Composition for solubilizing Chinese herbal medicine leaching preparation and preparation method

Abstract

The invention provides a composition for solubilizing a Chinese herbal medicine leaching preparation and a preparation method of the composition. The composition comprises tridecyl trimellitate, an oil-phase thickening agent and / or an oil-phase gel. The invention further relates to a Chinese herbal medicine composition containing a Chinese herbal medicine leaching preparation and the composition for solubilizing the Chinese herbal medicine leaching preparation, a preparation method of the Chinese herbal medicine composition and a pharmaceutical preparation or cosmetic containing the Chinese herbal medicine composition.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and relates to a composition for solubilizing a Chinese herbal medicine extract preparation. The present invention also relates to a preparation method and use of the composition for solubilizing a Chinese herbal medicine extract preparation. The present invention further relates to a pharmaceutical preparation or cosmetic comprising a Chinese herbal medicine extract preparation and the composition for solubilizing a Chinese herbal medicine extract preparation. Background Art

[0002] Chinese herbal medicine has a long history of use in my country. Many classic ancient books contain a large number of records and applications of Chinese herbal medicine in skin beauty. Traditional Chinese herbal medicine has its own unique advantages in solving many skin problems. At present, there are also many clinically verified and proven prescriptions with good efficacy in clinical hospitals.

[0003] Although traditional Chinese herbal medicine has been proven to have good efficacy in solving skin problems, its application range is relatively limited due to its medicinal properties. Based on the continuous progress and development of modern extraction technology, it is becoming increasingly feasible to obtain Chinese herbal extracts that can be used in the cosmetics field by using modern extraction technology based on the development of traditional prescriptions and proven prescriptions.

[0004] However, in actual applications, since the components of Chinese herbal medicines are relatively complex, especially when they are prepared into Chinese herbal medicine extract preparations, the ingredients are even more complex and diverse.

[0005] In order to restore the actual clinical dosage of Chinese herbal medicine to the maximum extent, it is usually necessary to retain the active substances therein to the maximum extent. The extract has the advantage of retaining the corresponding high concentration of activity, so the extract is a very common dosage form in Chinese herbal medicine preparations. However, the ingredients contained in the Chinese herbal extract obtained by this method are very complex, usually including alcohol-soluble ingredients, oil-soluble ingredients and water-soluble ingredients. And based on clinical experience, the amount of relevant extract added needs to reach a certain concentration to achieve the corresponding effect, so this makes it difficult to develop actual cosmetic products, and it is difficult to achieve large-scale application and large-scale production of products.

[0006] Usually, Chinese herbal medicine extracts contain complex ingredients. For example, the extract of Danggui Buxue Tang contains oil-soluble ingredients such as angelica essential oil, alcohol-soluble flavonoids and water-soluble saponins. It contains both water-soluble ingredients, alcohol-soluble ingredients and oil-soluble ingredients. How to apply it to actual formulas and realize commercial large-scale production is a practical technical problem that needs to be solved. Summary of the invention

[0007] In view of the deficiencies of the prior art, the present invention aims to provide a composition particularly suitable for solubilizing Chinese herbal medicine extract preparations. The inventors have found that the composition of the present invention can well stabilize and suspend various Chinese herbal medicine extract preparations containing complex ingredients, and obtain a Chinese herbal medicine composition with significantly improved stability. Unexpectedly, the composition obtained unexpectedly excellent sensory evaluation. Therefore, the inventors believe that the composition can be applied to the field of anhydrous and low-water content pharmaceutical preparations or cosmetics, thereby providing further support for the large-scale application and production of Chinese herbal medicines in the field of pharmaceutical preparations or cosmetics.

[0008] The objective of the present invention is achieved through the following technical solutions:

[0009] The first aspect of the present invention relates to a composition for solubilizing a Chinese herbal medicine extract preparation, the composition comprising tridecyl trimellitate and an oil phase thickener and / or an oil phase gelling agent.

[0010] When stabilizing Chinese herbal medicine preparations, the selection of the oil phase composition is the most critical. The inventors found that the composition containing tridecyl trimellitate and a suitable oil phase thickener and / or oil phase gelling agent can be well compatible with a variety of Chinese herbal medicine extract preparations containing complex ingredients, such as water-soluble ingredients, alcohol-soluble ingredients, and oil-soluble ingredients, thereby helping the preparations to stabilize and suspend, greatly enhancing the overall stability of the product.

[0011] In some embodiments, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gelling agent in the composition is 1-40: 1-10.

[0012] In some embodiments, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gelling agent in the composition is 1-30: 1-8.

[0013] In some embodiments, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gelling agent in the composition is 1-20: 1-5.

[0014] In some embodiments, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gelling agent in the composition is 5-20:1.

[0015] In some embodiments, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gelling agent in the composition is 10-20:1.

[0016] The inventors found that by adjusting the ratio of tridecyl trimellitate to a suitable oil phase thickener and / or oil phase gelling agent, the effect of the composition in stabilizing the Chinese herbal medicine extract preparation can be further optimized, thereby further enhancing the overall stability of the product.

[0017] In some embodiments, the oil phase thickener is selected from one or more of plant wax, animal wax, mineral wax and synthetic wax; and / or

[0018] The oil phase gelling agent is selected from one or more of castor oil / IPDI (isophorone diisocyanate) copolymer, dextrin palmitate, dextrin myristate and HDI (hexamethylene diisocyanate) / trimethylol hexyl lactone cross-linked polymer.

[0019] In some embodiments, the plant wax is selected from candelilla wax, carnauba wax, rice bran wax, rice bran wax, sunflower seed wax, wild sumac wax, lacquer wax, sugarcane wax, lacquer peel wax, lime peel wax, tulip tree leaf wax, apple peel wax, grape leaf wax, Channa intestine wax, multi-stemmed Ormanlis flower wax, waste malt meal wax, raspberry leaf wax, red mouth daffodil flower wax, bitter orange flower wax, rosemary flower wax, jasmine flower wax, green wattle flower wax, Su Fang flower wax, lime flower wax wax, frangipani flower wax, damask rose flower wax, tuberose flower wax, lavender flower wax, soap tree flower wax, centifolia flower wax, wild rose flower wax or silver wattle flower wax; the animal wax is selected from beeswax, lanolin wax, mink wax or shellac wax; the mineral wax is selected from ozokerite, paraffin, microcrystalline wax or montan wax; the synthetic wax is selected from polyethylene wax, synthetic beeswax, synthetic spermaceti, synthetic Japan wax, synthetic candelilla wax, hydrogenated microcrystalline wax, hydrogenated Japan wax or hydrogenated rice bran wax.

[0020] The second aspect of the present invention relates to a Chinese herbal medicine composition, which comprises a Chinese herbal medicine extract preparation and the composition for solubilizing the Chinese herbal medicine extract preparation according to the first aspect of the present invention.

