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Faropenem sodium granules and preparing method thereof

A technology of faropenem sodium and granules, which is applied in the field of medicine, can solve the problems of undiscovered creative technical inventions and unmentioned drug stability, etc., and achieve the effects of good drug stability, avoiding contraindications, and simple production process

Inactive Publication Date: 2014-09-10
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] CN 101744782 B discloses a tablet containing faropenem sodium, but does not mention how to improve the stability of the drug, and no creative technical inventions are found in the examples

Method used

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  • Faropenem sodium granules and preparing method thereof
  • Faropenem sodium granules and preparing method thereof
  • Faropenem sodium granules and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Faropenem Sodium 250g

[0030] Hydroxypropyl Beta Cyclodextrin 250g

[0031] 45% ethanol aqueous solution appropriate amount

[0032] Sucrose 400g

[0033] Aspartame 2g

[0034] Sweet Orange Flavor 4g

[0035] Preparation Process

[0036] Pass hydroxypropyl beta cyclodextrin and faropenem sodium through a 100-mesh sieve, mix well, add 45% ethanol solution to granulate, use an extruder to extrude strip-shaped granules, spheronize to obtain drug-containing pellets, dry and homogenize through 60 Mesh sieved sucrose, aspartame, and sweet orange essence are mixed and packaged.

Embodiment 2

[0038] Faropenem Sodium 250g

[0039] Hydroxypropyl Beta Cyclodextrin 1000g

[0040] 85% ethanol aqueous solution appropriate amount

[0041] Mannitol 500g

[0042] Stevia 2g

[0043] Coconut essence 3g

[0044] Preparation Process

[0045] Pass hydroxypropyl beta cyclodextrin and faropenem sodium through a 100-mesh sieve, mix well, add 45% ethanol solution to granulate, use an extruder to extrude strip-shaped granules, spheronize to obtain drug-containing pellets, dry and homogenize through 60 Mesh sieved mannitol, stevia, and coconut essence are mixed and packaged.

Embodiment 3

[0047] Faropenem Sodium 250g

[0048] Hydroxypropyl Beta Cyclodextrin 625g

[0049] 55% ethanol aqueous solution appropriate amount

[0050] Sucrose 500g

[0051] Aspartame 2g

[0052] Coconut essence 3g

[0053] Preparation Process

[0054] Pass hydroxypropyl beta cyclodextrin and faropenem sodium through a 100-mesh sieve, mix evenly, add 55% ethanol solution to granulate, use an extruder to extrude strip-shaped granules, spheronize to obtain drug-containing pellets, dry and homogenize through 60 Mesh sieved sucrose, aspartame and coconut essence are mixed and packaged.

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PUM

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Abstract

Faropenem sodium granules and a preparing method thereof are disclosed. The faropenem sodium granules can be prepared by: uniformly mixing faropenem sodium and hydroxypropyl-beta-cyclodextrin, adding an aqueous ethanol solution, granulating, extruding, rolling, drying, uniformly mixing with pharmaceutically accepted auxiliary materials and packaging.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a faropenem sodium granule and a preparation method thereof. Background technique [0002] Faropenem is an atypical β-lactam antibiotic, which is a derivative of penems. Two types of compounds, carbapenems and penems, have attracted great interest. Penems have more unique advantages. Currently, five penem derivatives are under development, and faropenem is convenient. is one of them. In addition to being weak against Pseudomonas aeruginosa, it has a broad antibacterial spectrum and is particularly effective against anaerobic bacteria, which is better than carbapenem antibiotics. It shows broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive bacteria and Gram-negative bacteria, especially against drug-resistant Staphylococcus, Enterococcus and other Gram-positive bacteria and Bacteroides and other anaerobic bacteria All are superior to...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/431A61K47/40A61P31/04
Inventor 沈若武张蓓孙勇徐晟伟夏玉军晁凡赵成管文敏
Owner QINGDAO UNIV
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