315 results about "Chemotherapy induced" patented technology

This invention provides a treatment regimen that is effective in inhibiting chemotherapy-induced apoptosis and promoting cell survival. The invention also relates to a treatment regimen that confers resistance to caspase activation, thereby inhibiting caspase-mediated, proteolytic cleavage of functional cellular enzymes. Specifically, subjects undergoing chemotherapy are first exposed to a pretreatment regimen. Under this regimen, a GLP-2 receptor activator, such as h[GLY2]-GLP2, is administered each day for a predetermined beneficial period, e.g., three consecutive days. Approximately about 1 week following pretreatment, the subjects are exposed to an appropriate chemotherapy treatment regimen. Pretreatment with a GLP-2 receptor activator followed by administration of chemotherapeutic agents improves cell survival, reduces bacteremia, attenuates epithelial injury, and inhibits cellular apoptosis. Moreover, it does not impair the effectiveness of chemotherapy nor result in weight loss. The anti-apoptotic effects of GLP-2 may be useful in the reduction of cytoxicity and bacterial infection induced by chemotherapeutic agents.

Compositions comprising hydroxytyrosol-containing formulations and treatment regiments comprising hydroxytyrosol and/or oleuropein and chemotherapeutic agents are disclosed. Compositions and/or regiments may optionally include the administration of vitamins, minerals, and anti-oxidants. Methods for using these compositions and treatment regimens for treating subjects for diseases, such as a malignancy, and for inducing or enhancing angiogenesis, treating or preventing oxidative stress, for treating or preventing high glucose-induced dysfunction, treating or preventing chemotherapy-induced dysfunction, and for improving cell viability are provided. Various methods for use of the hydroxytyrosol compositions for inhibition of lysine specific demethylase 1 (LSD1) in various cancers are also provided.

The invention relates to a natural pharmaceutical composition, a preparation method thereof and an application of the natural pharmaceutical composition in preparation of attenuated synergistic medicaments in cancer radiotherapy and chemotherapy. The natural pharmaceutical composition is prepared from extract obtained by decocting and concentrating ginger and dried orange peel decoction, gingerol, dried orange peel water extract and nobiletin according to the ratios of (3-5):(2-9):(1-6):(2-5). The composition has an excellent effect on treating emesis and other side effects caused by cancer radiotherapy and chemotherapy, and can simultaneously play a role in inhibiting tumors.

The present invention provides an anticancer auxiliary medicine using 20(S)-protopanaxadiol as effective component and its application. Said medicine possesses the action of raising therapeutic effect of anticancer medicine, reducing toxicity of anticancer medicine, preventing and curing leukopenia due to radiotherapy and chemotherapy and raising immunity of human body, and can be used for auxiliary therapy of carcinoma.

The invention provides a sterile lyophilized preparation containing fosaprepitant, and a preparation method thereof. According to the invention, an effective dosage of fosaprepitant dimeglumine is adopted as an effective component, and auxiliary materials such as a solubilizer, a complexing agent, a lyophilization excipient, and an acidity adjusting agent are contained in the preparation. The lyophilization excipient does not comprise lactose, and is selected from one or a combination of mannitol, glucose, dextran, sorbitol, arginine, and glycine. The components are dissolved in injection water. The solution is sterilized, filtered, sub-packaged, and lyophilized. The prepared sterile lyophilized preparation has excellent high-temperature stability, illumination stability, and accelerated-experiment stability. When in use, the sterile lyophilized preparation provided by the invention is added into a solvent, so that an injection solution with an appropriate concentration is prepared and can be used. The preparation has good treatment effect upon chemotherapy-induced nausea and vomiting. With the form of injection medication, patient compliance is improved. The preparation process of the lyophilized preparation is simple. The lyophilized preparation is suitable for industrialized productions.

Methods and apparatus are provided to prevent, treat, and cure chemotherapy induced nausea in human beings. The inhalation of an effective amount of vaporized essential oil from Mentha piperita (peppermint oil) has been shown in practice to prevent, treat, and cure chemotherapy induced nausea. A simple hand-held apparatus provides the vapors to be inhaled through the nostril to prevent, treat, and cure chemotherapy induced nausea.

The invention relates to a combination made of 20(R)-ginsenoside taken serving as active constitutent and the application of the combination as medicine or health products. The 20(R)-ginsenoside combination mainly comprises the following weight percentage compositions of the components: 30 percent to 60 percent of 20(R)-ginsenoside Rg3, 10 percent to 40 percent of 20(R)-ginsenoside Rh2 and 10 percent to 30 percent of ginsenoside III, wherein the ginsenoside III is 20(R)-protopanoxadiol-3-O-beta-pyrane xylopyranosyl (1-2) beta-D-pyrane glucosyl (1-2) beta -D-pyrane glucoside. The invention relates to application of the drug combination in preparing anticancer aided drug for preventing and curing leucocyte reduction caused by radiotherapy and chemotherapy and in medicine or health products improving human body immunity.

The invention provides a traditional Chinese medicine composition for supporting chemo-treatment. The composition comprises the following components: pangolin scales, membranous milkvetch root, curcuma aromatica, grape leaf, ginseng, radix linderae, giant knotweed, calculus bovis, laminaria, nostoc commune, cactus, pearl, realgar, croci stigma, centipede, bittersweet herb, trichosanthes root, black nightshade, radix rehmanniae recen, verbena, white paeony root, ganoderma, rhizome sparganii, fructus evodiae, puccoon, andrographis paniculata, deerhorn glue, bulb of edible tulip, daphne giraldii nitsche, and ramie root. The composition provided by the invention has the advantages of quick curative effect, high efficiency and small side effect aiming to the side effects caused by chemo-treatment.