[0021] In some embodiments, the extract preparation is a decoction, an alcoholic preparation, a tincture, a fluid extract, an extract, and a decoction.

[0022] In some embodiments, in the composition, the weight ratio of the Chinese herbal extract preparation to the composition for solubilizing the Chinese herbal extract preparation is 0.01-25:100.

[0023] In some embodiments, in the composition, the weight ratio of the Chinese herbal extract preparation to the composition for solubilizing the Chinese herbal extract preparation is 0.2-23:100.

[0024] In some embodiments, in the composition, the weight ratio of the Chinese herbal extract preparation to the composition for solubilizing the Chinese herbal extract preparation is 2-23:100.

[0025] In some embodiments, in the composition, the weight ratio of the Chinese herbal extract preparation to the composition for solubilizing the Chinese herbal extract preparation is 4-23:100.

[0026] In some embodiments, the Chinese herbal medicine is selected from at least two of Saxifraga herbacea (strawberry saxifrage), dandelion, liquorice, angelica, cinnamon, white peony root, smilax glabra, radix polygoni multiflori, sophora flavescens, sanguisorba officinalis, phellodendron amurense, dandelion, honeysuckle, trumpet creeper, peony root, schisandra chinensis, plum fruit and white bean.

[0027] In some embodiments, the Chinese herbal medicine extract preparation is selected from: an extract prepared from Saxifrage, Taraxacum and Licorice; an extract prepared from Angelica and Licorice; an extract prepared from Campsis, Peony Root, Schisandra, Prunus mume and Lablab dahliae; an extract prepared from Angelica, Cinnamon Bark, White Peony, Lycopodiella Cervi, and Radix Polygoni Multiflori; and an extract prepared from Sophora flavescens, Sanguisorba officinalis, Phellodendron amurense, Taraxacum and Flos Lonicerae.

[0028] The third aspect of the present invention relates to a method for preparing the Chinese herbal composition of the second aspect of the present invention, wherein the Chinese herbal composition contains the ingredients and their weight percentages described herein, wherein the method comprises:

[0029] (1) Weighing the corresponding raw materials, wherein phase A comprises: part of tridecyl trimellitate and a Chinese herbal medicine extract preparation; phase B comprises: the rest of tridecyl trimellitate, and an oil phase thickener and / or an oil phase gelling agent;

[0030] (2) Mixing phase A uniformly at room temperature to obtain material 1;

[0031] (3) heating phase B, dispersing it evenly, and cooling it to 60° C. or below to obtain material 2;

[0032] (4) slowly adding material 1 into material 2 under homogenization to mix the two phases evenly to obtain the Chinese herbal medicine composition;

[0033] Alternatively, the method comprises:

[0034] (1') Weighing the corresponding raw materials, wherein the A' phase comprises: a Chinese herbal medicine extract preparation; the B' phase comprises: tridecyl trimellitate, and an oil phase thickener and / or an oil phase gelling agent;

[0035] (2') stirring the A' phase at room temperature to obtain a material 1';

[0036] (3') heating phase B', dispersing it evenly, and cooling it to 60°C or below to obtain material 2';

[0037] (4') Slowly adding material 1' into material 2' under homogenization to mix the two phases evenly to obtain the Chinese herbal medicine composition.

[0038] The fourth aspect of the present invention relates to a medicine or cosmetic comprising the composition for solubilizing a Chinese herbal medicine extract preparation according to the first aspect of the present invention or the Chinese herbal medicine composition according to the second aspect of the present invention.

[0039] In some embodiments, the pharmaceutical or cosmetic product is applied to the skin.

[0040] In some embodiments, the drug or cosmetic is applied to the eyes or lips.

[0041] In some embodiments, the medicine or cosmetic is a paste, such as a Chinese herbal lip balm for preventing and or treating chronic cheilitis.

[0042] The fifth aspect of the present invention relates to the use of the composition for solubilizing Chinese herbal medicine extract preparations of the first aspect of the present invention, the Chinese herbal medicine composition of the second aspect of the present invention, or the Chinese herbal medicine composition prepared according to the method of the third aspect of the present invention in the preparation of medicines or cosmetics.

[0043] In some embodiments, the pharmaceutical or cosmetic product is applied to the skin.

[0044] In some embodiments, the drug or cosmetic is applied to the eyes or lips.

[0045] In some embodiments, the medicine or cosmetic is a paste, such as a Chinese herbal lip balm for preventing and or treating chronic cheilitis.

[0046] The present invention has the following beneficial effects:

[0047] 1) The Chinese herbal medicine composition prepared by the present invention has good stability and will not precipitate.

[0048] 2) The Chinese herbal medicine composition prepared by the present invention can be used directly as a cosmetic or medicine (such as lipstick) or added as an additive to various cosmetics or medicines (such as added to a lip cosmetic base to prepare a lip care product), which is simple and convenient to use.

[0049] 3) The Chinese herbal medicine composition prepared by the present invention can realize the effective addition of Chinese herbal medicine components, ensure the efficacy of the product, and provide application guidance for the application of similar formula extracts.

[0050] 4) The Chinese herbal medicine composition prepared by the present invention is delicate and has good sensory properties, which greatly improves the comfort and compliance of users. BRIEF DESCRIPTION OF THE DRAWINGS

[0051] Figure 1 Photographs showing the stability observation results of Examples 1 to 12 of the present invention after being placed at 43° C. for 90 days.

[0052] Figure 2Photographs showing the stability observation results of Examples 13-17 of the present invention after storage at 43°C for 90 days.

[0053] Figure 3 Photographs showing the stability observation results of Examples 18 and 21 of the present invention after storage at 43°C for 90 days.

[0054] Figure 4 Photographs showing the results of stability observation of Examples 19, 20, 22, 23, 24 and 25 of the present invention after storage at 43°C for 90 days.

[0055] Figure 5 Photographs showing the stability observation results of Comparative Examples 1-5 at 25°C on the same day. DETAILED DESCRIPTION

[0056] definition

[0057] As used herein, the terms "composition" or "solubilization composition" are used interchangeably and generally refer to a composition for solubilizing a Chinese herbal medicine extract preparation, which does not contain a Chinese herbal medicine active ingredient.

[0058] The term "Chinese herbal medicine composition" used herein generally refers to a composition comprising a composition for solubilizing a Chinese herbal medicine infusion preparation and a Chinese herbal medicine active ingredient (particularly a Chinese herbal medicine infusion preparation).

[0059] In this article, the terms "weight %" and "weight percentage" are used interchangeably. If not otherwise specified, percentage (%) refers to weight percentage. The terms "weight parts" or "weight parts" refer to the weight ratio between components. For example, 1 part of component A and 2 parts of component B means the ratio of component A to component B is 1:2.

