Patch clamp constant temperature device with good temperature control performance
By introducing the design of electric sliders and heat insulation covers into the diaphragm clamp constant temperature device, the temperature difference problem and low operating efficiency caused by the open workbench in the prior art are solved, and more efficient diaphragm operation and more stable constant temperature effect are achieved.
Patent Information
- Application Number
- CN202420658440.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-04-01
- Publication Date
- 2025-03-18
- Estimated Expiration
- 2034-04-01
AI Technical Summary
During the long-term cultivation process of the existing patch clamp constant temperature device, due to the influence of external temperature difference in the open workbench, the probability of living cells death is increased, the practicality of the equipment is reduced, and the operating table space is limited and the working efficiency is low.
A diaphragm clamp temperature constant device with good temperature control is designed, including a base, an adjustment mechanism and a constant temperature heater body. The workbench is driven forward and backward through an electric slider to facilitate the retention of the diaphragm, and the heat insulation cover is used to isolate the external temperature difference and improve the constant temperature effect.
The design of the electric slider improves the release efficiency of the diaphragm, the heat insulation cover reduces the impact of external temperature difference on the experiment, and improves the practicality and working efficiency of the equipment.
Smart Images
Figure CN222631440U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of patch clamp technology, in particular to a patch clamp constant temperature device with good temperature control performance. Background Art
[0002] In the patch clamp experiment, the diaphragm needs to be placed in a cell recording tank on the experimental operating table. The recording tank contains a culture liquid and needs to maintain a constant temperature. Most of the existing constant temperature devices are based on the principle of connecting a heating device and a temperature sensor at the bottom of the recording tank. The heating device and the temperature sensor are electrically connected to the controller to achieve a constant temperature effect inside the recording tank.
[0003] During the long-term cultivation process, the open workbench will increase the probability of living cells dying due to different external temperature differences, causing experimental failures and reducing the practicality of the equipment. In addition, the patch clamp operating table is mostly fixed, with limited space between it and the microscope, which is not convenient for the placement of the patch and has low work efficiency. Therefore, we propose a patch clamp thermostat with good temperature control. Utility Model Content
[0004] The purpose of the utility model is to solve the shortcomings existing in the prior art. During the long-term cultivation process, the open workbench will increase the probability of living cells dying due to different external temperature differences, causing experimental failures and reducing the practicality of the equipment. In addition, the patch clamp operating table is mostly fixed in a fixed form, and the space between it and the microscope is limited, which is not convenient for the placement of the patch and has low work efficiency.
[0005] In order to achieve the above purpose, the utility model adopts the following technical solutions:
[0006] A patch clamp thermostat with good temperature control performance, comprising a base, an adjustment mechanism is arranged at the top of the base, and a thermostat heater body is arranged at the bottom of the base;
[0007] A square groove is provided at the top of the base near the center, a first slide groove is provided at the top of the base and located on the front of the square groove, an electric slider is provided inside the first slide groove, a workbench is provided at the top of the electric slider, limiting grooves are symmetrically provided at the top of the base and located on the left and right sides of the square groove and the first slide groove, a limiting block is provided at the bottom of the workbench corresponding to the limiting groove, a groove is provided through the top of the workbench, and a diaphragm is provided inside the groove;
[0008] The adjustment mechanism comprises a fixing seat, a second slide groove is provided on the front of the fixing seat, a slider is provided inside the second slide groove, a microscope body is provided on the front of the slider near the bottom, and a heat insulation cover is provided at the bottom of the microscope body.
[0009] As a preferred solution of the utility model, the electric slider is slidably connected to the first sliding groove, and the workbench is fixedly connected to the electric slider.
[0010] The technical effect of adopting the above further solution is: the electric slider can drive the workbench to move back and forth inside the first slide groove, thereby facilitating the staff to place and take out the diaphragm inside the groove and improving work efficiency.
[0011] As a preferred solution of the utility model, the limit block is fixedly connected to the workbench, and the limit block is slidably connected to the limit groove.
[0012] The technical effect of adopting the above further solution is: through the sliding connection between the limit block and the limit groove, the workbench can be limited during its sliding process to prevent it from shaking and improve its stability in use.
[0013] As a preferred solution of the utility model, the groove is matched with the square groove, and the diaphragm is matched with the groove.
[0014] The technical effect of adopting the above further solution is: through the adaptation of the square groove and the groove, the constant temperature heater body can heat the diaphragm inside the groove at a constant temperature, making the use of the device more convenient.
[0015] As a preferred solution of the utility model, the slider is slidably connected to the second sliding groove, and a threaded rod is provided on the right side of the fixed seat extending to the inside of the slider, and the threaded rod is adapted to the slider.
