Application of 70dB white noise in preparation of device for promoting sleep

Abstract

The invention relates to the technical field of development of devices for promoting sleep, in particular to application of 70dB white noise in preparation of a device for promoting sleep. The research finds that the 70dB white noise has the effects of promoting sleep and improving the sleep quality. The invention provides an application of 70dB white noise in preparation of a device for promoting sleep. White noise is a uniformly distributed sound signal and can effectively cover burst noise in the environment, so that a more quiet sleep environment is created for a user. As one of non-invasive sensory stimulation, white noise can be used as a non-drug sleep disorder treatment method, side effects are small, and the method has a good application prospect.

Description

Technical Field

[0001] The present invention relates to the technical field of development of sleep-promoting devices, and in particular to application of 70 dB white noise in the preparation of sleep-promoting devices. Background Art

[0002] About one-third of a person's life is spent sleeping. Sleep is a ubiquitous and extremely important physiological activity in organisms. Sleep is closely related to behaviors such as cognition and homeostatic regulation. Good sleep helps the organism to clear metabolic waste, repair cell damage, and help the brain process memory information. According to the Global Sleep Report released in 2022, about 30% of the world's population experiences sleep disorders to varying degrees, and insomnia remains the most common type. According to a survey by the China Sleep Research Society in 2020, about 38% of people have experienced insomnia in the past year, especially in urban areas, where the problem of insomnia is more prominent. Sleep disorders are associated with a variety of health problems, including mental health problems (such as anxiety and depression), cardiovascular disease, obesity, etc.

[0003] The incidence of clinical insomnia has been rising year by year, seriously affecting people's quality of life and work efficiency. Long-term insomnia can lead to memory impairment, depression, physical and intellectual retardation, low immune function, aggravate other diseases or induce the onset of existing diseases (such as cardiovascular and cerebrovascular accidents), etc. Tranquilizers are currently an important means of treating insomnia, but they cause adverse reactions such as addiction, tolerance, residual effects, and changes in sleep patterns. There is still a lack of effective methods for the treatment of insomnia.

[0004] The sleeping pills currently used in clinical practice induce sleep waves that are significantly different from physiological sleep waves, suggesting that sleeping pills may change the normal sleep pattern of the human body, and the brain does not actually get enough rest. Patients often experience drowsiness, dizziness, fatigue, etc. the next morning after taking the medicine. Long-term use can also lead to drug resistance, physiological and psychological dependence. Therefore, the development of non-drug treatment methods has great social and economic significance. Summary of the invention

[0005] Based on the above content, the present invention provides an application of 70dB white noise in preparing a device for promoting sleep.

[0006] To achieve the above object, the present invention provides the following solutions:

[0007] One of the technical solutions of the present invention is the use of 70dB white noise in preparing a device for promoting sleep.

[0008] A second technical solution of the present invention is a device for promoting sleep, comprising a device capable of generating 70dB white noise.

[0009] The third technical solution of the present invention is the application of 70dB white noise in improving sleep disorders for non-disease diagnosis and treatment purposes.

[0010] The fourth technical solution of the present invention is a method for promoting sleep for non-disease diagnosis and treatment purposes, which applies 70dB white noise to the environment of mice.

[0011] The present invention discloses the following technical effects:

[0012] The purpose of the present invention is to develop a non-drug method for promoting sleep. The present invention has found that 70dB white noise has the effect of promoting sleep and improving sleep quality. White noise is a uniformly distributed sound signal that can effectively mask sudden noises in the environment, thereby creating a more peaceful sleeping environment for users. As one of the non-invasive sensory stimuli, white noise can be used as a non-drug treatment for sleep disorders, with few side effects and good application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0014] Figure 1 The effects of white noise of different intensities on NREM sleep of mice during 19:00-23:00; *P<0.05, t-test was used as the statistical method.

[0015] Figure 2 The effect of 70dB white noise on the sleep cycle of mice during the dark period; (a) is the schematic diagram of the experiment, (b) is the total NREM sleep per hour in the experimental and control groups within 24 hours, (c) is the total REM sleep per hour in the experimental and control groups within 24 hours, (d) is the EEG and EMG schematic diagram of the control group within 24 hours, and (e) is the EEG and EMG schematic diagram of the experimental group within 24 hours; the black hollow circles and blue hollow circles represent the NREM sleep per hour in the control group and the 70dB white noise group, respectively; *P<0.05, and the repeated t-test was used as the statistical method. DETAILED DESCRIPTION

[0016] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0017] It should be understood that the terms described in the present invention are only for describing a particular embodiment and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. The intermediate value in any stated value or stated range, and each smaller range between any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0018] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0019] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to the skilled artisan. The present invention description and examples are exemplary only.

[0020] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0021] A first aspect of the present invention provides a use of 70 dB white noise in preparing a device for promoting sleep.

[0022] A second aspect of the present invention provides a device for promoting sleep, comprising a device capable of generating 70 dB white noise.

