154 results about "Hb - Hemoglobin" patented technology

The invention provides a transcranial deep electrical stimulation closed-loop regulation and control system and method based on fNIRS dynamic guidance. The method comprises the steps that a transcranial alternating current electrical stimulation module applies an electrical signal to a target deep brain region according to preset parameters to carry out electrical stimulation regulation and control; the synchronous triggering module is used for realizing millisecond-level synchronization of a stimulation task and near-infrared brain function data acquisition; the brain function monitoring module analyzes the concentration change of cortex oxyhemoglobin in real time through the multi-channel head cap; the electrical stimulation-response coupling mapping module positions a significant activation channel by adopting statistical test, and establishes an oxyhemoglobin concentration variable and electrical stimulation current amplitude quantitative model; and the dynamic parameter adjusting module optimizes the output current in real time. Personalized closed-loop regulation and control of non-invasive deep brain stimulation can be achieved, cerebral cortex blood oxygen signals are monitored in real time through near-infrared brain function imaging, stimulation parameters are dynamically adjusted, and the accuracy and individualization level of deep brain stimulation are remarkably improved.

The invention relates to methods, devices, and software for distinguishing hemoglobin (Hb) from myoglobin (Mb) in urine samples using peroxidase-reactive test strips. A time-resolved video of the color change on the test pad is recorded, and hue values are extracted and analyzed over time. Diagnostic differentiation between Hb and Mb is achieved by evaluating the hue-time curve, in particular via endpoint hue values and the ratio of integrated hue values in distinct time intervals. The invention further comprises a standardized optical setup for recording, a software-based evaluation algorithm, and a refillable cartridge for in-situ urine analysis devices containing appropriate test fields. The invention enables combined testing with additional urine parameters and is suitable for medical and non-clinical applications such as sport and home diagnostics.

The invention relates to the technical field of medical detection, in particular to a microneedle array-containing S100A9 sample sampling and detecting device which comprises a base, a limiting column and a color developing assembly, the limiting column is fixedly connected to the top end of the base, and a working sliding groove for inserting the color developing assembly is formed between the limiting column and the base; a sampling groove is formed in the top end of the base, the inner bottom wall of the sampling groove is fixedly connected with a microneedle assembly used for puncturing the skin of a patient for sampling, and the top of the microneedle assembly communicates with a pretreatment assembly used for filtering an extracted sample; driving force is provided for the pretreatment assembly in the process that the color developing assembly is inserted into the working sliding groove, and the filtered sample is input into the color developing assembly to be detected. According to the invention, convenient sampling is realized through the microneedle assembly, and a sample is pertinently filtered by using the pretreatment assembly, so that macromolecular interference impurities such as cell debris and hemoglobin are effectively removed, the interference on S100A9 detection is reduced, and the accuracy and reliability of S100A9 detection are improved.

The invention relates to a continuous noninvasive physiological parameter detection method and device, and belongs to the technical field of physiological parameter detection. According to the method, on the basis of photoelectric volume pulse wave detection data under multiple wavelengths, absorbance related characteristic parameters and pulse wave related characteristic parameters are extracted, a hemoglobin concentration detection result is obtained through calculation of a hemoglobin concentration calculation model, and the absorbance related characteristic parameters comprise the adjacent surface difference, the relative difference, the adjacent surface ratio, the relative ratio and the progressive surface ratio. Extracting based on a normalized absorbance fluctuation amplitude curve; the pulse wave characteristic parameters comprise rising branch maximum slope, rising time, falling time, dicrotic wave slope, dicrotic amplitude ratio, rising branch time ratio, low-high frequency energy ratio and harmonic component ratio, and extraction is carried out based on normalized pulse waves. The detection device for implementing the method comprises a probe, a data processing circuit and the like. The accuracy of the noninvasive hemoglobin concentration detection result can be effectively improved.

A method for non-contact oxygen saturation prediction based on a hyperspectral camera, according to one embodiment of the present invention, may comprise the steps of: acquiring a hyperspectral image of a subject by using the hyperspectral camera; measuring the absorbance of at least one face region that is detected in consideration of the correlation with a change in oxygen saturation from among the face regions of the subject from the hyperspectral image; determining at least two optimal wavelength bands from among wavelength bands measured by using the hyperspectral camera in consideration of the absorbance of oxyhemoglobin and the absorbance of deoxyhemoglobin; and predicting the oxygen saturation of the subject on the basis of the absorbance of the at least one face region and the at least two optimal wavelength bands.

