Vacuum drying oven for targeted drug development
By introducing a vacuum generating mechanism and a servo motor-driven gear assembly into the vacuum drying oven, the problem of insufficient vacuum in the prior art has been solved, achieving efficient low-temperature drying of targeted drugs and improving drug purity and drying efficiency.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SHANGHAI PULSING IND CO LTD
- Filing Date
- 2025-07-31
- Publication Date
- 2026-06-23
AI Technical Summary
Existing vacuum drying ovens cannot achieve the high vacuum environment below 10 Pa required for targeted drug development, which prevents the solvent boiling point from being further reduced, affecting drying efficiency and drug purity.
The vacuum drying oven employs a vertical cabinet, graphite heating plate, and a loading grid. Combined with a vacuum-generating mechanism, it utilizes one-way valves in the suction and discharge pipes and a gear assembly driven by a servo motor to achieve efficient air extraction, creating a higher vacuum environment. The targeted drug is then dried at low temperature using the graphite heating plate.
It significantly reduces the boiling point of targeted drug solvents under low pressure, improves drying efficiency, ensures drug purity and stability, and meets the high-quality sample requirements for targeted drug development.
Smart Images
Figure CN224398162U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of vacuum drying technology, and in particular to a vacuum drying oven for targeted drug development. Background Technology
[0002] The core functions of vacuum drying for targeted drugs are: protecting sensitive active ingredients such as antibodies and peptides in a low-temperature environment to avoid structural denaturation caused by high temperatures and maintain their targeted binding ability; efficiently removing residual organic solvents and controlling the residual amount to an extremely low level to ensure drug purity; reducing oxidative degradation through a low-oxygen or anaerobic environment, combined with aseptic processing to reduce the risk of contamination and improve stability; and precisely controlling the degree of drying to ensure sample homogeneity and adaptability to various forms such as solutions and liposomes, providing high-quality samples for purity testing, formulation development, and other R&D stages. It is a key process to ensure the efficiency and quality of targeted drug development.
[0003] However, most existing vacuum drying ovens use rotary vane pumps or diaphragm pumps, and their vacuum level is usually between 100-133 Pa. But targeted drug development requires a higher vacuum environment, such as below 10 Pa, to further reduce the boiling point of the solvent. However, traditional vacuum drying ovens cannot achieve this pumping efficiency. Utility Model Content
[0004] The purpose of this invention is to solve the problems existing in the prior art by proposing a vacuum drying oven for targeted drug development.
[0005] To achieve the above objectives, this utility model adopts the following technical solution: a vacuum drying oven for targeted drug development, comprising a vertical cabinet, a graphite heating plate, and a loading grid. A vacuum gauge is fixedly installed on the top of the vertical cabinet via a three-way valve. An electrical control box is located at the lower part of the cavity of the vertical cabinet. A vacuum generating mechanism is installed inside the electrical control box and extends into the interior of the vertical cabinet. The vacuum generating mechanism includes a suction pipe, a branch top cover, a column chamber, a piston rod, an outlet pipe, and a power assembly. The suction pipe and the outlet pipe are respectively connected to the two outlets of the branch top cover via one-way valves. The other end of the suction pipe extends into the interior of the vertical cabinet, and the other end of the outlet pipe extends into the exterior of the vertical cabinet. The branch top cover is fixedly installed on the upper end of the column chamber, and the column chamber is slidably connected to the inner side of the column chamber. The lower end of the piston rod is connected to the power assembly for transmission.
[0006] Preferably, the power assembly includes a rocker arm, a dual-disc assembly, an outer casing, a bracket, a servo motor, a secondary gear, and a primary gear. The rocker arm is rotatably connected to the lower end of the piston rod, and the other end of the rocker arm is rotatably connected to the eccentric position of the dual-disc assembly.
[0007] Preferably, the two ends of the dual-disc component are rotatably connected to the inside of the outer casing, the outer casing is fixedly connected to the lower side of the column compartment, and the outer casing is fixedly connected to the bottom of the inner cavity of the electrical control box.
[0008] Preferably, one end of the dual-disc component is connected to the shaft of the secondary gear, and the upper side of the secondary gear meshes with the primary gear.
[0009] Preferably, both the secondary gear and the primary gear are rotatably connected inside the outer casing, and the shaft of the primary gear is connected to the output shaft of the servo motor.
