Axially-supported convection chromatographic column

Abstract

The utility model discloses an axial support convection chromatographic column which comprises at least two sections of convection chromatographic column layers, the diameters of the at least two sections of convection chromatographic column layers are the same, and the end surfaces of the at least two sections of convection chromatographic column layers are butted; and a sealing gasket is arranged between every two adjacent sections of convection chromatographic column layers. After the sealing gasket is arranged, the axial amplification is realized, the back pressure of a system is not increased, and the uniformity and the rigidity of a plurality of sections of convection chromatography column layers with smaller lengths are higher than those of a single section of convection chromatography column layer with longer length.

Description

Technical Field

[0001] The utility model relates to the field of chromatography, in particular to an axially supported convection chromatography column. Background Art

[0002] The convection chromatography column layer used in the field of chromatography is generally annular. When the overall chromatography column is enlarged in volume, there are two directions, one is axial enlargement, that is, increasing the height of the convection chromatography column layer; the other is radial enlargement, that is, increasing the thickness of the convection chromatography column layer. Since the path through which the liquid phase flows is in the radial direction, when the radial direction is enlarged, the path through which the liquid phase flows also becomes larger accordingly, resulting in an increase in back pressure. Simply increasing the height of the convection chromatography column layer will also face some uncertainties. First, since the production process of the convection chromatography column layer is a polymerization sedimentation process, when the height of the convection chromatography column layer increases, the uniformity will deteriorate in the axial direction due to the different order of sedimentation, resulting in poor column efficiency; second, after the height becomes higher, the rigidity of the middle part of the axial direction of the convection chromatography column layer will deteriorate due to the lack of effective support; third, after the height increases, the mold for making the convection chromatography column layer must become larger accordingly, which brings great challenges to mold processing and production technology. Utility Model Content

[0003] In order to solve the defects of the above-mentioned prior art, the utility model provides an axially supported convection chromatography column. After the sealing gasket is set, the utility model is axially enlarged and will not increase the back pressure of the system. The uniformity of the convection chromatography column layer with multiple sections of smaller lengths is higher than that of the convection chromatography column layer with a single section of longer lengths, the rigidity is also higher, and the production process is simpler.

[0004] To achieve the above technical objectives, the utility model adopts the following technical solutions: an axially supported convection chromatography column, comprising at least two convection chromatography column layers, wherein the diameters of the at least two convection chromatography column layers are the same and the end faces are butted against each other; a sealing gasket is arranged between two adjacent convection chromatography column layers, wherein the sealing gasket absorbs size fluctuations and forms a seal; and the at least two convection chromatography column layers are provided with a supporting structure.

[0005] Furthermore, the sealing gasket is made of silicone or fluororubber.

[0006] Furthermore, the support structure includes an inner support, an upper support, and a lower support; the inner support is arranged on the inner wall of the at least two sections of the convection chromatography column layer, the upper support is arranged on the end surface of the convection chromatography column layer at the outermost end, and the lower support is arranged on the end surface of the convection chromatography column layer at the outermost end.

[0007] Furthermore, the inner support adopts a filter structure.

[0008] In summary, the utility model has achieved the following technical effects:

[0009] The utility model is axially enlarged after the sealing pad is arranged, which will not increase the back pressure of the system, and the uniformity of the convection chromatography column layer with multiple sections of smaller lengths is higher than that of the convection chromatography column layer with a single section of longer lengths, and the rigidity is also higher. BRIEF DESCRIPTION OF THE DRAWINGS

[0010] Figure 1 It is a schematic diagram of a double-section convection chromatography column layer provided by an embodiment of the utility model;

[0011] Figure 2 yes Figure 1 Schematic cross-sectional view of ;

[0012] Figure 3 It is a schematic diagram of three sections of convection chromatography column;

[0013] Figure 4 yes Figure 3 Schematic cross-section diagram of . DETAILED DESCRIPTION

[0014] The utility model is further described in detail below in conjunction with the accompanying drawings.

