wedge block 8 on the side wall, and the first hybrid core temperature control plate body 1, the second hybrid core temperature control plate body 2 and the third hybrid core temperature control plate body 3 are provided with positioning holes 10 at the four corners;

[0025] The first mixing core temperature control plate body 1, the second mixing core temperature control plate body 2 and the third mixing core temperature control plate body 3: these three parts together constitute the entire temperature control plate, and they work together to achieve temperature control and mixing functions in the plasmid preparation process.

[0026] Mixing chamber 4: provides a space for mixed reaction. The design of mixing chamber 4 can carry out reaction or realize different stages of reaction, such as mixing of refrigerant or heat medium;

[0027] Railing 7: It serves to separate the mixing chamber 4, helps to maintain the relative independence of each reaction area, and avoids mutual interference between different reactions.

[0028] The diversion particles 5 have a variety of distribution directions, such as parallel and inclined and symmetrical distribution, which is beneficial to guiding the flow of the reaction substances and promoting more uniform and efficient mixing.

[0029] Flow channel 6: By distinguishing the inlet and outlet, it is convenient to control the entry and outflow of the reaction materials and realize an orderly reaction process.

[0030] Wedge block 8 and wedge groove 9: This connection structure enables the second hybrid core temperature control board body and the third hybrid core temperature control board body 3 to be tightly connected, thereby improving the overall stability and reliability, and the second hybrid core temperature control board body 2 can have multiple stacking structures;

[0031] Positioning hole 10: used to accurately position the temperature control plate during installation or use to ensure the accuracy of its position in the equipment, thereby ensuring the precise conduct of the reaction.

[0032] like Figure 1 As shown, in some embodiments, the distribution direction of the flow-guiding particles 5 is parallel, inclined, and symmetrical; the parallel distribution of the flow-guiding particles 5 can guide the fluid to flow more evenly in a specific direction to a certain extent, which helps to achieve a relatively smooth and orderly mixing process, while the inclined distribution increases the complexity and diversity of the fluid flow. It will produce some irregular flow paths, thereby enhancing the mixing effect and allowing different components to contact and react more fully.

[0033] like Figure 1 As shown, in some embodiments, the flow channel opening 6 is divided into an inlet and an outlet; clearly distinguishing the inlet and the outlet can ensure that the reaction substances enter and leave the mixing chamber 4 in a specific direction and order. This can achieve the orderliness of the reaction process and avoid chaotic flow and cross contamination of substances.

[0034] like Figure 1 As shown, in some embodiments, the height of the flow-guiding particles 5 inside the mixing chamber 4 is flush with the edge, and the height flush with the edge helps to maintain the stability of the flow field inside the mixing chamber 4 and can maintain the sealing of the stack.

[0035] like Figure 1 and 2 As shown, in some embodiments, the wedge block 8 is not provided on the first hybrid core temperature control board body 1, and the wedge groove 9 is not provided on the back of the third hybrid core temperature control board body 3; in practical applications, such design differences can provide more flexibility and adaptability for the assembly and use of the temperature control board.

[0036] Finally, it should be noted that the above description is only a preferred embodiment of the utility model and is not intended to limit the utility model. Although the utility model is described in detail with reference to the above embodiments, those skilled in the art can still modify the technical solutions recorded in the above embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A hybrid core temperature control plate for plasmid preparation, comprising a first hybrid core temperature control plate body (1), a second hybrid core temperature control plate body (2) and a third hybrid core temperature control plate body (3), characterized in that: The first hybrid core temperature control board body (1), the second hybrid core temperature control board body (2) and the third hybrid core temperature control board body (3) are all provided with a mixing chamber (4), the mixing chambers (4) are separated by railings (7), flow guide particles (5) are distributed on the mixing chambers (4), the first hybrid core temperature control board body (1), the second hybrid core temperature control board body (2) and the third hybrid core temperature control board body (3) are provided with flow channel openings (6), the sides of the second hybrid core temperature control board body (2) and the third hybrid core temperature control board body (3) are provided with wedge blocks (8), the side walls of the first hybrid core temperature control board body (1) and the second hybrid core temperature control board body (2) are provided with wedge grooves (9) corresponding to the wedge blocks (8), and the four corners of the first hybrid core temperature control board body (1), the second hybrid core temperature control board body (2) and the third hybrid core temperature control board body (3) are provided with positioning holes (10).

2. A mixed core temperature control plate for plasmid preparation according to claim 1, characterized in that: The distribution direction of the flow-guiding particles (5) is parallel or inclined, and is symmetrically distributed.

3. A mixed core temperature control plate for plasmid preparation according to claim 1, characterized in that: The flow channel opening (6) is divided into an inlet and an outlet.

4. A mixed core temperature control plate for plasmid preparation according to claim 2, characterized in that: The height of the flow-guiding particles (5) inside the mixing chamber (4) is flush with the edge.

5. A mixed core temperature control plate for plasmid preparation according to claim 1, characterized in that: The first hybrid core temperature control plate body (1) is not provided with a wedge block (8), and the back side of the third hybrid core temperature control plate body (3) is not provided with a wedge groove (9).

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