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Inclusion compound of koumine alkaloid and preparation method and application thereof

A technology of kelp alkaloids and clathrates, which is applied in the field of medicine and can solve problems such as restrictions on popularization and application, difficulties in making feed additives, and difficulty in controlling dosages.

Inactive Publication Date: 2014-08-20
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies at home and abroad have shown that Gelfish has various pharmacological effects, such as inhibiting the respiratory center and heart contraction, relaxing smooth muscle, analgesia, dilating pupils, promoting macrophage phagocytosis, and anti-inflammatory effects. The dose is close to the poisoning dose, clinically it is not easy to control the dose, and it is difficult to make feed additives, which limits its popularization and application

Method used

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  • Inclusion compound of koumine alkaloid and preparation method and application thereof
  • Inclusion compound of koumine alkaloid and preparation method and application thereof
  • Inclusion compound of koumine alkaloid and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Add 1g of alkaloids and 1g of β-cyclodextrin into a beaker, add 10ml of 50% (V / V) ethanol to dissolve the alkaloids and β-cyclodextrin, stir at 30°C for 2h, then reduce Ethanol was removed by pressure steaming, filtered, and the filtrate was vacuum-dried to obtain the clathrate.

Embodiment 2

[0016] Add 1g of alkaloids and 2g of β-cyclodextrin into a beaker, add 50ml of 50% (V / V) ethanol to dissolve the alkaloids and β-cyclodextrin, stir at 50°C for 6h, and depressurize Ethanol was evaporated, filtered, and the filtrate was vacuum-dried to obtain the clathrate.

Embodiment 3

[0018] Add 1g of alkaloids and 3g of β-cyclodextrin into a beaker, add 50ml of 50% (V / V) ethanol to dissolve the alkaloids and β-cyclodextrin, stir at 20°C for 10h, and depressurize Ethanol was evaporated, filtered, and the filtrate was vacuum-dried to obtain the clathrate.

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Abstract

The invention discloses an inclusion compound of koumine alkaloid. The host molecule of the inclusion compound is beta-cyclodextrin and the guest molecule of the inclusion compound is koumine alkaloid. By using the inclusion compound of koumine alkaloid, the toxicity of koumine alkaloid can be lowered remarkably; as a chicken feed additive, the inclusion compound is capable of greatly improving daily weight gain and food consumption of broilers and the feed conversion rate is increased; meanwhile, the utilization ratio of a nitrogen feed can be increased, and nitrogen deposit is increased; hypertrophic hyperplasia of muscle cells is promoted, and the bioprotein synthetic ability of muscles is improved.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to an inclusion compound of kelp alkaloids and a preparation method and application thereof. Background technique [0002] hook kiss ( Gelsemium elegans Benth ), also known as heartbroken grass, poisonous root, big tea medicine, etc., is a plant in the family of Strychtenaceae. It is warm in nature, pungent in taste, bitter, and highly toxic. Studies at home and abroad have shown that Gelfish has various pharmacological effects, such as inhibiting the respiratory center and heart contraction, relaxing smooth muscle, analgesia, dilating pupils, promoting macrophage phagocytosis, and anti-inflammatory effects. The dose is close to the poisoning dose, but clinically it is difficult to grasp the dose and it is difficult to make feed additives, which limits its popularization and application. Contents of the invention [0003] The object of the present invention is to provide a...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K36/56A23K1/18A23K1/16A61P43/00A61P37/04A23K20/116A23K20/121A23K50/75
Inventor 梁剑平郭文柱郝宝成王学红陶蕾刘宇赵凤舞尚若锋郭志廷贾忠
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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