Formula and preparation process of sterile wound nursing liquid dressing

Abstract

The invention relates to the technical field of medical instruments, in particular to a formula and a preparation process of a sterile wound nursing liquid dressing, the sterile wound nursing liquid dressing comprises the following components by weight percent: 0.5-5.0 wt% of polyethylene glycol 400, 0.05-0.5 wt% of olivate, 5.0-10.0 wt% of glycerol, 0.01-0.2 wt% of carbomer, 0.01-0.04 wt% of triethanolamine and the balance of purified water, the effective components of the liquid dressing are glycerol and polyethylene glycol 400, the total mass of the polyethylene glycol 400, the olivate, the glycerol, the carbomer, the triethanolamine and the purified water is 100%, and the total mass of the polyethylene glycol 400, the olivate, the glycerol, the carbomer, the triethanolamine and the purified water is 100%. Glycerin is used as a common skin moisturizer, has antibacterial and antiviral characteristics, can promote skin absorption, and ensures the skin surface to be moist; polyethylene glycol 400 is used as a lubricant and a common carrier substance, can dissolve various components in the product, has certain viscosity and weak acidity, can ensure that the solution can be effectively attached to the skin surface after being sprayed out, has small irritation to the skin and can effectively improve the skin surface environment, and in the formula research process, the formula of the product is changed into the formula of the product. The proportion of components which may cause anaphylactic reaction or have relatively strong irritation to skin is reduced, and the safety and comfort of the product are ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a formula and a preparation process of a sterile wound care liquid dressing. Background Art

[0002] Skin diseases are common among the elderly. Compared with other chronic diseases and cancer, they are more likely to be ignored. However, the effects they cause, such as scarring, damage, itching, etc., can easily affect daily life and reduce the quality of life. As age increases, the incidence rate also increases, and the demand for liquid dressings is also gradually increasing.

[0003] Liquid dressings are sterile medical devices used for non-chronic wounds, so there are certain requirements for the composition and sterilization method of the product. The ingredients need to be simple and easy to obtain, have no adverse biological reactions, and can be used for sterilization to ensure that the product is provided sterile.

[0004] There are various liquid dressing products on the market, and some of them may cause allergic reactions and skin irritation. The reasons are as follows: the ingredients in some liquid dressings, especially the drug ingredients or additives, are irritating to the skin and may cause allergic reactions. They may cause damage to the skin surface and may leave scars or trigger allergic reactions in severe cases. Long-term or repeated use will not only fail to protect the skin well, but will also further damage the health of the body and leave side effects. This also limits the scope of application to a certain extent. Summary of the invention

[0005] The purpose of the present invention is to provide a formula and preparation process of a sterile wound care liquid dressing, aiming to solve the problem that existing liquid dressing products have allergic reactions and skin irritation, which limits the scope of application of the product.

[0006] To achieve the above objectives, in a first aspect, the present invention provides a formula for a sterile wound care liquid dressing, which comprises, based on a total mass of 100wt%, 0.5-5.0wt% of polyethylene glycol 400, 0.05-0.5wt% of olive oil ester, 5.0-10.0wt% of glycerol, 0.01-0.2wt% of carbomer and 0.01-0.04wt% of triethanolamine, with the remainder being purified water.

[0007] In a second aspect, the present invention further provides a process for preparing a sterile wound care liquid dressing, which is applied to the sterile wound care liquid dressing formula as described in the first aspect above, and is characterized in that it comprises the following steps:

[0008] Prepare carbomer solution based on the sterile wound care liquid dressing formula;

[0009] Adding glycerol, polyethylene glycol 400 and olivetate to the carbomer solution in sequence and stirring to prepare a mixed solution;

[0010] Add triethanolamine into the mixed solution, stir and mix, and obtain a sterile wound care liquid dressing.

[0011] Among them, the specific method of preparing the carbomer solution based on the sterile wound care liquid dressing formula is:

[0012] Based on the formula of sterile wound care liquid dressing, weigh 0.01-0.2 wt % of carbomer and purified water for later use;

[0013] The carbomer and the purified water are put into a stirring tank and mixed evenly, and allowed to stand to obtain a carbomer solution.

[0014] The specific method of preparing the mixed solution by sequentially adding glycerol, polyethylene glycol 400 and olivetate to the carbomer solution and stirring is as follows:

[0015] Based on the formula of sterile wound care liquid dressing, 5.0-10.0 wt% of glycerol, 0.5-5.0 wt% of polyethylene glycol 400 and 0.05-0.5 wt% of olivetate are weighed and set aside;

[0016] The weighed glycerin, polyethylene glycol 400 and olivetolic acid ester are sequentially added to the carbomer solution and stirred to prepare a mixed solution.

