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Device and method for measuring blood components

a blood component and blood technology, applied in the field of blood component devices and methods, can solve the problems of increasing the risk of infection, inconvenience for patients, and increased risk of infection, and achieve the effects of convenient hand-held use, convenient portability, and simple structur

Pending Publication Date: 2022-05-05
SHANI BIOTECHNOLOGIES LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]The present disclosure is directed to the measurement of hemoglobin concentration using reflectance spectroscopy. The advantages of this technology are a simple, portable, and easy to use hand-held device (as described below) to measure the hemoglobin (Hb) concentration in real time, and a method for continuous (or nearly continuous) non-invasive Hb monitoring. This method also offers an advantage of measuring the ratio of oxy-hemoglobin (O-Hb) concentration to the deoxy-hemoglobin (d-Hb) concentration.

Problems solved by technology

The blood draw can cause discomfort to the patient and increases the risk of infection.
The adverse effects of constant and often difficult blood draws on newborns and infants are even more pronounced.
Although the available invasive techniques are established, they require the presence of medical personnel and laboratory equipment.
These requirements drive up the cost, as well as the amount of time for the results to be available for the clinical use.
However, it still requires obtaining a blood sample from the patient.
There are non-invasive methods, however they suffer from variability and limitations during low perfusion states such as shock, as well as inability to measure hemoglobin values across a broad range.

Method used

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  • Device and method for measuring blood components
  • Device and method for measuring blood components
  • Device and method for measuring blood components

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0078]In this example, a patient enters a clinical setting. The operator then places the probe 2 on a portion of the patient, for example the patient's wrist.

[0079]The one or more sensors 24 detect reflected light, in this example at 525 nm and 545 nm, such that the processor 4 can determine the ratio of both of E1 and E2. The processor 4 makes this determination by determining the ratio of returned light detected by the one or more sensors in comparison to the emitted light from the plurality of LEDs 22, at each wavelength.

[0080]The processor 4 then outputs two ratios (E1) and (E2). The processor 4 can then add those values (E1)+(E2) (or a user can manually add those ratios) to determine a total E value. Next, the VLS scale value is determined in one of two ways.

[0081]The first way is for a user to estimate the value by a visual inspection and assignment of the patient to a score of 1-36 on the VLS scale. Under this first option, the operator can then manually select the correspond...

example 2

[0083]In addition to the total hemoglobin as described above in Example 1, the disclosed device can also measure the ratio of oxy-hemoglobin to deoxy-hemoglobin as well as change in the ratio, as discussed in this example.

[0084]In this example, a patient enters a clinical setting. The operator then places the probe 2 on a portion of the patient, for example the patient's wrists. The total hemoglobin value is then obtained as discussed in Example 1.

[0085]Further, since E1 substantially corresponds to the data collected at the 525 nm wavelength, it is indicative of oxy-hemoglobin concentration, while E2, substantially corresponding to data collected at the 550 nm level (in this example, however, about 545 nm level can also be used for data collection), is indicative of deoxy-hemoglobin concentration. The ratio of E1 to E2 can be determined once, or sequentially to monitor the patient's condition.

[0086]In this example, blood hemoglobin was measured with the disclosed device for a patie...

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Abstract

The present disclosure is directed to a method and device to determine a hemoglobin value of a mammal. The device includes a plurality of light emitting diodes, one or more sensors and a processor.

Description

CROSS REFERENCE TO RELATED APPLICATION[0001]This application is a divisional application of co-pending application Ser. No. 17 / 317,171, filed on May 11, 2021, which claims the benefit of both of U.S. Provisional Patent Application Ser. No. 63 / 052,115 filed on Jul. 15, 2020 and U.S. Provisional Patent Application Ser. No. 63 / 072,504 filed on Aug. 31, 2020, the entire contents of each of which are herein incorporated by reference.BACKGROUND OF THE DISCLOSURE[0002]The measurement and monitoring of blood constituents such as hemoglobin (Hb) and its species such as oxy-hemoglobin (O-Hb) is often an invasive procedure. The blood draw can cause discomfort to the patient and increases the risk of infection. The adverse effects of constant and often difficult blood draws on newborns and infants are even more pronounced. Frequent and constant hemoglobin measurements are clinically indicated in a wide variety of conditions such as (but not limited to) anemia, emergency and critical care includ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/1455A61B5/00A61B5/103
CPCA61B5/14551A61B5/7435A61B5/1032A61B5/748A61B5/443
Inventor GOKHALE, SANJAY
Owner SHANI BIOTECHNOLOGIES LLC