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A kind of Sialon bone extract with anti-inflammatory and analgesic activity, preparation method and traditional Chinese medicine preparation

A technology of anti-inflammatory and analgesic, Theron bone, applied in the field of traditional Chinese medicine preparation, Theron bone extract, preparation

Active Publication Date: 2019-08-09
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, there is no relevant report on the separation and purification of components with significant anti-inflammatory and analgesic activity from the bone of Theron

Method used

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  • A kind of Sialon bone extract with anti-inflammatory and analgesic activity, preparation method and traditional Chinese medicine preparation
  • A kind of Sialon bone extract with anti-inflammatory and analgesic activity, preparation method and traditional Chinese medicine preparation
  • A kind of Sialon bone extract with anti-inflammatory and analgesic activity, preparation method and traditional Chinese medicine preparation

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Embodiment 1

[0028] Embodiment 1 Preparation of Theron bone extract of the present invention

[0029] 1. Method steps

[0030] (1) Take the air-dried product of Theron bone and pulverize it, which can be passed through a 120-mesh sieve after pulverization.

[0031] (2) Extraction: extract 4 times with 95% ethanol with a volume ratio of 95% in a rotary evaporator at 70 degrees Celsius, 2h / time, then combine the 4 extracts, concentrate under reduced pressure to dryness, and obtain Sialon bone fat-soluble extract parts. (High-concentration ethanol extraction can prevent large polar substances from being simultaneously proposed, reducing material interference during the separation process).

[0032] (3) Extraction of the fat-soluble part: dissolve in deionized water, extract with petroleum ether and ethyl acetate respectively, let stand for half an hour for each extraction, extract 4-6 times, combine the extracts and concentrate to dryness respectively to obtain petroleum ether part and the...

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Abstract

The invention discloses a preparation method of sailong bone extract, comprising the following steps: (1) grinding; (2) extracting bone fat soluble extraction part; (3) extracting, namely, extracting by using petroleum ether firstly, then extracting the water phase by ethyl acetate, and concentrating till the extract is dry, so as to obtain the ethyl acetate part; and (4) carrying out column separation, namely, eluting in a silicagel column by adopting a solvent with the ratio of ethyl acetate to methyl alcohol being 1 to 1 as an eluant, and drying to obtain the sailong bone extract. The invention further discloses the sailong bone extract prepared by the preparation method, an application of the sailong bone extract in preparing anti-inflammatory and pain-easing drugs, and a Chinese herbal preparation with the activities of resisting inflammation and easing pain. The sailong bone extract has the activities of resisting inflammation and easing pain, and can be used for preparing the anti-inflammatory and pain-easing drugs, especially the Chinese herbal preparation. The sailong bone extract can account for 20-90% of the total weight of the preparation, with the balance being common auxiliary materials in pharmacology and carriers acceptable in pharmacy.

Description

technical field [0001] The invention relates to a medicinal extract, in particular to a sialon bone extract with anti-inflammatory and analgesic activities, a preparation method and a traditional Chinese medicine preparation. Background technique [0002] Theron bone is the dry whole-frame skeleton of the plateau zokor (Myospalax baileyi Thomas), a hamster family animal, with the brain removed. They are caught with equipment in summer and autumn, and they are killed immediately after being hunted. The skin, meat, and brain are removed, and the remaining muscles are removed, and they are dried in the shade or at low humidity in time. Break into pieces when used, decoct in water or soak in wine. It has the functions of expelling wind, dispersing cold and dehumidification, dredging collaterals and relieving pain, and nourishing liver and kidney. It can be used for limb joint pain, swelling, difficulty in flexion and extension, skin numbness, and soreness of waist and knees cau...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/32A61P29/00
Inventor 赵晓辉岳会兰陶燕铎邵赟
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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