[0060] The term "room temperature" used herein refers to 25°C ± 1°C. Meanwhile, if no experimental temperature is specifically specified, it is room temperature.

[0061] As used herein, the terms "s", "min" and "h" stand for "seconds", "minutes" and "hours", respectively.

[0062] The term "about" as used herein refers to ±10%, more preferably ±5%, and most preferably ±2% of the value modified by the term, so that a person skilled in the art can clearly determine the scope of the term "about" based on the modified value.

[0063] The term "extract preparation" used in this article refers to a type of preparation for internal or external use obtained by extracting active ingredients from animal and plant medicinal materials using appropriate extraction solvents and methods, and then appropriately refining and concentrating them. Among them, extract preparations include decoctions, wine preparations, tinctures, fluid extracts, extracts, decoctions, etc.

[0064] The term "fluid extract" used in this article refers to a liquid extract preparation prepared by extracting the active ingredients of a medicinal material with a suitable solvent, evaporating part of the solvent, and adjusting the concentration to a specified standard.

[0065] The term "extract" as used herein refers to an extract preparation which is concentrated into a thick paste, block or powder after the effective ingredients of the medicinal material are extracted with a suitable solvent and all the solvents are evaporated.

[0066] The term "alcoholic preparation" as used herein refers to a clear liquid preparation prepared by extracting the raw drug with a solvent such as alcohol (ethanol).

[0067] The term "tincture" as used herein refers to a clear liquid preparation prepared by extracting or dissolving the raw drug with a solvent such as ethanol at a specified concentration, and can also be prepared by diluting a fluid extract.

[0068] The first aspect of the present invention relates to a composition for solubilizing a Chinese herbal medicine extract preparation, the composition comprising tridecyl trimellitate, and an oil phase thickener and / or an oil phase gelling agent, or consisting thereof.

[0069] When stabilizing Chinese herbal medicine preparations, the selection of the oil phase composition is the most critical. The inventors found that the composition containing tridecyl trimellitate and a suitable oil phase thickener and / or oil phase gelling agent can be well compatible with a variety of Chinese herbal medicine extract preparations containing complex ingredients, such as water-soluble ingredients, alcohol-soluble ingredients, and oil-soluble ingredients, thereby helping the preparations to stabilize and suspend, greatly enhancing the overall stability of the product.

[0070] In some embodiments, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gelling agent in the composition is 1:10, 1:9, 1:8, 1:7, 1:6, 1:5, 1:4, 1:3, 1:2, 1:1, 2:1, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1, 9:1, 11:1, 12:1, 13:1, 14:1, 15:1, 16:1, 17:1, 18:1, 19:1, 20:1, 21:1, 22:1, 23:1, 24:1, 25: 1, 26:1, 27:1, 28:1, 29:1, 30:1, 31:1, 32:1, 33:1, 34:1, 35:1, 36:1, 37:1, 38:1, 39:1, 40:1 and any ranges therebetween, including but not limited to,1 : 1-10、1 :1-9、1 : 1-8、1 : 1-7、1 : 1-6、1 : 1-5、1 : 1-4、1 : 1-3、1 : 1-2、1-2 : 1、1-3 : 1、1-4 : 1、1-5 : 1、1-6 : 1、1-7 : 1、1-8 : 1、1-9 : 1、1-10 : 1、1-11 : 1、1-12 : 1、1-13 : 1、1-14 : 1、1-15 : 1、1-16 : 1、1-17 : 1、1-18 : 1、1-19 : 1、1-20 : 1、1-21 :1, 1-22 : 1, 1-23 : 1, 1-24 : 1, 1-25 : 1, 1-26 : 1, 1-27 : 1, 1-28 : 1, 1-29 : 1, 1-30 : 1, 1-31 : 1, 1-32 : 1, 1-33 : 1, 1-34 : 1, 1-35 : 1, 1-36 : 1, 1-37 : 1, 1-38 :1, 1-39 : 1, 1-40 : 1, 2-20 : 1, 3-20 : 1, 4-20 : 1, 5-20 : 1, 6-20 : 1, 7-20 : 1, 8-20 : 1, 9-20 : 1, 10-20: 1, 15-20: 1, 1: 10 - 20: 1, 1: 9 - 20: 1, 1: 8 - 20: 1, 1: 7 - 20: 1, 1: 6 - 20: 1, 1: 5 - 20: 1, 1: 4 - 20: 1, 1: 3 - 20: 1, 1: 2 - 20: 1, 1: 1 - 20: 1. For example, in some embodiments, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gelling agent in the composition is 1-40: 1-10. In some embodiments, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gel in the composition is 1-30: 1-8. In some embodiments, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gel in the composition is 1-20: 1-5. In some embodiments, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gel in the composition is 5-20: 1. In some embodiments, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gel in the composition is 10-20: 1.

[0071] In some embodiments, the oil phase thickener is selected from one or more of plant wax, animal wax, mineral wax and synthetic wax; and / or

[0072] The oil phase gelling agent is selected from one or more of castor oil / IPDI copolymer, dextrin palmitate, dextrin myristate and HDI / trimethylol hexyl lactone cross-linked polymer.

[0073] In some embodiments, the plant wax is selected from candelilla wax, carnauba wax, rice bran wax, rice bran wax, sunflower seed wax, sumac wax, lacquer wax, sugarcane wax, lacquer peel wax, lime peel wax, tulip tree leaf wax, apple peel wax, grape leaf wax, Channa intestine wax, multi-stemmed Ormanlis flower wax, spent malt meal wax, raspberry leaf wax, daffodil flower wax, bitter orange flower wax, rosemary flower wax, jasmine flower wax, green wattle flower wax, safflower flower wax, lime flower wax, frangipani flower wax, Damask rose flower wax, tuberose flower wax, lavender flower wax, soap tree flower wax, centifolia flower wax, wild rose flower wax or silver wattle flower wax.

[0074] In some embodiments, the animal wax is selected from beeswax, lanolin wax, mink wax, or shellac wax.

[0075] In some embodiments, the mineral wax is selected from ozokerite, paraffin wax, microcrystalline wax, or montan wax.

[0076] In some embodiments, the synthetic wax is selected from polyethylene wax, synthetic beeswax, synthetic spermaceti wax, synthetic Japan wax, synthetic candelilla wax, hydrogenated microcrystalline wax, hydrogenated Japan wax, or hydrogenated rice bran wax.

[0077] In some embodiments, the oil phase thickener is a mixture of one or more of the above-listed plant waxes, animal waxes, mineral waxes and synthetic waxes. For example, in some embodiments, the oil phase thickener is one, two, three, four, five or all of candelilla wax, carnauba wax, beeswax, ozokerite, polyethylene wax and microcrystalline wax.

