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A method for evaluating drug sensitivity of tumor cells based on genetic material specificity

A drug sensitivity and tumor cell technology, which is applied in the field of tumor cell drug sensitivity assessment based on genetic material specificity, can solve the problems of different drug reactions or curative effects, toxic and side effects, etc., achieve fewer parameters to be adjusted, objective discrimination, avoid Effects of Artificial Subjectivity Influence

Active Publication Date: 2017-12-01
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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Problems solved by technology

However, clinical applications have shown that different individual tumor patients, even patients at the same stage, have significantly different responses or curative effects to drugs, and some even have severe side effects

Method used

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  • A method for evaluating drug sensitivity of tumor cells based on genetic material specificity
  • A method for evaluating drug sensitivity of tumor cells based on genetic material specificity
  • A method for evaluating drug sensitivity of tumor cells based on genetic material specificity

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Embodiment Construction

[0037] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0038] Such as figure 1 As shown, a method for assessing drug sensitivity of tumor cells based on genetic material specificity comprises the following steps:

[0039] S1. The tumor cell sample set is divided into a training sample subset and a test sample subset according to a certain ratio (such as 3:2), wherein the training sample subset is used to learn the relationship model between the gene mutation spectrum and the drug IC50 value index, A subset of test samples was used to select the best extreme learning machine prediction model for tumor cell drug IC50 value as a tumor cell drug sensitivity assessment model.

[0040] The training sample subset data can be expressed as:

[0041] x tr ={x i , t i |x i ∈ R p , t i ∈R,i=1,...L}

[0042] where x i Represents the gene mutation spectrum of the i-th training sample, p represents the ...

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Abstract

The invention provides a method for assessing tumor cell drug sensitivity based on genetic material specificity, comprising: dividing a tumor cell sample set into a training sample subset and a test sample subset; using the training sample subset to train and obtain A collection of extreme learning machine prediction models for tumor cell drug IC50 values; test the prediction models one by one with a subset of test samples, and select the prediction model with the best performance as the tumor cell drug sensitivity evaluation model; calculate the drug sensitivity of the tumor cells to be tested The assessed value. The invention realizes the drug sensitivity evaluation of tumor cells at the biological genetic level, and at the same time, the use of the drug IC50 value can avoid the influence of artificial subjectivity, making the drug sensitivity judgment more objective and reliable, and the extreme learning machine learning does not need iteration, to be adjusted The number of parameters is small and the global optimum can be guaranteed, which makes the detection of drug sensitivity of tumor cells more convenient, efficient and practical.

Description

technical field [0001] The invention relates to the technical field of detection and evaluation of drug sensitivity of tumor cells, in particular to a method for evaluating drug sensitivity of tumor cells based on genetic material specificity. Background technique [0002] Tumor has become the "number one killer" of human beings, seriously threatening human health. According to the report of the World Health Organization, the incidence and mortality of global tumors have increased by about 22% in the past 10 years. It is estimated that by 2020, new cases will Reaching 20 million, about 12 million people will die of cancer. In my country, due to the deterioration of environmental pollution in the past 10 years, many cancer villages, cancer counties and other high-incidence areas of cancer have emerged. How to effectively treat cancer is a worldwide problem, and it is also an urgent task for my country's medical and health services. [0003] Chemotherapy is one of the main m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F19/00
Inventor 王红强靖高见
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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