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Nano composition containing diaminopyrimidine oxide and pyrrolidinyl diaminopyrimidine oxide and preparation method and application of nano composition

A technology of pyrrolidinyl diaminopyrimidine and diaminopyrimidine, which is applied in the field of special functional cosmetics, can solve the problems of reducing the anti-hair loss effect, difficulty in ensuring stability and effectiveness, and low bioavailability, so as to enhance the anti-hair loss effect and improve Bioavailability, the effect of inhibiting the development of hair loss

Active Publication Date: 2019-03-29
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] However, hair growth products produced with plant extracts as the main raw material are difficult to guarantee stability and effectiveness due to the following reasons
One is that the plant extracts themselves have poor stability and are easy to decompose; the other is that the effective substance and content of these Chinese herbal medicine compound or related preparations are not sure, and the mechanism of action is unknown; Fourth, the plant extract hair growth products cannot jointly play an anti-hair loss effect on various targets of androgenetic alopecia, which greatly reduces the anti-hair loss effect; fifth, it is difficult for plant extracts to penetrate into the hair follicles and cannot directly act on the target parts of the hair follicles , low bioavailability

Method used

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  • Nano composition containing diaminopyrimidine oxide and pyrrolidinyl diaminopyrimidine oxide and preparation method and application of nano composition
  • Nano composition containing diaminopyrimidine oxide and pyrrolidinyl diaminopyrimidine oxide and preparation method and application of nano composition
  • Nano composition containing diaminopyrimidine oxide and pyrrolidinyl diaminopyrimidine oxide and preparation method and application of nano composition

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preparation example Construction

[0057] The present invention also provides a method for preparing a nanocomposite containing diaminopyrimidine oxide and pyrrolidinyl diaminopyrimidine oxide described in the above technical scheme, comprising the following steps:

[0058](1) Diaminopyrimidine oxides, pyrrolidinyl diaminopyrimidine oxides, 5α-reductase inhibitors, androgen receptor antagonists, vasodilators, anti-inflammatory and antibacterial agents, fat-soluble antioxidants, phospholipids, stable Mix the agent and the alcohol solvent, and heat in a water bath to obtain a lipid solution;

[0059] (2) mixing the emulsifier, water-soluble antioxidant and water, and heating in a water bath to obtain an aqueous phase solution;

[0060] (3) After mixing the lipid solution obtained in step (1) with the aqueous phase solution obtained in step (2), adding a preservative, performing shear emulsification treatment, to obtain a micron-scale dispersion;

[0061] (4) carrying out high-pressure homogenization treatment to...

Embodiment 1

[0076] In terms of mass percentage:

[0077] (1) 20.0% diaminopyrimidine oxide, 10.0% pyrrolidinyl diaminopyrimidine oxide, 3.0% kaempferol, 5.0% linoleic acid, 1.0% capsaicin, 3.0% magnolol, 1.0% soybean egg Phospholipids, 35.0% propylene glycol, and 0.2% cholesterol were stirred and dissolved in a water bath at a temperature of 70°C to obtain a lipid solution, which was set aside;

[0078] (2) Stir and dissolve 0.5% sodium cholate, 0.5% glutathione and 20.6% water in a water bath at a temperature of 70° C. to obtain an aqueous phase solution for subsequent use;

[0079] (3) After obtaining the lipid solution and the aqueous phase solution, add the aqueous phase solution to the lipid solution dropwise at a rate of 3 drops / second under the condition of a 70°C water bath. During the dropping process, control the stirring rate to 700rpm, and the mixing is completed Finally, add 0.2% p-hydroxyacetophenone, high-speed shear emulsification under the condition of 7000rpm for 6min, ...

Embodiment 2

[0083] In terms of mass percentage:

[0084] (1) 10.0% diaminopyrimidine oxide, 5.0% pyrrolidinyl diaminopyrimidine oxide, 10.0% oleanolic acid, 8.0% quercetin, 3.0% naringenin, 6.0% glycyrrhetinic acid, 3.0% Silymarin, 3.0% egg yolk lecithin, 30.0% pentylene glycol, and 0.4% stigmasterol were stirred and dissolved in a water bath at a temperature of 65° C. to obtain a lipid solution for subsequent use;

[0085] (2) Stir and dissolve 8.0% sodium deoxycholate and 13.1% water in a water bath at a temperature of 65° C. to obtain an aqueous phase solution for subsequent use;

[0086] (3) After obtaining the lipid solution and the aqueous phase solution, add the aqueous phase solution to the lipid solution dropwise at a rate of 5 drops / second under the condition of a water bath at 65°C, and control the stirring rate to 700rpm during the dropping process, and the mixing is completed Finally, add 0.5% octanoyl hydroxamic acid, high-speed shear emulsification for 4 minutes under the ...

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Abstract

The invention provides a nano composition containing diaminopyrimidine oxide and pyrrolidinyl diaminopyrimidine oxide and a preparation method and application of the nano composition, and belongs to the technical field of cosmetics with special functions. The provided nano composition comprises the following components in percentages by mass: 5-20% of diaminopyrimidine oxide, 2.5-10% of pyrrolidinyl diaminopyrimidine oxide, 0.1-10% of 5 alpha-reductase inhibitor, 0.1-10% of an androgen receptor antagonist, 0.1-5% of a vasodilator agent, 0.1-10% of an anti-inflammation bacteriostatic agent, 0.1-5% of an antioxidant, 0.5-10% of phospholipid, 0.1-40% of a softening agent, 0.1-5% of a stabilizer, 0.01-1% of a preservative and the balance of water. By the nano composition, transdermal co-transportation of multi-target hair loss prevention active components is realized, and the nano composition deepens into hair follicles, is synergistic, has double effects of preventing hair loss and promoting hair growing, and can be widely applied to cosmetics for preventing hair loss and promoting hair growing.

Description

technical field [0001] The invention relates to the technical field of special functional cosmetics, in particular to a nano composition containing diaminopyrimidine oxide and pyrrolidinyl diaminopyrimidine oxide. Background technique [0002] With the increasingly fierce social competition, increasing people's mental pressure, deteriorating environment and the popularity of hair dyeing and perm, the proportion of hair loss is on the rise, and the trend of younger people is becoming more and more obvious. [0003] Among them, androgenetic alopecia (AGA) is the most common alopecia disease clinically, accounting for about 90% of alopecia. In addition to genetic factors, the main causes of AGA are the following: excessive activity of 5α-reductase, increased expression of androgen receptor, bacterial infection and skin inflammation, blood circulation disorder around hair follicles, and oxidation of hair follicles. [0004] At present, the commonly used chemical hair growth age...

Claims

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Application Information

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IPC IPC(8): A61K31/505A61K31/506A61K8/49A61P17/04A61Q7/00A61P17/14
CPCA61K8/4953A61K31/505A61K31/506A61K2800/21A61K2800/5922A61K2800/805A61Q7/00A61P17/04A61P17/14A61K2300/00
Inventor 刘卫沈慧慧程能王志鹏罗丹洪延涵韩非
Owner WUHAN BEST CARRIER NANO TECH
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