Pi3k inhibitors for treating cough

Abstract

The present invention relates to compounds or pharmaceutically acceptable salts thereof for use in the treatment of cough, in particular idiopathic chronic cough, cough variant asthma, cough associated with thoracic tumour or lung cancer, viral and post-viral cough, upper airways cough syndrome (UACS) or post nasal drip cough, and cough associated with disorders such as gastro oesophageal reflux disease (both acid and non acid reflux), chronic bronchitis, chronic obstructive pulmonary disease (COPD), interstitial lung disease (the as idiopathic pulmonary fibrosis (IPF)), congestive heart disease, sarcoidosis and infection (the as whooping cough).

Description

field of invention [0001] The present invention relates to compounds and pharmaceutically acceptable salts thereof, which are members of the phosphoinositide 3'OH kinase family (hereinafter referred to as PI3K, including PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ) and the mammalian target of rapamycin (hereinafter referred to as mTOR , an inhibitor of the activity or function of PI3K downstream signaling target), for the treatment of cough, especially idiopathic chronic cough, cough variant asthma, cough associated with thoracic tumors or lung cancer, viral and postviral cough (post-viral cough), upper airway cough syndrome (UACS) or postnasal drip cough, and cough associated with conditions such as gastroesophageal reflux disease (acid reflux and non-acid reflux), chronic Bronchitis, chronic obstructive pulmonary disease (COPD), interstitial lung disease (such as idiopathic pulmonary fibrosis (IPF)), congestive heart disease, sarcoidosis, and infections (such as whooping cough). Backgro...

AI Technical Summary

Problems solved by technology

Although some of the underlying mechanisms of cough are now better understood, no substantial progress has been made in the treatment of this condition, and some authors have emphasized the need for safe and effective antitussive treatments [Dicpinigaitis, 2011; McGarvey, 2010; Chung, 2008 ]

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