159 results about "Hb - Hemoglobin" patented technology

Method and apparatus for reflected imaging analysis. Reflected imaging is used to perform non-invasive, in vivo analysis of a subject's vascular system. A raw reflected image (110) is normalized with respect to the background to form a corrected reflected image (120). An analysis image (130) is segmented from the corrected reflected image to include a scene of interest for analysis. The method and apparatus can be used to determine such characteristics as the hemoglobin concentration per unit volume of blood, the number of white blood cells per unit volume of blood, a mean cell volume, the number of platelets per unit volume of blood, and the hematocrit. Cross-polarizers can be used to improve visualization of the reflected image.

The present invention relates to a method for detecting blood characteristics including hemoglobin in a fluid medium using both transmission and reflection of a light beam which forms a quotient.

The apparatus for evaluating biological function of the present invention has living body probes 1, a behavioral information measuring part 2 and an apparatus body 3, and it utilizes near-infrared spectroscopy to evaluate biological function; apparatus body 3 has a controller 8 for calculating (based on light information from living body probes 1) a variety of parameters derived from two-dimensional diagrams showing relationships between changes in oxyhemoglobin and changes in deoxyhemoglobin and two-dimensional diagrams showing relationships between absolute amounts of oxyhemoglobin and absolute amounts of deoxyhemoglobin, a behavioral information input part for entering behavioral information measured by means of behavioral information measuring part 12, and a display part 10 for performing various types of image displays based on various parameters calculated by means of controller 8 and / or behavioral information entered in the behavioral information input part.

Methods for measuring the total hemoglobin of whole blood include measuring reflective light at multiple wavelengths within the visible spectrum, calculating light absorbance at each of the multiple wavelengths, performing a comparison in a change in like absorbance between the multiple wavelengths, and / or relating the comparison to total hemoglobin. A system for measuring total hemoglobin of whole blood may include at least one light source, a catheter, optical fibers, at least one photodetector, data processing circuitry, and / or a display unit.

A non-enzymatic electrochemical method of simultaneous measurement of hemoglobin (Hb) and percentage of glycated hemoglobin (% HbA1c) in a blood sample is disclosed. The method includes determining the total amount of hemoglobin in a sample by electrochemically measuring the voltammetric current due to iron (II) and iron (III) redox portions in hemoglobin and determining the percentage of glycated hemoglobin (HbA1c) by potentiometry. Also disclosed is a novel screen-printed electrode (SPE) strip modified for potentiometric measurement of HbA1c.

Systems, methods, and related computer program products for non-invasive NIR spectrophotometric (NIRS) monitoring of total blood hemoglobin levels and / or other blood constituent levels based on a hybrid combination of phase modulation spectrophotometry (PMS) and continuous wave spectrophotometry (CWS) are described. PMS-based measurements including both amplitude and phase information used in the determination of a non-pulsatile component of an absorption property for each of at least three distinct wavelengths are processed to compute PMS-derived intermediate information at least partially representative of a scattering characteristic. CWS-based measurements including amplitude information is processed in conjunction with the PMS-derived intermediate information to compute a pulsatile component of the absorption property. A metric representative of at least one chromophore level, such as the total blood hemoglobin level, is computed from the pulsatile component of the absorption property at the at least three wavelengths and displayed on an output display.

A system, method and computer program product is provided for analyzing spectral images of a micrcirculatory system to measure the volume and concentration of a blood vessel. The images are analyzed to identify vessel structure, measure the light absorption and develop a contrast gradient plus (KGP) estimate. The KGP estimate is used to predict blood characteristics, such as hemoglobin concentration and hematocrit. The KGP is estimated in three distinct phases. First, the images are screened to measure a mean image intensity and motion blur. Second, each image is analyzed to identify background curvate, and create vessel, background and diameter masks. To identify background curvate, the images are analyzed to detect shadows caused by larger blood vessels in the background image. The diameter and area of the vessels are also calculated. During the Prediction and Calibration phase, the images are screened to eliminate all images failing thresholds for mean intensity, motion blur, background curvature and area-to-perimeter ratio. Finally, the KGP estimate is determined from the selected images.

