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A clam extract for promoting postpartum uterine contractions

A technology of uterine contraction and extract, applied in medical raw materials derived from molluscs, drug combinations, diseases, etc., can solve problems such as uterine contraction that has not been reported

Inactive Publication Date: 2018-10-02
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Razor clam meat can treat postpartum wasting, dysphoria and thirst, damp and hot water swelling, heat stroke, dysentery, dysuria, etc., but the effect of promoting uterine contraction has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1, preparation has the razor clam extract that promotes postpartum uterine contraction:

[0011] (1) Appropriate amount of razor clam meat, homogenized;

[0012] (2) Add 1.5 times the volume of distilled water, and ultrasonically assist extraction at 30°C for 25 minutes;

[0013] (3) Stir and extract in a water bath at 30°C for 2 hours, centrifuge at 4000r / min for 5 minutes, take the supernatant, repeat the above operation for the residue, combine the filtrates, concentrate under reduced pressure to 1 / 3 volume, and freeze-dry to obtain the razor clam extract.

Embodiment 2

[0014] Example 2: Effect of razor clam extract on uterine contraction of isolated mice

[0015] Preparation of isolated mouse uteri: 2 days before the experiment, non-pregnant female mice were intraperitoneally injected with estradiol valerate every day to improve the sensitivity of the uterus to drugs; the mice were killed quickly by cervical dislocation, and the uteri were taken out by laparotomy to make about 1.0 cm strips of uterine smooth muscle. Put the uterus ligated with silk thread into a Maxwellian bath filled with 20ml, fix one end of the silk thread ligated to the specimen fixing hook in the bath, and connect the other end to the tension transducer, and give the uterus a load of 1g. After the uterine contraction is stable, the normal contraction curve is recorded. Add 1 drop of motherwort aqueous solution (as a control) and various concentrations of razor clam extract to each group, and after the uterine contraction is stable, use Biolap420E + The biological sig...

Embodiment 3

[0018] Embodiment 3: the preparation of razor clam extract tablet

[0019] prescription:

[0020] Razor clam extract 100mg

[0021] Lactose 100mg

[0022] Starch 295mg

[0023] Magnesium Stearate 5mg

[0024] Total 500mg

[0025] Weigh out the main ingredients respectively, mix the powder of razor clam extract through an 80-mesh sieve, lactose, and starch, use wet granulation, dry, mix with magnesium stearate after integration, and compress into tablets of 500 mg each agent.

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PUM

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Abstract

The invention discloses a razor clam extractive used for promoting postpartum uterus contraction; the razor clam extractive is the water-soluble matter extracted from the razor clam meat, has the function of contracting uterus and is used for treating postpartum hemorrhage and incomplete restoration of uterus after medical abortion operation and induced abortion operation.

Description

technical field [0001] The invention relates to a new application of marine active substance razor clam extract in preparing medicine for uterine contraction. Background technique [0002] Razor clam is a shellfish of the bivalve clam order, which lives in the ocean and is a common marine food. Razor clam meat is sweet, salty and cold, and is used for postpartum deficiency and cold, dysphoria due to dysphoria. Traditional Chinese medicine believes that razor clam meat has the effects of clearing away heat and detoxification, nourishing yin and eliminating troubles, nourishing kidney and diuresis, and tonifying deficiency after childbirth. "Jiayou Materia Medica" records: razor clam meat: "replenishing deficiency, main cold dysentery, cooking it, housewives postpartum deficiency, evil heat and depression in the chest". "Suixiju Diet Spectrum" records: razor clam meat "clears the stomach, cures dysentery, relieves restlessness, and supplements postpartum deficiency". Razor ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/618A61P15/04
CPCA61K35/618
Inventor 石振艳高华刘坤张惠芳朱兆明
Owner QINGDAO UNIV
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