[0010] Preferably, the servo motor is fixedly mounted on one side of the bracket, and the bracket is fixedly connected to the bottom of the electrical control box cavity.
[0011] Preferably, multiple sets of the load-bearing grids are horizontally and evenly distributed and installed inside the vertical cabinet cavity.
[0012] Compared with the prior art, the advantages and positive effects of this utility model are as follows:
[0013] 1. In this invention, during the upward movement of the column chamber, the air inside the cavity is transported to the outside through the one-way valve of the exhaust pipe. During the downward movement of the column chamber, the air inside the vertical cabinet is drawn out through the extraction pipe and its one-way valve. This reciprocating motion continuously extracts the gas from the vertical cabinet cavity. With the cabinet door well-sealed, a higher vacuum environment is created. Once the set vacuum level is reached, as observed by a vacuum gauge, the graphite heating plate is energized and activated to transfer heat to the targeted drug. Due to the low ambient pressure, the boiling point of the solvent in the targeted drug is significantly reduced, requiring only a lower temperature for heat absorption and evaporation, thus improving drying efficiency.
[0014] 2. In this utility model, the servo motor starts and drives the first-stage gear to rotate, thereby meshing with the large-diameter second-stage gear below. The shaft of the second-stage gear drives the double disk to rotate, causing the rocker arm to reciprocate to push and pull the piston column up and down on the inner wall of the column chamber. Since the diameter of the first-stage gear is smaller than that of the second-stage gear, the power of the servo motor is reduced and the torque is increased. Even when the pressure difference between the inside and outside of the vertical cabinet is large, it can still reciprocate to push and pull the piston column, ensuring that a higher vacuum environment can be created. Attached Figure Description
[0015] Figure 1 A three-dimensional structural schematic diagram of a vacuum drying oven for targeted drug development is provided for this utility model;
[0016] Figure 2 This utility model provides a three-dimensional structural diagram of the interior of a vacuum drying oven for targeted drug development;
[0017] Figure 3This utility model provides a three-dimensional structural diagram of the internal vacuum mechanism of a vacuum drying oven for targeted drug development.
[0018] Figure 4 This invention presents a three-dimensional structural diagram of a portion of the vacuum-generating mechanism in a vacuum drying oven for targeted drug development.
[0019] Legend: 1. Vertical cabinet; 2. Vacuum gauge; 3. Graphite heating plate; 4. Loading grid; 5. Electrical control box; 6. Vacuum control mechanism; 61. Evacuation pipe; 62. Branch top cover; 63. Column compartment; 64. Piston column; 65. Rocker arm; 66. Double disk assembly; 67. Outer casing; 68. Bracket; 69. Servo motor; 610. Exhaust pipe; 611. Secondary gear; 612. Primary gear. Detailed Implementation
[0020] To better understand the above-mentioned objectives, features, and advantages of this utility model, the present utility model will be further described below with reference to the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.
[0021] Many specific details are set forth in the following description in order to provide a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Therefore, the present invention is not limited to the specific embodiments disclosed in the following specification.
[0022] Example 1: As Figure 1 - Figure 4 As shown, this utility model provides a vacuum drying oven for targeted drug development, including a vertical cabinet 1, a graphite heating plate 3, and a material-carrying grid 4. A vacuum gauge 2 is fixedly installed on the top of the vertical cabinet 1 via a three-way valve. An electrical control box 5 is provided at the lower part of the cavity of the vertical cabinet 1. A vacuum generating mechanism 6 is installed inside the electrical control box 5 and extends into the interior of the vertical cabinet 1. The vacuum generating mechanism 6 includes an extraction pipe 61, a branch top cover 62, a column chamber 63, a piston column 64, an outlet pipe 610, and a power assembly. The extraction pipe 61 and the outlet pipe 610 are respectively connected to the two outlets of the branch top cover 62 via one-way valves. The other end of the extraction pipe 61 extends into the interior of the vertical cabinet 1, and the other end of the outlet pipe 610 extends into the exterior of the vertical cabinet 1. The branch top cover 62 is fixedly installed on the upper end of the column chamber 63, and the column chamber 63 is slidably connected to the inner side of the column chamber 63. The lower end of the piston column 64 is connected to the power assembly for transmission. Multiple sets of material-carrying grids 4 are horizontally and evenly distributed in the interior cavity of the vertical cabinet 1.