[0015] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

[0016] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0017] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present utility model, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0018] In the present invention, unless otherwise clearly specified and limited, the terms "install", "connect", "connect", "fix" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0019] In the present utility model, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being "above", "above" or "above" a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being "below", "below" or "below" a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0020] Example:

[0021] An axially supported convection chromatography column comprises at least two convection chromatography column layers, wherein the at least two convection chromatography column layers have the same diameter and are butted end-to-end; a sealing gasket is arranged between two adjacent convection chromatography column layers to absorb dimensional fluctuations and form a seal.

[0022] The sealing gasket is used to form a seal between the sections. The convective chromatography column layer is axially enlarged, and the back pressure of the system will not be increased after adding the sealing gasket. Moreover, the uniformity and rigidity of the convective chromatography column layer with multiple sections and smaller lengths are higher than those of the convective chromatography column layer with a single section and longer length.

[0023] The sealing pad is made of silicone or fluororubber, which can absorb axial size fluctuations to a certain extent and also has a sealing function. During the chromatography process, the mobile phase can only pass through the chromatography column but cannot pass through the sealing pad area.

[0024] like Figure 1 The diagram is a schematic diagram of a double-section convection chromatography column. Figure 2 Shown is Figure 1 A cross-sectional schematic diagram of the present invention is shown in FIG. 1 , wherein a sealing gasket 2 is provided between the upper convection chromatography column layer 1 and the lower convection chromatography column layer 3 to play the role of supporting and sealing and absorbing size fluctuations. Figure 3 The diagram shows a three-section convective chromatography column. Figure 4 Shown is Figure 3A cross-sectional schematic diagram shows that a sealing gasket 2 is arranged between the upper convection chromatography column layer 1 and the middle convection chromatography column layer 3, and a sealing gasket 2 is arranged between the middle convection chromatography column layer 3 and the lower convection chromatography column layer 4, which play the role of supporting and sealing and absorbing size fluctuations.

[0025] In the utility model, at least two sections of convection chromatography column layers are provided with a support structure, and the support structure includes an inner support, an upper support, and a lower support; the inner support is arranged on the inner wall of the at least two sections of convection chromatography column layers, the upper support is arranged on the end surface of the convection chromatography column layer at the outermost upper end, and the lower support is arranged on the end surface of the convection chromatography column layer at the outermost lower end. The inner support adopts a filter structure.

[0026] The inner support adopts a circular plate structure in the form of a filter and is placed on the inner wall of the center hole of the convection chromatography column layer. All convection chromatography column layers and sealing gaskets are sleeved on the inner support, which can support all convection chromatography column layers and filter at the same time. The upper support and the lower support adopt a circular ring structure, which covers the two end faces of the entire device, clamps the inner support, and can fix the inner support. At the same time, all convection chromatography column layers are tightened in cooperation with the inner support. The upper support and the lower support are solid structures and can form a seal on the two end faces. The upper support and the lower support can be made of stainless steel, rubber, plastic and other materials.

[0027] The above description is only a preferred implementation mode of the present invention, and does not limit the present invention in any form. Any simple modification, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention are within the scope of the technical solution of the present invention.

Claims

1. An axially supported convection chromatography column, characterized in that: The invention comprises at least two sections of convection chromatography column layers, wherein the diameters of the at least two sections of convection chromatography column layers are the same and the end surfaces are butted against each other; a sealing gasket is arranged between two adjacent sections of the convection chromatography column layers, and the sealing gasket absorbs the size fluctuation and forms a seal; and the at least two sections of convection chromatography column layers are provided with a supporting structure.

2. The axially supported convection chromatography column according to claim 1, characterized in that: The sealing gasket is made of silicone or fluororubber.

3. The axially supported convection chromatography column according to claim 1, characterized in that: The support structure comprises an inner support, an upper support and a lower support; the inner support is arranged on the inner wall of the at least two sections of the convection chromatography column layer, the upper support is arranged on the end surface of the convection chromatography column layer at the outermost end of the upper end, and the lower support is arranged on the end surface of the convection chromatography column layer at the outermost end of the lower end.

4. The axially supported convection chromatography column according to claim 3, characterized in that: The inner support adopts a filter structure.

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