45 results about "Vasodilator agents" patented technology

The invention is directed to a method of administering hydrogen sulfide (H2S) slowly and sustainably to an individual in need thereof comprising administering an effective amount of a compound represented by the following structural formula:or a pharmaceutically acceptable salt thereof.

This disclosure provides methods and pharmaceutical compositions for reducing or eliminating cardiotoxicity, particularly cardiotoxicity induced by a cancer treatment or other therapy. In some cases, the methods and compositions prevent or reduce cardiotoxicity caused by anthracycline treatment. The methods provided herein often comprise administering a protective agent such as myricetin, tricetin, robinetin, ficetin, vitexin, quercetin, dihydrorobinetin, kaempferol, 7,3′,4′,5′-tetrahydroxyflavone, and myricitrin in conjunction with the administration of a cancer drug or other treatment. They may comprise administering a protective agent in combination with dexrazoxane. The compositions provided herein include co-formulations of a protective agent with a different protective agent or with a cancer treatment (e.g., anthracycline drug).

The present invention relates to a medicine composite with imidazoline acceptor excitation activity, and preparation method of said medicine composite and its application. Said medicine composite contains the extracts of Chinese medicinal materials of prunella spike, gentian root, leonurus, white peony root and licorice. Said medicine composite can be used for preparing the medicines for curing heart failure, arrhythmia, dementia for curing heart failure, arrhythmia, dementia and reducing blood pressure, etc.

The compound for treating cardiac and cerebral vascular diseases is triethoxyl quercetin. The preparation process includes the following steps: A. hydrolyzing Troxerutin as material with beteroside hydrolase through stirring at 30-70 deg c for 3-5 days; and B. filtering, water washing the precipitate and drying. Triethoxyl quercetin has pharmacological activity obviously superior to Troxerutin. Different forms of medicine may be prepared with the compound as active component for preventing and treating cardiac and cerebral vascular diseases and cerebral apoplexy.

The invention provides a nano composition containing diaminopyrimidine oxide and pyrrolidinyl diaminopyrimidine oxide and a preparation method and application of the nano composition, and belongs to the technical field of cosmetics with special functions. The provided nano composition comprises the following components in percentages by mass: 5-20% of diaminopyrimidine oxide, 2.5-10% of pyrrolidinyl diaminopyrimidine oxide, 0.1-10% of 5 alpha-reductase inhibitor, 0.1-10% of an androgen receptor antagonist, 0.1-5% of a vasodilator agent, 0.1-10% of an anti-inflammation bacteriostatic agent, 0.1-5% of an antioxidant, 0.5-10% of phospholipid, 0.1-40% of a softening agent, 0.1-5% of a stabilizer, 0.01-1% of a preservative and the balance of water. By the nano composition, transdermal co-transportation of multi-target hair loss prevention active components is realized, and the nano composition deepens into hair follicles, is synergistic, has double effects of preventing hair loss and promoting hair growing, and can be widely applied to cosmetics for preventing hair loss and promoting hair growing.

A method, composition, and kit for topical application of a composition to a male penis to delay premature ejaculation during intercourse without adversely affecting response in a female partner are disclosed. The method includes applying to the penis a topical composition immediately prior to intercourse. The composition includes an effective amount of a vasodilator agent and a desensitizing agent such as an acetyl dipeptide-1 cetyl ester.

Disclosed are derivatives of isosorbid mononitrate and pharmaceutically acceptable salts thereof which have a vasodilator activity with a reduced tolerance effect, having the general formula (I) wherein A and B represent independently any of the groups NO2 and-CO-R, Z being an atom of oxygen or sulfur, and R being optionally substituted C1-C4 alkyl, aryl or aralkyl group or the group (a) wherein R<1> is hydrogen or optionally substituted C1-C4 alkyl, aryl or aralkyl group,so that always either A or B is NO2 but never both at the same time, when Z is a sulfur atom R is optionally substituted C1-C4 alkyl, aryl or aralkyl group, and when Z is an oxygen atom R is the group (a).

