Catalyst composition and method for preparing faropenem sodium

Abstract

The invention provides a catalyst composition, mainly containing palladium carbon (Pd / C) and triphenylphosphine, wherein the molar ratio of palladium to the triphenylphosphine is 1:2-1:6. The invention also provides a method for preparing faropenem sodium of a formula I, comprising the following step of: performing a reaction of a compound as an intermediate in a formula II and an allyl receptor under the action of a catalyst for removing allyl to produce the faropenem sodium of the formula I. The adopted catalyst for removing the allyl is the catalyst composition containing the palladium carbon (Pd / C) and the triphenylphosphine. The catalyst composition is easy to recover, thereby greatly reducing pollution of the palladium in a product.

Description

technical field The present invention relates to a catalyst composition, and a specific aspect of the present invention relates to a preparation method of faropenem sodium. Background technique Tetrakis(triphenylphosphine)palladium (Pd(PPh 3 ) 4 ) is a homogeneous catalyst with important uses in the field of organic synthesis, often used to catalyze various couplings, such as Suzuki coupling, Stille coupling, Kumada coupling, Negishi coupling, Murahashi coupling, Hiyama coupling and Sonogashira coupling et al. However, in the existing use of Pd(PPh 3 ) 4 Under certain reaction conditions, the catalyst is usually soluble in the reaction system and is not easily separated after the reaction is completed, so this expensive catalyst cannot be recycled, and sometimes it will cause heavy metal pollution to the product. This is the case, for example, for its use in the synthesis of faropenem sodium. Faropenem sodium is a new oral antibacterial drug. The drug acts not only o...

AI Technical Summary

Problems solved by technology

In this reaction, Pd(PPh 3 ) 4 Soluble in a system that uses a mixture of dichloromethane and acetic acid as a solvent, it is difficult to recover, which not only makes it difficult to recycle this expensive catalyst, but also has the risk of product being contaminated by the catalyst, causing the heavy metal in the product to exceed the standard

In addition, Pd(PPh 3 ) 4 The nature of the catalyst is unstable, and it will deteriorate if left for a long time

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