[0078] In some embodiments, the oil phase gelling agent is one, two, three or all selected from castor oil / IPDI copolymer, dextrin palmitate, dextrin myristate and HDI / trimethylol hexyllactone cross-linked polymer.

[0079] In some embodiments, the composition for solubilizing the Chinese herbal medicine extract preparation comprises tridecyl trimellitate, and candelilla wax, carnauba wax, beeswax, ozokerite, polyethylene wax, microcrystalline wax, castor oil / IPDI copolymer, dextrin palmitate, dextrin myristate and HDI / trimethylol hexyllactone cross-linked polymer, optionally one, two, three, four, five, six, seven, eight, nine or all thereof.

[0080] The second aspect of the present invention relates to a Chinese herbal medicine composition, which comprises a Chinese herbal medicine extract preparation and the composition for solubilizing the Chinese herbal medicine extract preparation according to the first aspect of the present invention.

[0081] In some embodiments, the extract preparation is a decoction, an alcoholic preparation, a tincture, a fluid extract, an extract, and a decoction.

[0082] In some embodiments, the weight ratio of the Chinese herbal leaching preparation to the composition for solubilizing the Chinese herbal leaching preparation is 0.01:100, 0.2:100, 0.3:100, 0.4:100, 0.5:100, 1:100, 2:100, 3:100, 4:100, 5:100, 6:100, 7:100, 8:100, 9:100, 11:100, 12:100, 13:100, 14:100, 15:100, 16:100, 17:100, 18:100, 19:100, 20:100 and ranges therebetween.

[0083] For example, in some embodiments, in the composition, the weight ratio of the Chinese herbal leaching preparation to the composition for solubilizing the Chinese herbal leaching preparation is 0.1-25: 100. In some embodiments, in the composition, the weight ratio of the Chinese herbal leaching preparation to the composition for solubilizing the Chinese herbal leaching preparation is 0.2-23: 100. In some embodiments, in the composition, the weight ratio of the Chinese herbal leaching preparation to the composition for solubilizing the Chinese herbal leaching preparation is 2-23: 100. In some embodiments, in the composition, the weight ratio of the Chinese herbal leaching preparation to the composition for solubilizing the Chinese herbal leaching preparation is 4-23: 100. In some embodiments, in the composition, the weight ratio of the Chinese herbal leaching preparation to the composition for solubilizing the Chinese herbal leaching preparation is 8-20: 100. In some embodiments, in the composition, the weight ratio of the Chinese herbal extract preparation to the composition for solubilizing the Chinese herbal extract preparation is 8-10:100.

[0084] In some embodiments, the Chinese herbal medicine is selected from at least two of Saxifraga (strawberry saxifrage), Dandelion, Licorice, Angelica, Cinnamon, White Peony, Lycopodiella, Herba Sophorae Flavescentis, Sanguisorba Officinalis, Cortex Phellodendri, Honeysuckle, Campsis Flos, Root of Peony, Schisandra Chinensis, Plum Blossom, and White Laba. For example, in some embodiments, the Chinese herbal medicine is selected from at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, at least ten, at least eleven, at least twelve, at least thirteen, at least fourteen, at least fifteen, at least sixteen, at least seventeen, or all of Saxifraga, Dandelion, Licorice, Angelica, Cinnamon, White Peony, Lycopodiella, Herba Sophorae Flavescentis, Sanguisorba Officinalis, Cortex Phellodendri, Honeysuckle, Campsis Flos, Root of Peony, Schisandra Chinensis, Plum Blossom, and White Laba. For example, in some embodiments, the Chinese herbal medicine extract is selected from extracts prepared from saxifrage, dandelion and licorice; extracts prepared from angelica and licorice; extracts prepared from trumpet creeper, peony root, schisandra, plum fruit and white hyacinth bean; extracts prepared from angelica, cinnamon, white peony, lycopodiella, and radix schisandrae; extracts prepared from sophora flavescens, sanguisorba officinalis, phellodendron, dandelion and honeysuckle. In some embodiments, the Chinese herbal medicine extract is prepared from 1-10 parts by weight of one or more selected from the following Chinese herbs: saxifrage (strawberry saxifrage), dandelion, licorice, angelica, cinnamon, white peony, lycopodiella, radix schisandrae, radix schisandrae, sophora flavescens, sanguisorba officinalis, phellodendron, honeysuckle, trumpet creeper, peony root, schisandra, plum fruit and white hyacinth bean. In some embodiments, the Chinese herbal medicine extract is prepared from one or more of the following Chinese herbs in 1-5 parts by weight each: Saxifraga (strawberry saxifrage), dandelion, licorice, angelica, cinnamon, white peony, schizonepeta, radix schizonepetae, sophora flavescens, sanguisorba officinalis, phellodendron, honeysuckle, trumpet creeper, peony root, schisandra, plum fruit and white hyacinth bean. In some embodiments, the Chinese herbal medicine extract is prepared from one or more of the following Chinese herbs in 1-3 parts by weight each: Saxifraga (strawberry saxifrage), dandelion, licorice, angelica, cinnamon, white peony, schizonepeta, radix schizonepetae, sophora flavescens, sanguisorba officinalis, phellodendron, honeysuckle, trumpet creeper, peony root, schisandra, plum fruit and white hyacinth bean.

[0085] Saxifraga is the dried whole herb of Saxifraga stolonifera Curtis or Saxifraga sarmentosa, plants of the Saxifragaceae family. Licorice is the dried root and rhizome of Glycyrrhiza uralensis, Glycyrrhiza inflata or Glycyrrhiza glabra, plants of the Leguminosae family. Angelica sinensis is the dried root of Angelica sinensis (Oliv.) Diels, a plant of the Apiaceae family. Cinnamon is the bark of Cinnamomum cassia Pres1., a plant of the Lauraceae family. White peony root is the dried root of Paeonialactiflora Pall., a plant of the Ranunculaceae family. Lycopodium jaPonicum Thunb. is the dried whole herb of Lycopodium jaPonicum Thunb., a plant of the Lycopodiaceae family. The whole herb of Phryma leptostachya subsp. asiatica (Hara) Kitamura, a plant of the family Phrygium. It is a perennial herb. Sophora flavescens is the dried root of Sophora flavescens Ait., a plant of the family Leguminosae. Sanguisorba officinalis is the dried root of Sanguisorba officinalis L. or Sanguisorba officinalis L. var. longifolia (Bert.) Yüet Li, a plant of the family Rosaceae. Phellodendron chinense Schneid. is the dried bark of Phellodendron chinense Schneid., a plant of the family Rutaceae. Taraxacum is the dried whole herb of Taraxacum mongolicum Hand.-Mazz., Taraxacum borealis inense Kitam., or several plants of the same genus, a plant of the family Asteraceae. Honeysuckle, also known as honeysuckle, is the dried buds or flowers with early opening of Lonicera japonica Thunb., a plant of the Caprifoliaceae family. Trumpet creeper is the dried flower of Campsis grandiflora (Thunb.) K. Schum. or Campsis radicans (L.) Seem., a plant of the Bignoniaceae family. Peony root is the dried root of Paeonia lactiflora Pall., a plant of the Ranunculaceae family. Schisandra chinensis is the dried mature fruit of Schisandra chinensis (Turcz.) Baill., a plant of the Magnoliaceae family. Plum fruit is the fruit of Armeniaca mume Sieb., a plant of the Rosaceae family.White lentil is the dried mature seed of Dolichos lablab L., a plant of the legume family.