A method of measuring a hemoglobin parameter of a test sample of blood comprises diluting and lysing a test sample. Then, a temperature corresponding to the test sample is obtained. The diluted and lysed test sample is then delivered to a cuvette, and a spectrophotometer determines the absorbance and / or transmittance of the sample in the cuvette. With the absorbance and / or transmittance of the test sample, a first measurement of the hemoglobin parameter of the test sample is obtained. After a first measurement of the hemoglobin parameter is obtained, a processor determines a corrected measurement of the hemoglobin parameter of the test sample. The corrected measurement is a function of the measured temperature that corresponds to the test sample and the first measurement of the hemoglobin parameter. The method of measuring a hemoglobin parameter is valid over a range of test sample temperatures.

The present invention provides devices, methods, and kits for the collection of a solid or semi-solid sample and analysis for the presence, absence, or quantity of an analyte. The invention provides a collection slide having a first card and a second card. The first card has a sample collection area. The first and second cards have orifices allowing the passage of fluid through the sample collection area, and the cards are hingeably connected to each other. The invention also provides an assay device having a housing with a test element, a results window, and a docking area for receiving and engaging the collection slide. In one embodiment the collection slide and device can be used to detect the presence of fecal occult blood (human hemoglobin) in a stool sample. Many other embodiments are described herein.

A fluid flow sensing and bubble detecting apparatus includes a housing comprising a channel configured to receive a tube through which fluid flows; a sensor apparatus disposed within the housing, which includes a first sensor operable to measure flow rate of fluid and to detect bubbles in flowing fluid; and a temperature sensor operable to detect temperature of the flowing fluid; and a processor connected to receive fluid flow rate data obtained by the first sensor, to receive bubble detection data obtained by the first sensor, and to receive fluid temperature data obtained by the temperature sensor, wherein when a tube through which fluid flows is disposed in the channel of the housing, the first sensor measures the flow rate of the flowing fluid and detects bubbles therein, and the temperature sensor measures the temperature of the flowing fluid, and the processor calculates in a short period of time a fluid flow rate corrected for temperature. All sensors are non-invasive and have no direct contact to the fluid in the tube, which might be blood. In accordance with additional embodiments, the fluid flow rate is additionally corrected for hemoglobin or hematocrit, and the effect of oxygen saturation on the hemoglobin or hematocrit data.

A system of measuring hemoglobin and bilirubin parameters in a whole blood sample using optical absorbance. The system includes an optical-sample module, a spectrometer module, an optical fiber module optically connecting the optical-sample module to the spectrometer module, and a processor module. The optical-sample module has a light-emitting module having a LED light source, a cuvette and a calibrating-light module. The processor module receives and processes an electrical signal from the spectrometer module and transforms the electrical signal into an output signal useable for displaying and reporting hemoglobin parameter values and / or total bilirubin parameter values for the whole blood sample.

Methods and systems for analyzing ratios of analytes within a flowing sample are provided. The flowing sample can be processed in real-time to determine a time interval over which a predetermined amount of a group of analytes passes by a fixed point in a flow cell. The predetermined amount can be routed to a sample container for future processing. The sample can comprise diluted blood and the analytes can comprise a component of hemoglobin, such as A1c, and the total amount of hemoglobin, of which the predetermined amount is metered.

The present invention relates to a method for non-invasive local quantification of angiogenesis or destruction of existing blood vessels in living tissue, the use of the said method for local measurements of hemoglobin concentration and blood perfusion at the same location on the subject and an apparatus for carrying out the method according to the invention. The apparatus comprises a xenon flash unit, an optical filter and a Y-shaped optical fiber-bundle, one branch of the fiber-bundle being coupled to the flash unit and the other branch of the fiber-bundle being coupled to a detection unit and the merged part of the fiber-bundle being adapted to couple the apparatus to the tissue to be tested.

A system comprised of a device for measuring hemoglobin content and / or determining a hematocrit value and / or measuring a hematocrit value, and a device for measuring or detecting an analyte, and a method for measuring or determining the presence of at least one analyte are described.

