Trachea epiglottis opening positioning medicine administration method suitable for rat noninvasive respiratory tract medicine administration
A method of drug administration and respiratory technology, which is applied in the field of drug administration to laboratory rats, can solve the problems of increased infection rate, disadvantage, and death of animals, and achieve free control of drug dosage, accurate infusion method, and simple infusion method Effect
Inactive Publication Date: 2018-09-18
NINGBO UNIV
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This method has an open wound, which is easy to damage the experimental animals, and as time goes on, the infection rate of the animals increases, which may cause the death of the animals, and may also affect the accuracy of the exp
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[0023] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments.
[0024] Such as Figure 1 to Figure 2 Shown is the structural representation of the present invention,
[0025] The reference signs therein are: height H, length L, locator main body 1 , spherical structure 11 , handle 2 .
[0026] The tracheal epiglottis opening positioning method for non-invasive respiratory drug administration in rats comprises the following steps:
[0027] Step 1. After the rat is anesthetized, hang the rat vertically on a glass plate, the mouth of the rat is below the experimenter's field of vision, and a shadowless lamp is used as the transmitted light source;
[0028] Step 2. One experimenter fixes the rat's head and pulls out the rat's tongue to expose it to the outside of the mouth, and focuses the light source on the rat's mouth. The other experimenter slowly inserts the locator from the mouth to the epiglottis of t...
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Abstract
The invention discloses a trachea epiglottis opening positioning medicine administration method suitable for rat noninvasive respiratory tract medicine administration. The method comprises the following steps that step1, after a rat is anesthetized, the rat is hung on a glass plate, a rat oral cavity is located below the view of experimenters, and a shadowless lamp is a transmission light source;step two, after one experimenter fixes the rat head, the rat tongue is pulled out to be exposed to the external of the oral cavity, and the light source is focused on the rat oral cavity; the other experimenter slowly inserts a locator into the trachea epiglottis through the oral cavity, when white bubbles generated by the rat trachea respiration floating up and down is watched, it is indicated that the exposed position of the rat trachea is correct; step three, at the moment, medicine administration equipment is adopted to slowly drip the medicine into the trachea through the locator, after the medicine dripping is completed, the locator is shifted out. The trachea epiglottis opening positioning medicine administration method suitable for the rat noninvasive respiratory tract medicine administration has the advantages that the operation is convenient and safe, the method is suitable for big batch animal experiments, and the accuracy of medicine administration is good.
Description
technical field [0001] The invention relates to the technical field of drug administration to laboratory rats, in particular to a tracheal epiglottis opening-positioned drug delivery method suitable for non-invasive respiratory tract drug delivery in rats. Background technique [0002] In contemporary life science research, animal experiments are indispensable. Most of the various physiological phenomena and pathological mechanisms need to be clarified or confirmed with the help of animal experiments. A safe and effective drug delivery method is the key to ensure the success of the experiment and the premise of accurate, true and reliable experimental results. With the development of science and technology and the progress of human civilization, people pay more and more attention to animal ethics. To ensure that experimental animals enjoy the welfare they deserve, to minimize the pain of animals during the experiment, and to provide them with a comfortable and painless envi...
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Login to View More IPC IPC(8): A61D7/00
CPCA61D7/00
Inventor 李洲赵进顺汤雨晴宋新王亚飞苏红邹宝波塞缪尔·瑟洛姆·费亚提-肯斯顿
Owner NINGBO UNIV