[0086] The third aspect of the present invention relates to a method for preparing the Chinese herbal composition of the second aspect of the present invention, wherein the Chinese herbal composition contains the ingredients and their weight percentages described herein, wherein the method comprises:

[0087] (1) Weighing the corresponding raw materials, wherein phase A comprises: part of tridecyl trimellitate and a Chinese herbal medicine extract preparation; phase B comprises: the rest of tridecyl trimellitate, and an oil phase thickener and / or an oil phase gelling agent;

[0088] (2) Mixing phase A uniformly at room temperature to obtain material 1;

[0089] (3) heating phase B, dispersing it evenly, and cooling it to 60° C. or below to obtain material 2;

[0090] (4) Slowly adding material 1 to material 2 under homogenization to mix the two phases evenly to obtain the Chinese herbal medicine composition.

[0091] For example, the amount of the tridecyl trimellitate in phase A is one, two, three, four, five, six times the weight of the Chinese herbal medicine extract preparation, and any range therebetween. For example, the amount of the tridecyl trimellitate in phase A is one-half, one-third, one-quarter, one-fifth, one-sixth, and any range therebetween of the total weight of the tridecyl trimellitate.

[0092] In some embodiments, the amount of tridecanol trimellitate in phase A is one-sixth to one-half of the total weight of tridecanol trimellitate. In some embodiments, the amount of tridecanol trimellitate in phase A is one-fifth to one-half of the total weight of tridecanol trimellitate. In some embodiments, the amount of tridecanol trimellitate in phase A is one-quarter to one-half of the total weight of tridecanol trimellitate. In some embodiments, the amount of tridecanol trimellitate in phase A is one-third to one-half of the total weight of tridecanol trimellitate. In some embodiments, the amount of tridecanol trimellitate in phase A is one-half of the total weight of tridecanol trimellitate.

[0093] Alternatively, the method comprises:

[0094] (1') Weighing the corresponding raw materials, wherein the A' phase comprises: a Chinese herbal medicine extract preparation; the B' phase comprises: tridecyl trimellitate, and an oil phase thickener and / or an oil phase gelling agent;

[0095] (2') stirring the A' phase at room temperature to obtain a material 1';

[0096] (3') heating phase B', dispersing it evenly, and cooling it to 60°C or below to obtain material 2';

[0097] (4') Slowly add the material 1' into the material 2' under homogenization to mix the two phases evenly to obtain the Chinese herbal medicine composition.

[0098] The Chinese herbal medicine extract preparations in the above steps (1) and (1') can be prepared by conventional extract preparation preparation methods in the art.

[0099] The fourth aspect of the present invention relates to a medicine or cosmetic comprising the composition for solubilizing a Chinese herbal medicine extract preparation according to the first aspect of the present invention or the Chinese herbal medicine composition according to the second aspect of the present invention.

[0100] In some embodiments, the medicament or cosmetic is applied to the skin. In some embodiments, the medicament or cosmetic is applied to the eyes or lips.

[0101] In some embodiments, the medicine or cosmetic is a paste, such as a Chinese herbal lip balm for preventing and or treating chronic cheilitis.

[0102] The fifth aspect of the present invention relates to the use of the composition for solubilizing Chinese herbal medicine extract preparations of the first aspect of the present invention, the Chinese herbal medicine composition of the second aspect of the present invention, or the Chinese herbal medicine composition prepared according to the method of the third aspect of the present invention in the preparation of medicines or cosmetics. Example

[0103] The present invention can be implemented through the following embodiments, but the present invention is not limited thereto.

[0104] The instruments and equipment used in the embodiments of the present invention are all conventional instruments and equipment in the field and can be replaced by instruments and equipment that meet the corresponding standards.

[0105] Unless otherwise specified, the reagents used in the embodiments of the present invention are all commercially available analytically pure reagents.

[0106] The raw materials and instruments and equipment mentioned in the present invention are all commonly used raw materials and instruments and equipment in the field, which are only examples and are not intended to limit the scope of protection of the present invention. Those skilled in the art can select equivalent raw materials and related instruments and equipment based on the disclosure of the present invention.

[0107] 1. Preparation of the composition

[0108] The Chinese herbal medicine composition of the present invention can be prepared by the following method:

[0109] Method 1:

[0110] Firstly, a portion of tridecyl trimellitate and a Chinese herbal medicine extract are mixed at room temperature and stirred evenly to obtain a uniform mixture phase A;

[0111] Add the remaining components (the remaining tridecyl trimellitate, and the oil phase thickener and / or oil phase gelling agent) into the main pot and heat as phase B. Heat and stir until phase B is fully dissolved and evenly dissolved. Then start to cool to 60 o C. Slowly add phase A into phase B, stir evenly and then remove from the pan to form.

[0112] Method 2:

[0113] First, a Chinese herbal medicine extract preparation was prepared as phase A';

[0114] Heat and stir tridecyl trimellitate and the oil phase thickener and / or the oil phase gelling agent until dissolved, and stir evenly to obtain a uniform mixture B' phase;

[0115] Cool down phase B' to 60 o Below C, slowly add phase A' into phase B', stir evenly and then remove from the pan to form.

[0116] As an example, the present invention uses the following as the Chinese herbal medicine extract preparation to be solubilized:

[0117] Chinese herbal medicine extract preparation I refers to an alcohol-soluble extract prepared by adding ethanol to extract, filter, concentrate and purify a compound raw material of Saxifrage (strawberry Saxifrage), dandelion and licorice in a weight ratio of 1:1:1.

[0118] Chinese herbal medicine extract preparation II refers to a water-soluble decoction prepared by mixing the compound raw materials of trumpet creeper, peony root, angelica, schisandra, plum fruit and white labiata in a ratio of 1:1:1:1:1:1 by weight, adding water for extraction, filtering, concentrating and refining.

[0119] Chinese herbal medicine extract preparation III refers to a compound raw material of angelica, cinnamon, white peony root, smilax china, and herba spatholobi in a weight ratio of 1:1:2:3:3, with water and ethanol added for mixed extraction, and the oil-soluble, water-soluble and alcohol-soluble fluid extract prepared by filtering, concentrating and refining processes.

