43 results about "Vasodilator agents" patented technology

Disclosed are derivatives of isosorbid mononitrate and pharmaceutically acceptable salts thereof which have a vasodilator activity with a reduced tolerance effect, having the general formula (I) wherein A and B represent independently any of the groups NO2 and-CO-R, Z being an atom of oxygen or sulfur, and R being optionally substituted C1-C4 alkyl, aryl or aralkyl group or the group (a) wherein R<1> is hydrogen or optionally substituted C1-C4 alkyl, aryl or aralkyl group,so that always either A or B is NO2 but never both at the same time, when Z is a sulfur atom R is optionally substituted C1-C4 alkyl, aryl or aralkyl group, and when Z is an oxygen atom R is the group (a).

The invention is directed to a method of administering hydrogen sulfide (H2S) slowly and sustainably to an individual in need thereof comprising administering an effective amount of a compound represented by the following structural formula:or a pharmaceutically acceptable salt thereof.

The invention relates to a preparation method of solid proliposome with acne removing efficacy. The method is characterized by adopting the following steps that 1, an acne removing compound, a compound emulsifier, ethyl alcohol, isododecane, sponge spicules, mannitol and the balance distilled water are weighed according to a mass ratio, wherein the acne removing compound is prepared from vitamin B6, heparin sodium, glucosyl hesperidin, nocardia rubra cell wall skeletons, retinol, chlorogenic acid and dihydroquercetin with a specific mass ratio; 2, the compound emulsifier and the distilled water are added into an emulsifying pot, and an alcohol-soluble acne-removing active component is added into the emulsifying pot after being dissolved in the ethyl alcohol; 3, the retinol and the isododecane are mixed to obtain a liquid oil phase; 4, the liquid oil phase is added into the emulsifying pot, a mixture is stirred evenly to obtain a premixed solution, and then high-pressure homogenizing isconducted to obtain liquid lipidosome; 5, the sponge spicules and the mannitol are added into the liquid lipidosome, and vacuum freeze drying is conducted to obtain the solid proliposome with the acne removing efficacy.

The invention provides production of an isoquercetin derivative used for scavenging free radicals. A production method of the isoquercetin derivative comprises the steps of connecting a 5' position ofisoquercetin with isoprene, and then treating prenylisoquercetin by means of biological enzymes to produce the isoquercetin derivative with high purity, high solubility and high bioavailability. Theisoquercetin derivative has effects, 3-5 times those of isoquercetin, in the aspects of scavenging of free radicals, anti-inflammation and bacteriostasis, and has effects, better than those of the isoquercetin, in the aspects of cardiovascular protection, blood fat reduction and blood pressure reduction.

The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

The invention relates to application of morusin N or salt thereof in preparation of a product for preventing and treating ferroptosis-related diseases. It is found for the first time that morusin N can effectively antagonize ferroptosis or glutathione level reduction caused by glutamic acid, effectively increase the content level of glutathione in cells, and well improve, prevent and treat relateddiseases induced by ferroptosis or glutamic acid, especially nerve injury diseases; and the activity of the morusin N is remarkably superior to the activity of quercetin serving as a neuroprotectionregulator.

The invention discloses a traditional Chinese medicine monomer composition for antagonizing lung injury. The traditional Chinese medicine monomer composition comprises main active ingredients such asquercetin, glycyrrhizic acid and ferulic acid. The invention also discloses a use of the traditional Chinese medicine monomer composition. The traditional Chinese medicine monomer composition can adjust the respiratory immune system through activating the cAMP-dependent CFTR, prevent the pathological damage caused by the excessive immune response caused by the loss or inhibition of the immune tolerance mechanism, inhibit the lung fibrosis and promote the repair of damaged cells into normal cells.

The invention provides a method for analyzing and identifying dihydroquercetin in larches by capillary electrophoresis-mass spectrometry (CE-MS). The method includes the steps: (1) preparing standardsolution of pure dihydroquercetin, injecting a sample into a capillary electrophoresis apparatus and performing analysis in a mass spectrometer to obtain a mass spectrum; (2) drawing a standard curveand calculating the lowest detection limit; (3) acquiring the mass spectrum of the sample by a method in the step (1) and calculating sample injection recovery rate; (4) identifying the dihydroquercetin in the larches according to sample chromatographic peak and characteristic daughter ion information; (5) quantitatively analyzing the dihydroquercetin in the larches according to the standard curve. The method has the advantages of simplicity in operation, time-saving property, high detection efficiency, good repeatability and the like. The needed sample is less in dosage, detection results areaccurate and reliable, and the method is an excellent method for qualitatively and quantitatively analyzing the dihydroquercetin in the larches.

The invention discloses a novel application of a medicine of 1-[2-(3-amino-6-methylthiophene [2,3-b] quinolyl)] ethyl ketone. The new application of the compound (PU-14) disclosed by the invention is an application in the preparation of a vasodilator agent medicine. The PU14 has an effect of directly relaxing blood vessels by adopting in vitro thoracic aorta and mesenteric artery models in mice and rats. The effect is similar to that of acetyl choline, and has endothelial dependence and NO dependence; the action can be blocked off by an NOS inhibitor L-NAME and a cyclooxygenase inhibitor indometacin part; and meanwhile, in vivo and in vitro research results both prove that the UT-B gene deletion or function deficiency can play a role in relaxing blood vessels by adjusting the interaction between L-Arg-NOS-NO and L-Arg-arginase-urea systems.

The invention relates to the use of a composition comprising dihydroquercetin, alpha-tocopherol, and optionally bisabolol and / or a compound of formula (I) for use in the treatment of leishmaniasis, especially cutaneous leishmaniasis. The invention further relates to the use of such a composition for treating inflammation induced by leishmaniasis, especially cutaneous leishmaniasis. The invention also relates to a method for treating leishmaniasis, especially cutaneous leishmaniasis, and / or the associated inflammation by administering an effective amount of a composition comprising dihydroquercetin, bisabolol, alpha-tocopherol and optionally bisabolol and / or a compound of formula (I) to a subject in need thereof.