Biological fermentation tank

Abstract

The utility model provides a biological fermentation tank which comprises a cylinder body and at least one heat exchange unit group, the heat exchange unit group comprises a plurality of sections of heat exchange units which are uniformly arranged along the axial direction of the inner wall of the barrel body; each section of heat exchange unit comprises a heat exchange connecting pipe and a heat exchange shell; the two sections of heat exchange connecting pipes are connected to the two ends of the heat exchange shell correspondingly. The heat exchange efficiency of the fermentation tank can be improved through a special array structure of the heat exchange units in the cylinder body, a heat exchange path of one cold / heat medium or two cold / heat mediums can be realized through a multi-layer interface form of the heat exchange unit group and different connection modes adjusted according to working conditions, and the cost can be reduced while accurate temperature control is realized.

Description

Technical Field

[0001] The utility model relates to the field of biopharmaceuticals and machinery for fermentation tanks, in particular to a device for heat exchange and layered sampling of fermentation tanks. Background Art

[0002] In the field of biopharmaceuticals, fermentation tanks are the core components of biological stock solution reactions and are particularly important in the entire pharmaceutical process. According to process requirements, the temperature of the fermentation tank needs to be controlled to adjust the temperature inside the tank to the most suitable range for production.

[0003] Existing fermentation tank heat exchange technology often uses a single jacket heat exchange unit for heat exchange. In a jacketed heat exchange unit, heat must first be transferred through the barrel, and the thermal resistance of this process limits the speed and efficiency of heat exchange. Some fermentation tank heat exchange technologies use a coil heat exchange unit inside the barrel. Although the directness of heat exchange is improved, the overall efficiency of the heat exchange unit is still limited because the coil can only cover a limited area of ​​the barrel; when using these two heat exchange units, the temperature inside the fermentation tank barrel varies greatly, and it is difficult to accurately control the overall temperature. In addition, due to the complex structure of the jacketed heat exchange unit and the coil heat exchange unit inside the barrel, it is not easy to clean and cannot be guaranteed to avoid contamination. Moreover, in the existing fermentation tank pharmaceutical field, the real-time status of the material inside the barrel cannot be directly tracked and verified, which further increases the uncertainty of the production process.

[0004] Therefore, it is urgent to propose a new fermentation tank heat exchange unit group to improve the heat exchange efficiency and solve the problem of inability to accurately control temperature. Utility Model Content

[0005] The utility model aims to provide a biological fermentation tank and a heat exchange unit group thereof, aiming to achieve precise temperature control through an optimized heat exchange structure, thereby improving the heat exchange efficiency and temperature management of the fermentation process.

[0006] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0007] A biological fermentation tank comprises a cylinder and at least one group of heat exchange unit groups; the heat exchange unit group comprises a plurality of sections of heat exchange units uniformly arranged axially along the inner wall of the cylinder; each section of the heat exchange unit comprises a heat exchange pipe and a heat exchange shell; two sections of the heat exchange pipe are respectively connected to the two ends of the heat exchange shell.

[0008] Furthermore, it also includes a plurality of circulating ring pipes arranged on the outer wall of the cylinder; a circulating ring pipe is respectively provided at both ends of any section of the heat exchange unit; along the axial direction of the cylinder, the same layer is defined as equidistant from one end of the cylinder, and the heat exchange pipes located on the same layer are all connected to the circulating ring pipes located on the layer; each of the circulating ring pipes is provided with an independent ring pipe outlet and a ring pipe inlet.

[0009] Furthermore, there are 6 heat exchange unit groups, which are evenly distributed in the cylinder; each of the heat exchange unit groups includes 2 sections of heat exchange units.

[0010] Furthermore, the heat exchange unit further comprises a guide plate, one end of which is staggered and opposedly arranged inside the heat exchange shell, and the other end of the guide plate leaves a gap with the heat exchange shell on the opposite side.

[0011] Furthermore, it also includes a spray ball, which is installed in the cylinder.

[0012] Furthermore, a plurality of the spray balls are provided, and the plurality of the spray balls are respectively arranged at the top, the middle and the bottom of the cylinder.