[0017] The specific method of adding triethanolamine to the mixed solution and stirring to obtain the sterile wound care liquid dressing is as follows:

[0018] Add triethanolamine to the mixed solution, stir and mix to obtain a solution to be tested;

[0019] Take a portion of the solution to be tested to observe its appearance and detect its pH value. If both the appearance and pH tests are qualified, a sterile wound care liquid dressing is obtained.

[0020] The invention discloses a formula for a sterile wound care liquid dressing, wherein the total mass is 100wt%, and the components include 0.5-5.0wt% of polyethylene glycol 400, 0.05-0.5wt% of olive oil ester, 5.0-10.0wt% of glycerol, 0.01-0.2wt% of carbomer and 0.01-0.04wt% of triethanolamine, and the balance is purified water;

[0021] The effective ingredients of the liquid dressing are glycerin and polyethylene glycol 400. Glycerin, as a common skin moisturizer, not only has antibacterial and antiviral properties, but also can promote skin absorption and ensure a certain degree of moisture on the skin surface. Polyethylene glycol 400, as a lubricant and a commonly used carrier substance, can effectively dissolve the various components in the present invention. In terms of physical properties, polyethylene glycol 400 has a certain viscosity and is weakly acidic. When using this product, it can effectively ensure that the solution can effectively adhere to the skin surface after being sprayed, and has less irritation to the skin and can effectively improve the skin surface environment.

[0022] Olivic acid ester is a common ingredient in cosmetics and is mostly used as an emulsifier, softener and skin care regulator. When used, glycerin and polyethylene glycol 400 moisturize the wound to form a moist environment to inhibit the growth of bacteria and other species. Olivic acid ester regulates, improves and repairs the skin environment.

[0023] The pH value of the product is weakly acidic, and the pH value of the human skin surface is also weakly acidic. Spraying it on the skin surface will not change the microenvironment of the skin surface, and can buffer and astringe the skin to play a protective role. In a weakly acidic environment, it can also prevent various bacteria from infecting the wound, thereby reducing the risk of infection.

[0024] Carbomer has certain anti-inflammatory and bactericidal effects. After being configured into a solution, it has a certain affinity to the skin, can reduce the damage of irritating substances to the skin and mucous membranes, and has an anti-ultraviolet effect, which can reduce ultraviolet radiation when used. Carbomer solution also has a good carrier that can increase viscosity to allow other ingredients to be effectively mixed together.

[0025] Irradiation sterilization is selected to sterilize the product and the product is provided in a sterile condition. Through the synergistic effect of multiple ingredients in the solution, a protective film can be formed on the wound surface after cleaning the wound, which separates the air from the skin epidermis to form a weakly acidic viscous aqueous solution environment to inhibit the growth of bacteria or other pathogens. The ingredients such as polyethylene glycol 400 and olive oil ester in the product can promote wound healing and improve the skin surface microenvironment, thereby achieving the effect of protecting the wound and caring for the skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0027] Figure 1 The present invention provides a flow chart of a preparation process of a sterile wound care liquid dressing.

[0028] Figure 2It is a flow chart of the specific method of preparing carbomer solution based on the formula of sterile wound care liquid dressing.

[0029] Figure 3 The present invention is a flow chart of a specific method for preparing a mixed solution by sequentially adding glycerol, polyethylene glycol 400 and olivetate to the carbomer solution and stirring.

[0030] Figure 4 The present invention is a flow chart of a specific method of adding triethanolamine into the mixed solution, stirring and mixing, and obtaining a sterile wound care liquid dressing. DETAILED DESCRIPTION

[0031] Embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, and should not be construed as limiting the present invention.

[0032] In the first aspect, the present invention provides a formula for a sterile wound care liquid dressing, which, based on a total mass of 100wt%, comprises components including 0.5-5.0wt% of polyethylene glycol 400, 0.05-0.5wt% of olivetate, 5.0-10.0wt% of glycerol, 0.01-0.2wt% of carbomer and 0.01-0.04wt% of triethanolamine, with the remainder being purified water.

[0033] Specifically, the effective ingredients of the liquid dressing are glycerol and polyethylene glycol 400. Glycerol, as a common skin moisturizer, not only has antibacterial and antiviral properties, but also can promote skin absorption and ensure a certain degree of moisture on the skin surface. Polyethylene glycol 400, as a lubricant and a commonly used carrier substance, can effectively dissolve the various components in the present invention. In terms of physical properties, polyethylene glycol 400 has a certain viscosity and is weakly acidic. When using this product, it can effectively ensure that the solution can effectively adhere to the skin surface after being sprayed, and it has less irritation to the skin and can effectively improve the skin surface environment.

[0034] Olivic acid ester is a common ingredient in cosmetics and is mostly used as an emulsifier, softener and skin care regulator. When used, glycerin and polyethylene glycol 400 moisturize the wound to form a moist environment to inhibit the growth of bacteria and other species. Olivic acid ester regulates, improves and repairs the skin environment.