The present invention belongs to the field of medicine technology. The compound coenzyme medicine contains CoA, NAD, GSH and ATP; and features that it contains also FMN, FAD, ADP, AMP and SAM. The present invention has improved compound coenzyme medicine preparing process. The compound coenzyme medicine can protect liver cell, myocardial cell and other cells, maintain or restore their normal metabolism, and may be used in heart and liver surgical operation, restoring of damaged liver, restoring damaged cell caused by radiotherapy and chemotherapy.

The invention relates to a natural medicinal composition and a preparation method thereof, and application of the natural medicinal composition in preparation of attenuation and synergy medicaments for radiotherapy and chemotherapy of cancers. The natural medicinal composition comprises the following components in part by weight: 1 to 9 parts of ginger and dark plum fruit water decoction and concentration extract, 2 to 6 parts of gingerol, 3 to 5 parts of dark plum fruit extract and 2 to 4 parts of dark plum fruit ethanol extract. The composition has a good curative effect on side effects such as emesis and the like caused by the radiotherapy and the chemotherapy for the cancers and has the effects of inhibiting tumors at the same time.

The invention provides a novel application of a fullerene and/or metallic fullerene micro-nano material. The novel application is that of the fullerene and/or metallic fullerene micro-nano material in the preparation of drugs or drug carriers having at least one property as in 1) to 5): 1), preventing and/or treating bone marrow suppression; 2), clearing free radicals; 3), enriching bone marrow; 4), preventing and/or treating at least one of leukocyte decrease, platelet decrease, hemoglobin decrease and monocyte decrease caused by bone marrow suppression; 5), protecting bone marrow cells and/or hematopoietic cells. The fullerene and/or metallic fullerene micro-nano material is simple and quick to prepare, is good in biocompatibility and highly rich in bone marrow area, has certain residence time, can also be finally discharged out of the body by metabolism, has no evident cytotoxicity on bone marrow cells and normal cells and is safe and nontoxic. The fullerene and/or metallic fullerene micro-nano material has a promising application prospect as a protectant for bone marrow suppression caused by chemotherapy.

The present invention relates to palonosetron as medicine for treating chemotherapy caused vomiting and its pharmaceutically acceptable salt, and is especially medicine powder of palonosetron and its pharmaceutically acceptable salt for injection and its preparation process. The medicine powder for injection consists of palonosetron and its pharmaceutically acceptable salt and excipient, and may have also pH regulator, antioxidant and other supplementary material.

The invention relates to a natural pharmaceutical composition, a preparation method of the natural pharmaceutical composition and the use of the natural pharmaceutical composition for preparing toxicity-reducing efficacy-improving medicine in cancer radiotherapy and chemotherapy. The natural pharmaceutical composition consists of decocted and concentrated extract of ginger and elecampane, gingerol, elecampane chloroform extract and elecampane hexane extract based on the proportion of 4 to 8: 3 to 8: 4 to 5: 2 to 4, and the composition has extremely good therapeutic effect for vomiting and other side effects caused by cancer radiotherapy and chemotherapy and can simultaneously play the role of inhibiting tumor.

This invention relates to food components such as phytochemicals including anthocyanins that can enhance the effectiveness of a chemotherapeutic agent in treating a cell proliferative disorder and/or reduce chemotherapy-induced side effects during treatment of a cell proliferative disorder.

The present invention relates to novel and improved compositions of anticancer drugs, preferably taxanes, such as paclitaxel and docetaxel, their derivatives or their analogues, methods of manufacturing these compositions and methods of fractionating the particles in particular size range and methods of treating cancer patients with these compositions, which provide reduced chemotherapy-induced side-effects especially reduced chemotherapy-induced- alopecia. The composition is such that there is substantially no free drug in the said composition.

This disclosure provides methods and pharmaceutical compositions for reducing or eliminating cardiotoxicity, particularly cardiotoxicity induced by a cancer treatment or other therapy. In some cases, the methods and compositions prevent or reduce cardiotoxicity caused by anthracycline treatment. The methods provided herein often comprise administering a protective agent such as myricetin, tricetin, robinetin, ficetin, vitexin, quercetin, dihydrorobinetin, kaempferol, 7,3′,4′,5′-tetrahydroxyflavone, and myricitrin in conjunction with the administration of a cancer drug or other treatment. They may comprise administering a protective agent in combination with dexrazoxane. The compositions provided herein include co-formulations of a protective agent with a different protective agent or with a cancer treatment (e.g., anthracycline drug).

Methods and apparatus are provided to prevent, treat, and cure chemotherapy induced nausea in human beings. The inhalation of an effective amount of vaporized essential oil from Mentha piperita (peppermint oil) has been shown in practice to prevent, treat, and cure chemotherapy induced nausea. A simple hand-held apparatus provides the vapors to be inhaled through the nostril to prevent, treat, and cure chemotherapy induced nausea.

The present invention relates to a kind of Chinese medicine with functions of nourishing vital energy, warming Yang and invigorating spleen and its preparation process. The medicine is prepared with ten kinds of Chinese medicinal materials, including ginseng, prepared rhizome of rehmannia, white atractylodes rhizome, astragalus root, tuckahoe, white peony root, angelica, etc. The Chinese medicine with functions of nourishing vital energy, warming Yang and invigorating spleen is used in treating vital energy and blood deficiency caused by radiotherapy and chemotherapy of tumor patient, can reduce the toxic side effect of radiotherapy and chemotherapy and raise immunity, and has no obvious negative reaction.