A kind of pharmaceutical composition for treating cor pulmonale

A cor pulmonale and composition technology, applied in the field of natural medicinal chemistry, can solve problems such as unfavorable long-term treatment, viscosity, and poor tolerance of cardiotonic agents, so as to prevent and treat cor pulmonale, reduce inflammatory reactions, The effect of high development potential

Active Publication Date: 2020-06-30
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When heart failure occurs in patients with chronic cor pulmonale, clinical treatment is difficult due to its pathophysiological characteristics. At present, anti-heart failure treatment is still carried out on the basis of relieving hypoxia, carbon dioxide retention, and correcting acid-base balance and electrolyte disturbance. Including the application of cardiotonic agents, diuretics and vasodilators, but the patients have hypoxia and respiratory failure, and their tolerance to cardiotonic agents is poor. Diuretics can easily cause electrolyte imbalance, blood concentration and sputum viscosity, etc., which are not conducive to long-term treatment
[0003] At present, Western medicine can only prescribe the right medicine in the prevention and treatment of cor pulmonale, and cannot play the role of "preventing the disease". Because the pharmaceutical composition has the characteristics of synergistic effect between the components, it is effective in the prevention and treatment of cor pulmonale. Therefore, there is an urgent need for a multi-pronged approach from all aspects of "prevention, supplementation and treatment", which has the effect of reducing inflammation and can achieve the effect of preventing and treating cor pulmonale substances and their applications

Method used

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  • A kind of pharmaceutical composition for treating cor pulmonale
  • A kind of pharmaceutical composition for treating cor pulmonale
  • A kind of pharmaceutical composition for treating cor pulmonale

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The parts by weight of dihydroquercetin are 55, the parts by weight of proanthocyanidins are 45, and the parts by weight of cochinol A are 15. made into an oral solution.

[0027] Both dihydroquercetin and proanthocyanidins are commercially available.

[0028] The preparation method of pokeweed phenol A is as follows: take appropriate amount of pokeweed seeds, dry to constant weight, pulverize, add 70% ethanol and heat reflux to extract twice, the amount of ethanol added is 10 times the dry weight of medicinal materials, and the extracts are combined , concentrated to 1 / 10 of the dry weight of the medicinal materials, filtered, and the filtrate was placed on D101 macroporous adsorption resin, after static adsorption for 4 hours, washed with water for 10 column volumes, eluted with 10% ethanol for 6 column volumes, and 40% ethanol for 3 column volumes Column volume, 70% ethanol elution for 5 column volumes, collect 70% ethanol eluate, concentrate until no alcohol smell,...

Embodiment 2

[0031] The parts by weight of dihydroquercetin are 65, the parts by weight of proanthocyanidins are 35, and the parts by weight of cochinol A are 20. After mixing the above dihydroquercetin, proanthocyanidins and cochinol A with auxiliary Compressed to make tablets.

[0032] Both dihydroquercetin and proanthocyanidins are commercially available.

[0033] The preparation method of pokeweed phenol A is as follows: take appropriate amount of pokeweed seeds, dry to constant weight, pulverize, add 95% ethanol and heat reflux extraction for 3 times, the amount of ethanol added is 20 times of the dry weight of medicinal materials, and the extracts are combined , concentrated to 1 / 5 of the dry weight of the medicinal materials, filtered, and the filtrate was applied to HPD-100 macroporous adsorption resin, after static adsorption for 5 hours, washed with water for 12 column volumes, eluted with 20% ethanol for 8 column volumes, and eluted with 50% ethanol 5 column volumes, 80% ethano...

Embodiment 3

[0036] The difference between this embodiment and Example 1 is only that the parts by weight of dihydroquercetin are 15, the parts by weight of proanthocyanidins are 80, and the parts by weight of methol A are 10, and the above dihydroquercetin Capsules are prepared by mixing proanthocyanidins, proanthocyanidins and methacryl A with auxiliary materials.

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PUM

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Abstract

The invention provides a medicinal composition for treating pulmonary heart disease. The medicinal composition comprises the following components in parts by weight 15 to 70 parts of dihydroquercetin,20 to 80 parts of procyanidine and 10 to 30 parts of americanol A. The invention also provides application of the medicinal composition in treating pulmonary heart diseases. The medicinal compositionis used jointly with a heart failure-resistant drug and can be used for improving the heart failure caused by the pulmonary heart disease. The three compounds are wide in source and convenient to obtain; and the composition is produced into relevant products such as food additives, healthcare food, drugs, so that the development potential is high.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cor pulmonale and its application, belonging to the technical field of natural medicine chemistry. Background technique [0002] Cor pulmonale (referred to as cor pulmonale) is a heart disease caused by chronic lesions of the lungs, thorax or pulmonary artery, resulting in increased pulmonary circulatory resistance and pulmonary hypertension, which in turn causes right ventricular hypertrophy, enlargement, or even right heart failure. Most of them have a long course of disease and are in critical condition, so far, the morbidity and mortality are relatively high. When heart failure occurs in patients with chronic cor pulmonale, clinical treatment is difficult due to its pathophysiological characteristics. At present, anti-heart failure treatment is still carried out on the basis of relieving hypoxia, carbon dioxide retention, and correcting acid-base balance and electrolyte disturbance....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/357A61K31/352A61K31/353A61P9/00A61P9/04
CPCA61K31/352A61K31/353A61K31/357A61P9/00A61P9/04A61K2300/00
Inventor 顾媛媛刘旭董晓红周忠光
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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