Desalination and concentration system for production of traditional Chinese medicine injection

Abstract

The utility model discloses a desalination and concentration system for production of traditional Chinese medicine injection. The desalination and concentration system comprises a pretreatment device, a nanofiltration device, a refrigerant production device, a heat exchanger, a booster pump and an offline conductivity meter, a liquid outlet of the pretreatment device is connected with a liquid medicine inlet of the heat exchanger through a first pipeline; the nanofiltration device comprises a nanofiltration membrane element and a membrane shell, a nanofiltration inlet of the nanofiltration membrane element is connected with a liquid medicine outlet of the heat exchanger through a second pipeline, a concentrated liquid outlet of the nanofiltration membrane element is connected with a third pipeline, the third pipeline is connected to the interior of the pretreatment device, and a permeate liquid outlet is formed in the side end of the membrane shell. The system adopts a nanofiltration technology to achieve integrated production of desalination and concentration of the traditional Chinese medicine injection, solves the problems of high energy consumption and high cost of desalination and concentration in traditional production, is suitable for production of the traditional Chinese medicine injection, and can concentrate heat-sensitive components, reduce the production cost and improve the production efficiency.

Description

TECHNICAL FIELD

[0001] The utility model relates to a traditional Chinese medicine injection production technical field, specifically a kind of for traditional Chinese medicine injection. BACKGROUND

[0002] In the production process of traditional Chinese medicine injection, the removal of potassium ions and the concentration of liquid medicine usually rely on high-energy and high-cost processes. Traditional Chinese medicine injection is usually prepared by complex steps such as extraction, concentration, alcohol precipitation, water precipitation, potassium removal, concentration, heat treatment, preparation, filling and sealing, and sterilization. However, the potassium ion concentration of the preparation is relatively high, and methods such as cation resin exchange, electrodialysis adsorption, and vacuum concentration and heat concentration are often used to remove potassium in production. These traditional methods have many drawbacks, not only low efficiency, but also high operating cost, greatly increasing the production cost, which is not conducive to the industrialized mass production of traditional Chinese medicine injection.

[0003] With the development of science and technology, nanofiltration technology emerges as the times require as a new green high-tech in the 21st century. It has the characteristics of energy saving, high efficiency, no pollution and simple operation, and its unique pore size screening effect, charge effect and dissolution-diffusion effect can effectively remove monovalent inorganic salts, small molecular organic substances and solvents in the liquid medicine, providing an innovative solution to the desalination and concentration problems in the production of traditional Chinese medicine injection.

[0004] Therefore, the development of a desalination and concentration system for the production of traditional Chinese medicine injection can not only remove potassium ions from traditional Chinese medicine water precipitation liquid, but also concentrate the water precipitation liquid while ensuring the quality of the preparation, effectively reducing the production time, reducing the production cost and improving the production efficiency. Utility model content

[0005] The utility model provides a kind of energy-saving, efficient desalination and concentration system, realizes the desalination and concentration in the production of traditional Chinese medicine injection.

[0006] To achieve the above purpose, the technical scheme of the utility model is as follows: a desalination and concentration system for the production of traditional Chinese medicine injection, comprising a pretreatment device, a nanofiltration device, a refrigerant production device, a heat exchanger, a booster pump and an offline electrical conductivity meter.

[0007] The liquid outlet of the pretreatment device is connected to the liquid inlet of the heat exchanger through a first pipeline. The nanofiltration device comprises a nanofiltration membrane element and a membrane shell. The nanofiltration inlet of the nanofiltration membrane element is connected to the liquid outlet of the heat exchanger through a second pipeline. The concentrated liquid outlet of the nanofiltration membrane element is connected to a third pipeline, which is connected to the inside of the pretreatment device. The side end of the membrane shell is provided with a permeate liquid outlet.

[0008] The utility model discloses a desalination concentration system for traditional Chinese medicine injection production, preferably, the refrigerant import, export of pretreatment device and the refrigerant import, export of heat exchanger are connected through refrigerant production device and pipeline and form the refrigerant circulation flow.

