Markers for breast cancer

a breast cancer and marker technology, applied in the field of breast cancer markers, can solve the problems of not knowing whether such susceptibility alleles are common or rare in the population, and achieve the effect of improving the safety and efficacy of breast cancer treatmen

Inactive Publication Date: 2009-09-24
PERLEGEN SCIENCES INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

Provides robust and precise methods for identifying breast cancer risk and modulating susceptibility, enhancing early detection and diagnosis, and offering targeted treatment options by correlating specific polymorphisms with breast cancer phenotypes.

Problems solved by technology

Secondly, despite extensive efforts over the past nine years, genetic linkage studies have not identified any further linked loci9,10.
Moreover, in the prior art, it is unclear whether such susceptibility alleles are common or rare in the population.

Method used

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  • Markers for breast cancer
  • Markers for breast cancer
  • Markers for breast cancer

Examples

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example 1

Strategies for Identification of Breast Cancer Markers

[0228]Introduction: Identifying Common Genetic Variants

[0229]There are important applications to public health in the identification of breast cancer marker alleles. Where genetic variation is due to many loci, risks to individuals vary widely, depending upon the number of high-risk alleles inherited at susceptibility loci. Our analyses based on the model of Antoniou et al13 suggest that there may be as much as 40-fold difference in risk between the top and bottom 20% of the population. Under the same model, half of all breast cancers occur in the 12% of women at greatest risk, and these women have risks of at least 1 in 8 by age 70. By contrast, the 50% of women at least risk have only 12% of the cancers, and individual risks of less than 1 in 3014. Genes that are identified as being correlated to breast cancer risk can be used for estimation of associated and individual risks. The practical consequences of this risk estimation ...

example 2

Marker Polymorphisms Associated with Breast Cancer Predisposition

[0322]SNPs identified as being associated with breast cancer risk (predisposition) are set forth in FIGS. 1 and 2. FIG. 1 provides the currently most preferred associations; FIG. 2 provides additional associations.

[0323]Sequences for given dbSNP_rsID numbers (see, “REFSNP_ID,” column 2 from the Figures) are found at: http: / / www.ncbi.nlm.nih.gov / SNP / .

In FIGS. 1 and 2, the second column is labeled “REFSNP_ID”. The values in this column are SNP identification numbers according to the dbSNP database established and maintained by NCBI of the US National Library of Medicine at the US National Institute of Health. The NCBI dbSNP database is publicly accessible and considerable additional information can be easily viewed by searching the database using the rsID numbers provided in the Figures by entering the number prefixed by “rs” in the database search window and clicking on “Search.” The information provided can include, bu...

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Abstract

Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a divisional of U.S. application Ser. No. 11 / 606,634, filed Nov. 29, 2006, which claims priority to and benefit of U.S. Provisional Application Ser. No. 60 / 740,971, filed Nov. 29, 2005, and also claims priority to and benefit of U.S. Provisional Application Ser. No. 60 / 781,483, filed Mar. 10, 2006. Each of these prior applications are incorporated herein by reference in their entirety.BACKGROUND OF THE INVENTION[0002]Breast cancer, like other common cancers, shows familial clustering. Numerous epidemiological studies have demonstrated that, overall, the disease is approximately twice as common in first degree relatives of breast cancer patients1. Family studies, and particularly twin studies, suggest that most if not all of this clustering has a genetic basis2,3. For example, Peto and Mack3 estimated that the risk of breast cancer in the MZ twin of an affected woman was approximately four-fold greater than the risk to ...

Claims

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Application Information

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Patent Type & AuthorityApplications(United States)
IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/106C12Q2600/16C12Q2600/156C12Q2600/136C12Q2600/118A61P35/00C12Q1/6827C12M1/34C12P19/34
InventorCOX, DAVIDBALLINGER, DENNISPONDER, BRUCEEASTON, DOUG
OwnerPERLEGEN SCIENCES INC