Combination comprising zidovudine and an antimicrobial compound
An anti-microbial, zidovudine technology, used in the field of treating microbial infections and killing proliferating microorganisms associated with microbial infections, can solve the problems of unpredictable and unpredictable synergy
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Embodiment 1
[0150] Example 1: In Vitro Synergy of Zidovudine (AZT) and Nitrofurantoin
[0151] The tessellation method used in Example 1 followed the protocol detailed in Antimicrob Chemo (2013) 68, 374-384. Zidovudine and nitrofurantoin were obtained from commercial sources. The bacterium used was E. coli k12; E. coli k12 is a susceptible strain which is considered sensitive to all antibiotics against Gram-negative bacteria. Such strains were obtained from commercial sources and the bacteria were grown in log phase using methods known in the art.
[0152] The effect of the combinations of the present invention is examined by calculating the Fractional Inhibitory Concentration Index (FICI) of each combination, as follows:
[0153] (MIC of drug A tested in combination) / (MIC of drug A tested alone)+(MIC of drug B tested in combination) / (MIC of drug B tested alone).
[0154]Interactions for combinations were defined as showing synergy if FICI 0.5 but 4.0.
[0155]
[0156] FICI valu...
Embodiment 2
[0157] Example 2: In vitro synergistic effect of the combination of zidovudine and faropenem
[0158] Method and bacterial strain are identical with embodiment 1. Zidovudine and faropenem were obtained from commercial sources. The effect of the combination of the present invention was examined in the same manner as in Example 1 by calculating the MIC of each drug alone and in combination.
[0159]
[0160] The FICI values indicate that zidovudine (AZT) and faropenem have a synergistic effect against log-phase E. coli k12 when used in combination at various concentrations.
Embodiment 3
[0161] Example 3: In Vitro Synergy of Combination of Zidovudine and Mecillin
[0162] Method and bacterial strain are identical with embodiment 1. Zidovudine and mecillin were obtained from commercial sources. The effect of the combination of the present invention was examined in the same manner as in Example 1 by calculating the MIC of each drug alone and in combination.
[0163]
[0164] FICI values indicate that zidovudine (AZT) and mecillin are synergistic against log-phase E. coli k12 when used in combination at various concentrations.
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