31 results about "Chemotherapy induced" patented technology

The present invention relates to a use to be used for the purpose of preventing, alleviating or treating diabetic peripheral neuropathy or chemotherapy-induced peripheral neuropathy by administering a pharmaceutical composition containing a carbamate compound of chemical formula 1.

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for improving ovarian function damage and degeneration and a preparation method thereof. The invention discloses the GnRH agonist effect of dihydromyricetin DMY for the first time, and the affinity of dihydromyricetin DMY to a GnRH receptor and the GnRH agonist effect of dihydromyricetin DMY are verified through in-vitro experiments. Model animal experiments further prove that the dihydromyricetin DMY has a protective effect on ovarian function impairment caused by chemotherapy. Experiments prove that the dihydromyricetin DMY is given while the cyclophosphamide (CTX) is used for chemotherapy, so that the damage of the dihydromyricetin DMY to the ovarian function during chemotherapy can be reduced, and a protection effect is also achieved on the recovery of the ovarian function after drug withdrawal. The protection effect is reflected on the endocrine function and the reserve function of the ovary, and the preserved ovary reserve function can achieve the pregnancy result after chemotherapy is finished, which indicates that the dihydromyricetin DMY also plays the protection effect on the fertility function of the ovary.

Methods and compositions for treating chemotherapy induced cognitive disorders, e.g., cognitive impairment, are provided. The compositions used in the methods include blood plasma and blood plasma fractions derived from blood plasma with efficacy in treating chemotherapy induced cognitive disorders.

The application discloses a chromone spiro compound, a preparation method and application thereof, and the chromone spiro compound is shown as formula I. The compound has selective CDK4 / 6 inhibitory activity, can relieve and / or treat myelosuppression caused by chemotherapy, improve weight loss caused by chemotherapy and improve survival rate, and has good drug safety. The compound has simple preparation method, is convenient for large-scale production, and has great application prospect.

The present invention provides a scalp cooling device, including a covering part for wrapping a patient's scalp and a cooling part disposed within the covering part. This device can wrap around the patient's scalp and provide a cooling effect, causing the blood vessels in the scalp skin to constrict, reducing the blood flow to the scalp hair follicles, thereby reducing the intake of chemotherapeutic drugs by the hair follicles. Additionally, it lowers biochemical activity, thereby reducing the sensitivity of hair follicles to chemotherapy damage, and reduces the metabolic rate of the hair follicles, thus protecting the patient's hair follicles and preventing or mitigating hair loss caused by chemotherapy. Notably, the cooling part includes a gel-like coolant, which contains a moisture moderator and edible propylene glycol that maintains moisture and provides emulsifying and stabilizing effects, thus offering a long-lasting and stable cooling effect, enhancing the device's effectiveness in preventing hair loss.

The invention discloses an effective part for chemoradiotherapy-induced oral mucositis in traditional Chinese medicinal material white flower and a preparation process of the effective part. The effective part is identified as a flavonoid component through standard substance spectrogram comparison. Tests prove that the production process of the effective part is practical and feasible, and the total flavonoids in the finally obtained extracting solution are greater than or equal to 50%. Besides, pharmacodynamic studies show that the effective part has a remarkable bacteriostasis effect on staphylococcus aureus, escherichia coli and candida albicans, the bacteriostasis rate is larger than or equal to 80%, the effective part has a remarkable treatment effect on rat oral mucosa acute inflammation caused by chemoradiotherapy, and the application prospect of the effective part in the adaptation disease is shown.

The application discloses a preparation method and application of an anti-adhesion nano composite drug delivery system, relates to the technical field of adhesives, and discloses the following technical scheme: polyacrylamide and aldehyde functionalized starch with a preset mass ratio are taken, different amounts of zeolite imidazolate framework materials are added after mixing, and then the mixture after mixing is ground and sieved to obtain the anti-adhesion nano composite drug delivery system. The application can be used as a peritoneal tumor local drug delivery system, has high drug encapsulation efficiency and drug loading rate, can release antitumor drugs in tumor tissues specifically, continuously and stably through a tumor acid microenvironment, prolongs the exposure time of the drugs, improves the curative effect of the drugs, reduces the side effects of chemotherapy, can reshape an immune microenvironment, has a good killing effect on tumor cells, and has no systemic toxicity; meanwhile, the gel powder forms a physical barrier on a surgical wound after being changed into a gel by water, so that abdominal cavity adhesion caused by surgical trauma and chemotherapy can be reduced.