[0016] The technical effect of adopting the above further solution is: the microscope body can be driven to slide up and down through the sliding connection between the slider and the second slide groove. After moving to the appropriate position, the threaded rod is rotated to cooperate with the slider to fix the position of the microscope body, thereby improving ease of use.
[0017] As a preferred solution of the utility model, the microscope body is fixedly connected to the slider, the heat insulation cover is fixedly connected to the microscope body, and the heat insulation cover is adapted to the workbench.
[0018] The technical effect of adopting the above further solution is: by matching the heat insulation cover with the workbench, the workbench can be isolated from the outside world, reducing the probability of experimental failure caused by external temperature difference and improving practicality.
[0019] Compared with the prior art, the beneficial effects of the utility model are:
[0020] In the utility model, through the design of the base, the adjustment mechanism and the main body of the constant temperature heater, the electric slider can drive the workbench to slide back and forth, so that it is convenient for the staff to put in and take out the diaphragm, and the work efficiency is effectively improved. The use of the heat insulation cover can isolate the workbench from the outside world, reduce the probability of experimental failure caused by the external temperature difference, and improve practicality. BRIEF DESCRIPTION OF THE DRAWINGS
[0021] Figure 1 The utility model provides a patch clamp thermostat with good temperature control performance.
[0022] Figure 2 The overall side structural anatomical diagram of a patch clamp thermostat with good temperature control provided by the utility model;
[0023] Figure 3 A partial front structural anatomical diagram of a patch clamp thermostat with good temperature control provided by the utility model.
[0024] Legend: 1. Base; 101. Square groove; 102. First slide groove; 103. Electric slider; 104. Workbench; 105. Limit groove; 106. Limit block; 107. Groove; 108. Diaphragm; 2. Adjustment mechanism; 201. Fixed seat; 202. Second slide groove; 203. Slider; 204. Microscope body; 205. Heat insulation cover; 206. Threaded rod; 3. Constant temperature heater body. DETAILED DESCRIPTION
[0025] The technical solutions in the embodiments of the utility model will be clearly and completely described below in conjunction with the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the utility model.
[0026] In order to facilitate the understanding of the present invention, the present invention will be described more comprehensively below with reference to the relevant literature, and several embodiments of the present invention are given. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.
[0027] It should be noted that when an element is referred to as being "fixed on" another element, it may be directly on the other element or there may also be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used in this article are for illustrative purposes only.
[0028] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by technicians in the technical field of the present invention. The terms used in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used in this article includes any and all combinations of one or more related listed items.
[0029] Example 1
[0030] like Figure 1-3 As shown, the utility model provides a technical solution: a patch clamp thermostat with good temperature control performance, including a base 1, an adjustment mechanism 2 is arranged at the top of the base 1, a thermostat heater body 3 is arranged at the bottom of the base 1, the top of the thermostat heater body 3 is matched with a square groove 101, the thermostat heater body 3 is electrically connected to an external controller, and a temperature sensor is arranged inside it, and the temperature change can be observed in real time by the external controller, and adjusted in real time to achieve a constant temperature effect, a square groove 101 is opened near the center of the top of the base 1, a first slide groove 102 is opened at the top of the base 1 and located on the front of the square groove 101, an electric slider 103 is arranged inside the first slide groove 102, and the electric slider 103 is electrically connected to the external controller A workbench 104 is provided at the top of the electric slider 103, and limiting grooves 105 are symmetrically provided at the top of the base 1 and on the left and right sides of the square groove 101 and the first slide groove 102. A limiting block 106 is provided at the bottom of the workbench 104 corresponding to the limiting groove 105. A groove 107 is provided through the top of the workbench 104, and a diaphragm 108 is provided inside the groove 107. The adjusting mechanism 2 includes a fixed seat 201, and the fixed seat 201 is fixedly connected to the base 1 by bolts. A second slide groove 202 is provided on the front of the fixed seat 201, and a slider 203 is provided inside the second slide groove 202. A microscope body 204 is provided on the front of the slider 203 near the bottom, and a heat insulation cover 205 is provided at the bottom of the microscope body 204.