[0023] The equipment that generates 70dB white noise includes but is not limited to white noise machines, sleep-aiding pillows with built-in speakers, mattresses, etc.

[0024] A third aspect of the present invention provides the use of 70 dB white noise in improving sleep disorders for non-disease diagnosis and treatment purposes.

[0025] A fourth aspect of the present invention provides a method for promoting sleep for non-disease diagnosis and treatment purposes, wherein 70 dB white noise is applied to the environment of mice.

[0026] In a preferred embodiment of the present invention, the time for applying 70 dB white noise is from 19:00 on the first day to 07:00 on the second day.

[0027] 70dB white noise can significantly reduce the interference of external noise on sleep, help users fall asleep faster and prolong deep sleep time, and has good application potential for sleep disorders. The white noise stimulation proposed in the present invention is a non-invasive intervention. Compared with drug treatment, it can avoid the side effects that may be caused by drugs, and it is simpler and more controllable to use. Through practical application, 70dB white noise can coordinate with the user's natural sleep cycle, reduce the frequency of awakening, and improve the continuity and depth of sleep, providing a safe and effective solution for the treatment of sleep disorders.

[0028] The technical solutions described in the present invention, unless otherwise specified, are all conventional solutions in the art, and the reagents or raw materials used, unless otherwise specified, are purchased from commercial channels or have been disclosed.

[0029] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0030] Example 1

[0031] The effects of different decibels of white noise on sleep.

[0032] The experimental materials are as follows:

[0033] Male C57BL / 6J mice, SPF grade, 10-13 weeks old, 23-25 ​​g, were purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences. Rearing conditions: room temperature (22±1)°C, humidity (50±10)%, 12-h light-dark rhythmic cycle, free access to water and food.

[0034] The experimental method is as follows:

[0035] Electrodes for recording EEG and EMG were installed on the surface of the mouse skull. The experiment was conducted after the animals recovered for 10 days, and the electrode connection wires were connected 3 days before the experiment. The experimental groups were: control group (no white noise was given under the same recording environment); 70dB white noise group. The mice were given 12 hours of continuous white noise during the dark period.

[0036] The EEG and EMG signals of mice were amplified, filtered, and converted into digital-to-analog signals by the sleep bioanalysis system and then recorded using SleepSign software (Kissei Comtec, Nagano, Japan). The recording started at 19:00 and lasted for 48 hours. The baseline on the first day was used as the control group. At 19:00 on the second day, white noise of different intensities (40dB, 45dB, 50dB, 55dB, 60dB, 65dB, 70dB, 75dB, 80dB, 85dB, 90dB, 95dB, and 100dB) was given for 12 hours. After the EEG / EMG recording was completed, SleepSign analysis software was used to automatically scan and distinguish wakefulness (W), non-rapid eye movement sleep (NREM) sleep, and rapid eye movement sleep (REM) sleep according to the unified set standards with 4s as the analysis unit. After the automatic scanning was completed, manual inspection was performed and corrections were made if necessary.

[0037] The experimental results are as follows:

[0038] Figure 1 The effect of white noise of different intensities on NREM sleep of mice during 19:00-23:00 (the blank columns in the figure represent the control group of each group (i.e. the baseline of the first day), and the columns of different colors correspond to the sound decibels on the X-axis. *P<0.05, the statistical method is t-test); Figure 1 As shown, 70 dB white noise significantly increased the NREM sleep of mice during the active 19:00-23:00 period compared with other groups, indicating that 70 dB is the optimal stimulation intensity to promote sleep in mice.

[0039] Figure 2 The figure shows the effect of giving mice 70dB white noise during the dark period on the sleep cycle of mice for 24 hours; (a) is the experimental schematic diagram, (b) is the total amount of NREM sleep per hour in the experimental and control groups within 24 hours, (c) is the total amount of REM sleep per hour in the experimental and control groups within 24 hours, (d) is the EEG and EMG schematic diagram of the control group mice within 24 hours, and (e) is the EEG and EMG schematic diagram of the experimental group mice within 24 hours; Figure 2 As shown in the figure, compared with the control group, 70dB white noise significantly increased the total amount of NREM and REM sleep in the dark period of mice. The above results show that 70dB white noise can promote sleep.

[0040] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

Application of 1.70dB white noise in preparing a device for promoting sleep.

2. A device for promoting sleep, characterized in that: Includes equipment capable of generating 70dB white noise. Application of 3.70dB white noise in improving sleep disorders for non-disease diagnosis and treatment purposes.

4. A method for promoting sleep for purposes other than disease diagnosis and treatment, characterized in that: 70 dB white noise was applied to the environment where the mice were.

5. The method for promoting sleep for non-disease diagnosis and treatment purposes according to claim 4, characterized in that: The time for applying the 70 dB white noise is from 19:00 on the first day to 07:00 on the second day.

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