The objective of the present invention is to provide a brain water monitoring method and apparatus based on near-infrared spectroscopy, which can non-invasively and accurately measure the brain water activity of brain tissue according to sleep-wakefulness and a sleep structure on the basis of near-infrared spectroscopy without injecting a contrast agent, an aqueous solution, or the like to the human body (intravenously or intrathecally). To achieve the objective, the present invention comprises: a calculation step of calculating the fractions of oxidized hemoglobin, reduced hemoglobin, and water on the basis of signals measured by near-infrared spectroscopy; an extraction step of extracting a pure water fraction from the water fraction calculated in the calculation step; and an output step of outputting the water fraction extracted in the extraction step.

The invention relates to the technical field of spectral component measurement, in particular to a high performance liquid chromatography detection method of glycosylated hemoglobin for a diabetic pregnant woman. According to the method, high performance liquid chromatograms at different temperatures are obtained, the chromatograms are processed through EMD mode decomposition, screening is carried out according to peak value characteristics, and the IMF component of the hemoglobin component is determined. Matching the IMF components of the hemoglobin components at different temperatures, and obtaining the hemoglobin type of each IMF component of the hemoglobin components according to the obtained temperature matching components and the retention time of the middle components. And counting the content of each hemoglobin type at all temperatures to obtain the content of each hemoglobin type in the blood sample. According to the method, errors in detection are eliminated through chromatographic detection and data statistics, and a more accurate detection result of glycosylated hemoglobin of a diabetic pregnant woman is obtained.

The invention provides a palm vein high-security identity authentication system based on spectral analysis and deep learning, and relates to the technical field of biological recognition, the system comprises a hardware layer, a data processing layer, an algorithm layer and an application layer, through an antagonistic living body detection module in the algorithm layer, in combination with physical modeling and a GAN (Generative Adversarial Network), the high-security identity authentication of a complex imitation is realized. The method comprises the following steps: carrying out effective identification of a high-biomimetic material, carrying out physical modeling to analyze the absorption characteristics of palm veins in a hyperspectral range, such as the difference between oxyhemoglobin and oxyhemoglobin and periodic spectrum micro-interference caused by heart rate, and providing living body evidence based on physiological dynamics; meanwhile, a high-simulation template sample generated by the GAN is used for training a discriminator, the insight ability of the system to a template means is further enhanced, and compared with single traditional texture or static signal detection, the system combines physical characteristics with deep learning, and the confidence coefficient of in-vivo detection reaches up to 99.99%.

The utility model discloses a multifunctional blood glucose detector for detecting glycosylated hemoglobin, which comprises a shell, a control panel, a screen, a battery pack and a multifunctional detection mechanism, the multifunctional detection mechanism is provided with an electrochemical detection assembly and a photochemical detection assembly which can be used for performing electrochemical detection and photochemical detection on the test strip respectively, and the screen, the battery pack and the multifunctional detection mechanism are electrically connected with the control panel respectively; a user can directly complete electrochemical detection and photochemical detection on one machine in sequence, the operation is convenient, the efficiency is high, and the detection accuracy of glycosylated hemoglobin can be improved by utilizing dual detection.

The present disclosure relates to systems and methods for measuring glycated A1c hemoglobin. A glycated hemoglobin level measuring system includes a sample testing apparatus having a microchannel that compresses a blood sample traveling through, a first pair of electrodes coupled to the microchannel, and a second pair of electrodes coupled to the microchannel. The glycated hemoglobin level measuring system further includes an analysis apparatus having sensors coupled to the first and second pairs of electrodes and configured to calculate a travel time taken by a red blood cell to pass through the first and second pairs of electrodes. The glycated hemoglobin level measuring system can use the travel time to measure a rigidity of the red blood cells and the corresponding glycated hemoglobin level.

The invention discloses an anticoagulant sample agglutination detection device for hemoglobin analysis, and relates to the technical field of biomedical detection.The anticoagulant sample agglutination detection device comprises a machine shell, a blood collection tube and a machine cover rotationally installed on the machine shell, and further comprises a plurality of laser receiving plates rotationally installed on the machine cover and a light blocking cylinder fixedly installed in the machine shell; a support is installed in the machine shell through a damping support, a motor is fixedly installed on the support, a rotating disc is rotatably installed on the support, a storage disc is fixedly installed on the rotating disc, and a plurality of sets of tube frame stations used for storing blood collection tubes are installed on the storage disc. The method has the advantages that the centrifugal light transmittance is adopted to detect the agglutination condition in the blood sample, multiple batches of samples can be detected at a time, the detection efficiency is higher, the detection has higher real-time performance, the detection result is more accurate, the horizontal position of agglutination can be judged, and the type of agglutination can be judged according to the agglutination position.