[0023] The specific settings and functions of this embodiment are described below: The cabinet door of the vertical cabinet 1 is opened, and the targeted drugs are placed on different carrying grids 4. After closing the cabinet door, the vacuum mechanism 6 and the graphite heating plate 3 are controlled via the switch, touch screen, and display screen of the electrical control box 5. First, the power assembly causes the piston column 64 to move up and down on the inner wall of the column chamber 63 with the help of the sealing ring. During the upward movement of the column chamber 63, the column chamber 63 compresses the cavity formed by the branch top cover 62 and the piston column 64, and the air inside is transported to the outside through the one-way valve of the exhaust pipe 610. During the downward movement of the column chamber 63, the cavity formed by the branch top cover 62 and the piston column 64 is under negative pressure, and the air inside the vertical cabinet 1 is extracted through the extraction pipe 61 and its one-way valve. This reciprocating motion continuously extracts the gas from the cavity of the vertical cabinet 1. With the cabinet door of the vertical cabinet 1 well sealed, a higher vacuum environment is created. Observing through the vacuum gauge 2, after the inner cavity of the vertical cabinet 1 reaches the set vacuum level, the graphite heating plate 3 is powered on and started to transfer heat to the targeted drugs. Because the ambient air pressure is low at this time, the boiling point of the solvent in the targeted drug is greatly reduced, and it can absorb heat and evaporate at a lower temperature, thus improving the drying efficiency. In the later stage of drying, turn on the valve of the three-way valve below the vacuum gauge 2 to make the air pressure inside and outside the vertical cabinet 1 almost the same, and then open the cabinet door to take it out.
[0024] Example 2: Figure 1 - Figure 4 As shown, the power assembly includes a rocker arm 65, a double-disc assembly 66, an outer casing 67, a bracket 68, a servo motor 69, a secondary gear 611, and a primary gear 612. The rocker arm 65 is rotatably connected to the lower end of the piston rod 64, and the other end of the rocker arm 65 is rotatably connected to the eccentric position of the double-disc assembly 66. Both ends of the double-disc assembly 66 are rotatably connected to the inside of the outer casing 67. The outer casing 67 is fixedly connected to the lower side of the piston cylinder 63 and to the bottom of the inner cavity of the electrical control box 5. One end of the double-disc assembly 66 is drivenly connected to the shaft of the secondary gear 611. The upper side of the secondary gear 611 meshes with the primary gear 612. Both the secondary gear 611 and the primary gear 612 are rotatably connected to the inside of the outer casing 67. The shaft of the primary gear 612 is drivenly connected to the output shaft of the servo motor 69. The servo motor 69 is fixedly mounted on one side of the bracket 68, and the bracket 68 is fixedly connected to the bottom of the inner cavity of the electrical control box 5.
[0025] The overall effect of this embodiment is that the operation of the power component is as follows: the servo motor 69 starts, driving the primary gear 612 to rotate, which in turn meshes with the large-diameter secondary gear 611 below. The shaft of the secondary gear 611 drives the double disc 66 to rotate. The double disc 66 consists of two identical disc-shaped structures that are mirror-symmetrically distributed and the rocker arm 65 is rotatably mounted in the middle of the two discs with bolts. After the double disc 66 receives power, it drives the lower end of the rocker arm 65 to make a circular motion, causing the rocker arm 65 to push and pull the piston column 64 up and down on the inner wall of the column chamber 63. Since the diameter of the primary gear 612 is smaller than the diameter of the secondary gear 611, the power of the servo motor 69 is reduced in speed and increased in torque. Even when the pressure difference between the inside and outside of the vertical cabinet 1 is large, it can still push and pull the piston column 64 back and forth, ensuring that a higher vacuum environment can be created.