[0120] Chinese herbal medicine extract preparation IV refers to an alcohol-soluble extract prepared by adding ethanol to a compound raw material of Sophora flavescens, Sanguisorba officinalis, Phellodendron amurense, Taraxacum officinale, and Lonicera japonica in a weight ratio of 2:2:1:1:1, followed by extraction, filtration, concentration, and refining. Example 1

[0121] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0122] Tridecyl trimellitate 40 g

[0123] Beeswax 4 g

[0124] Chinese herbal medicine extract preparation I4 g Example 2

[0125] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0126] Tridecyl trimellitate 40 g

[0127] Beeswax 4 g

[0128] Chinese herbal medicine extract II 4 g Example 3

[0129] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0130] Tridecyl trimellitate 40 g

[0131] Beeswax 4 g

[0132] Chinese herbal medicine extract III 4 g Example 4

[0133] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0134] Tridecyl trimellitate 40 g

[0135] Beeswax 4 g

[0136] Chinese herbal medicine extract IV 4 g Example 5

[0137] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0138] Tridecyl trimellitate 40 g

[0139] Candelilla wax 4 g

[0140] Chinese herbal medicine extract preparation I4 g Example 6

[0141] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0142] Tridecyl trimellitate 40 g

[0143] Microcrystalline wax 4 g

[0144] Chinese herbal medicine extract preparation I4 g Example 7

[0145] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0146] Tridecyl trimellitate 40 g

[0147] Castor oil / IPDI copolymer 2 g

[0148] Chinese herbal medicine extract preparation I4 g Example 8

[0149] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0150] Tridecyl trimellitate 40 g

[0151] HDI / Trimethylol Hexyllactone Crosspolymer 2 g

[0152] Chinese herbal medicine extract preparation I4 g Example 9

[0153] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0154] Tridecyl trimellitate 40 g

[0155] Dextrin palmitate 2 g

[0156] Chinese herbal medicine extract preparation I4 g Example 10

[0157] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0158] Tridecyl trimellitate 40 g

[0159] Dextrin myristate 2 g

[0160] Chinese herbal medicine extract preparation I4 g Embodiment 11

[0161] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0162] Tridecyl trimellitate 40 g

[0163] Beeswax 4 g

[0164] Butanediol 4 g Example 12

[0165] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0166] Tridecyl trimellitate 40 g

[0167] Beeswax 4 g

[0168] Water 4 g Embodiment 13

[0169] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0170] Tridecyl trimellitate 40 g

[0171] Beeswax 4 g

[0172] Chinese herbal medicine extract preparation I0.1 g Embodiment 14

[0173] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0174] Tridecyl trimellitate 40 g

[0175] Beeswax 4 g

[0176] Chinese herbal medicine extract preparation I2 g Embodiment 15

[0177] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0178] Tridecyl trimellitate 40 g

[0179] Beeswax 4 g

[0180] Chinese herbal medicine extract preparation I6 g Example 16

[0181] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0182] Tridecyl trimellitate 40 g

[0183] Beeswax 4 g

[0184] Chinese herbal medicine extract preparation I8 g Embodiment 17

[0185] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0186] Tridecyl trimellitate 40 g

[0187] Beeswax 4 g

[0188] Chinese herbal medicine extract preparation I10 g Embodiment 18

[0189] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0190] Tridecyl trimellitate 40 g

[0191] Beeswax 1 g

[0192] Chinese herbal medicine extract preparation I4 g Embodiment 19

[0193] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0194] Tridecyl trimellitate 40 g

[0195] Beeswax 10 g

[0196] Chinese herbal medicine extract preparation I4 g Embodiment 20

[0197] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0198] Tridecyl trimellitate 20 g

[0199] Beeswax 20 g

[0200] Chinese herbal medicine extract preparation I4 g Embodiment 21

[0201] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0202] Tridecyl trimellitate 30 g

[0203] Beeswax 1 g

[0204] Chinese herbal medicine extract preparation I4 g Embodiment 22

[0205] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0206] Tridecyl trimellitate 30 g

[0207] Beeswax 8 g

[0208] Chinese herbal medicine extract preparation I4 g Embodiment 23

[0209] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0210] Tridecyl trimellitate 8 g

[0211] Beeswax 30 g

[0212] Chinese herbal medicine extract preparation I4 g Embodiment 24

[0213] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0214] Tridecyl trimellitate 20 g

[0215] Beeswax 5 g

[0216] Chinese herbal medicine extract preparation 15 g Embodiment 25

[0217] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0218] Tridecyl trimellitate 40 g

[0219] Beeswax 8 g

[0220] Chinese herbal medicine extract preparation I1 g

[0221] Comparative Example 1

[0222] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0223] 40 g olive oil

[0224] Beeswax 4 g

[0225] Chinese herbal medicine extract preparation I4 g

[0226] Comparative Example 2

[0227] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0228] Octyldodecanol 40 g

[0229] Beeswax 4 g

[0230] Chinese herbal medicine extract preparation I4 g

[0231] Comparative Example 3

[0232] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0233] 40g olive oil

[0234] PEG-100 stearate 5 g

[0235] Beeswax 4 g

[0236] Chinese herbal medicine extract preparation I4 g

[0237] Comparative Example 4

[0238] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0239] Tridecyl trimellitate 40 g

[0240] Chinese herbal medicine extract preparation I4 g

[0241] Comparative Example 5

[0242] According to the above preparation method, a Chinese herbal medicine composition is prepared from the following raw materials by weight:

[0243] Polyglyceryl-3 diisostearate 40 g

[0244] Beeswax 4 g

[0245] Chinese herbal medicine extract preparation I4 g

[0246] Result analysis:

[0247] Examples 1-17 of the present application use tridecyl trimellitate as the main solvent, and beeswax, candelilla wax or castor oil / IPDI copolymer as the oil phase thickener / oil phase gelling agent, which can well solubilize and stabilize the components of the Chinese herbal medicine extract preparation or water or butanediol evenly in the formula system.

[0248] Four different Chinese herbal medicine extract preparations were selected for illustration in Examples 1-4. Different oil phase thickeners were replaced for comparison in Examples 5-10. Among them, 5-6 used different waxes as oil phase thickeners, and 7-10 used castor oil / IPDI copolymer, HDI / trimethylol hexyl lactone cross-linked polymer, etc. as oil phase thickeners / oil phase gelling agents; it can be seen that these oil phase thickeners or oil phase gelling agents can uniformly solubilize and stabilize the components of the Chinese herbal medicine extract preparation in the formula system.

[0249] Examples 11 and 12 illustrate that the solubilizing composition of the present invention can not only solubilize the Chinese herbal medicine extract preparation, but also solubilize stable water or butylene glycol.

