Formula of puncture opening seepage-proofing traditional Chinese medicine smearing ointment as well as preparation method and use method of puncture opening seepage-proofing traditional Chinese medicine smearing ointment

Abstract

The invention discloses a formula of a puncture opening seepage-proofing traditional Chinese medicine smearing ointment as well as a preparation method and a use method of the puncture opening seepage-proofing traditional Chinese medicine smearing ointment. The puncture opening seepage-proofing liquid traditional Chinese medicine smearing ointment is prepared from the following components in parts by mass: 30 to 60 parts of honeysuckle flower, 15 to 30 parts of herba portulacae, 30 to 60 parts of radix astragali preparata, 30 to 60 parts of pericarpium arecae, 30 to 60 parts of herba speranskiae tuberculatae, 15 to 30 parts of rhizoma bletillae, 10 to 20 parts of carbonized hair and 30 to 60 parts of pericarpium zanthoxyli. The medicinal materials and water are mixed and decocted into thick decoction, the thick decoction is cooled into ointment, and the ointment is smeared on the periphery of a puncture opening for use. After clinical specific use, the first-pass effect generated by oral administration of the medicine can be reduced, the medicine can be in direct contact with a wound, the local blood concentration of a lesion is improved, the medicine can quickly act on the lesion part, and the anti-inflammatory and sterilization effects are directly achieved, so that the treatment effect on wound edema and seepage is better improved.

Description

Technical Field

[0001] The invention relates to the technical field of medicament preparation, and in particular to a formula of a puncture-stoma anti-seepage Chinese medicine smear ointment and a preparation and use method thereof. Background Art

[0002] Ointments in traditional Chinese medicine external treatment are one of a set of unique and effective treatment methods summarized by our ancestors in the fight against diseases for thousands of years.

[0003] In recent years, with the continuous expansion of minimally invasive diagnosis and treatment technology in clinical practice, the incidence of redness, swelling and exudation of puncture sites such as deep vein catheterization and serosal cavity puncture catheterization drainage has continued to increase for patients with extremely poor nutritional status due to diseases or patients with advanced malignant tumors combined with malignant pleural effusion and malignant pericardial effusion. However, there is currently no specific and widely recognized formula and its preparation and use method for improving the above situation. In clinical work, combined with the unique advantages of ethnic medicine in Yunnan Province, we selected a specific Chinese medicine formula to make an ointment and apply it to the local wound of the patient, and found that it can promote local wound healing and reduce local redness, swelling or exudation.

[0004] The puncture wound anti-seepage liquid Chinese medicine smear ointment involved in the present invention has potential application value in the medical field, especially in promoting wound healing and reducing infection risks.

[0005] Therefore, in order to solve the above problems, this paper proposes a formula of a puncture port anti-seepage liquid Chinese medicine smear ointment and its preparation and use method. Summary of the invention

[0006] The purpose of the present invention is to provide a formula of a "puncture site anti-seepage liquid Chinese medicine smear ointment" which has the effects of detoxification, moisture removal, hemostasis, tissue regeneration, wound healing, and can reduce wound infection and exudation.

[0007] In order to achieve the above-mentioned technical effect, the present invention is realized through the following technical scheme: a formula of a puncture port anti-seepage liquid Chinese medicine smear ointment, characterized in that, by mass, it includes the following components: 30-60 parts of honeysuckle, 15-30 parts of goldenseal vine, 30-60 parts of roasted astragalus, 30-60 parts of tangerine peel, 30-60 parts of radix polyphyllae, 15-30 parts of bletilla striata, 10-20 parts of charcoal from blood stasis, and 30-60 parts of Sichuan pepper.

[0008] Furthermore, the following components are included, by mass: 30 parts of honeysuckle, 15 parts of Cynanchum wilfordii, 30 parts of roasted astragalus, 30 parts of tangerine peel, 30 parts of radix polygoni lobatae, 15 parts of bletilla striata, 10 parts of charcoal from blood stasis and 30 parts of Zanthoxylum bungeanum.