[0026] The device's operation and working principle are as follows: Open the cabinet door of the vertical cabinet 1, and place the targeted drugs in different storage grids 4. After closing the cabinet door, control the vacuum mechanism 6 and the graphite heating plate 3 via the switch, touch screen, and display screen of the electrical control box 5. First, the servo motor 69 starts, driving the primary gear 612 to rotate, which in turn meshes with the large-diameter secondary gear 611 below. The shaft of the secondary gear 611 drives the double-disc component 66 to rotate. The double-disc component 66 consists of two identical disc-shaped structures, mirror-symmetrically distributed, and the rocker arm 65 is rotatably mounted in the middle of the two discs with bolts. After the double-disc component 66 receives power, it drives the lower end of the rocker arm 65 to perform a circular motion, causing the rocker arm 65 to reciprocate to push and pull the piston rod 64. The column 64 moves up and down within the column chamber 63 with the aid of a sealing ring. As the column chamber 63 moves upward, it compresses the cavity formed by the branch top cover 62 and the piston column 64, allowing air inside to be expelled through the one-way valve of the exhaust pipe 610. As the column chamber 63 moves downward, the cavity formed by the branch top cover 62 and the piston column 64 is under negative pressure, drawing air from the vertical cabinet 1 through the extraction pipe 61 and its one-way valve. This reciprocating motion continuously extracts gas from the cavity of the vertical cabinet 1, creating a higher vacuum environment when the cabinet door is well-sealed. Once the set vacuum level is reached, as observed by the vacuum gauge 2, the graphite heating plate 3 is energized to transfer heat to the targeted drug. Due to the low ambient pressure, the boiling point of the solvent in the targeted drug is significantly reduced, requiring only a lower temperature for heat absorption and evaporation. Near the final drying stage, the valve of the three-way valve below the vacuum gauge 2 is opened to bring the internal and external pressures of the vertical cabinet 1 closer together, allowing the cabinet door to be opened and the drug removed.
[0027] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments for application in other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present utility model without departing from the technical solution of the present utility model shall still fall within the protection scope of the technical solution of the present utility model.
Claims
1. A vacuum drying oven for targeted drug development, comprising a vertical cabinet (1), a graphite heating plate (3), and a storage grid (4), characterized in that: A vacuum gauge (2) is fixedly installed on the top of the vertical cabinet (1) via a three-way valve. An electrical control box (5) is provided at the lower part of the cavity of the vertical cabinet (1). A vacuum generating mechanism (6) is installed inside the electrical control box (5). The vacuum generating mechanism (6) extends into the interior of the vertical cabinet (1). The vacuum generating mechanism (6) includes a suction pipe (61), a branch top cover (62), a column chamber (63), a piston column (64), an exhaust pipe (610), and a power assembly. The air pipe (61) and the air outlet pipe (610) are respectively connected to the two outlets of the branch top cover (62) through one-way valves. The other end of the air extraction pipe (61) extends into the interior of the vertical cabinet (1), and the other end of the air outlet pipe (610) extends into the exterior of the vertical cabinet (1). The branch top cover (62) is fixedly installed on the upper end of the column compartment (63). The column compartment (63) is slidably connected to the inner side of the column compartment (63). The lower end of the piston column (64) is connected to the power assembly for transmission.
2. The vacuum drying oven for targeted drug development according to claim 1, characterized in that: The power assembly includes a rocker arm (65), a double disc assembly (66), an outer casing (67), a bracket (68), a servo motor (69), a secondary gear (611), and a primary gear (612). The rocker arm (65) is rotatably connected to the lower end of the piston rod (64), and the other end of the rocker arm (65) is rotatably connected to the eccentric position of the double disc assembly (66).
3. The vacuum drying oven for targeted drug development according to claim 2, characterized in that: The two ends of the double disc (66) are rotatably connected to the inside of the outer cover (67), the outer cover (67) is fixedly connected to the lower side of the column compartment (63), and the outer cover (67) is fixedly connected to the bottom of the inner cavity of the electrical control box (5).
4. The vacuum drying oven for targeted drug development according to claim 3, characterized in that: One end of the double-disc component (66) is connected to the shaft of the secondary gear (611), and the upper side of the secondary gear (611) meshes with the primary gear (612).
5. The vacuum drying oven for targeted drug development according to claim 4, characterized in that: The secondary gear (611) and the primary gear (612) are both rotatably connected inside the outer casing (67), and the shaft of the primary gear (612) is connected to the output shaft of the servo motor (69) for transmission.
6. The vacuum drying oven for targeted drug development according to claim 5, characterized in that: The servo motor (69) is fixedly installed on one side of the bracket (68), which is fixedly connected to the bottom of the inner cavity of the electrical control box (5).
7. The vacuum drying oven for targeted drug development according to claim 1, characterized in that: Multiple sets of the load-bearing grids (4) are horizontally and evenly distributed and installed in the inner cavity of the vertical cabinet (1).