The disclosure relates generally to compositions comprising a CDA inhibitor, e.g., tetrahydrouridine or an analog or derivative thereof, and methods for treating, reducing or inhibiting a symptom, complication or side effect, such as palmar-plantar erythrodysesthesia, caused by chemotherapy, such as 5-fluorouracil chemotherapy, especially, capecitabine chemotherapy, by administering a CDA inhibitor, e.g., tetrahydrouridine or an analog or derivative thereof. The disclosure also relates to treating cancer by co-administering capecitabine and a CDA inhibitor, e.g., tetrahydrouridine or an analog or derivative thereof to a subject.

The invention relates to application of Chinese yam protein, in particular to application of Chinese yam active protein in preparation of medicine for regulating blood testis barrier to treat testis dysfunction. L-YP has unique fluorescence characteristics and remarkable antioxidant activity, and can effectively improve testis immune microenvironment disorder by repairing blood testis barriers and inhibiting NLRP3 and TLR4 / MyD88 / NF-kappa B inflammatory pathways. In combination with a molecular docking technology, a molecular mechanism that key components such as YP2 (mitochondrial ornithine aminotransferase) and the like realize immunoregulation through high-affinity binding is clarified for the first time. According to the application disclosed by the invention, a molecular docking technology is creatively combined with system experimental analysis, and a molecular mechanism of improving testis injury by the Chinese yam protein is illuminated from the perspective of a'structure-function-target 'synergistic effect, so that a novel dietary intervention strategy is provided for preventing reproductive toxicity caused by chemotherapy; the application potential of medicinal and edible components in the field of male reproductive health is highlighted.

The invention discloses application of a compound containing a dibenzofuran structure in preparation of a medicine for preventing and / or treating nausea and vomiting, and relates to the technical field of medicinal chemistry. The invention provides application of a compound containing a dibenzofuran structure in preparation of a medicine for preventing and / or treating nausea and vomiting, the molecular formula of the compound is C19H11ClN2O4, and the CAS number is 328255-08-9. The compound can effectively reduce the number of times of canine retching and vomiting caused by cis-platinum, has an effect superior to that of metoprazole, has the potential of preventing and / or vomiting caused by chemotherapy, and has an application prospect in development of drugs for treating vomiting caused by chemotherapy drugs.

The invention discloses hydrogel for repairing skin injury caused by chemotherapy and a preparation method and application thereof, and belongs to the technical field of medicines.The hydrogel is prepared from a copper ion solution, sodium alginate, carbomer and an alkaline regulator, the concentration of copper ions in the copper ion solution is 1-2 mmol, during preparation, sodium alginate and carbomer are added into the copper ion solution, and the alkaline regulator is added into the copper ion solution; uniformly mixing to obtain a mixed system; the copper ion hydrogel for repairing the skin injury caused by chemotherapy is obtained by adding an alkaline regulator into a mixed system, can realize wound microenvironment remodeling and copper ion stable loading and on-demand slow release, has high safety and treatment controllability, provides a new external preparation choice for the chemotherapy-induced skin injury, and has a wide application prospect. The method can be extensively used for skin injury repair in the pet tumor treatment process.

This disclosure relates to heterocyclic compounds of Formula (I) as well as the preparation and use thereof. As contemplated herein, heterocyclic compounds of Formula (I) can be any one of a carbohydrate conjugate and an amino acid conjugate. The heterocyclic compounds of Formula (I) may be used for the treatment of neuropsychiatric, and neurodegenerative, neuroinflammatory and pain disorders including depression, as well as tobacco, opiate, and cocaine addiction, alcoholism, post-traumatic stress disorder (PTSD), and pain syndromes including cluster headaches and chemotherapy induced peripheral neuropathy.