[0013] Furthermore, three spray balls are evenly arranged on the top of the cylinder, two spray balls are symmetrically arranged in the middle of the cylinder, and two spray balls are symmetrically arranged at the bottom of the cylinder. The four spray balls arranged in the middle and bottom of the cylinder divide the circumference of the cylinder into four equal parts in the projection along the axial direction of the cylinder.

[0014] Furthermore, it also includes a jacket half-tube insulation unit, which is arranged around the outer wall of the cylinder, and the two ends of the jacket half-tube insulation unit are respectively provided with a jacket insulation inlet and a jacket insulation outlet.

[0015] Furthermore, it also includes a liquid transfer sampling unit, which is inserted into the cylinder from the top of the cylinder.

[0016] Furthermore, the pipetting sampling unit includes a locking seal, a locking nut, a sealing O-ring, a locking assembly and a pipetting sampling main tube; the locking seal, the locking nut, the sealing O-ring and the locking assembly are arranged on the pipetting sampling main tube; the barrel includes a quick-release interface, and the locking assembly passes through the quick-release interface and is also installed on the outer wall of the barrel.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] The utility model can improve the heat exchange efficiency of the fermentation tank through the special array structure of the heat exchange unit inside the cylinder. The multi-layer interface form of the heat exchange unit group and the different connection methods adjusted according to the working conditions can realize the heat exchange path of one cold / hot medium or two cold / hot mediums, which can reduce costs while achieving precise temperature control.

[0019] Furthermore, the design of multiple groups of layered spray balls combined with the special structure of the heat exchange unit greatly reduces the difficulty of cleaning the inside of the cylinder. The design of the half-tube insulation unit on the outside of the cylinder plays a role in strengthening insulation and reducing heat loss. This structure effectively improves the insulation efficiency of the fermenter, reduces energy consumption, and optimizes the overall energy efficiency performance. The design of the pipetting sampling unit can easily sample from different height levels inside the fermenter cylinder to accurately control the status of materials at each level, providing a more convenient means for monitoring and management of the fermentation process. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a general assembly diagram of a fermentation tank in an embodiment of the utility model;

[0021] Figure 2 In one embodiment of the utility model, the cylinder Figure 1 Cross-section view along the AA direction;

[0022] Figure 3 In one embodiment of the utility model, the cylinder Figure 1 Cross-section along the BB direction;

[0023] Figure 4 In one embodiment of the utility model, the cylinder Figure 1 Cross-section view in the CC direction;

[0024] Figure 5 This is a schematic diagram of the connection between the heat exchange pipe and the circulation ring pipe in one embodiment of the utility model;

[0025] Figure 6 This is an installation diagram of a liquid transfer sampling unit in one embodiment of the utility model;

[0026] Figure 7 This is a structural diagram of a liquid transfer sampling unit in one embodiment of the utility model;

[0027] Figure 8 It is a structural diagram of a heat exchange unit in one embodiment of the utility model.

[0028] In the figure: 1. Cylinder; 11. Upper spray ball; 12. Middle spray ball; 13. Lower spray ball; 2. Heat exchange unit; 21. Outlet layer 1; 22. Inlet layer 1; 23. Outlet layer 2; 24. Inlet layer 2; 25. Fixed ring; 26. Circulation ring pipe; 27. Heat exchange pipe; 28. Heat exchange shell; 29. ​​Guide plate; 3. Jacket half-tube insulation unit; 31. Jacket insulation outlet; 32. Jacket insulation inlet; 4. Liquid transfer sampling unit; 41. Locking seal; 42. Locking nut; 43. Sealing O-ring; 44. Locking assembly; 45. Liquid transfer sampling main pipe. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings of the embodiments of the utility model to clearly and completely describe the biological fermentation tank in the embodiment of the utility model. It goes without saying that the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. The description of these embodiments does not constitute a limitation on the protection scope of the utility model.

[0030] This embodiment provides a biological fermentation tank, such as Figure 1 As shown, Figure 1 The fermentation tank in one embodiment of the utility model is generally assembled. The biological fermentation tank comprises a cylinder 1 and at least one set of heat exchange unit groups; the heat exchange unit group comprises a plurality of heat exchange units 2 uniformly arranged along the inner wall of the cylinder 1 in the axial direction; Figure 8 As shown, each section of the heat exchange unit 2 includes a heat exchange pipe 27 and a heat exchange shell 28; two sections of the heat exchange pipe 27 are respectively connected to the two ends of the heat exchange shell 28.