[0031] Example 2
[0032] like Figure 1-3As shown, the electric slider 103 is slidably connected to the first slide groove 102, and the workbench 104 is fixedly connected to the electric slider 103. The electric slider 103 can drive the workbench 104 to move back and forth inside the first slide groove 102, so as to facilitate the staff to put in and take out the diaphragm 108 inside the groove 107, thereby improving work efficiency. The limit block 106 is fixedly connected to the workbench 104, and the limit block 106 is slidably connected to the limit groove 105. Through the sliding connection between the limit block 106 and the limit groove 105, the workbench 104 can be limited during its sliding process to prevent it from shaking, thereby improving the stability of use. The groove 107 is adapted to the square groove 101, and the diaphragm 108 is adapted to the groove 107. Through the adaptation of the square groove 101 and the groove 107, the constant temperature heater body 3 can perform constant temperature heating on the diaphragm 108 inside the groove 107. Heat, making the use of the equipment more convenient, the slider 203 is slidably connected to the second slide groove 202, and the right side of the fixed seat 201 extends to the inside of the slider 203 and is provided with a threaded rod 206, the threaded rod 206 is adapted to the slider 203, and the sliding connection between the slider 203 and the second slide groove 202 can drive the microscope body 204 to slide up and down. After moving to a suitable position, the threaded rod 206 is rotated to cooperate with the slider 203 to fix the position of the microscope body 204, thereby improving the convenience of use. The microscope body 204 is fixedly connected to the slider 203, and the heat insulation cover 205 is fixedly connected to the microscope body 204, and the heat insulation cover 205 is adapted to the workbench 104. Through the adaptation of the heat insulation cover 205 to the workbench 104, the workbench 104 can be isolated from the outside world, thereby reducing the probability of experimental failure caused by the external temperature difference and improving practicality.
[0033] The working process of the utility model is as follows: when a patch clamp thermostat with good temperature control is used for living cell cultivation, the electric slider 103 is first controlled by an external controller to drive the workbench 104 to slide toward the front inside the first slide groove 102, so that it moves to the bottom of the heat insulation cover 205, which is convenient for the staff to put and take the diaphragm 108, effectively improving the work efficiency. After the staff places the diaphragm 108 inside the groove 107, the electric slider 103 is controlled to drive the workbench 104 to reset. At the same time, the external controller controls the three main parts of the thermostat heater 104 to move to the bottom of the heat insulation cover 205. Heat is performed according to actual use requirements, and the slider 203 is slid downward to drive the microscope body 204 and the heat insulation cover 205 to slide downward inside the second slide groove 202 until the heat insulation cover 205 fits with the workbench 104. Finally, the threaded rod 206 is rotated to cooperate with the slider 203 to clamp and fix the fixing seat 201, thereby completing the positioning of the microscope body 204 and the heat insulation cover 205 and completing the entire use process. The heat insulation cover 205 can isolate the workbench 104 from the outside world, reduce the probability of experimental failure caused by the external temperature difference, and effectively improve practicality.
[0034] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A patch clamp thermostat with good temperature control performance, comprising a base (1), characterized in that: The top of the base (1) is provided with an adjustment mechanism (2), and the bottom of the base (1) is provided with a constant temperature heater body (3); A square groove (101) is provided at the top of the base (1) near the center, a first slide groove (102) is provided at the top of the base (1) and located on the front of the square groove (101), an electric slider (103) is provided inside the first slide groove (102), a workbench (104) is provided at the top of the electric slider (103), limiting grooves (105) are symmetrically provided at the top of the base (1) and located on the left and right sides of the square groove (101) and the first slide groove (102), a limiting block (106) is provided at the bottom of the workbench (104) corresponding to the limiting groove (105), a groove (107) is provided through the top of the workbench (104), and a diaphragm (108) is provided inside the groove (107); The adjustment mechanism (2) comprises a fixing seat (201), a second slide groove (202) is provided on the front of the fixing seat (201), a slider (203) is provided inside the second slide groove (202), a microscope body (204) is provided on the front of the slider (203) near the bottom, and a heat insulation cover (205) is provided at the bottom of the microscope body (204).
2. A patch clamp thermostat with good temperature controllability according to claim 1, characterized in that: The electric slide block (103) is slidably connected to the first slide groove (102), and the workbench (104) is fixedly connected to the electric slide block (103).
3. A patch clamp thermostat with good temperature controllability according to claim 1, characterized in that: The limiting block (106) is fixedly connected to the workbench (104), and the limiting block (106) is slidably connected to the limiting groove (105).
4. A patch clamp thermostat with good temperature controllability according to claim 1, characterized in that: The groove (107) is matched with the square groove (101), and the diaphragm (108) is matched with the groove (107).
5. A patch clamp thermostat with good temperature controllability according to claim 1, characterized in that: The slider (203) is slidably connected to the second slide groove (202); a threaded rod (206) is provided on the right side of the fixed seat (201) extending to the interior of the slider (203); and the threaded rod (206) is adapted to the slider (203).
6. A patch clamp thermostat with good temperature controllability according to claim 1, characterized in that: The microscope body (204) is fixedly connected to the slider (203), the heat insulation cover (205) is fixedly connected to the microscope body (204), and the heat insulation cover (205) is adapted to the workbench (104).