The invention provides a composition for treating qi and blood deficiency and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine. The invention discloses a composition for treating qi and blood deficiency. The composition is prepared from the following raw materials: astragalus membranaceus, salvia miltiorrhiza, codonopsis pilosula, fructus lycii, hairyvein agrimony, caulis spatholobi, radix rehmanniae recen, fried malt, fried rhizoma atractylodis macrocephalae, angelica sinensis, fried endothelium corneum gigeriae galli, wine-processed glossy privet fruit, herba epimedii, coptis chinensis, deer-horn glue, tortoise-shell glue and pseudo-ginseng powder. The composition for treating qi and blood deficiency is prepared from a plurality of traditional Chinese medicinal materials with mild properties, not only can tonify yang qi, essence and blood, but also can treat anemia symptoms such as aplastic anemia and the like, myelosuppression caused by platelet, leucopenia and tumor radiotherapy and chemotherapy, and can treat diseases causing qi and blood deficiency. In addition, the invention further provides a preparation method of the composition for treating the qi and blood deficiency, the preparation method of the composition for treating the qi and blood deficiency not only improves the medicine property of the composition for treating the qi and blood deficiency, but also is simple in process, easy to operate and convenient to master.

The present invention relates to a pharmaceutical composition comprising a protein complex, and its pharmaceutical applications for treating or preventing conditions characterized by impaired leukocyte production, such as neutropenia. The protein complex can also be formed by linking an immunoglobulin Fc region to a bioactive polypeptide via a non-peptide polymer linked to the immunoglobulin Fc region. [Solution] The present invention provides a method for treating chemotherapy-induced neutropenia in patients who require it by administering an effective amount of efrapegrastim to the patient, and a method for treating radiation-induced neutropenia in patients who require it by administering an effective amount of efrapegrastim to the patient.

The application provides a use of vincristine and lithium carbonate as co-active ingredients in the preparation of a medicament for treating tumors. The vincristine and lithium carbonate as co-active ingredients of the application have a killing effect on various leukemia cells, including human acute lymphoblastic leukemia cell lines, chronic myeloid leukemia cells, acute monocytic leukemia cell lines; in particular, for human acute lymphoblastic leukemia cell lines, compared with single free drugs (lithium carbonate or vincristine), lithium carbonate and vincristine free drug combination, the leukemia cell proliferation can be more effectively inhibited; in addition, the vincristine and lithium carbonate as co-active ingredients of the application can obviously stimulate the generation of granulocyte colony-stimulating factor, and alleviate the neutropenia side effect caused by chemotherapy.

Stapled peptides and mutant BCL-2 family peptides and compositions comprising the same are provided. Also provided are methods of using the stapled peptides and mutant BCL-2 family peptides for selectively protecting sensory neurons from age-related and / or chemotherapy induced axonal degeneration in a human subject in need thereof, treating or preventing chemotherapy induced peripheral neuropathy (CIPN) in a human subject in need thereof, averting neuropathic side effects of chemotherapy and / or other causes of axonal degeneration in a human subject in need thereof, and treating or preventing hearing loss in a human subject in need thereof. The methods involve administering to the human subject a stapled peptide and a mutant BCL-2 family peptide disclosed herein.

The present invention involves a method of treating pain. The method treats a patient having post-operative pain or chemotherapy induced neuropathic pain, and it involves a) assessing the patient to determine if they are experiencing post-operative pain or chemotherapy induced neuropathic pain, and if such pain is diagnosed; b) administering to the patient a therapeutically effective amount of an agonist for the nuclear receptor subfamily 4, group A, member 1 (NR4A1). In one embodiment, the agonist is selected from the group consisting of Cytosporone B, Ethyl 2-[2,3,4-trimethoxy-6-(1-octanoyl)-phenyl] acetate (TMPA), 1,3,7-trihydroxy-2,4-diprenylxanthone (CCE9), 1-(3,4,5-trihydroxyphenyl)-nonan-1-one (THPN), DIM-C-pPhOCH3 (C-DIM-5), 1,1-bis(3′-indolyl)-1-(phenyl)methane (DIM-C-Ph) and 1,1-bis(3′-indolyl)-1-(p-anisyl)methane (DIM-C-pPhOCH3).