[0009] Another object of the present invention is to provide a method for preparing a puncture-stoma anti-seepage liquid Chinese medicine smear ointment, characterized in that it comprises the following steps:

[0010] S1. Weigh all the above Chinese medicines by mass and soak them in clean water for 60 to 90 minutes;

[0011] S2, placing the soaked Chinese medicine in a decoction pot, decocting it on medium-high heat until boiling, then turning to low heat to keep boiling, decocting for 45 to 60 minutes, filtering with gauze and pouring out the medicine liquid, and placing it at room temperature to obtain the first medicine liquid for standby use;

[0012] S3, add 600-800 ml of water to the decoction pot again, decoct again for 30-40 min in the same way, filter with gauze and pour out the medicine liquid, put it at room temperature, and obtain the second medicine liquid for standby use;

[0013] S4, mixing the first liquid and the second liquid and stirring them evenly to obtain a mixed liquid for standby use;

[0014] S5. Finally, the mixed medicinal liquid is placed in a constant temperature water bath at 40-60° C. to decoct the medicinal liquid into 110-150 ml of a viscous liquid, and then the medicinal liquid is placed in a storage bottle, cooled at room temperature to form an ointment, and sealed and stored at room temperature; the puncture-port anti-seepage liquid Chinese medicine smear ointment is obtained.

[0015] Another object of the present invention is to provide a method for using a puncture-stoma anti-seepage Chinese medicine ointment, which is characterized in that the ointment is applied around the puncture site for use; the ointment is applied 2 to 4 times a day, or used as prescribed by a doctor.

[0016] The beneficial effects of the present invention are:

[0017] Among the eight herbs in the formula of the puncture port anti-seepage Chinese medicine smear ointment of the present invention, honeysuckle and radix schizonepetae are monarch herbs, astragalus and cortex cyrtonemae are ministerial herbs, herba scutellariae, bletilla striata and charcoal are adjuvant herbs, and Zanthoxylum bungeanum is a guiding herb. The herbs cooperate with each other to achieve the effects of detoxification, infiltration of dampness, hemostasis, tissue regeneration and wound healing, and promotion of wound healing. Meanwhile, the present invention can reduce the first-pass effect of oral administration of the drug, enable the drug to directly contact the wound, increase the local blood drug concentration of the lesion, quickly act on the lesion site, and directly play the role of anti-inflammatory and bactericidal, thereby better improving the therapeutic effect on wound edema and exudation. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for describing the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0019] Figure 1 The present invention is a flow chart of the preparation of the puncture port anti-seepage liquid Chinese medicine smear ointment. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] Example 1

[0022] See also Figure 1 As shown, a preparation process of a puncture port anti-seepage liquid Chinese medicine smear ointment;

[0023] Step 1, material preparation: weigh 30 parts of honeysuckle, 15 parts of golden vine, 30 parts of roasted astragalus, 30 parts of tangerine peel, 30 parts of radix schizonepetae, 15 parts of bletilla striata, 10 parts of charcoal and 30 parts of Sichuan pepper according to mass; prepare equipment (decoction pot or decoction pot), clean water (purified water);

[0024] Step 2, preparation of the drug: soak 30 parts of honeysuckle, 15 parts of golden vine, 30 parts of roasted astragalus, 30 parts of dried tangerine peel, 30 parts of radix schizonepetae, 15 parts of bletilla striata, 10 parts of charcoal and 30 parts of Sichuan pepper in clean water for 70 minutes;

[0025] Step 3, placing the soaked Chinese medicine in a decoction pot, decocting over medium-high heat until boiling, then turning to low heat and keeping boiling for 50 minutes, filtering with gauze and pouring out the medicine liquid, and placing it at room temperature to obtain the first medicine liquid for standby use;

[0026] Step 4: add 700 ml of water to the decoction pot again, boil again for 35 min, filter with gauze and pour out the medicinal solution, place at room temperature to obtain the second medicinal solution for standby use;

[0027] Step 5: Mix the first liquid medicine and the second liquid medicine and stir them evenly to obtain a mixed liquid medicine for later use;

[0028] Step 6. Finally, place the mixed medicinal liquid in a constant temperature water bath at 50°C and boil it into a viscous liquid of about 120 ml. Then place the medicinal liquid in a storage bottle and seal it for storage. Store it in a room temperature environment for use. The puncture-proof liquid Chinese medicine smear ointment is thus obtained.

[0029] The puncture-stoma seepage-proof Chinese medicine ointment prepared by the above steps is applied by smearing, specifically by dipping a cotton swab in the ointment and then smearing the ointment around the puncture stoma 2 to 4 times a day, or by following a doctor's advice.