[0031] like Figure 5 As shown, the biological fermentation tank also includes a plurality of circulation loop pipes 26 arranged on the outer wall of the cylinder 1; a circulation loop pipe 26 is respectively provided at both ends of any section of the heat exchange unit 2; the same layer is defined as being equidistant along the axial direction of the cylinder 1 and from one end of the cylinder 1, and the heat exchange pipes 27 located in the same layer are all connected to the circulation loop pipes 26 located in the layer; each of the circulation loop pipes 26 is provided with an independent loop pipe outlet and a loop pipe inlet.

[0032] like Figure 1 As shown, there are 6 heat exchange unit groups, and the heat exchange unit groups are evenly distributed in the cylinder 1; each heat exchange unit group includes 2 sections of heat exchange units 2. The 6 heat exchange unit groups have a total of two layers of inlets (the first layer of inlets 22 and the second layer of inlets 24) and two layers of outlets (the first layer of outlets 21 and the second layer of outlets 23).

[0033] like Figure 2 As shown, a total of 6 quick-install interfaces are welded on the cylinder 1 (N2a.bcdef) as an outlet layer 21; Figure 3 As shown, a total of 12 quick-install interfaces are welded on the cylinder 1 (N4&5a.bcdef), including the first layer of inlet 22 and the second layer of outlet 23; Figure 4 As shown, a total of 6 quick-install interfaces are welded on the cylinder 1 (N6a.bcdef) as the inlet second layer 24; the quick-install interfaces are reserved for installing the heat exchange unit 2.

[0034] like Figure 8As shown, the heat exchange unit 2 further includes a guide plate 29, one end of which is staggered and oppositely arranged inside the heat exchange shell 28, and the other end of the guide plate 29 leaves a gap with the heat exchange shell 28 on the opposite side; the main body of each section of the heat exchange unit 2 is a rectangular heat exchange shell 28 welded with stainless steel plates, and the outer surface of the shell is polished. One end of the fixing ring 25 is welded to the outside of the heat exchange unit 2, and the heat exchange unit 2 is welded to the cylinder 1 through the fixing ring 25.

[0035] like Figure 5 As shown, each layer of the heat exchange unit group of this embodiment is provided with 6 quick-install interfaces, which are snap-connected with the reserved interfaces of the circulation ring tube 26 to achieve quick connection. Each circulation ring tube 26 is independently configured with an inlet and an outlet to ensure smooth circulation of the fluid. In the preferred embodiment, the 4 layers of inlets and outlets (6 quick-install interfaces per layer) can be independently connected or combined into one, providing a flexible choice of heat exchange forms. According to the temperature control requirements of the fermentation tank, two heat exchange methods can be selected: one is to introduce cold / hot media of different temperatures into the upper and lower parts of the cylinder 1 to cope with the temperature difference in the cylinder during the biological reaction; the other is that under the working conditions where the temperature control requirements are not high, the upper and lower sections of each group of heat exchange unit groups are internally connected, and a single temperature of cold / hot media is used to reduce costs and working conditions. This design not only meets the temperature control requirements of the fermentation process, but also optimizes cost-effectiveness.

[0036] According to different operating conditions and the height requirements of the fermenter, a corresponding number of heat exchange unit groups can be flexibly configured, and an appropriate number of heat exchange units 2 can be further arranged in each heat exchange unit group to meet specific heat exchange efficiency requirements.

[0037] like Figure 1 As shown, three connection interfaces (N1a.bc) are welded on the top of the cylinder 1, of which there are a total of three upper spray balls 11, which are installed on the quick-install port on the top head of the fermentation tank by snap-fitting; Figure 3 and Figure 4 As shown, two quick-install interfaces (N3a.b & N7a.b) are symmetrically welded at the middle and bottom of the cylinder 1, and two middle spray balls 12 and two lower spray balls 13 are arranged. The middle spray balls 12 and the lower spray balls 13 arranged at the middle and bottom of the cylinder 1 divide the circumference of the cylinder 1 into four equal parts in the projection along the axial direction of the cylinder 1.