Stapled peptides and mutant BCL-2 family peptides and compositions comprising the same are provided. Also provided are methods of using the stapled peptides and mutant BCL-2 family peptides for selectively protecting sensory neurons from age-related and / or chemotherapy induced axonal degeneration in a human subject in need thereof, treating or preventing chemotherapy induced peripheral neuropathy (CIPN) in a human subject in need thereof, averting neuropathic side effects of chemotherapy and / or other causes of axonal degeneration in a human subject in need thereof, and treating or preventing hearing loss in a human subject in need thereof. The methods involve administering to the human subject a stapled peptide and a mutant BCL-2 family peptide disclosed herein.

Compositions and methods for control of DNMT1-mediated site-specific copy gains and genomic insertions associated with mixed lineage leukemia are provided.

Embodiments of the present invention are directed to devices, systems and methods adapted for implementing intermittent displacement of blood to mitigate peripheral nerve neuropathy such as that induced by chemotherapeutic agents (i.e., chemotherapy-induced neuropathy (CIN)) that are administered to a patient. Such devices, systems and methods advantageously provide for precise, uniform and controlled blood flow occluding (and optionally blood displacing) compression along irregular surfaces of an appendage of a patient. Such precise, uniform and controlled blood occluding compression is imparted upon the epidermal and dermis skin layers within the aforementioned areas of a patient's extremities to decrease the time that free nerve endings located in the epidermal and encapsulated nerve endings located in the dermis skin layers are exposed to nerve damaging chemotherapy chemicals, thereby substantially decreasing CIN caused by prolonged exposure to such chemicals.

The application relates to the field of medicinal chemistry and discloses a pyrimidine diamine compound and application thereof. The pyrimidine diamine compound is shown as formula I: The pyrimidine diamine compound of the application can be applied to preparing a product for promoting hair growth and / or preventing hair loss, can promote the hair in the resting phase to enter the growth phase, can stimulate hair growth, can inhibit the hair loss caused by a chemotherapy agent, can resist the chemotherapy toxicity and prevent the hair loss caused by chemotherapy, can inhibit androgen, thereby preventing androgen-induced hair loss, can accelerate the natural growth speed of the hair, can increase the growth weight and length of newly-added hair or the remaining hair after hair loss, and the effect is better than that of minoxidil approved by the FDA.

The invention discloses a preparation method and application of an armillariella tabescens-wolfberry bidirectional fermentation product, and belongs to the technical field of microbial fermentation and treatment of chemotherapy-induced intestinal mucosal lesion. The armillariella tabescens-wolfberry bidirectional fermentation product is prepared from armillariella tabescens mycelia and a basic culture medium added with wolfberry through a bidirectional fermentation technology. Functional evaluation is performed by constructing a 5-FU induced colon cancer tumor-bearing mouse intestinal mucosa injury model, and experimental results show that the armillariella-wolfberry bidirectional fermentation product can remarkably relieve weight loss and diarrhea symptoms of model animals caused by chemotherapy, remarkably reduce the level of diamine oxidase (DAO) in serum and effectively improve intestinal mucosa injury.

The present invention relates to a composition comprising a Leuconostoc citreum strain or a culture thereof as an active ingredient for preventing, improving or treating intestinal damage, specifically intestinal damage caused by inflammatory bowel disease, non-alcoholic steatohepatitis or chemotherapy.According to the present invention, since the composition exhibits excellent preventive and therapeutic effects on various intestinal damages such as inflammatory bowel disease, non-alcoholic steatohepatitis, and chemotherapy, the composition can be usefully used as a composition for the treatment, prevention or improvement of human or animal intestinal damage.

