Faropenem sodium granule and preparation method thereof

Abstract

The invention provides a faropenem sodium granule and a preparation method thereof. The faropenem sodium granule contains faropenem sodium, polyvinyl alcohol, dextran and a sweetening agent. The faropenem sodium granule has the advantages of low polymer content, good stability and simple preparation technology.

Description

technical field

[0001] The invention belongs to the technical field of medicines, and in particular relates to faropenem sodium granules and a preparation method thereof. Background technique

[0002] Faropenem (Faropenem) is an atypical β-lactam antibiotic, which belongs to the derivatives of carbapenems. Faropenem shows broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive bacteria and Gram-negative bacteria, especially against drug-resistant Staphylococcus, Enterococcus and other Gram-positive bacteria and Bacteroides and other anaerobic bacteria. The activity is better than the existing oral antibacterial drugs. Faropenem has a good affinity with penicillin-binding protein and good stability of β-lactamase, less drug resistance, mainly used for respiratory system infection, urinary system infection, reproductive system infection, biliary tract infection caused by sensitive bacteria infection etc.

[0003] Faropenem sodium, molecular formula...

Examples

Embodiment 1

[0026] prescription:

[0027]

[0028] Preparation Process:

[0029] Faropenem sodium, polyvinyl alcohol, dextran and aspartame were pulverized through a 100-mesh sieve, weighed and mixed evenly according to the prescription amount, added 50% ethanol solution to granulate, passed through a 20-mesh sieve for granulation, dried at 40°C, passed through 10 Mesh and 80 mesh sieves, determine the content of semi-finished products, and pack.

Embodiment 2

[0031] prescription:

[0032]

[0033] Preparation Process:

[0034] Faropenem sodium, polyvinyl alcohol, dextran and stevia were crushed through a 100-mesh sieve, weighed and mixed evenly according to the prescription amount, added 50% ethanol solution to granulate, passed through a 20-mesh sieve for granulation, dried at 40°C, passed through 10 mesh, Sieve with 80 mesh sieve, determine the content of semi-finished products, and pack.

Embodiment 3

[0036] prescription:

[0037]

[0038] Preparation Process:

[0039] Faropenem sodium, polyvinyl alcohol, dextran and sodium saccharin were crushed through a 100-mesh sieve, weighed and mixed evenly according to the prescription amount, added 50% ethanol solution to granulate, passed through a 20-mesh sieve for granulation, dried at 40°C, passed through 10 mesh, Sieve with 80 mesh sieve, determine the content of semi-finished products, and pack.

technical field

[0001] The invention belongs to the technical field of medicines, and in particular relates to faropenem sodium granules and a preparation method thereof. Background technique

[0002] Faropenem (Faropenem) is an atypical β-lactam antibiotic, which belongs to the derivatives of carbapenems. Faropenem shows broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive bacteria and Gram-negative bacteria, especially against drug-resistant Staphylococcus, Enterococcus and other Gram-positive bacteria and Bacteroides and other anaerobic bacteria. The activity is better than the existing oral antibacterial drugs. Faropenem has a good affinity with penicillin-binding protein and good stability of β-lactamase, less drug resistance, mainly used for respiratory system infection, urinary system infection, reproductive system infection, biliary tract infection caused by sensitive bacteria infection etc.

[0003] Faropenem sodium, molecular formula...

Examples

Embodiment 1

[0026] prescription:

[0027]

[0028] Preparation Process:

[0029] Faropenem sodium, polyvinyl alcohol, dextran and aspartame were pulverized through a 100-mesh sieve, weighed and mixed evenly according to the prescription amount, added 50% ethanol solution to granulate, passed through a 20-mesh sieve for granulation, dried at 40°C, passed through 10 Mesh and 80 mesh sieves, determine the content of semi-finished products, and pack.

Embodiment 2

[0031] prescription:

[0032]

[0033] Preparation Process:

[0034] Faropenem sodium, polyvinyl alcohol, dextran and stevia were crushed through a 100-mesh sieve, weighed and mixed evenly according to the prescription amount, added 50% ethanol solution to granulate, passed through a 20-mesh sieve for granulation, dried at 40°C, passed through 10 mesh, Sieve with 80 mesh sieve, determine the content of semi-finished products, and pack.

Embodiment 3

[0036] prescription:

[0037]

[0038] Preparation Process:

[0039] Faropenem sodium, polyvinyl alcohol, dextran and sodium saccharin were crushed through a 100-mesh sieve, weighed and mixed evenly according to the prescription amount, added 50% ethanol solution to granulate, passed through a 20-mesh sieve for granulation, dried at 40°C, passed through 10 mesh, Sieve with 80 mesh sieve, determine the content of semi-finished products, and pack.

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