[0035] The pH value of the product is weakly acidic, and the pH value of the human skin surface is also weakly acidic. Spraying it on the skin surface will not change the microenvironment of the skin surface, and can buffer and astringe the skin to play a protective role. In a weakly acidic environment, it can also prevent various bacteria from infecting the wound, thereby reducing the risk of infection.

[0036] Carbomer has certain anti-inflammatory and bactericidal effects. After being configured into a solution, it has a certain affinity to the skin, can reduce the damage of irritating substances to the skin and mucous membranes, and has an anti-ultraviolet effect, which can reduce ultraviolet radiation when used. Carbomer solution also has a good carrier that can increase viscosity to allow other ingredients to be effectively mixed together.

[0037] Irradiation sterilization is selected to sterilize the product and the product is provided in a sterile condition. Through the synergistic effect of multiple ingredients in the solution, a protective film can be formed on the wound surface after cleaning the wound, which separates the air from the skin epidermis to form a weakly acidic viscous aqueous solution environment to inhibit the growth of bacteria or other pathogens. The ingredients such as polyethylene glycol 400 and olive oil ester in the product can promote wound healing and improve the skin surface microenvironment, thereby achieving the effect of protecting the wound and caring for the skin.

[0038] See also Figures 1 to 4 In a second aspect, the present invention further provides a process for preparing a sterile wound care liquid dressing, which is applied to the sterile wound care liquid dressing formula as described in the first aspect above, and is characterized in that it comprises the following steps:

[0039] S1 prepares carbomer solution based on the formula of sterile wound care liquid dressing;

[0040] Specific method:

[0041] S11 Based on the formula of sterile wound care liquid dressing, weigh 0.01-0.2 wt % of carbomer and purified water for later use;

[0042] S12: putting the carbomer and the purified water into a stirring tank, mixing them evenly, and letting them stand to obtain a carbomer solution.

[0043] S2: adding glycerol, polyethylene glycol 400 and olivetate to the carbomer solution in sequence and stirring to prepare a mixed solution;

[0044] Specific method:

[0045] S21: based on the formula of sterile wound care liquid dressing, weigh 5.0-10.0 wt% of glycerol, 0.5-5.0 wt% of polyethylene glycol 400 and 0.05-0.5 wt% of olivetate for later use;

[0046] S22: adding the weighed glycerol, polyethylene glycol 400 and olivetolic acid ester to the carbomer solution in sequence and stirring to prepare a mixed solution.

[0047] S3: adding triethanolamine into the mixed solution, stirring and mixing, and obtaining a sterile wound care liquid dressing.

[0048] Specific method:

[0049] S31 Add triethanolamine to the mixed solution, stir and mix to obtain a solution to be tested;

[0050] S32: taking a portion of the solution to be tested, observing its appearance, and detecting its pH value; after both the appearance and pH tests are qualified, a sterile wound care liquid dressing is obtained.

[0051] Specifically, the appearance should meet the requirements of being a viscous, uniform, impurity-free water-soluble liquid, and the pH should be between 2.5 and 7.0.

[0052] In order to better understand the present technical solution, the following embodiments are provided for further explanation:

[0053] Embodiment 1:

[0054] Formula components: Formula components: Based on the total mass of 100wt%, the components are as follows: 0.5-5.0wt% of polyethylene glycol 400, 0.05-0.5wt% of olive oil ester, 5.0-10.0wt% of glycerol, 0.01-0.2wt% of carbomer, 0.01-0.04wt% of triethanolamine, and the balance is purified water. First, dissolve the carbomer to prepare a carbomer solution, then add other ingredients, and mix well to obtain a finished product.

[0055] Process steps:

[0056] 1. Weigh Carbomer: According to the formula components, weigh 0.01-0.2 wt% of Carbomer.

[0057] 2. Weigh purified water: Weigh purified water according to the formula components.

[0058] 3. Preparation of carbomer solution: weigh carbomer and purified water and put them all into a stirring tank, stir evenly, and let it stand to allow the carbomer to fully dissolve to prepare a carbomer solution.

[0059] 4. Weigh glycerol: According to the formula components, weigh 5.0-10.0wt% of glycerol.

[0060] 5. Weigh polyethylene glycol 400: According to the formula components, weigh 0.5-5.0 wt% of polyethylene glycol 400.

[0061] 6. Weigh olive oil ester: According to the formula components, weigh 0.05-0.5wt% of olive oil ester.

[0062] 7. Mixing: Add weighed glycerin to the carbomer solution to make the solution have a certain viscosity, then weigh polyethylene glycol 400 and olivetate, add them to the solution and stir evenly.