[0009] The utility model discloses a desalination concentration system for traditional Chinese medicine injection production, preferably, the pretreatment device includes liquid medicine tank and jar body, the liquid medicine tank is wrapped by jar body, and the cavity that can supply the refrigerant circulation is formed between the liquid medicine tank and jar body, and the bottom of jar body is equipped with refrigerant import cavity mouth, and the lateral wall of jar body is equipped with refrigerant export cavity mouth.

[0010] The utility model discloses a desalination concentration system for traditional Chinese medicine injection production, preferably, the heat exchanger is column type heat exchanger.

[0011] The utility model discloses a desalination concentration system for traditional Chinese medicine injection production, preferably, the top of pretreatment device is equipped with the backflow port that is connected with third pipeline, offline electric conductivity appearance, and the bottom of pretreatment device is equipped with liquid discharge port.

[0012] The utility model discloses a desalination concentration system for traditional Chinese medicine injection production, preferably, the booster pump is installed on first pipeline, and the first pipeline is also installed with thermometer and pressure gauge, and the booster pump is located between thermometer and pressure gauge.

[0013] The utility model discloses a desalination concentration system for traditional Chinese medicine injection production, preferably, the third pipeline is installed with pressure valve.

[0014] The utility model discloses a desalination concentration system for traditional Chinese medicine injection production, preferably, the nanofiltration membrane element adopts the roll type nanofiltration membrane.

[0015] The utility model has the advantages of:

[0016] The system utilizes nanofiltration technology to reduce the loss of effective components in the production process of traditional Chinese medicine injection, realize the integration of desalination and concentration of water-sediment, optimize the production process, reduce the frequency of equipment cleaning, reduce the energy consumption of water, electricity and steam by more than 20%, and improve the production efficiency by more than 40%.

[0017] The system monitors the conductivity of liquid medicine in real time to ensure that the quality of traditional Chinese medicine injection meets the production requirements, reduces energy consumption and operating costs, reduces waste emissions in the production process, is more friendly to the environment, and meets the development concept of green pharmacy.

[0018] Compared with traditional concentration equipment, this system realizes the integrated production of desalting and concentration of traditional Chinese medicine injections, solving the problems of high energy consumption and high cost in traditional production. It is suitable for the production of traditional Chinese medicine injections and can also concentrate heat-sensitive components, reducing production costs and improving production efficiency. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the process flow of a desalting and concentration system for the production of traditional Chinese medicine injections according to this utility model.

[0020] Wherein: 1-Tank body, 2-Medicine liquid tank, 3-Cavity, 4-Refrigerant inlet to cavity, 5-Outlet, 6-Drain, 7-Refrigerant outlet to cavity, 8-Thermometer, 9-Booster pump, 10-Pressure gauge, 11-Row heat exchanger, 12-Medicine liquid inlet, 13-Refrigerant inlet to heat exchanger, 14-Refrigerant outlet to heat exchanger, 15-Medicine liquid outlet, 16-Membrane shell, 17-Nanofiltration membrane element, 18-Nanofiltration inlet, 19-Permeate outlet, 20-Concentrate outlet, 21-Pressure valve, 22-First pipeline, 23-Second pipeline, 24-Third pipeline, 25-Reflux port, 26-Offline conductivity meter, 27-Refrigerant production device, 28-Fourth pipeline, 29-Fifth pipeline, 30-Sixth pipeline. Detailed Implementation

[0021] The technical solutions in the embodiments of this utility model will now be clearly and completely described with reference to the accompanying drawings.

[0022] like Figure 1 As shown, a desalting and concentration system for the production of traditional Chinese medicine injections includes a pretreatment device, a nanofiltration device, a refrigerant production device 27, a heat exchanger, a booster pump 9, and an offline conductivity meter 26. The outlet 5 of the pretreatment device is connected to the drug inlet 12 of the heat exchanger via a first pipeline 22. The nanofiltration device includes a nanofiltration membrane element 17 and a membrane housing 16. The nanofiltration inlet 18 of the nanofiltration membrane element 17 is connected to the drug outlet 15 of the heat exchanger via a second pipeline 23. The concentrated liquid outlet 20 of the nanofiltration membrane element 17 is connected to a third pipeline 24. The third pipeline 24 is connected to the interior of the pretreatment device via a reflux port 25 located at the top of the pretreatment device. The membrane housing 16 has a permeate outlet 19 on its side.

