Red fading composition as well as preparation method and application thereof

Abstract

The invention provides a red fading composition, which is prepared from the following components in percentage by weight: 0.1 to 3 percent of inositol, 0.01 to 3 percent of saffron crocus extract, 0.01 to 1 percent of escin, 0.1 to 5 percent of butanediol, 0.1 to 3 percent of pentanediol, 0.1 to 2 percent of hexanediol and the balance of deionized water, and the sum of the weight percentages of the components is 100 percent. The invention also provides a preparation method and application of the red fading composition. The red fading composition provided by the invention has a relatively good red fading effect.

Description

Technical Field

[0001] The invention relates to a red-fading composition and a preparation method and application thereof. Background Art

[0002] The skin is the largest organ in the human body, accounting for about 5-15% of the body weight. The main function of the skin is to participate in the balance of the human body and the unity with the external environment, and to protect the tissues and organs in the body from chemical, mechanical, physical and pathogenic microbial invasions. However, with the increase of work pressure and the accelerated pace of life of modern people, a large number of cosmetics are frequently used on the face, and excessive cleaning causes the skin to be unable to maintain normal functions, and the number of people with sensitive skin is increasing.

[0003] People with sensitive skin are prone to redness, peeling, stinging, itching and other problems, and their emotions are easily affected. Among them, peeling is due to damaged skin barrier and increased transepidermal water loss TEWL, which leads to reduced skin water content. It can be solved by applying moisturizing cream, which is a relatively easy problem to solve. The main reason for stinging and itching is the high sensitivity of skin nerves. External environmental factors can easily activate the capsaicin receptor TRPV1, leading to the above symptoms. There are now a variety of raw materials on the market that can inhibit TRPV1, such as kava extract and bisabolol, which can effectively reduce irritation, itching and other symptoms through the above mechanism. However, skin redness is a major problem that bothers people with sensitive skin. It is easy to cause appearance anxiety, and anxiety will affect the function of the skin, forming a vicious circle. Skin redness is caused by the reduced elasticity and increased fragility of the capillary walls of the face, and the continuous and uneven expansion, rupture and proliferation of blood vessels. Therefore, it is urgent to solve the problem of skin redness in people with sensitive skin.

[0004] Patent CN113842340A discloses an antibacterial, antipruritic, anti-redness, and anti-acne repairing composition and its application, characterized in that the active ingredients only include Centella asiatica extract and White Viburnum extract, and the weight ratio of the two is 1:0.5-1.5. Although the invented composition can simultaneously play the functions of antibacterial, antipruritic, anti-redness, and anti-acne repairing, it has no penetration-promoting ingredients, and it is difficult to repair the dermis layer, and it cannot deeply repair the dilated capillaries. The mechanism is single, the redness fading speed is not obvious, and the effect is weak. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide a redness-removing composition, which has a good redness-removing effect.

[0006] In order to solve the above technical problems, the technical solution of the present invention is:

[0007] A red-removing composition is prepared from the following components in percentage by weight: 0.1-3% inositol, 0.01-3% saffron extract, 0.01-1% aescin, 0.1-5% butanediol, 0.1-3% pentanediol, 0.1-2% hexanediol, and the balance is deionized water, and the sum of the percentages by weight of the components is 100%.

[0008] Inositol, also known as cyclohexanehexol, is a widely distributed cyclohexanehexol-type monosaccharide with a structure similar to glucose. It exists in all animals and plants and is a growth factor for animals and microorganisms. Inositol can maintain the cell size of keratinocytes under hypertonic conditions, prevent keratinocytes from losing water due to hypertonic pressure, and achieve the effect of moisturizing, thereby improving dry and peeling skin. It has good permeability through the skin and can promote the penetration of other ingredients.

[0009] Furthermore, the present invention is made of the following components in weight percentage: inositol 0.2-1%, saffron extract 0.02-1%, aescin 0.02-0.5%, butanediol 0.1-5%, pentanediol 0.1-3%, hexanediol 0.1-2%, and the balance is deionized water, and the sum of the weight percentages of the components is 100%.