The invention belongs to the technical field of preparation of platelet rich plasma, and in particular discloses a method for preparing PRP (Platelet Rich Plasma) through a manual two-step centrifugation method. The method comprises the following steps: centrifuging 25 ml of whole blood mixed with an anticoagulant for 6 minutes at centrifugal force of 800 g for the first time by adopting the two-step centrifugation method, absorbing plasma on the upper layer and on boundary layer in the layered whole blood, and arranging the plasma in an another centrifugal tube; centrifuging for the second time, namely centrifuging for 5 minutes at centrifugal force of 1400 g, and absorbing about 4 ml of the layered plasma on the middle layer to obtain the platelet rich plasma. According to the PRP prepared by the technology, the platelet concentration is 886.33*10<9> / L, the mean corpuscular hemoglobin in the PRP is 27.72 g / L, and the clinical treatment requirements are met.

The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.

An apparatus and method for directly determining the hemoglobin content (CH) of individual sphered red blood cells and for directly determining the width of the cell hemoglobin distribution of a red blood cell sample. Such apparatus and method monitors the light reflected by individual sphered cells as they are made to pass through an optical flow cell while being irradiated by a suitable source of radiation.

The preparation method for hemoglobin chip comprises: 1) preparing the print carbon electrode; 2) preparing and modifying the Prussian blue nano particle; 3) evaporating and drying the particle to dissolve into 0.1M phosphate buffer solution with pH value as 7.0 and spraying on the electrode surface, drying in icebox for standby. Besides, the electrochemical detection method comprises: 1) optimizing the test condition: a) preparing standard solution; b) selecting detection potential; c) setting pH value for the buffer solution; 2) plotting the normal curve; 3) correcting the curve. This invention is simple and fast with low cost.

A method for functional magnetic resonance imaging (fMRI) uses steady-state free precession (SSFP) to image changes in blood oxygenation between two time periods. A center frequency of the SSFP sequence is placed between the different resonant frequencies for oxyhemoglobin and deoxyhemoglobin whereby the signals have a phase difference of 180° and tend to cancel. By repeating the SSFP imaging sequence at different times, the difference in the measured signals provides a measure of change in oxyhemoglobin. RF flip angle of the SSFP sequence is chosen to maximize signal level in the frequency range from that of water in the presence of oxyhemoglobin and that of water in the presence of deoxyhemoglobin.

The device enables measurement of both of blood glucose level and hemoglobin A1c level, being small-sized and thus portable, allowing the measurement of a small amount of a specimen and, being usable in POC. The device comprises: a test-piece-mounting section (1) for detachably mounting test pieces (200) on which the blood specimen is to be spotted; a light-emitting section (2) for emitting light for irradiating the test pieces; a light-receiving section (3) for receiving reflected lights from the test pieces; and an operating section (4) for calculating the blood glucose level and hemoglobin A1c level of the blood specimen on the basis of photometric values obtained from the light-receiving section. For measuring the blood glucose level of the blood specimen, test piece (A) carries a composition reacting with glucose and showing color change. Test piece (B) carries a composition reacting with glycated hemoglobin and showing color change.

The invention relates to a method and device for quickly detecting hemoglobin. Detection results can be given in three seconds. According to the device, the influence of uneven distribution of hemoglobin cells in blood samples can be eliminated through optical modulation, meanwhile, the influence of scattering on the detection results can be well eliminated according to a compensation algorithm, and more prominently, quick detection can be achieved only by using two wave lengths.

The invention provides a multifunctional blood detector. The multifunctional blood detector comprises a central processing unit, a blood collecting bottle energy heating and reagent bottle energy refrigerating stirring arm, a blood detection unit and a remote display device; the central processing unit has properties of an automatic controller and comprises a Bluetooth module, a wireless local area network, an alarming module, a fingerprint confirmation and storage module and a blood collecting needle, blood collecting bottle and reagent bottle holder for storing a blood collecting needle, a blood collecting bottle and a reagent bottle, blood is stirred and mixed to be uniform through the blood collecting bottle energy heating and reagent bottle energy refrigerating stirring arm, the blood detection unit comprises a CRP detection device, a red blood cell counting chamber, a hemoglobin detection device, a laser detection device and a blood reagent strip corresponding item detection position, and the remote display device is used for setting detection items including CRP detection, red cell counting, hemoglobin detection, laser detection and blood reagent strip corresponding item detection.