The invention relates to heat-resistant alpha-rhamnosidase, which can efficiently transform rutin to isoquercetin, and the heat-resistant alpha-rhamnosidase of the invention has excellent thermal stability; the alpha-rhamnosidase of the present invention can be almost completely transformed after being incubated with rutin under suitable conditions, and more active isoquercetin can be obtained.

The invention is directed to a method of administering hydrogen sulfide (H2S) slowly and sustainably to an individual in need thereof comprising administering an effective amount of a compound represented by the following structural formula:or a pharmaceutically acceptable salt thereof.

The invention discloses a human immunity enhancer for cancer prevention and treatment. The human immunity enhancer comprises components in parts by weight as follows: 111-222 parts of Echinacea phenol, 144-288 parts of astragaloside, 111-177 parts of chrysin, 333-666 parts of coriolus versicolor polysaccharide, 22-33 parts of diindolymethane, 60-111 parts of resveratrol, 80-111 parts of curcumin,111-222 parts of dihydroquercetin, 111-222 parts of tea polyphenols, 2.22-11.1 parts of L-selenomethionine, 80-130 parts of phosphatidylcholine, 90-140 parts of phosphatidylserine, 444-888 parts of methionine and 3000-4000 parts of a lipidosome matrix emulsion. The natural traditional Chinese medicine extracts and multiple active compounds are matched in proportion, a lipidosome matrix convenientto absorb is adopted, the immunity of the human body can be improved, and cancer, AIDS and other immunodeficiency diseases can be resisted effectively.

The invention relates to a preparation method and a quality detection method of a detoxification antidiarrheal tablet. The antidiarrheal tablet has no adverse effect, toxic effect or side effect in long term clinical application, cannot stimulate an alimentary system, has no side effect on liver or kidney, cannot cause a series of adverse effects such as stomach discomfort, nausea, dizziness and the like, cannot generate drug resistance, and has remarkable effect on treatment on acute enteritis, syndrome drain abdominal distension in traditional Chinese medicine differentiation, abdominal pain and the like compared with traditional antidiarrheal. In preparation process, parts of medicinal materials are made into power, and parts of medicinal materials are extracted, so that effective components of products are ensured, production process is advanced, and production process is controllable. Simultaneously, raw material knowledge composition quercitin with strong specificity is adopted to serve as content control index, quality standard is explicit, quality checking method is advanced, terminal product quality is effectively controlled, and product curative effect can be ensured.

The invention belongs to the field of medicines, and discloses a novel oxazolidinone compound, as well as a preparation method and application thereof. The compound has a chemical structure shown in the formula (I), wherein R1 and R2 are hydrogen, fluorine or chlorine; R3 is -OR4, -NR5R6, -NHCOR7, fluorine, azide group, primary amine group, triazole, triazole containing side chain radicals, mono-phosphate, metal phosphate, sulfonate or metal sulfonate. The novel oxazolidinone compound can be applied to preparation of antibacterial agents or active vasodilator agents.

The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

The present invention discloses a medicine for preventing and treating Alzheimer's disease. The active ingredient is meletin-3-O-beta-D-xylopyransoyl(1-2)-beta-D-galactopyranoside. The active ingredient RNFG of medicine according to the invention has estrogenic activity, oxidation resisting activity, neuroprotection function for restricting Abeta aggregation and toxicity, and can reduce the memory damage caused by scopolamine. The active ingredient RNFG of medicine according to the invention can be used for preparing the medicine and health product for preventing and treating AD and further has the advantages of usual crude raw material for extracting and easy acquisition.

The invention relates to a preparation method of solid proliposome with acne removing efficacy. The method is characterized by adopting the following steps that 1, an acne removing compound, a compound emulsifier, ethyl alcohol, isododecane, sponge spicules, mannitol and the balance distilled water are weighed according to a mass ratio, wherein the acne removing compound is prepared from vitamin B6, heparin sodium, glucosyl hesperidin, nocardia rubra cell wall skeletons, retinol, chlorogenic acid and dihydroquercetin with a specific mass ratio; 2, the compound emulsifier and the distilled water are added into an emulsifying pot, and an alcohol-soluble acne-removing active component is added into the emulsifying pot after being dissolved in the ethyl alcohol; 3, the retinol and the isododecane are mixed to obtain a liquid oil phase; 4, the liquid oil phase is added into the emulsifying pot, a mixture is stirred evenly to obtain a premixed solution, and then high-pressure homogenizing isconducted to obtain liquid lipidosome; 5, the sponge spicules and the mannitol are added into the liquid lipidosome, and vacuum freeze drying is conducted to obtain the solid proliposome with the acne removing efficacy.