[0030] Example 2

[0031] This embodiment describes the situation of a specific patient after using the puncture port anti-seepage liquid Chinese medicine ointment, as follows:

[0032] Step 1: Diagnose the patient as follows:

[0033] Patient Yang Moufeng, female, 58 years old, was admitted to the hospital on August 27, 2024 due to advanced rectal malignant tumor combined with malignant ascites. The preoperative diagnosis was: 1. Advanced rectal malignant tumor combined with malignant ascites (large amount); 2. Large amount of fluid in the left chest cavity; 3. Severe malnutrition with weight loss. After admission, the electrocardiogram, blood routine and other related examinations were completed. There were no contraindications to surgery. On August 30, 2024, ultrasound-guided abdominal puncture and catheter drainage (anti-McBurney's point) and left chest puncture and catheter drainage (9th intercostal space of the inferior angle of the scapula) were performed under local anesthesia. The operation was successful and the postoperative diagnosis was: 1. Advanced rectal malignant tumor combined with malignant ascites (large amount); 2. Large amount of fluid in the left chest cavity; 3. Severe malnutrition with weight loss. After the operation, the patient returned to the ward safely, and symptomatic treatment such as fluid support was given, blood pressure was monitored, wound exudation was carefully observed, and pain at the puncture point was closely observed. If necessary, analgesia and other treatments were given.

[0034] Step 2: Treatment and recovery, as follows:

[0035] On the first day after surgery, the patient complained of local redness, swelling, and exudation at the abdominal and left thoracotomy puncture sites, moist dressings, no local chronic pain, good diet and sleep, normal bowel movements, and dressing changes showed unobstructed drainage of abdominal and thoracotomy puncture tubes, and redness, swelling, and exudation at the edges of the puncture wounds;

[0036] The medical staff prescribed the following treatment drugs: 30 portions of honeysuckle, 15 portions of golden vine, 30 portions of roasted astragalus, 30 portions of tangerine peel, 30 portions of radix polyphyllae, 15 portions of bletilla striata, 10 portions of charcoal from blood stasis, and 30 portions of Sichuan pepper; 3 doses, for external use.

[0037] Medical personnel will use the following steps to apply the "puncture site anti-seepage Chinese medicine ointment". The ointment is applied by dipping a cotton swab in the ointment and then applying it around the puncture site. This should be done 2 to 4 times a day.

[0038] The steps for preparing the "puncture site anti-seepage liquid Chinese medicine smear ointment" are as follows:

[0039] (1) Soak 30 parts of honeysuckle, 15 parts of golden vine, 30 parts of roasted astragalus, 30 parts of dried tangerine peel, 30 parts of radix polygoni lobatae, 15 parts of bletilla striata, 10 parts of charcoal from blood stasis, and 30 parts of Zanthoxylum bungeanum in clean water for 70 minutes;

[0040] (2) placing the soaked Chinese medicine in a decoction pot, decocting over medium-high heat until boiling, then decocting over low heat and keeping boiling for 50 minutes, filtering with gauze and pouring out the medicinal solution, and placing it at room temperature to obtain a first medicinal solution for later use;

[0041] (3) Add 700 ml of water to the decoction pot again, and boil again for 35 min. Filter through gauze and pour out the medicinal solution. Place at room temperature to obtain the second medicinal solution for later use.

[0042] (4) mixing the first liquid and the second liquid and stirring them evenly to obtain a mixed liquid for later use;

[0043] (5) Finally, the mixed medicinal liquid is placed in a constant temperature water bath at 50° C. to decoct the medicinal liquid into a viscous liquid of about 120 ml, and then the medicinal liquid is placed in a storage bottle and sealed for storage, and stored in a room temperature environment for use; thus, the puncture-proof liquid Chinese medicine smear ointment is obtained.