[0250] In Examples 13-17, different concentrations of Chinese herbal medicine extract preparation I were used for experiments. It was found that using tridecyl trimellitate as the main solvent and beeswax as the oil phase thickener can well solubilize and stabilize different concentrations of Chinese herbal medicine extract preparation I. The stability is very good at both low and high content levels, and the high content can be as high as about 18.5% by weight.

[0251] Examples 18-25 selected different ratios of tridecyl trimellitate to a suitable oil phase thickener and / or oil phase gelling agent, and confirmed that a specific ratio of tridecyl trimellitate to a suitable oil phase thickener and / or oil phase gelling agent can better solubilize the Chinese herbal composition and enhance stability.

[0252] Comparative Example 1 uses common vegetable oil-olive oil as a representative, and Comparative Example 2 uses octyl dodecanol as a common synthetic oil representative, and also adds beeswax and Chinese herbal medicine extract preparation to prepare a Chinese herbal medicine composition. Since neither octyl dodecanol nor olive oil can be well mixed with the Chinese herbal medicine extract preparation, the herbal medicine extract preparation in the final product obtained cannot be evenly dispersed in the system, and there will be precipitation and precipitation. Comparative Example 3 adds a commonly used cosmetic emulsifier ingredient on the basis of Comparative Example 1, but the inventor found that the problem of precipitation and precipitation cannot be solved by adding an emulsifier alone. Comparative Example 4 only uses tridecyl alcohol trimellitate as the main solvent. Although it is stirred to form a liquid system with a uniform appearance, since it does not contain an oil phase thickener, after being placed for a period of time, the mixture will be layered, and the Chinese herbal medicine extract preparation will settle out of the system. Comparative Example 5 replaces the main solvent with polyglycerol-3 diisostearate, which can evenly and disperse the Chinese herbal medicine extract preparation, but due to the emulsification properties of the emulsifier, it will cause poor skin feel when used, especially when used on the lips, it will turn white when exposed to water.

[0253] 2. Stability analysis

[0254] The Chinese herbal medicine compositions prepared by using Examples 1-25 provided by the present invention have good stability and exhibit good uniformity.

[0255] The stability test method is as follows:

[0256] 1. Test samples: 30 samples in total from Examples 1-25 and Comparative Examples 1-5, respectively packed in 5 30g sealed transparent glass bottles;

[0257] 2. Testing period: December 2, 2023 - March 2, 2024;

[0258] 3. Test conditions: placed in refrigerator, room temperature and biochemical incubator (temperature see Table 1);

[0259] 4. Observe for stratification, discoloration, etc. on the 15th, 30th, 60th, and 90th days respectively;

[0260] 5. The test results are shown in Tables 1 and Figure 1-5 In Table 1, “-” indicates that the paste is normal, fine and uniform; “+” indicates that the paste is slightly stratified; “※” indicates that the paste is obviously stratified. Figure 1-4It can be seen from the above that the pastes of Examples 1-25 of the present application are in a normal state even if left for a long time at 25°C, and are smooth and uniform. Figure 5 It can be seen that comparative examples 1-4 showed obvious stratification on the day of preparation. At a high temperature of 43°C, examples 18 and 22 showed that stratification did not occur until the 15th day.

[0261] Table 1

[0262] 1 The temperature was maintained at 4°C for 10 h, then raised from 4°C to 43°C within 2 h, maintained at 43°C for another 10 h, and then cooled from 43°C to 4°C within 2 h.

[0263] 3. Sensory evaluation

[0264] Paste uniformity:

[0265] 10 professionals were selected to score the uniformity of the paste. The scoring criteria are as follows, and the average value is rounded off.

[0266] 1 point: obviously uneven;

[0267] 2 points: local unevenness;

[0268] 3 points: Very even.

[0269] Paste particle aggregation:

[0270] 10 professionals were selected to score the paste aggregation performance. The scoring criteria were as follows, and the average value was rounded off.

[0271] 1 point: obvious aggregation;

[0272] 2 points: small amount of aggregation;

[0273] 3 points: No aggregation.

[0274] Paste applicability:

[0275] 10 professionals were selected to rate the application performance of the paste. The rating criteria were as follows, and the average value was rounded off.

[0276] 1 point: The cream feels very greasy and sticky when applied on the skin, and is difficult to spread;

[0277] 2 points: The cream feels smoother and easier to spread on the skin, but still has a certain stickiness.

[0278] 3 points: The cream feels very smooth and light when applied on the skin, with almost no stickiness and is very easy to spread.

[0279] Whitening of the paste:

[0280] 10 professionals were selected to score the whitening of the paste. The scoring criteria are as follows, and the average value is rounded off.

[0281] 1 point: The cream turns white when it comes into contact with water when applied to the lips;

[0282] 2 points: The cream turns a little white when it comes into contact with water when applied on the lips;

[0283] 3 points: The cream does not turn white easily when it comes into contact with water when applied on the lips.

[0284] Overall preference of the paste:

[0285] It refers to consumers' overall satisfaction and preference for pastes, usually including evaluation of multiple aspects, such as product appearance, uniformity, spreadability, ease of use, color, etc.

[0286] The following are the scoring criteria:

[0287] 1 point: Consumers have no preference for the paste and may even have a strong aversion to it;

[0288] 2 points: Consumers have a moderate preference for the paste, with some neutral or positive comments;

[0289] 3 points: Consumers have a very high degree of preference for the paste and there may be many positive reviews.

[0290] Table 2 Comparative sensory evaluation table of pastes

[0291] According to the above comparison results, it can be known that the pastes in Comparative Examples 1-4 show unevenness from the beginning of preparation, indicating that the traditional ointment system is not suitable for Chinese herbal medicine extract preparations. Although Comparative Example 4 can be mixed evenly at the beginning, it is easy to settle and cannot be stable for a long time. Comparative Example 5 shows that even if a large amount of polyglycerol emulsifier is used to solubilize the formula into the system, due to the emulsification characteristics of the emulsifier, it will cause poor skin feel when used, especially when used on the lips, it will turn white when exposed to water. Therefore, it can only be used in small amounts as an auxiliary stabilizing ingredient. Therefore, the present invention provides an application solution idea and method for using Chinese herbal medicine extract preparations with complex components in an oil phase system, and provides a solution for promoting the large-scale commercial use of Chinese herbal medicine extract preparations with complex components.

[0292] In summary, the present application provides a solubilizing composition and a Chinese herbal medicine composition comprising the solubilizing composition. The Chinese herbal medicine composition in the form of a paste of the present invention can remain stable for a long time under high temperature and high humidity conditions, and is particularly suitable for further processing of Chinese herbal medicine extract preparations containing complex ingredients.

[0293] It should be understood that this specification is not limited to the technical solutions shown above, and various modifications and changes can be made to various technical solutions without departing from its scope. This specification is intended to cover any modification, use or adaptive change of the present invention, which follows the general principles of this specification and includes common knowledge or common technical means in the technical field. This specification and embodiments are only regarded as exemplary, and the scope of protection of the present invention is defined by the appended claims.