The present disclosure relates to systems, devices, and methods for measuring analyte levels. A glycosylated hemoglobin level measurement system includes a sample test cartridge having microchannels that can passively transfer and compress cells. The system may execute one or more calibration or normalization routines on the sensor data to generate calibrated or normalized data. The calibrated or normalized data may be used to determine one or more analyte levels.

The utility model relates to the technical field of medical detection devices, and discloses a glycosylated hemoglobin detection device, which comprises a sampling mechanism, a detection mechanism and a control mechanism, the sampling mechanism comprises an injection pump set, a sampling needle and a sampling valve, the sampling valve is a six-way sampling valve, the injection pump set is connected with a first port of the sampling valve, and the sampling needle is connected with a second port of the sampling valve; the separation mechanism comprises an eluent group, a mixer and a chromatographic separator, the eluent group is connected with a fifth port of the sample injection valve, the chromatographic separator is connected with a sixth port of the sample injection valve, and two ends of the mixer are connected with a third port and a fourth port of the sample injection valve; the inspection mechanism comprises a filter and an inspector, the filter is arranged between the mixer and the chromatographic separator, and the inspector is connected with the chromatographic separator. According to the utility model, the glycosylated hemoglobin can be rapidly and accurately detected through an accurate sample introduction and separation mechanism, so that the detection efficiency is improved. The automation degree of the detection process is high, the requirement for manual operation is reduced, and the possibility of human errors is reduced.

To provide a color and shape change monitoring system capable of accurately monitoring the color and shape change of a human body caused by a blood flow change.SOLUTION: The image processing apparatus includes a three dimensional point cloud data acquisition unit configured to acquire three dimensional point cloud data of a measurement target portion of a human body, a color data acquisition unit configured to acquire color data of the measurement target portion, a color-shape-data generation unit configured to generate color-shape data of the measurement target portion in which the color data is associated with the three dimensional point cloud data, and a pigment component separation unit configured to separate the color-shape data into a hemoglobin pigment component, a melanin pigment component, and a shade component.SELECTED DRAWING: Figure 1

The present invention belongs to the field of medical technology, and in particular relates to a combined hemoglobin and chyle detection device and method. The device comprises a housing, an analysis mechanism disposed within the housing, and a colorimetric tube inserted into the upper surface of the housing. The analysis mechanism comprises a light source module, a sample processing module, an optical detection module, and a data processing module. The optical detection module synchronously acquires absorbance signals at two wavelengths using dual detectors. The data processing module calculates hemoglobin concentration and chyle level based on the dual-wavelength absorbance values. Unlike traditional single-index detection, the present invention achieves for the first time the simultaneous analysis of dual parameters of hemoglobin and chyle, significantly improving the efficiency of initial screening before blood donation. A dual-wavelength correction algorithm is employed to eliminate the interference of residual absorption of hemoglobin at 540 nm that affects the determination of the chyle index, and to eliminate the interference of absorption of chyle at 600 nm that affects the determination of hemoglobin. The device is suitable for rapid screening at the blood collection site to achieve information management of detection data.

A method of implementing changes in deoxyhemoglobin concentration, the method comprising: targeting a sequence of partial pressures of oxygen in arterial blood (PaCh) values in a subject using a sequential gas delivery device in a periodic input pattern; measuring a blood-oxygen level dependent (BOLD) signal in a voxel of the subject's brain using a magnetic resonance imaging device while targeting the sequence of values; comparing the pattern to the signal; and determining a vascular tissue characteristic (vessel type, vessel orientation, or pathological condition) for the voxel based on the comparison.