[0063] 8. Preparation: Add a certain amount of triethanolamine to the above mixed solution to adjust the pH of the solution. After stirring evenly, take part of the solution to observe the appearance and test the pH. If both are qualified, the finished product can be obtained.

[0064] Embodiment 2:

[0065] Formula components: Formula components: Based on the total mass of 100wt%, the components are as follows: 0.5-5.0wt% of polyethylene glycol 400, 0.05-0.5wt% of olive oil ester, 5.0-10.0wt% of glycerol, 0.01-0.2wt% of carbomer, 0.01-0.04wt% of triethanolamine, and the balance is purified water. First, dissolve the carbomer to prepare a carbomer solution, then add other ingredients, and mix well to obtain a finished product.

[0066] 1. Weigh Carbomer: According to the formula components, weigh 0.01-0.2 wt% of Carbomer.

[0067] 2. Weigh purified water: Weigh purified water according to the formula components.

[0068] 3. Preparation of carbomer solution: weigh carbomer and purified water and put them all into a stirring tank in equal and increasing proportions, stirring while adding. After stirring for a while until most of the carbomer is dissolved, turn on the heating function of the stirring tank and stir at 50°C for about 2-3 hours to fully dissolve the carbomer to prepare a carbomer solution.

[0069] 4. Weigh glycerol: According to the formula components, weigh 5.0-10.0wt% of glycerol.

[0070] 5. Weigh polyethylene glycol 400: According to the formula components, weigh 0.5-5.0 wt% of polyethylene glycol 400.

[0071] 6. Weigh olive oil ester: According to the formula components, weigh 0.05-0.5wt% of olive oil ester.

[0072] 7. Mixing: After the carbomer solution has cooled to room temperature, add the weighed polyethylene glycol 400, glycerol, and olivetate to the carbomer solution at the same time, stir for 30 minutes and then homogenize for 5 minutes. Repeat the stirring and homogenizing process 2-3 times to confirm whether the added ingredients in the solution are uniform, such as whether the appearance and viscosity are consistent.

[0073] 8. Preparation of finished products: Add a certain amount of triethanolamine to the above mixed solution to adjust the pH of the solution. After stirring evenly, take part of the solution to observe the appearance and test the pH. If both are qualified, the finished product can be obtained.

[0074] The above disclosure is only a preferred embodiment of the formula and preparation process of a sterile wound care liquid dressing of the present invention. Of course, this cannot be used to limit the scope of rights of the present invention. Ordinary technicians in this field can understand that all or part of the processes of the above embodiments and equivalent changes made according to the claims of the present invention still fall within the scope of the invention.

Claims

1. A formula for a sterile wound care liquid dressing, characterized in that: Based on the total mass of 100wt%, the components include 0.5-5.0wt% of polyethylene glycol 400, 0.05-0.5wt% of olive oil ester, 5.0-10.0wt% of glycerol, 0.01-0.2wt% of carbomer and 0.01-0.04wt% of triethanolamine, and the balance is purified water.

2. A process for preparing a sterile wound care liquid dressing, applied to the sterile wound care liquid dressing formula as claimed in claim 1, characterized in that: The following steps are involved: Prepare carbomer solution based on the sterile wound care liquid dressing formula; Adding glycerol, polyethylene glycol 400 and olivetate to the carbomer solution in sequence and stirring to prepare a mixed solution; Add triethanolamine into the mixed solution, stir and mix, and obtain a sterile wound care liquid dressing.

3. The process for preparing the sterile wound care liquid dressing according to claim 2, characterized in that: The specific method of preparing the carbomer solution based on the sterile wound care liquid dressing formula is: Based on the formula of sterile wound care liquid dressing, weigh 0.01-0.2 wt% of carbomer and purified water for later use; The carbomer and the purified water are put into a stirring tank and mixed evenly, and allowed to stand to obtain a carbomer solution.

4. The process for preparing the sterile wound care liquid dressing according to claim 2, characterized in that: The specific method of preparing the mixed solution by sequentially adding glycerol, polyethylene glycol 400 and olivetate to the carbomer solution and stirring the mixture is as follows: Based on the formula of sterile wound care liquid dressing, 5.0-10.0 wt% of glycerol, 0.5-5.0 wt% of polyethylene glycol 400 and 0.05-0.5 wt% of olivetate are weighed and set aside; The weighed glycerol, polyethylene glycol 400 and olivetolic acid ester are sequentially added to the carbomer solution and stirred to prepare a mixed solution.

5. The process for preparing the sterile wound care liquid dressing according to claim 2, characterized in that: The specific method of adding triethanolamine into the mixed solution and stirring to mix to obtain the sterile wound care liquid dressing is: Add triethanolamine to the mixed solution, stir and mix to obtain a solution to be tested; Take a portion of the solution to be tested to observe its appearance and detect its pH value. If both the appearance and pH tests are qualified, a sterile wound care liquid dressing is obtained.

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