[0010] Furthermore, the preparation steps of the saffron extract of the present invention are:

[0011] The saffron petals are dried and crushed, and then passed through a 40-mesh sieve to obtain saffron powder, the saffron powder is added into 8-12 times the volume of an ethanol aqueous solution with a volume concentration of 70-90%, and refluxed for extraction for 1-3 hours to obtain an extract, the extract is filtered and the filtrate is collected to obtain an alcohol extract, the alcohol extract is decompressed to recover ethanol until there is no alcohol taste, and the total flavonoid content is continued to be higher than 0.3 g / L to obtain a saffron extract.

[0012] The soothing and stress-resistant effects of saffron extract are widely recognized, and studies have also confirmed that saffron extract has analgesic and anti-inflammatory effects and antagonistic effects on TRPV1 pain receptors. Saffron is a perennial flower of the genus Crocus in the family Iridaceae. The flower has pistils and stamens, which are composed of 6 tepals: 3 petals and 3 sepals. Each saffron has 3 yellow stamens and 3 dark red stigmas on the top of the pistil. The style is 3 to 4 cm long, slightly flat, wedge-shaped at the top, and has shallow teeth. The pistils of saffron are screened and dried to become a very rare spice, and people give it the reputation of "red gold". Since ancient times, saffron has been used to treat low back pain and gingivitis due to its analgesic effect.

[0013] Furthermore, the preparation steps of aescin of the present invention are as follows:

[0014] The horse chestnut seeds are dried and crushed, and then passed through an 80-mesh sieve to obtain horse chestnut seed powder, the horse chestnut seed powder is added into 8-12 times the volume of an ethanol aqueous solution with a volume concentration of 70-90%, and refluxed for extraction for 1-3 hours to obtain an extract, the extract is filtered and the filtrate is collected to obtain an alcohol extract, the alcohol extract is concentrated under reduced pressure to remove ethanol, and vacuum dried at 60° C. to constant weight to obtain aescin extract.

[0015] Aesculus hippocastanum has the function of promoting blood circulation and maintaining the wall of veins, and can effectively improve the problem of skin redness. Modern pharmacological studies have confirmed that aesculus hippocastanum, as the main component of horse chestnut extract, has the functions of anti-inflammatory exudation, increasing venous tension, improving microcirculation, and promoting limb function recovery. Horse chestnut can protect the integrity of arterial vessels and structures, improve venous function, and play multiple roles such as anti-inflammatory and anti-oxidation. With the further development of research, the role of horse chestnut in inhibiting collagenase, hyaluronidase, B-glucuronidase and elastase (which can catalyze the destruction of the integrity of venous structure and increase the exudation of capillaries) has also been confirmed. In external use formulas, it can promote blood circulation, promote wound healing, anti-edema, anti-inflammatory and anti-exudation, and vascular protection (removing dark circles, removing red blood, anti-wrinkle, and repairing).

[0016] Another technical problem to be solved by the present invention is to provide a method for preparing the above-mentioned redness-removing composition.

[0017] To solve the above technical problems, the technical solution is:

[0018] A method for preparing a redness-removing composition comprises the following steps:

[0019] Weigh each component by weight, add deionized water, butanediol, pentanediol and inositol into the water phase pot, heat to 80°C and stir for 15-25 minutes, cool to 40°C, add saffron extract, aescin and hexylene glycol into the water phase pot, stir until mixed evenly to obtain the red-removing composition.

[0020] Furthermore, the stirring speed of the present invention is 30-100 rpm.

[0021] The present invention also provides application of the redness-removing composition in cosmetics.

[0022] Furthermore, the cosmetics of the present invention are used for reducing redness.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] (1) The anti-redness composition provided by the present invention is of natural origin, highly safe, and does not burden sensitive skin. It can also inhibit capsaicin receptors, reduce the reaction of sensitive skin to the outside world, and reduce the recurrence of redness.

