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Tablet containing faropenem sodium

A technology of faropenem sodium and tablets, which is applied in the field of pharmaceutical preparations and can solve problems such as poor stability and difficulty in swallowing

Active Publication Date: 2010-06-23
LUNAN BETTER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the deficiencies in the prior art, the present invention provides a tablet of faropenem sodium, which overcomes the disadvantages of ordinary faropenem sodium tablets, such as bitter taste, hard to swallow, poor stability in acidic environment and thermal environment, etc. Reduce the side effects of medication, improve the compliance of patients with medication, and at the same time achieve the purpose of rapid onset of effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 Faropenem sodium tablet

[0040] Faropenem sodium (main ingredient) 123.5g

[0041] Microcrystalline cellulose (filler) 44g

[0042] Micronized silica gel (filler) 12g

[0043] Cross-linked polyvinylpyrrolidone (disintegrant) 64g

[0044] Low-substituted hydroxypropyl cellulose (disintegrant) 20g

[0045] Aspartame 4g

[0046] 5% PVPk30 95% ethanol solution appropriate amount

[0047] Magnesium stearate (lubricant) 0.8%

[0048] A total of 1000 tablets were produced, each tablet weighed 0.28g, and the main drug was 0.10g calculated as faropenem.

[0049] Preparation process: crush the raw material through a 100-mesh sieve; crush the rest of the excipients through a 80-mesh sieve; accurately weigh the raw and excipients in the prescribed amount, mix them evenly, granulate with 5% PVPk3095% ethanol solution, granulate with a 18-mesh sieve, ℃ dry. Add the prescribed amount of magnesium stearate, mix evenly, pass through a 18-mesh sieve, measure the con...

Embodiment 2

[0050] Example 2 Faropenem Sodium Tablets

[0051] Faropenem sodium (main ingredient) 123.5g

[0052] Microcrystalline cellulose (filler) 72g

[0053] Micronized silica gel (filler) 12g

[0054] Cross-linked polyvinylpyrrolidone (disintegrant) 36g

[0055] Low-substituted hydroxypropyl cellulose (disintegrant) 20g

[0056] Aspartame 4g

[0057]5% PVPk30 95% alcohol solution appropriate amount

[0058] Magnesium stearate (lubricant) 0.8%

[0059] A total of 1000 tablets were produced, each tablet weighed 0.28g, and the main drug was 0.10g calculated as faropenem.

[0060] Preparation process: crush the raw material through a 100-mesh sieve; crush the rest of the excipients through a 80-mesh sieve; accurately weigh the raw and excipients in the prescribed amount, mix them evenly, granulate with 5% PVPk3095% ethanol solution, granulate with a 18-mesh sieve, ℃ dry. Add the prescribed amount of magnesium stearate, mix evenly, pass through a 18-mesh sieve, measure the conten...

Embodiment 3

[0061] Example 3 Faropenem Sodium Tablets

[0062] Faropenem sodium (main ingredient) 123.5g

[0063] Microcrystalline cellulose (filler) 60g

[0064] Micronized silica gel (filler) 10g

[0065] Cross-linked polyvinylpyrrolidone (disintegrant) 60g

[0066] Low-substituted hydroxypropyl cellulose (disintegrant) 10g

[0067] Aspartame 4g

[0068] 5% PVPk30 95% ethanol solution appropriate amount

[0069] Magnesium stearate (lubricant) 0.8%

[0070] A total of 1000 tablets were produced, each tablet weighed 0.28g, and the main drug was 0.10g calculated as faropenem.

[0071] Preparation process: crush the raw material through a 100-mesh sieve; crush the rest of the excipients through a 80-mesh sieve; accurately weigh the raw and excipients in the prescribed amount, mix them evenly, granulate with 5% PVPk3095% ethanol solution, granulate with a 18-mesh sieve, ℃ dry. Add the prescribed amount of magnesium stearate, mix evenly, pass through a 18-mesh sieve, measure the conte...

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Abstract

The invention relates to a tablet containing faropenem sodium, belonging to the field of pharmaceutical preparation. The faropenem sodium tablet of the invention comprises 20-50 parts of faropenem sodium, 20-25 parts of disintegrant, 2-10 parts of 95% ethanol solution containing 5% of polyvinylpyrrolidone, 20-30 parts of filler and 0.5-2 parts of lubricant. The faropenem sodium tablet of the invention has the advantages of fast disintegration speed and stable properties in high-temperature and high-humidity environment, can effectively improve the effect-taking concentration and bioavailability of faropenem, and is very suitable for old people and children with dysphagia to take.

Description

technical field [0001] The invention relates to a tablet containing faropenem sodium, which belongs to the field of pharmaceutical preparations. Background technique [0002] Faropenem is an atypical β-lactam antibiotic, which is a derivative of penems. [0003] Two types of compounds, carbapenems and penems, have attracted great interest. Penems have more unique advantages. Currently, five penem derivatives are under development, and faropenem is convenient. is one of them. In addition to being weak against Pseudomonas aeruginosa, it has a broad antibacterial spectrum and is particularly effective against anaerobic bacteria, which is better than carbapenem antibiotics. It shows broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive bacteria and Gram-negative bacteria, especially against drug-resistant Staphylococcus, Enterococcus and other Gram-positive bacteria and Bacteroides and other anaerobic bacteria All are superior to existing oral anti...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/431A61K47/32A61K47/38A61K47/36A61P31/04A61P11/00A61P13/00A61P15/00A61P1/16
Inventor 赵志全
Owner LUNAN BETTER PHARMA
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