The invention relates to a medicine which is prepared by the compatibility and the compounding of active ingredients extracted from traditional Chinese medicines and is used for affusing the bladder and treating bladder neoplasms. The medicine is prepared by the following traditional Chinese medical monomers of panaxoside Rg3, meletin and curcumin in a mol ratio of 20:5:3, and the optimal medicalcomposition comprises the three traditional Chinese medical monomers: 120-200 micromole / l of panaxoside Rg3, 18-30 micromole / l of meletin and 29-47 micromole / l of curcumin.

The invention relates to a detection method of a pharmaceutical composition for treating hyperplasia of mammary glands and mastitis, in particular to a detection method of a mammary lump relieving capsule for treating hyperplasia of mammary glands and mastitis, which adds high performance liquid chromatography content determination of active ingredient quercetin in monarch drug trichosanthes peeland minister drug dandelion on the basis of the original quality standard. The detection method is sensitive, strong in specificity, accurate and good in reproducibility, and can make up for the defects of the existing method, effectively control the quality of the medicine and enable the quality of the medicine to be associated with effective components of clinical treatment, so that the stable,controllable, efficient and safe standard is achieved, and the medical requirements are further better met.

The invention provides production of an isoquercetin derivative used for scavenging free radicals. A production method of the isoquercetin derivative comprises the steps of connecting a 5' position ofisoquercetin with isoprene, and then treating prenylisoquercetin by means of biological enzymes to produce the isoquercetin derivative with high purity, high solubility and high bioavailability. Theisoquercetin derivative has effects, 3-5 times those of isoquercetin, in the aspects of scavenging of free radicals, anti-inflammation and bacteriostasis, and has effects, better than those of the isoquercetin, in the aspects of cardiovascular protection, blood fat reduction and blood pressure reduction.

A food or nutritional or dietary composition or food or nutritional or dietary supplement suited for buccal delivery of cannabinoids comprises a source of cannabinoids in combination with a vasodilator agent selected from essentials oils or components of same, flavors or components of same and spices or components of same. Preferred source of cannabinoids is standardized oil or extract of hemp (Cannabis sativa L.).

The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

The invention relates to application of morusin N or salt thereof in preparation of a product for preventing and treating ferroptosis-related diseases. It is found for the first time that morusin N can effectively antagonize ferroptosis or glutathione level reduction caused by glutamic acid, effectively increase the content level of glutathione in cells, and well improve, prevent and treat relateddiseases induced by ferroptosis or glutamic acid, especially nerve injury diseases; and the activity of the morusin N is remarkably superior to the activity of quercetin serving as a neuroprotectionregulator.

The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

The invention relates to the technical field of medicines, and particularly discloses application of isoquercetin in treatment of steatohepatitis. The invention discloses application of the isoquercetin in treatment of the steatohepatitis, the isoquercetin can significantly improve liver lipid accumulation, liver inflammation, liver oxidative stress and liver injury levels caused by HFD, has a significant medicinal effect, and is suitable for wide popularization and application.

In one aspect, the disclosure relates to compositions, methods, and devices pertaining to polymeric nanoparticle compositions (pNP), pNP compositions comprising a therapeutic agent, devices comprisinga drug-coated balloon comprising a disclosed pNP comprising a therapeutic agent, and methods for treating peripheral artery disease using the disclosed compositions and devices. In further aspects, the pNP comprises a poly(lactic-co-glycolic) acid possessing a positive charge for firm attachment to the balloon matrix, followed by adhesion to the negatively charged bilayer of the vascular wall. Instill further aspects, the therapeutic agent comprises a resveratrol or derivative thereof, a quercetin or derivative thereof, or combinations thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

The invention relates to a detection method of a fingerprint spectrum of a traditional Chinese medicine preparation for treating stroke, which comprises the following steps: establishing the fingerprint spectrum of the traditional Chinese medicine preparation by adopting an HPLC (High Performance Liquid Chromatography) method, and determining nine index components such as quercetin, gallic acid, protocatechuic acid, syringin, chlorogenic acid, paeoniflorin, eleutheroside E, isofraxidin and calycosin-7-glucoside; the internal quality of the traditional Chinese medicine preparation is effectively controlled, and safety and effectiveness of clinical medication are further guaranteed.