[0025] (2) The redness-removing composition provided by the present invention can deeply repair capillaries. Capillaries exist in the dermis, and the degree of facial redness is affected by capillaries. Although the products on the market have added active ingredients for redness-removing, it is difficult for the ingredients to reach the dermis and can only stay in the epidermis, which cannot play a role in rapid redness-removal. A small number of products have added penetration enhancers, but the penetration enhancers are chemically synthesized ingredients and are easy to irritate the skin. The inositol used in the present invention naturally exists in the skin and is a natural permeability factor that can help penetration and solve the above problems well. At the same time, inositol has a good ability to scavenge superoxide anions, which can play a role in anti-aging and reducing wrinkles.

[0026] (3) The red-removing composition provided by the present invention has a reasonable ratio. Inositol helps the two plant active ingredients to penetrate, and saffron extract and aescin synergistically enhance their effectiveness in a certain ratio, strengthen blood vessels, and help promote venous blood circulation. By increasing the tension of capillaries, the permeability of capillaries and the fragility of veins are reduced, capillary dilation is reduced, and the effect of rapid red-removing is achieved. DETAILED DESCRIPTION

[0027] The present invention will be described in detail below in conjunction with specific embodiments. The illustrative embodiments of the present invention and their descriptions are used to explain the present invention but are not intended to limit the present invention.

[0028] Example 1

[0029] The red-removing composition is prepared from the following components in weight percentage: 3% inositol, 3% saffron extract, 1% aescin, 5% butanediol, 3% pentanediol, 0.5% hexanediol, and the balance is deionized water, and the sum of the weight percentages of the components is 100%.

[0030] The preparation steps of saffron extract are:

[0031] The saffron petals are dried and crushed, and then passed through a 40-mesh sieve to obtain saffron powder. The saffron powder is added into 10 times the volume of 80% ethanol aqueous solution and refluxed for extraction for 2 hours to obtain an extract. The extract is filtered and the filtrate is collected to obtain an alcohol extract. The alcohol extract is decompressed to recover ethanol until there is no alcohol taste, and the concentration is continued until the total flavonoid content is higher than 0.3 g / L to obtain a saffron extract.

[0032] The preparation steps of aescin are:

[0033] The horse chestnut seeds are dried and crushed, and then passed through an 80-mesh sieve to obtain horse chestnut seed powder, the horse chestnut seed powder is added into 10 times the volume of 80% ethanol aqueous solution, and refluxed for extraction for 2 hours to obtain an extract, the extract is filtered and the filtrate is collected to obtain an alcohol extract, the alcohol extract is concentrated under reduced pressure to remove ethanol, and vacuum dried at 60°C to constant weight to obtain aescin extract.

[0034] The preparation method of Example 1 comprises the following steps:

[0035] Weigh each component by weight, add deionized water, butanediol, pentanediol and inositol into the water phase pot, heat to 80°C and stir at 30rpm for 20min, cool to 40°C, add saffron extract, aescin and hexylene glycol into the water phase pot, stir at 30rpm until mixed evenly to obtain the red-removing composition.

[0036] Example 2

[0037] The red-removing composition is prepared from the following components in percentage by weight: 3% inositol, 0.1% saffron extract, 1% aescin, 5% butanediol, 3% pentanediol, 0.5% hexanediol, and the balance is deionized water, and the sum of the percentages by weight of the various components is 100%.

[0038] The preparation steps of saffron extract and aescin are the same as those in Example 1.

[0039] The preparation method of Example 2 comprises the following steps:

[0040] Weigh each component by weight, add deionized water, butanediol, pentanediol and inositol into the water phase pot, heat to 80°C and stir at 30rpm for 20min, cool to 40°C, add saffron extract, aescin and hexylene glycol into the water phase pot, stir at 30rpm until mixed evenly to obtain the red-removing composition.

