The invention relates to a preparation method of Faropenem sodium (I). The preparation method of Faropenem sodium includes: using (1'R, 2''R, 5R, 65)-6-[(1'-R)-2''-tetrahydrofuran base]penem-3-carboxylic ether as raw material, R is hydroxyethyl, or tert-butyl dimethyl silica ethyl, in the presence of palladium catalyst and alkylene capturing agent, removing allyl group of carboxyl acid or cinnamon base protecting group, in the presence of alkaline producing Faropenem sodium; Or, B: when the R is tert-butyl dimethyl silica ethyl, in the presence of palladium catalyst, triphenylphosphine and alkylene capturing agent, after removing allyl group of carboxyl acid or cinnamon base protecting group, under the actions of fluorine hydride acid, ammonium acid fluoride or dilute acid, removing silicone base protecting group of hydroxyl group, under the action of alkali, producing Faropenem sodium, the alkylene capturing agent is 5, 5-dimethyl cyclohexanedione; the palladium catalyst contains palladiurn bichloride, mixture of palladiurn bichloride and triphenylphosphine, and di (triethoxy phosphine) palladiurn bichloride, etc.