The invention relates to the technical field of blood sample detection, and discloses a method and a device for detecting sample absorption of a sample analyzer, and the method comprises the followingsteps: a sampling needle enters a wbc pool under the movement of a movement assembly to discharge blood at the head section, and an instrument absorbs a sample; a collection instruction is issued toa hemoglobin concentration detection device, and a current liquid voltage signal AD value in the wbc pool is read; it is judged whether the AD value belongs to a preset range or not; and if the AD value is within the preset range, the detection instrument executes a detection time sequence and outputs a detection result. The instrument cost is not increased; whether an instrument normally sucks asample or not can be detected, judgment can be made in time, the called test time sequence is adjusted, unnecessary actions and reagent consumption are reduced, and the working efficiency is improved.

The invention proposes a large-visual field multi-modal imaging system. The system includes an illumination subsystem, an infinity relay imaging subsystem and a data processing subsystem; and the dataprocessing subsystem is used to calculate a blood flow velocity in an area to be measured according to a speckle signal received by an image sensor, calculate a hemoglobin concentration in the area to be measured according to a reflected light intensity signal received by the image sensor, and calculate a relative oxygen metabolism rate according to registration of the obtained blood flow velocity and hemoglobin concentration. According to the large-visual field multi-modal imaging system provided by embodiments of the invention, the infinity relay imaging subsystem is added, so that a spectroscopic component can be conveniently inserted into the relay subsystem to provide more imaging optical paths, and the system realizes data collection of the blood flow velocity and the hemoglobin concentration without switching light sources and is conducive to real-time, large-visual field multi-modal tissue hemodynamic parameter monitoring.

The invention belongs to the technical field of biochemical detection, and particularly relates to a G-6-PD detection kit free from anemia influences and a detection method thereof. The kit comprisesa sample detection device, hemolytic agent dry powder, hemoglobin test paper, a sample adding colorimetric card, G-6-PD test paper and a detection colorimetric card, wherein the sample detection device comprises a sample adding pipe, a first clamping groove and a second clamping groove. According to the kit and the detection method thereof provided by the invention, the anemia degree of a subjectcan be conveniently determined, the sample adding amount can be rapidly determined, the method is used for screening detection of erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, thesample adding amount can be compensated according to hemoglobin test results, the test method is small in blood consumption and flexible and convenient in test, and meanwhile, the accuracy of the detection results is improved.

The invention relates to a piece of test paper for stool examination. The test paper comprises a base plate, a calprotectin detection part, a lactoferrin detection part, a hemoglobin detection part, atransferring detection part, a vibrio cholera detection part, a pH detection part, and a lactose detection part. A plurality of chambers that are spaced and are not communicated are formed on the base plate. In addition, the invention also relates to a kit for stool examination. The kit includes a stool collection device, a stool transfer device, and a stool extraction buffer solution. The test paper and the kit have advantages of small size, light weight, high portability, and simple usage method. Multiple indicators of a sample can be detected once. The detection speed and sensitivity are high; the price is low. The test paper and the kit can be used in a communication hospital widely, thereby enhancing the capability of preliminary detection of diarrhea in a community hospital.

The invention provides a micro-fluidic chip for detecting glycosylated hemoglobin and a detection method thereof. The micro-fluidic chip is sequentially provided with a cover plate layer, a fluid layer with a hollow channel structure and a substrate layer from top to bottom, and the hollow channel structure and the substrate layer jointly form a sample detection unit. A sample injection through hole and a waste liquid leading-out through hole are respectively formed in the cover plate layer. The sample detection unit comprises one or more sample injection chambers, a dilution chamber, an affinity chromatography channel, a detection chamber and a waste liquid pool. The sample injection through hole is communicated with the sample injection chamber, and the waste liquid leading-out through hole is communicated with the waste liquid pool. Sample introduction, sample dilution and optical and electrical detection are integrated through the micro-fluidic chip; the operation process is greatly simplified, the consumption of samples and reagents is reduced, expensive equipment is not needed, the use cost is largely reduced, the on-site instant detection of glycosylated hemoglobin can be realized, and huge economic value and social value are created.

A system for detecting deception is provided. The system comprises a camera, an image processing unit, and a notification device. The camera is configured to capture an image sequence of a person of interest. The image processing unit is trained to determine a set of bit planes of a plurality of images in the captured image sequence that represent the hemoglobin concentration (HC) changes of the person, and to detect the person's invisible emotional states based on HC changes. The image processing unit is trained using a training set comprising a set of subjects for which emotional state is known. The notification device provides a notification of at least one of the person's detected invisible emotional states.