To provide a blood glucose level measuring device and a blood glucose level measuring method capable of accurately measuring a blood glucose level of a living body.SOLUTION: A blood glucose level measuring device 1 includes: a light output unit 3 that outputs measurement light L to a living body 6; a light detection unit 4 that detects the measurement light L transmitted through the living body 6; a temporal phase difference calculation unit that calculates a temporal phase difference between an oxygenated hemoglobin waveform related to an oxygenated hemoglobin concentration of blood of the living body 6 and a deoxygenated hemoglobin waveform related to a deoxygenated hemoglobin concentration of the blood of the living body 6, based on a detection result of the light detection unit 4; a blood glucose level calculation unit that calculates a blood glucose level of the living body 6 based on the temporal phase difference; and a reliability estimation unit that estimates the reliability of the temporal phase difference. The reliability estimation unit estimates that the reliability of the temporal phase difference is lower as an SN ratio of the detection result of the light detection unit 4 is smaller.SELECTED DRAWING: Figure 1

The invention discloses a split-type glycosylated hemoglobin analysis device, and relates to the field, the split-type glycosylated hemoglobin analysis device comprises a host and a split-type isolation cover, the top of the host is provided with a modular analysis part, and the upper edge of the modular analysis part is provided with four modular assembly ports; a sample tube, a first analysis module, a second analysis module and a cleaning module are detachably assembled in the four modular assembly ports respectively, the split type isolation hood is detachably assembled above the main machine, and a control part and a sampling device are mounted at the positions, above the modular analysis part, in the split type isolation hood; the control part can control the sampling device to respectively move to a first position, a second position, a third position and a fourth position. A split modular mounting structure is adopted, and the sample tube, the first analysis module, the second analysis module and the cleaning module in the device can be taken out from modular assembly ports in the modular analysis part, so that the modules are more convenient to replace, clean and disinfect.

Disclosed are an apparatus and method for estimating a target component value. The apparatus for estimating a target component value may include: a sensor configured to obtain a spectrum of light scattered or reflected from an object; and a processor configured to correct a first reflectance value of the spectrum based on a melanin index; obtain a second reflectance value based on the correction of the first reflectance value; convert the second reflectance value into an absorbance value; estimate the target component value based on the absorbance value; and correct the target component value based on a hemoglobin index.

This disclosure relates to a method and device for determining the hemoglobin level of a mammal. The device includes several light-emitting diodes, one or more sensors, and a processor.

The present invention relates to a method for determining hemoglobin in a sample comprising red blood cells, said method comprising (a) dispensing a first aliquot of said sample on a first working area of a substrate; (b) providing a hemolyzed second aliquot of said sample and dispensing said second aliquot on a second working area; and (c) determining the hemoglobin in said first and second working area, wherein said method comprises a further step of contacting said first working area, but not the second working area, with a treatment solution. The present invention also relates to systems and diagnostic methods related to said method.

The application discloses an imaging method for fusing photon weight and diffuse light brain tissue blood oxygen concentration change quantity and related products, and relates to the technical field of biological tissue blood oxygen imaging. The method comprises the following steps: acquiring experimental data obtained by irradiating a measured tissue with light sources of two wavelengths; performing the following calculation on the experimental data corresponding to each wavelength of the light source: calculating the average photon transmission path of the kth light probe combination in the ith voxel unit by using a formula; calculating the photon weight of the kth light probe combination in the ith voxel unit by using a formula; calculating the change quantity of the tissue absorption coefficient of the ith voxel unit by using a formula; and finally calculating the change quantity of the concentrations of oxyhemoglobin and deoxyhemoglobin by using the calculation data obtained by the two wavelengths. The application proposes a method for fusing photon weight, and by means of weight calculation, the accurate brain tissue blood oxygen concentration change quantity can be obtained by using a small amount of S-D combination photon signals.

1. The name of the design product: blood analyzer (SZH-MF03A). 2. The use of the design product: for testing the concentration of blood glucose, uric acid, hemoglobin in blood samples. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

A blood analyzer and a hemoglobin detection method, the method comprising: a control device controls a sampling device (11) to obtain a sample to be tested (201); a control device controls a sample preparation device (12) to mix a portion of the sample to be tested with a first reagent to prepare a first sample liquid to be tested, and a control device controls a portion of the sample to be tested with a second reagent to prepare a second sample liquid to be tested (202); a control device controls a colorimetric detection device (13) to perform a hemoglobin detection on the first sample liquid to be tested using a colorimetric method to obtain a first measurement value (203); a control device controls an optical detection device (14) to perform a hemoglobin detection on the second sample liquid to be tested using a light scattering method to obtain a second measurement value (204); and a control device determines whether the sample to be tested is a sample with a falsely high hemoglobin level (205); if the sample to be tested is a sample with a falsely high hemoglobin level, the control device outputs a second measurement value (206); if the sample to be tested is a sample with a falsely high hemoglobin level, the control device outputs a first measurement value (207).