[0041] Example 3

[0042] The red-removing composition is prepared from the following components in weight percentage: 3% inositol, 1.5% saffron extract, 0.1% aescin, 5% butanediol, 3% pentanediol, 0.5% hexanediol, and the balance is deionized water, and the sum of the weight percentages of the components is 100%.

[0043] The preparation steps of saffron extract and aescin are the same as those in Example 1.

[0044] The preparation method of Example 3 comprises the following steps:

[0045] Weigh each component by weight, add deionized water, butanediol, pentanediol and inositol into the water phase pot, heat to 80°C and stir at 30rpm for 20min, cool to 40°C, add saffron extract, aescin and hexylene glycol into the water phase pot, stir at 30rpm until mixed evenly to obtain the red-removing composition.

[0046] Comparative Example 1

[0047] The difference between Comparative Example 1 and Example 1 is that the components do not include saffron extract and aescin.

[0048] Comparative Example 2

[0049] The difference between Comparative Example 2 and Example 1 is that inositol is not included in the components.

[0050] Comparative Example 3

[0051] The difference between Comparative Example 2 and Example 1 is that the components do not include inositol, saffron extract, and aescin.

[0052] Experimental example: efficacy test

[0053] (1) Preparation before testing:

[0054] Selection of subjects: 120 men and women with sensitive skin, aged 20-45 years old, were selected and randomly divided into 6 groups. 20 people in each group tried Examples 1-3 and Comparative Examples 1-3 for 30 minutes, and the degree of facial redness was observed.

[0055] (2) Experimental instruments and materials:

[0056] German CK company Mexameter MX18 (skin melanin and hemoglobin tester)

[0057] USA Company, VISIA-7 (Facial High Definition Imager)

[0058] (3) Experimental method: After washing the face, the subjects rested for 30 minutes in a constant temperature and humidity chamber (ambient temperature of 21±1°C, relative humidity of 45±5%), and used the facial high-definition imager VISIA-7 to collect images of the face, obtain the initial score of the facial red area, and measure the initial hemoglobin value E of the subjects. The test samples were distributed and the product usage was informed. The subjects were followed up after using the product in the constant temperature and humidity chamber for 30 minutes, and the hemoglobin value E of the subjects after using the product was measured. The facial high-definition imager VISIA-7 was used to collect images of the face to obtain the facial redness discrimination value after using the product. The rapid redness fading effect of the product was determined by comparing the facial redness discrimination value and the degree of reduction of the hemoglobin value E 30 minutes before and after use, and all data were statistically analyzed. The test results are shown in Table 1.

[0059] The efficacy judgment criteria are as follows:

[0060] Rapid redness fading: facial redness discrimination value decreases by more than 10%; hemoglobin value E decreases by more than 10%;

[0061] General speed redness fading: facial redness discrimination value decreased by more than 5%; hemoglobin value E decreased by more than 5%;

[0062] Ineffective: The redness discrimination value of the face decreased by less than 5%; the hemoglobin value E decreased by less than 5%.

[0063] Table 1 Efficacy test results

[0064]

[0065]

[0066] As can be seen from Table 1, Example 1 is the best example. Compared with Comparative Examples 1-3, Examples 1-3 have a rapid redness-removing effect on sensitive groups with reddened skin. The reason may be that inositol in the redness-removing composition of the present invention acts as a natural penetration-promoting factor, which enables the redness-removing composition to reach the dermis to exert its effect without causing any burden on the skin. The analgesic and anti-inflammatory effects of saffron extract and its antagonistic effect on TRPV1 pain receptors avoid the continuous expansion of dermal capillaries under the action of inflammatory factors. Aescin can promote blood circulation and maintain the normal physiological function of capillaries. The two natural plant ingredients work synergistically to repair capillaries and quickly achieve facial redness-removing effect, which has good application prospects.

[0067] Example 4

[0068] The red-removing composition is prepared from the following components in weight percentage: 0.1% inositol, 0.01% saffron extract, 0.05% aescin, 0.1% butanediol, 2% pentanediol, 2% hexanediol, and the balance is deionized water, and the sum of the weight percentages of the components is 100%.

