1 results about "V region" patented technology

The present disclosure provides a system for producing bispecific antibodies. In some embodiments, the system may comprise (a) a first library of nucleic acids, wherein the members of the first library encode a light chain fusion polypeptide comprising: (i) a common light chain comprising a light chain C region and a light chain V region; and (ii) the antigen binding region of a single chain antibody that binds to a first antigen, wherein: the sequence of the antigen binding region of the single chain antibody varies and the sequence of the common light chain does not vary; and (b) a second library of nucleic acids, wherein the members of the second library encode antibody heavy chain comprising a heavy chain V region and a heavy chain C region, where the sequence of the heavy chain V region varies. Methods of screening are also provided.