The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating anorexia and weight loss, comprising a Bupleuri Radix extract. Specifically, the present invention provides a pharmaceutical composition having effects in preventing, ameliorating, or treating anorexia and weight loss, wherein a Bupleuri Radix extract increases ghrilin, which is a hormone that stimulates appetite, and decreases TPH1(I), which is a serotonin synthase. In addition, a health functional food for preventing or ameliorating anorexia and weight loss, comprising a Bupleuri Radix extract, can be developed, and the extract can be effectively used for the treatment and the development of therapeutic agents for anorexia induced by chemotherapy in the future.

The present invention relates to new uses of a 5-HT4 receptor agonist, specifically Isopropyl-3 - { 5- [ 1 -(3 - methoxypropyl) piperidin-4-yl] - [ 1,3,4] oxadiazol-2-yl } - 1 H- indazole (Compound- 1) or a pharmaceutically acceptable salts thereof, for the treatment of dementia due to menopause, senile dementia, cognitive deficits associated with schizophrenia, depression, chemotherapy-induced cognitive impairment and behavioural and psychological symptoms of dementia such as apathy / indifference, agitation, aggression, depression, anxiety, irritability / lability, dysphoria, aberrant motor behaviour, delusions, hallucinations, elation / euphoria, psychosis, disinhibition, sleep and night time behaviour disorders or appetite and eating disorders. The present invention further provides use of the said compounds in the manufacture of medicament intended for the treatment of the disorders described herein.

A traditional Chinese medicine composition for treating myelosuppression during chemotherapy is prepared from the following traditional Chinese medicine materials in a weight ratio: 6-150 parts of raw astragalus, 2-50 parts of angelica, 2-50 parts of euphorbia humifusa, 2-50 parts of ligustrum lucidum, 2-50 parts of psoralea, and 2-30 parts of cuscuta. The traditional Chinese medicine composition can act on hematopoietic function through multiple components and multiple pathways, effectively improve myelosuppression caused by chemotherapy, and can be used to cooperate with chemotherapy, improve the completion rate of chemotherapy, and improve the quality of life during chemotherapy, with remarkable effects.

The present disclosure relates to a use of Herombopag or a pharmaceutically acceptable salt thereof in treatment of tumor chemotherapy-induced thrombocytopenia. Specifically, the present disclosure relates to a disease treatment method, comprising: administering to a patient Herombopag or a pharmaceutically acceptable salt thereof, which can significantly increase the blood platelet count of a subject.

To provide a composition for the prevention, improvement, or treatment of mucositis induced by radiotherapy, chemotherapy, or a combination thereof, comprising a glucagon-like peptide-2 (GLP-2) derivative and / or a sustained-release conjugate thereof. [Solution] The present invention relates to the prophylactic or therapeutic use of GLP-2 and its sustained-release conjugates against mucositis induced by radiotherapy, chemotherapy, or a combination thereof. The GLP-2, its sustained-release conjugates, or compositions comprising the same of the present invention may be applied to the prevention, treatment, and improvement of mucositis induced by radiotherapy and / or chemotherapy.

A traditional Chinese medicine composition for treating bone marrow suppression during chemotherapy is prepared from the following medicinal materials in the indicated weight ratios: 6-150 parts Astragalus membranaceus, 2-50 parts Angelica sinensis, 2-50 parts Eclipta prostrata, 2-50 parts Ligustrum lucidum, 2-50 parts Psoralea corylifolia, and 2-30 parts Cuscuta chinensis. This composition can exert effects on hematopoietic function through multiple components and pathways, effectively improving bone marrow suppression caused by chemotherapy. It can be used to synergistically with chemotherapy, improve chemotherapy completion rate, and enhance quality of life during chemotherapy, with significant effects.

A composition and method of treating diabetes or chemotherapy-induced neuropathy is presented. The composition is comprised of at least one extracellular vesicle encapsulating at least one cannabinoid. Administration of a therapeutically effective amount of this composition of extracellular vesicles encapsulating at least one cannabinoid can be used to treat both diabetic and chemotherapy-induced neuropathic pain in a patient.