[0069] The preparation steps of saffron extract are:

[0070] The saffron petals are dried and crushed, and then passed through a 40-mesh sieve to obtain saffron powder. The saffron powder is added into 8 times the volume of 90% ethanol aqueous solution, and refluxed for extraction for 1 hour to obtain an extract. The extract is filtered and the filtrate is collected to obtain an alcohol extract. The alcohol extract is decompressed to recover ethanol until there is no alcohol taste, and the saffron extract is continuously concentrated until the total flavonoid content is higher than 0.3 g / L to obtain a saffron extract.

[0071] The preparation steps of aescin are:

[0072] The horse chestnut seeds are dried and crushed, and then passed through an 80-mesh sieve to obtain horse chestnut seed powder, the horse chestnut seed powder is added to 8 times the volume of an ethanol aqueous solution with a volume concentration of 90%, and refluxed for extraction for 1 hour to obtain an extract, the extract is filtered and the filtrate is collected to obtain an alcohol extract, the alcohol extract is concentrated under reduced pressure to remove ethanol, and vacuum dried at 60°C to constant weight to obtain aescin extract.

[0073] The preparation method of Example 4 comprises the following steps:

[0074] Weigh each component by weight, add deionized water, butanediol, pentanediol and inositol into the water phase pot, heat to 80°C and stir at 30rpm for 15min, cool to 40°C, add saffron extract, aescin and hexylene glycol into the water phase pot, stir at 100rpm until mixed evenly to obtain the red-removing composition.

[0075] Example 5

[0076] The red-removing composition is prepared from the following components in weight percentage: 1% inositol, 1% saffron extract, 0.01% aescin, 2% butanediol, 0.1% pentanediol, 1% hexanediol, and the balance is deionized water, and the sum of the weight percentages of the components is 100%.

[0077] The preparation steps of saffron extract are:

[0078] The saffron petals are dried and crushed, and then passed through a 40-mesh sieve to obtain saffron powder. The saffron powder is added into 12 times the volume of 70% ethanol aqueous solution and refluxed for extraction for 3 hours to obtain an extract. The extract is filtered and the filtrate is collected to obtain an alcohol extract. The alcohol extract is decompressed to recover ethanol until there is no alcohol taste, and the concentration is continued until the total flavonoid content is higher than 0.3 g / L to obtain a saffron extract.

[0079] The preparation steps of aescin are:

[0080] The horse chestnut seeds are dried and crushed, and then passed through an 80-mesh sieve to obtain horse chestnut seed powder, the horse chestnut seed powder is added into 12 times the volume of 70% ethanol aqueous solution, and refluxed for extraction for 3 hours to obtain an extract, the extract is filtered and the filtrate is collected to obtain an alcohol extract, the alcohol extract is concentrated under reduced pressure to remove ethanol, and vacuum dried at 60°C to constant weight to obtain aescin extract.

[0081] The preparation method of Example 5 comprises the following steps:

[0082] Weigh each component by weight, add deionized water, butanediol, pentanediol and inositol into the water phase pot, heat to 80°C and stir at 30rpm for 25min, cool to 40°C, add saffron extract, aescin and hexylene glycol into the water phase pot, stir at 30rpm until mixed evenly to obtain the red-removing composition.

[0083] Example 6

[0084] The red-removing composition is prepared from the following components in weight percentage: 2% inositol, 2% saffron extract, 1% aescin, 4% butanediol, 1% pentanediol, 0.1% hexanediol, and the balance is deionized water, and the sum of the weight percentages of the components is 100%.

[0085] The preparation steps of saffron extract are:

[0086] The saffron petals are dried and crushed, and then passed through a 40-mesh sieve to obtain saffron powder. The saffron powder is added into 9 times the volume of 85% ethanol aqueous solution and refluxed for extraction for 2.5 hours to obtain an extract. The extract is filtered and the filtrate is collected to obtain an alcohol extract. The alcohol extract is decompressed to recover ethanol until there is no alcohol taste, and the concentration is continued until the total flavonoid content is higher than 0.3 g / L to obtain a saffron extract.