Claims

1. A composition for solubilizing a Chinese herbal medicine extract preparation, characterized in that: The composition comprises tridecyl trimellitate, and an oil phase thickener and / or an oil phase gelling agent.

2. The composition according to claim 1, wherein The weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gelling agent in the composition is 1-40:1-10; Preferably, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gelling agent in the composition is 1-30:1-8; Preferably, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gelling agent in the composition is 1-20:1-5; Preferably, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gelling agent in the composition is 5-20:1; Preferably, the weight ratio of tridecyl trimellitate to the oil phase thickener and / or oil phase gelling agent in the composition is 10-20:

1.

3. The composition according to claim 1 or 2, wherein The oil phase thickener is selected from one or more of plant wax, animal wax, mineral wax and synthetic wax; and / or The oil phase gel is selected from one or more of castor oil / IPDI copolymer, dextrin palmitate, dextrin myristate and HDI / trimethylol hexyl lactone cross-linked polymer; Preferably, the plant wax is selected from candelilla wax, carnauba wax, rice bran wax, rice bran wax, sunflower seed wax, wild sumac wax, lacquer wax, sugarcane wax, sumac peel wax, lime peel wax, tulip tree leaf wax, apple peel wax, grape leaf wax, Channa intestine wax, multi-stemmed Ormanlis flower wax, waste malt meal wax, raspberry leaf wax, red narcissus flower wax, bitter orange flower wax, rosemary flower wax, jasmine flower wax, green wattle flower wax, Su Fang flower wax, lime flower wax, Frangipani flower wax, Turkic rose flower wax, tuberose flower wax, lavender flower wax, soap tree flower wax, centifolia flower wax, wild rose flower wax or silver wattle flower wax; the animal wax is selected from beeswax, lanolin wax, mink wax or shellac wax; the mineral wax is selected from ozokerite, paraffin, microcrystalline wax or montan wax; the synthetic wax is selected from polyethylene wax, synthetic beeswax, synthetic spermaceti, synthetic Japan wax, synthetic candelilla wax, hydrogenated microcrystalline wax, hydrogenated Japan wax or hydrogenated rice bran wax.

4. A Chinese herbal medicine composition, comprising a Chinese herbal medicine extract preparation and the composition for solubilizing the Chinese herbal medicine extract preparation according to any one of claims 1 to 3.

5. The Chinese herbal medicine composition according to claim 4, wherein: The Chinese herbal medicine extract preparation is selected from decoction, wine, tincture, fluid extract, extract and decoction; Preferably, in the Chinese herbal medicine composition, the weight ratio of the Chinese herbal medicine extract preparation to the composition for solubilizing the Chinese herbal medicine extract preparation is 0.01-25:100; Preferably, in the composition, the weight ratio of the Chinese herbal medicine extract preparation to the composition for solubilizing the Chinese herbal medicine extract preparation is 0.2-23:100; Preferably, in the composition, the weight ratio of the Chinese herbal medicine extract preparation to the composition for solubilizing the Chinese herbal medicine extract preparation is 2-23:100; Preferably, in the composition, the weight ratio of the Chinese herbal extract preparation to the composition for solubilizing the Chinese herbal extract preparation is 4-23:

100.

6. The Chinese herbal medicine composition according to claim 5 or 6, wherein: The Chinese herbal medicine is selected from two or more of saxifrage, dandelion, liquorice, angelica, cinnamon, white peony root, schizonepeta tenuifolia, radix spatholobi, sophora flavescens, sanguisorba officinalis, phellodendron amurense, dandelion, honeysuckle, trumpet creeper, peony root, schisandra chinensis, plum fruit and white dung bean; Preferably, the Chinese herbal medicine extract preparation is selected from: an extract prepared from Saxifrage, Taraxacum and Licorice; and / or an extract prepared from Angelica and Licorice; and / or an extract prepared from Campsis, Paeonia lactiflora, Schisandra chinensis, Prunus mume and Lablab dahliae; and / or an extract prepared from Angelica, Cinnamon bark, White Peony Root, Lycopodiella cuneata and Radix Polygoni Multiflori; and / or an extract prepared from Sophora flavescens, Sanguisorba officinalis, Phellodendron amurense, Taraxacum and Flos Lonicerae.

7. A method for preparing a Chinese herbal composition according to any one of claims 4 to 6, the method comprising combining the composition of the solubilized Chinese herbal extract preparation according to any one of claims 1 to 3 with a Chinese herbal extract preparation.

8. The method according to claim 7, wherein: The method comprises: (1) Weighing the corresponding raw materials, wherein phase A comprises: part of tridecyl trimellitate and a Chinese herbal medicine extract preparation; phase B comprises: the rest of tridecyl trimellitate, and an oil phase thickener and / or an oil phase gelling agent; (2) mixing the raw materials of phase A uniformly at room temperature to obtain material 1; (3) heating the phase B raw material, dispersing it evenly, and cooling it to 60° C. or below to obtain material 2; (4) slowly adding material 1 to material 2 under homogenization to mix the two phases evenly to obtain the Chinese herbal medicine composition; Alternatively, the method comprises: (1') Weighing the corresponding raw materials, wherein the A' phase comprises: a Chinese herbal medicine extract preparation; the B' phase comprises: tridecyl trimellitate, and an oil phase thickener and / or an oil phase gelling agent; (2') stirring the A' phase at room temperature to obtain a material 1'; (3') heating phase B', dispersing it evenly, and cooling it to 60°C or below to obtain material 2'; (4') Slowly adding material 1' into material 2' under homogenization to mix the two phases evenly to obtain the Chinese herbal medicine composition.

9. A medicine or cosmetic comprising the composition for solubilizing a Chinese herbal medicine extract preparation according to any one of claims 1 to 3 or the Chinese herbal medicine composition according to any one of claims 4 to 6; Preferably, the medicine or cosmetic is applied to the skin; Preferably, the medicine or cosmetic is applied to the eyes or lips; Preferably, the medicine or cosmetic is a paste, more preferably a Chinese herbal lipstick for preventing and / or treating chronic cheilitis.

10. Use of the composition for solubilizing a Chinese herbal medicine extract preparation according to any one of claims 1 to 3, or the Chinese herbal medicine composition according to any one of claims 4 to 6, or the Chinese herbal medicine composition prepared by the method according to claim 7 or 8 in the preparation of medicines or cosmetics; Preferably, the medicine or cosmetic is applied to the skin; Preferably, the medicine or cosmetic is applied to the eyes or lips; Preferably, the medicine or cosmetic is a paste, more preferably a Chinese herbal lipstick for preventing and / or treating chronic cheilitis.

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