The invention belongs to the technical field of ground shoot melon research, and specifically relates to a method for preparing three monomer compounds from the medicinal plant ground shoot melon and its in vitro antioxidative effect. The invention provides a method for preparing three kinds of monomeric compounds from the medicinal plant Melon Gourd, and for the first time, three monomeric compounds (Hypericum wort) which have not been reported in this plant are isolated and prepared from the medicinal plant Melon glycosides, dihydroquercetin and adenosine), and carried out the research on the antioxidant effect of three monomeric compounds in vitro, which will provide a basis for the future development of the treatment of related diseases (cardiovascular diseases) , arthritis, age-related macular degeneration, neurasthenia, etc.) provide reliable experimental data support and theoretical basis.

The invention discloses a traditional Chinese medicine monomer composition for antagonizing lung injury. The traditional Chinese medicine monomer composition comprises main active ingredients such asquercetin, glycyrrhizic acid and ferulic acid. The invention also discloses a use of the traditional Chinese medicine monomer composition. The traditional Chinese medicine monomer composition can adjust the respiratory immune system through activating the cAMP-dependent CFTR, prevent the pathological damage caused by the excessive immune response caused by the loss or inhibition of the immune tolerance mechanism, inhibit the lung fibrosis and promote the repair of damaged cells into normal cells.

The invention provides a method for analyzing and identifying dihydroquercetin in larches by capillary electrophoresis-mass spectrometry (CE-MS). The method includes the steps: (1) preparing standardsolution of pure dihydroquercetin, injecting a sample into a capillary electrophoresis apparatus and performing analysis in a mass spectrometer to obtain a mass spectrum; (2) drawing a standard curveand calculating the lowest detection limit; (3) acquiring the mass spectrum of the sample by a method in the step (1) and calculating sample injection recovery rate; (4) identifying the dihydroquercetin in the larches according to sample chromatographic peak and characteristic daughter ion information; (5) quantitatively analyzing the dihydroquercetin in the larches according to the standard curve. The method has the advantages of simplicity in operation, time-saving property, high detection efficiency, good repeatability and the like. The needed sample is less in dosage, detection results areaccurate and reliable, and the method is an excellent method for qualitatively and quantitatively analyzing the dihydroquercetin in the larches.

The invention discloses a novel application of a medicine of 1-[2-(3-amino-6-methylthiophene [2,3-b] quinolyl)] ethyl ketone. The new application of the compound (PU-14) disclosed by the invention is an application in the preparation of a vasodilator agent medicine. The PU14 has an effect of directly relaxing blood vessels by adopting in vitro thoracic aorta and mesenteric artery models in mice and rats. The effect is similar to that of acetyl choline, and has endothelial dependence and NO dependence; the action can be blocked off by an NOS inhibitor L-NAME and a cyclooxygenase inhibitor indometacin part; and meanwhile, in vivo and in vitro research results both prove that the UT-B gene deletion or function deficiency can play a role in relaxing blood vessels by adjusting the interaction between L-Arg-NOS-NO and L-Arg-arginase-urea systems.

The invention relates to the use of a composition comprising dihydroquercetin, alpha-tocopherol, and optionally bisabolol and / or a compound of formula (I) for use in the treatment of leishmaniasis, especially cutaneous leishmaniasis. The invention further relates to the use of such a composition for treating inflammation induced by leishmaniasis, especially cutaneous leishmaniasis. The invention also relates to a method for treating leishmaniasis, especially cutaneous leishmaniasis, and / or the associated inflammation by administering an effective amount of a composition comprising dihydroquercetin, bisabolol, alpha-tocopherol and optionally bisabolol and / or a compound of formula (I) to a subject in need thereof.