The invention relates to the technical field of blood detection, and particularly discloses a spectrum detection method, system, device, equipment and medium for detecting the free hemoglobin content of a plasma braid, and the method comprises the following steps: taking out a to-be-detected sample of the plasma braid to obtain an original optical measurement object to obtain the to-be-detected sample; performing multi-wavelength alternate irradiation on the to-be-detected sample and collecting continuous time sequence photoelectric response to obtain an original time sequence signal set; obtaining an absorbance set; a normalized absorption characteristic subjected to scattering and temperature dual compensation is obtained; obtaining an initial free hemoglobin concentration estimated value; the final free hemoglobin concentration and a judgment result are obtained; by directly detecting the separated plasma tube braid, the sealing performance and safety of the main blood bag are not influenced at all, and the pollution risk caused by puncture sampling is thoroughly avoided. The method is objective and accurate, results are quantified, manual subjective errors are thoroughly eliminated by adopting a spectral analysis technology, and particularly, judgment on critical value samples is extremely accurate.

The invention discloses a blood microscopic imaging detection and blood evaluation method and device. The method comprises the following steps: preparing blood into a microscopic examination sample; adding a microscopic examination sample into the cavity of the detection chip; irradiating the detection chip cavity by using a light source A; shooting to obtain a microscopic examination sample image; detecting to obtain an image of a single red blood cell in the microscopic examination sample image, and obtaining the volume of the single red blood cell and the hemoglobin parameter of the single red blood cell according to the image of the single red blood cell; storing the volume and hemoglobin parameters of a single red blood cell; calculating the number of single red blood cells in the shot picture, and if the number of single red blood cells in the shot picture does not reach the set measurement number, moving the position of the detection chip cavity corresponding to shooting, changing the position of the X coordinate or the Y coordinate, and obtaining the volume of single red blood cells of red blood cells with the set measurement number and corresponding hemoglobin parameters.

A non-invasive biosignal measurement device based on skin effect removal, includes: a signal measurement instrument measuring a PPG signal of a measurement subject in contact with the skin on one side of a specific body part of the measurement subject; a signal reception unit receiving the PPG signal from the signal measurement instrument; and a ratio value calculation unit removing noise due to a skin effect from the PPG signal, and then calculating ratio values at different wavelengths for measuring a biosignal including blood sugar and glycated hemoglobin of the measurement subject. The signal measurement instrument includes a first sensor module including an optical barrier and a second sensor module for removing the skin effect.

To provide an image processing device that estimates spectral reflectance, enabling more accurate reproduction of skin color than conventional methods. [Solution] An image processing apparatus comprising: a skin pigment estimation unit that estimates the amount of melanin and hemoglobin components in the skin region of a person in a target image; a spectral reflectance estimation unit that estimates the spectral reflectance of the skin region based on the amount of melanin and hemoglobin components estimated by the skin pigment estimation unit; and a spectral reflectance correction unit that corrects the spectral reflectance estimated by the spectral reflectance estimation unit based on a generated image generated using the spectral reflectance estimated by the spectral reflectance estimation unit and the target image.

The present invention provides a method for detecting hemoglobin concentration and a blood cell analyzer, wherein the method comprises: detecting a first test sample injected into a reaction cell and obtaining a first HGB value; wherein the first test sample comprises a diluent, a blood sample, and a first hemolytic agent; detecting a second test sample injected into the reaction cell and obtaining a second HGB value; wherein the second test sample is obtained by adding the second hemolytic agent to the first test sample in the reaction cell and mixing them; and selecting the minimum of the first and second HGB values as the HGB value of the blood sample. Because the presence of bubbles during the detection process can lead to an inflated HGB value, the present application proposes selecting the minimum of the first and second HGB values as the HGB value of the blood sample. This minimizes the impact of bubbles on the HGB value and improves the accuracy of the HGB detection result.

The application provides a molecular marker related to immune traits of Lake sheep, a detection method and application thereof. Through PCR amplification and sequence analysis of a PD-L1 gene of the Lake sheep, a G / A polymorphic site at the 135th position of the amplified fragment is found, further detection of the polymorphic site of 898 Lake sheep is carried out by using KASPar primers, a least square model is established, and correlation analysis of the genotype and growth traits is carried out, and finally it is determined that the amplified PD-L1 gene fragment can be used as a molecular marker of immune traits related to the total number of red blood cells and the average concentration of hemoglobin of red blood cells of the Lake sheep. Through detection of the molecular marker, the application can be used for disease-resistant breeding of the Lake sheep, so as to guarantee the health of the Lake sheep and help to increase economic benefits.