[0087] The preparation steps of aescin are:

[0088] The horse chestnut seeds are dried and crushed, and then passed through an 80-mesh sieve to obtain horse chestnut seed powder. The horse chestnut seed powder is added into 9 times the volume of 85% ethanol aqueous solution, and refluxed for extraction for 2.5 hours to obtain an extract. The extract is filtered and the filtrate is collected to obtain an alcohol extract. The alcohol extract is concentrated under reduced pressure to remove ethanol, and vacuum dried at 60°C to constant weight to obtain a horse chestnut saponin extract.

[0089] The preparation method of Example 6 comprises the following steps:

[0090] Weigh each component by weight, add deionized water, butanediol, pentanediol and inositol into the water phase pot, heat to 80°C and stir at 30rpm for 20min, cool to 40°C, add saffron extract, aescin and hexylene glycol into the water phase pot, stir at 50rpm until mixed evenly to obtain the red-removing composition.

[0091] The above embodiments are merely illustrative of the principles and effects of the present invention, and are not intended to limit the present invention. Anyone familiar with the art may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by a person of ordinary skill in the art without departing from the spirit and technical concept disclosed by the present invention shall still be covered by the claims of the present invention.

Claims

1. A red-fading composition, characterized in that: The invention is prepared from the following components in percentage by weight: 0.1-3% inositol, 0.01-3% saffron extract, 0.01-1% aescin, 0.1-5% butanediol, 0.1-3% pentanediol, 0.1-2% hexanediol, and the balance is deionized water, and the sum of the percentages by weight of the components is 100%.

2. A redness-removing composition according to claim 1, characterized in that: The invention is prepared from the following components in weight percentage: 0.2-1% inositol, 0.02-1% saffron extract, 0.02-0.5% aescin, 0.1-5% butanediol, 0.1-3% pentanediol, 0.1-2% hexanediol, and the balance is deionized water, and the sum of the weight percentages of the components is 100%.

3. A red-removing composition according to claim 1, characterized in that: The preparation steps of the saffron extract are: The saffron petals are dried and crushed, and then passed through a 40-mesh sieve to obtain saffron powder, the saffron powder is added into 8-12 times the volume of an ethanol aqueous solution with a volume concentration of 70-90%, and refluxed for extraction for 1-3 hours to obtain an extract, the extract is filtered and the filtrate is collected to obtain an alcohol extract, the alcohol extract is decompressed to recover ethanol until there is no alcohol taste, and the total flavonoid content is continued to be higher than 0.3 g / L to obtain a saffron extract.

4. A red-removing composition according to claim 1, characterized in that: The preparation steps of the aescin are: The horse chestnut seeds are dried and crushed, and then passed through an 80-mesh sieve to obtain horse chestnut seed powder, the horse chestnut seed powder is added into 8-12 times the volume of an ethanol aqueous solution with a volume concentration of 70-90%, and refluxed for extraction for 1-3 hours to obtain an extract, the extract is filtered and the filtrate is collected to obtain an alcohol extract, the alcohol extract is concentrated under reduced pressure to remove ethanol, and vacuum dried at 60° C. to constant weight to obtain aescin extract.

5. The method for preparing a red-fading composition according to any one of claims 1 to 4, characterized in that: The following steps are involved: Weigh each component by weight, add deionized water, butanediol, pentanediol and inositol into the water phase pot, heat to 80°C and stir for 15-25 minutes, cool to 40°C, add saffron extract, aescin and hexylene glycol into the water phase pot, stir until mixed evenly to obtain the red-removing composition.

6. The method for preparing a red-fading composition according to claim 5, characterized in that: The stirring speed is 30-100 rpm.

7. Use of the redness-removing composition according to any one of claims 1 to 6 in cosmetics.

8. The use according to claim 7, characterized in that: The cosmetic is used to reduce redness.

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