[0023] like Figure 1As shown in the utility model desalination concentration system, the coolant inlet and outlet of the pretreatment device are connected with the coolant inlet and outlet of the heat exchanger through the coolant production device 27 and the pipeline to form a coolant circulation flow. The specific path is: the coolant production device 27 outputs the coolant from the fourth pipeline 28, then the coolant flows into the pretreatment device through the coolant inlet of the pretreatment device, and the coolant is used for cooling treatment of the liquid medicine in the device. After that, the coolant flows out from the coolant outlet of the pretreatment device, and enters the heat exchanger through the fifth pipeline 29 at a certain flow rate and pressure, and then the coolant is used for further cooling of the cooled liquid medicine. After completing heat exchange, the coolant is heated and flows back to the coolant production device 27 through the sixth pipeline 30 from the coolant outlet of the heat exchanger, to form a coolant circulation flow. In the desalination concentration system, the coolant provided by the coolant production device 27 is generally cooling water.

[0024] As Figure 1 shown, the pretreatment device of the desalination concentration system of the utility model includes a liquid medicine tank 2 and a tank body 1, the liquid medicine tank 2 is wrapped by the tank body 1, a cavity 3 for coolant circulation is formed between the liquid medicine tank 2 and the tank body 1, the bottom of the tank body 1 is provided with a coolant inlet cavity 4, and the side wall of the tank body is provided with a coolant outlet cavity 7. The heat exchanger generally adopts a column type heat exchanger 11. The first pipeline 22 is provided with a thermometer 8, a booster pump 9 and a pressure gauge 10, and the booster pump 9 is located between the thermometer 8 and the pressure gauge 10. The third pipeline 25 is provided with a pressure valve 21 for controlling the pressure of the whole system. The offline electric conductivity instrument 26 extends to the inside through the backflow port 25 arranged at the top of the pretreatment device to detect the electric conductivity of the liquid medicine after desalination and concentration in real time. The bottom of the pretreatment device is provided with a liquid discharge port 6 for discharging the liquid medicine after desalination and concentration.

[0025] As Figure 1As shown, first, the medicine liquid is preliminarily cooled: the traditional Chinese medicine extract is injected into the medicine liquid tank 2, at the same time, the refrigerant flows out from the refrigerant production device 27, enters the cavity 3 through the fourth pipeline 28 and the refrigerant inlet cavity port 4 at the bottom of the tank body 1, and cools the medicine liquid. Then, the heat exchange process is entered: the refrigerant in the cavity 3 enters the column heat exchanger 11 through the fifth pipeline 29 and the refrigerant inlet heat exchanger port 13; the cooled medicine liquid in the medicine liquid tank 2 is pressurized by the booster pump 9 through the liquid outlet 5, enters the column heat exchanger 11 through the first pipeline 22 and the medicine liquid inlet 12; in the column heat exchanger 11, the medicine liquid and the refrigerant are heat exchanged, the warmed refrigerant enters the refrigerant production device 27 through the sixth pipeline 30 and the refrigerant outlet heat exchanger port 14 to realize the circulation of the refrigerant, and the cooled medicine liquid flows out from the medicine liquid outlet 15 of the column heat exchanger 11. Subsequently, the nanofiltration operation is started: the fully cooled medicine liquid enters the nanofiltration inlet 18 of the nanofiltration membrane element 17 through the second pipeline 23, the pressure regulating valve 21 starts desalination and concentration, the permeate is collected from the permeate liquid outlet 19, and the concentrated liquid is recovered to the medicine liquid tank 2 through the third pipeline 24 for circulation treatment. The whole process is monitored and controlled in real time by the thermometer 8, the pressure gauge 10 and the offline electric conductivity meter 26: the thermometer 8 ensures that the temperature of the medicine liquid is appropriate to avoid affecting the quality; the pressure gauge 10 monitors the pressure to prevent fluctuations; the offline electric conductivity meter 26 is monitored in real time, and when the electric conductivity of the medicine liquid is reduced to the production index, the pressure regulating valve 21 is adjusted to collect the medicine liquid from the liquid outlet 6.

