Hierarchical diagnosis method for liquid-based cytology
A technology of hierarchical diagnosis and cytology, applied in the field of cytology diagnosis, it can solve the problems of misdiagnosis, difficult diagnosis, and inability to reflect the comprehensive characteristics of cells, so as to avoid misdiagnosis.
Inactive Publication Date: 2013-02-27
南昌百特生物高新技术股份有限公司
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Problems solved by technology
Especially for sedimentation-type specimens, the cells have a three-dimensional structure. If they are only collected on one plane, the overall characteristics of the cells cannot be reflected at all, which makes it difficult to diagnose, and the phenomenon of misdiagnosis is even more serious.
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[0014] specific example
[0015] As can be seen from the accompanying drawings, if only one piece is collected in this field of view, no matter which one of the five pictures, it is impossible to fully observe the morphological and structural characteristics of the three cells of A, B, and C. The method of layered collection, collecting 5 sheets, can clearly observe the structural characteristics of the three cells of A, B, and C.
[0016] Such as figure 1 As shown, the A cell is very clear, while the B cell is slightly blurred, and the C cell is completely blurred. In the figure, the morphology and structure of the A cell can be clearly observed. Then through the transformation of the focal length, the collected image 3 When the B cells become very clear, the structural features of B can be observed. When zooming to the fifth picture, the C cells become clear, so that the structural features of C cells can be observed. while in figure 2 and Figure 4 When the f...
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Disclosed is a hierarchical diagnosis method for liquid-based cytology. According to stereoscopic characteristics of cells in a liquid-based cervical settling film making specimen, by the aid of a hierarchical collection method, sharp images of all cells in a view field can be collected by dividing the view field into two to ten hierarchies, so that morphological structural characteristics of each cell can be clearly observed. The cells of the whole specimen can be collected by the same method. After collection, the structural characteristics of morphology, grains, nucleuses, pulp and the like of the cells can be observed according to cell images in different hierarchies of each view field by simulating the cell observation process of people under a microscope, so that discriminating diagnosis for the cytology is performed. By the aid of the hierarchical diagnosis method, all the cells in different hierarchies of the settling film making specimen can be clearly collected, accordingly, the structural characteristics of the morphology, the grains, the nucleuses, the pulp and the like of the cells can be completely observed, accurate diagnosis is further performed, and the problem of specimen misdiagnosis caused by fuzzy cell images is avoided.
Description
technical field [0001] The invention belongs to the field of cytological diagnosis, in particular to a method for cervical liquid-based cytological image diagnosis. technical background [0002] With the widespread promotion and application of liquid-based cytology testing (LCT) technology, the diagnostic level of cervical lesions has been continuously improved, and the positive detection rate of cervical precancerous lesions has been greatly improved. But this is a new technology after all, and there are still many reports of false negatives. There are many reasons for this, among which the uncertainty of the collection method and the emergence of unsatisfactory specimens are the most important factors. Especially for sedimentation-type specimens, the cells have a three-dimensional structure. If they are only collected on one plane, the overall characteristics of the cells will not be reflected at all, making it difficult to diagnose, and the phenomenon of misdiagnosis is ...
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IPC IPC(8): G01N21/00
Inventor汪传忠伍柏青赵雄锋王士信杨元年尧莲英傅新文王超袁俊
Owner南昌百特生物高新技术股份有限公司