A kind of clathrate compound of gynecine alkaloid and its preparation method and application

A technology of kelp alkaloids and clathrates, which is applied in the field of medicine, and can solve problems such as difficult control of dosage, restrictions on popularization and application, and difficulty in making feed additives.

Inactive Publication Date: 2016-03-23
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies at home and abroad have shown that Gelfish has various pharmacological effects, such as inhibiting the respiratory center and heart contraction, relaxing smooth muscle, analgesia, dilating pupils, promoting macrophage phagocytosis, and anti-inflammatory effects. The dose is close to the poisoning dose, clinically it is not easy to control the dose, and it is difficult to make feed additives, which limits its popularization and application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Add 1g of alkaloids and 1g of β-cyclodextrin into a beaker, add 10 ml of 50% (V / V) ethanol to dissolve the alkaloids and β-cyclodextrin, stir at 30°C for 2 hours, then decompress Ethanol was evaporated, filtered, and the filtrate was vacuum-dried to obtain the clathrate.

Embodiment 2

[0016] Add 1g of alkaloids and 2g of β-cyclodextrin into a beaker, add 50ml of 50% (V / V) ethanol to dissolve the alkaloids and β-cyclodextrin, stir at 50°C for 6h, evaporate under reduced pressure Remove ethanol, filter, and vacuum-dry the filtrate to obtain clathrate.

Embodiment 3

[0018] Add 1g of alkaloids and 3g of β-cyclodextrin into a beaker, add 50ml of 50% (V / V) ethanol to dissolve the alkaloids and β-cyclodextrin, stir at 20°C for 10h, evaporate under reduced pressure Remove ethanol, filter, and vacuum-dry the filtrate to obtain clathrate.

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PUM

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Abstract

The invention discloses an inclusion compound of a kinesin alkaloid, wherein the main molecule of the inclusion compound is β-cyclodextrin, and the guest molecule is a kinesis alkaloid. The clathrate of gynecine alkaloids of the present invention can significantly reduce the toxicity of gynecine alkaloids. As a chicken feed additive, it can obviously increase the daily weight gain and feed intake of broilers, and improve the feed conversion rate; at the same time, it can also increase feed nitrogen. Increase the utilization rate of nitrogen, promote the hypertrophic hyperplasia of muscle cells, and enhance the biological protein synthesis ability of muscles.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to an inclusion compound of kelp alkaloids and a preparation method and application thereof. Background technique [0002] hook kiss ( Gelsemium elegans Benth ), also known as heartbroken grass, poisonous root, big tea medicine, etc., is a plant in the family of Strychtenaceae. It is warm in nature, pungent in taste, bitter, and highly toxic. Studies at home and abroad have shown that Gelfish has various pharmacological effects, such as inhibiting the respiratory center and heart contraction, relaxing smooth muscle, analgesia, dilating pupils, promoting macrophage phagocytosis, and anti-inflammatory effects. The dose is close to the poisoning dose, but clinically it is difficult to grasp the dose and it is difficult to make feed additives, which limits its popularization and application. Contents of the invention [0003] The object of the present invention is to provide a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/48A61K36/56A23K50/75A23K10/30A61P43/00A61P37/04A23K20/116A23K20/121
Inventor 梁剑平郭文柱郝宝成王学红陶蕾刘宇赵凤舞尚若锋郭志廷贾忠
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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