[0044] On the second day after the operation, the patient reported that the local redness and swelling of the left lower abdomen and left thoracotomy wounds had been alleviated, with a small amount of exudation, and the moisture of the dressings was improved compared with before; the vital signs were stable, the diet and sleep were good, and the bowel movements were normal. When changing the dressing, the local edges of the left lower abdomen and left thoracotomy wounds were slightly red and swollen, with a small amount of exudation; the ointment was continuously applied around the puncture site as prescribed by the doctor, 2 to 4 times a day;

[0045] On the third day after the operation, the patient's local redness and swelling of the left lower abdomen and left thoracotomy wounds were significantly reduced, with very little exudation, and the dressing was basically dry; the patient was generally in good condition, with stable vital signs, and reported that the local redness and swelling of the left lower abdomen and left thoracotomy wounds were significantly reduced, with very little exudation, stable vital signs, good diet and sleep, and dressing changes showed that the redness and swelling of the edges of the left lower abdomen and left thoracotomy wounds had basically subsided, with very little exudate visible; the ointment was continuously applied around the puncture site as prescribed by the doctor, 2 to 4 times a day;

[0046] On the 5th day after the operation, the patient reported that the local redness and swelling of the left lower abdomen and left thoracotomy wound had completely subsided, there was no exudation, and the dressing was dry; the patient's vital signs were stable, his diet and sleep were good, and his bowel movements were normal. When changing the dressing, no edema or exudation was found at the edge of the left lower abdomen and left thoracotomy wound; the ointment application was stopped as ordered by the doctor;

[0047] From the above, it can be seen that the patient in this case is in the late stage of malignant tumor, with extremely poor nutritional status and low immune function. The wound is prone to redness, swelling, exudation, and even local infection. The use of the puncture site anti-seepage Chinese medicine smear ointment described in the present invention can alleviate the patient's wound edema, exudation, pain and other discomfort symptoms after thoracic and abdominal puncture and catheter drainage surgery, and can prevent wound infection and promote local growth and healing of the wound.

[0048] In summary, the improvement of traditional Chinese medicine symptoms before and after using the puncture site anti-seepage Chinese medicine ointment, observed the changes in wound edema and exudate, and compared the differences before and after treatment. It can be concluded that the puncture site anti-seepage Chinese medicine ointment has a relatively obvious therapeutic effect in the treatment of puncture site edema and exudate, and can further develop to prevent and delay the occurrence of the disease. The effect is definite and its efficacy is obvious.

Claims

1. A formula of a puncture-stoma anti-seepage Chinese medicine smear ointment, characterized in that: The invention comprises the following components by weight: 30-60 parts of roasted astragalus, 30-60 parts of radix polygoni lobatae, 15-30 parts of radix schizonepetae, 15-30 parts of rhizoma bletillae, 30-60 parts of cortex cyrtonemae, 10-20 parts of charcoal from the blood stasis, 30-60 parts of honeysuckle, and 30-60 parts of Zanthoxylum bungeanum.

2. The formula of a puncture-stoma impermeable liquid Chinese medicine smear ointment according to claim 1, characterized in that: The invention comprises the following components by weight: 30-60 parts of honeysuckle, 15-30 parts of golden vine, 30-60 parts of roasted astragalus, 30-60 parts of tangerine peel, 30-60 parts of radix polygoni lobatae, 15-30 parts of bletilla striata, 10-20 parts of charcoal from blood stasis, and 30-60 parts of Zanthoxylum bungeanum.

3. A method for preparing a puncture-stoma anti-seepage Chinese medicine smear ointment, characterized in that: The following steps are involved: S1. Weigh all the Chinese medicines according to the mass fraction in claim 1 or 2, and soak them in clean water for 60 to 90 minutes; S2, placing the soaked Chinese medicine in a decoction pot, decocting it on medium-high heat until boiling, then turning to low heat to keep boiling, decocting for 45 to 60 minutes, filtering with gauze and pouring out the medicine liquid, and placing it at room temperature to obtain the first medicine liquid for standby use; S3, add 600-800 ml of water to the decoction pot again, decoct again for 30-40 min in the same way, filter with gauze and pour out the medicine liquid, put it at room temperature, and obtain the second medicine liquid for standby use; S4, mixing the first liquid and the second liquid and stirring them evenly to obtain a mixed liquid for standby use; S5. Finally, the mixed medicinal liquid is placed in a constant temperature water bath at 40-60° C. to decoct the medicinal liquid into 110-150 ml of a viscous liquid, and then the medicinal liquid is placed in a storage bottle, cooled at room temperature to form an ointment, and sealed and stored at room temperature; the puncture-port anti-seepage liquid Chinese medicine smear ointment is obtained.

4. A method for using a puncture-stoma impermeable liquid Chinese medicine smear ointment, characterized in that: Use by applying the ointment around the puncture site; apply 2 to 4 times a day, or use as directed by your doctor.

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