[0026] Nanofiltration principle: nanofiltration technology is the core technology of the system and plays a key role in the desalination and concentration process. Nanofiltration removes monovalent inorganic salts, small molecule organic substances and solvents through pore size screening, charge and solubility diffusion effects. Specifically, the pore size screening effect screens the substances in the medicine liquid according to the pore size of the nanofiltration membrane, so that small molecule solvents and part of the effective components permeate, and macromolecular substances and monovalent inorganic salts such as potassium ions are retained; the charge effect is based on the charge characteristics of the membrane surface, which enhances the repulsion of charged ions and further improves the removal efficiency of potassium ions; the solubility diffusion effect promotes the permeation of solvents and small molecule substances.

[0027] In the actual application of traditional Chinese medicine injection, the nanofiltration membrane element 17 adopts a roll-type nanofiltration membrane. The nanofiltration membrane has a molecular weight cut-off between reverse osmosis membrane and ultrafiltration membrane, about 200-1000 Da. The optimal molecular weight cut-off is 200 Da. The roll-type nanofiltration membrane is usually installed in the nanofiltration membrane element 17 in a roll structure, and the medicine liquid enters the membrane assembly under the action of pressure and flows along the membrane surface. Under the joint action of screening and charge effects, part of the medicine liquid permeates the membrane to become the permeate and flows out from the permeate liquid outlet 19; the retained substances form the concentrated liquid and flow out from the concentrated liquid outlet 20, realizing desalination and concentration. In the production of other traditional Chinese medicine injections, different molecular weight cut-off roll-type nanofiltration membranes can be selected according to the needs, or multiple roll-type nanofiltration membranes can be assembled to achieve the purposes of separation, concentration and purification, etc.

[0028] In summary, the desalination and concentration system has significant technical advantages and economic value, and is suitable for the production field of traditional Chinese medicine injection.

[0029] The described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor belong to the protection scope of the utility model.

Claims

1. A desalting and concentration system for the production of traditional Chinese medicine injections, characterized in that, It includes a pretreatment unit, a nanofiltration unit, a refrigerant production unit, a heat exchanger, a booster pump, and an offline conductivity meter; among which, The outlet of the pretreatment device is connected to the inlet of the heat exchanger via a first pipeline; the nanofiltration device includes a nanofiltration membrane element and a membrane housing, the nanofiltration inlet of the nanofiltration membrane element is connected to the outlet of the heat exchanger via a second pipeline, the concentrate outlet of the nanofiltration membrane element is connected to a third pipeline, the third pipeline is connected to the interior of the pretreatment device, and the membrane housing has a permeate outlet on its side.

2. The desalting and concentration system for the production of traditional Chinese medicine injections according to claim 1, characterized in that, The refrigerant inlet and outlet of the pretreatment device are connected to the refrigerant inlet and outlet of the heat exchanger through a refrigerant production device and pipelines to form a refrigerant circulation flow.

3. A desalting and concentration system for the production of traditional Chinese medicine injections according to claim 1 or 2, characterized in that, The pretreatment device includes a liquid medicine tank and a tank body. The liquid medicine tank is enclosed by the tank body, and a cavity for refrigerant to flow is formed between the liquid medicine tank and the tank body. The bottom of the tank body is provided with a refrigerant inlet, and the side wall of the tank body is provided with a refrigerant outlet.

4. A desalting and concentration system for the production of traditional Chinese medicine injections according to claim 1 or 2, characterized in that, The heat exchanger is a column heat exchanger.

5. A desalting and concentration system for the production of traditional Chinese medicine injections according to claim 1, characterized in that, The top of the pretreatment device is provided with a reflux port connected to the third pipeline and the offline conductivity meter, and the bottom of the pretreatment device is provided with a liquid discharge port.

6. A desalting and concentration system for the production of traditional Chinese medicine injections according to claim 1, characterized in that, The booster pump is installed on the first pipeline, which is also equipped with a thermometer and a pressure gauge. The booster pump is located between the thermometer and the pressure gauge.

7. A desalting and concentration system for the production of traditional Chinese medicine injections according to claim 1, characterized in that, A pressure valve is installed on the third pipeline.

8. A desalting and concentration system for the production of traditional Chinese medicine injections according to claim 1, characterized in that, The nanofiltration membrane element is a spiral wound nanofiltration membrane.

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