[0038] like Figure 1 As shown, the biological fermentation tank further comprises a jacket half-tube insulation unit 3, which is arranged around the outer wall of the cylinder 1, and a jacket insulation inlet 32 ​​and a jacket insulation outlet 31 are respectively arranged at both ends of the jacket half-tube insulation unit 3.

[0039] like Figure 6As shown, the biological fermentation tank further includes a liquid transfer sampling unit 4 , and the liquid transfer sampling unit 4 is inserted into the cylinder 1 through a quick-install interface at the top of the cylinder 1 .

[0040] like Figure 7 As shown, the liquid sampling unit 4 includes a liquid sampling main pipe 45, the upper part of which is sequentially mounted with a locking seal 41, a locking nut 42, a sealing O-ring 43 and a locking assembly 44. The end face of the locking assembly 44 is directly mounted on the quick-install interface on the top of the fermenter to ensure the stability and sealing of the overall structure.

[0041] In summary, the biofermentation tank proposed in this embodiment can improve the heat exchange efficiency of the fermentation tank through the special array structure of the heat exchange unit inside the cylinder. The multi-layer interface form of the heat exchange unit group and the different connection methods adjusted according to the working conditions can realize a heat exchange path of one cold / hot medium or two cold / hot mediums, which can reduce costs while achieving precise temperature control.

[0042] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A biological fermentation tank, characterized in that: It includes a cylinder and at least one set of heat exchange unit groups; The heat exchange unit group includes a plurality of heat exchange units uniformly arranged axially along the inner wall of the cylinder; Each section of the heat exchange unit includes a heat exchange pipe and a heat exchange shell; The two sections of the heat exchange pipe are respectively connected to the two ends of the heat exchange shell.

2. The biological fermentation tank according to claim 1, characterized in that: It also includes a plurality of circulation loops arranged on the outer wall of the cylinder; one of the two ends of any section of the heat exchange unit corresponds to one of the circulation loops; The same layer is defined along the axial direction of the cylinder and equidistant from one end of the cylinder. The heat exchange pipes located in the same layer are all connected to the circulation ring pipes located in the layer; each of the circulation ring pipes is provided with an independent ring pipe outlet and ring pipe inlet.

3. The biological fermentation tank according to claim 1, characterized in that: There are 6 heat exchange unit groups, and the heat exchange unit groups are evenly distributed in the cylinder; each of the heat exchange unit groups includes 2 sections of heat exchange units.

4. The biological fermentation tank according to claim 1, characterized in that: The heat exchange unit further comprises a guide plate, one end of which is staggered and arranged in opposition inside the heat exchange shell, and the other end of the guide plate leaves a gap with the heat exchange shell on the opposite side.

5. The biological fermentation tank according to claim 1, characterized in that: It also includes a spray ball, which is installed in the cylinder.

6. The biological fermentation tank according to claim 5, characterized in that: There are multiple spray balls, which are respectively arranged at the top, middle and bottom of the cylinder.

7. The biological fermentation tank according to claim 6, characterized in that: The top of the cylinder is evenly provided with three spray balls, the middle of the cylinder is symmetrically provided with two spray balls, and the bottom of the cylinder is symmetrically provided with two spray balls.

8. The biological fermentation tank according to claim 1, characterized in that: It also comprises a jacket half-tube heat preservation unit, which is arranged around the outer wall of the cylinder, and the two ends of the jacket half-tube heat preservation unit are respectively provided with a jacket heat preservation inlet and a jacket heat preservation outlet.

9. The biological fermentation tank according to claim 1, characterized in that: The invention also comprises a pipetting sampling unit, wherein the pipetting sampling unit is inserted into the cylinder from the top of the cylinder.

10. The biological fermentation tank according to claim 9, characterized in that: The liquid transfer sampling unit comprises a locking seal, a locking nut, a sealing O-ring, a locking assembly and a liquid transfer sampling main pipe; The locking seal, the locking nut, the sealing O-ring and the locking assembly are arranged on the pipetting sampling main tube; The cylinder comprises a quick-install interface, and the locking assembly passes through the quick-install interface and is also installed on the outer wall of the cylinder.

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