149 results about "Hb - Hemoglobin" patented technology

The present invention relates to a method for detecting blood characteristics including hemoglobin in a fluid medium using both transmission and reflection of a light beam which forms a quotient.

Systems, methods, and related computer program products for non-invasive NIR spectrophotometric (NIRS) monitoring of total blood hemoglobin levels and/or other blood constituent levels based on a hybrid combination of phase modulation spectrophotometry (PMS) and continuous wave spectrophotometry (CWS) are described. PMS-based measurements including both amplitude and phase information used in the determination of a non-pulsatile component of an absorption property for each of at least three distinct wavelengths are processed to compute PMS-derived intermediate information at least partially representative of a scattering characteristic. CWS-based measurements including amplitude information is processed in conjunction with the PMS-derived intermediate information to compute a pulsatile component of the absorption property. A metric representative of at least one chromophore level, such as the total blood hemoglobin level, is computed from the pulsatile component of the absorption property at the at least three wavelengths and displayed on an output display.

A system, method and computer program product is provided for analyzing spectral images of a micrcirculatory system to measure the volume and concentration of a blood vessel. The images are analyzed to identify vessel structure, measure the light absorption and develop a contrast gradient plus (KGP) estimate. The KGP estimate is used to predict blood characteristics, such as hemoglobin concentration and hematocrit. The KGP is estimated in three distinct phases. First, the images are screened to measure a mean image intensity and motion blur. Second, each image is analyzed to identify background curvate, and create vessel, background and diameter masks. To identify background curvate, the images are analyzed to detect shadows caused by larger blood vessels in the background image. The diameter and area of the vessels are also calculated. During the Prediction and Calibration phase, the images are screened to eliminate all images failing thresholds for mean intensity, motion blur, background curvature and area-to-perimeter ratio. Finally, the KGP estimate is determined from the selected images.

A fluid flow sensing and bubble detecting apparatus includes a housing comprising a channel configured to receive a tube through which fluid flows; a sensor apparatus disposed within the housing, which includes a first sensor operable to measure flow rate of fluid and to detect bubbles in flowing fluid; and a temperature sensor operable to detect temperature of the flowing fluid; and a processor connected to receive fluid flow rate data obtained by the first sensor, to receive bubble detection data obtained by the first sensor, and to receive fluid temperature data obtained by the temperature sensor, wherein when a tube through which fluid flows is disposed in the channel of the housing, the first sensor measures the flow rate of the flowing fluid and detects bubbles therein, and the temperature sensor measures the temperature of the flowing fluid, and the processor calculates in a short period of time a fluid flow rate corrected for temperature. All sensors are non-invasive and have no direct contact to the fluid in the tube, which might be blood. In accordance with additional embodiments, the fluid flow rate is additionally corrected for hemoglobin or hematocrit, and the effect of oxygen saturation on the hemoglobin or hematocrit data.

The present invention relates to a method for non-invasive local quantification of angiogenesis or destruction of existing blood vessels in living tissue, the use of the said method for local measurements of hemoglobin concentration and blood perfusion at the same location on the subject and an apparatus for carrying out the method according to the invention. The apparatus comprises a xenon flash unit, an optical filter and a Y-shaped optical fiber-bundle, one branch of the fiber-bundle being coupled to the flash unit and the other branch of the fiber-bundle being coupled to a detection unit and the merged part of the fiber-bundle being adapted to couple the apparatus to the tissue to be tested.

The invention belongs to the technical field of preparation of platelet rich plasma, and in particular discloses a method for preparing PRP (Platelet Rich Plasma) through a manual two-step centrifugation method. The method comprises the following steps: centrifuging 25 ml of whole blood mixed with an anticoagulant for 6 minutes at centrifugal force of 800 g for the first time by adopting the two-step centrifugation method, absorbing plasma on the upper layer and on boundary layer in the layered whole blood, and arranging the plasma in an another centrifugal tube; centrifuging for the second time, namely centrifuging for 5 minutes at centrifugal force of 1400 g, and absorbing about 4 ml of the layered plasma on the middle layer to obtain the platelet rich plasma. According to the PRP prepared by the technology, the platelet concentration is 886.33*10<9>/L, the mean corpuscular hemoglobin in the PRP is 27.72 g/L, and the clinical treatment requirements are met.

A method for functional magnetic resonance imaging (fMRI) uses steady-state free precession (SSFP) to image changes in blood oxygenation between two time periods. A center frequency of the SSFP sequence is placed between the different resonant frequencies for oxyhemoglobin and deoxyhemoglobin whereby the signals have a phase difference of 180° and tend to cancel. By repeating the SSFP imaging sequence at different times, the difference in the measured signals provides a measure of change in oxyhemoglobin. RF flip angle of the SSFP sequence is chosen to maximize signal level in the frequency range from that of water in the presence of oxyhemoglobin and that of water in the presence of deoxyhemoglobin.

The device enables measurement of both of blood glucose level and hemoglobin A1c level, being small-sized and thus portable, allowing the measurement of a small amount of a specimen and, being usable in POC. The device comprises: a test-piece-mounting section (1) for detachably mounting test pieces (200) on which the blood specimen is to be spotted; a light-emitting section (2) for emitting light for irradiating the test pieces; a light-receiving section (3) for receiving reflected lights from the test pieces; and an operating section (4) for calculating the blood glucose level and hemoglobin A1c level of the blood specimen on the basis of photometric values obtained from the light-receiving section. For measuring the blood glucose level of the blood specimen, test piece (A) carries a composition reacting with glucose and showing color change. Test piece (B) carries a composition reacting with glycated hemoglobin and showing color change.

The invention relates to a method and device for quickly detecting hemoglobin. Detection results can be given in three seconds. According to the device, the influence of uneven distribution of hemoglobin cells in blood samples can be eliminated through optical modulation, meanwhile, the influence of scattering on the detection results can be well eliminated according to a compensation algorithm, and more prominently, quick detection can be achieved only by using two wave lengths.

The invention provides a multifunctional blood detector. The multifunctional blood detector comprises a central processing unit, a blood collecting bottle energy heating and reagent bottle energy refrigerating stirring arm, a blood detection unit and a remote display device; the central processing unit has properties of an automatic controller and comprises a Bluetooth module, a wireless local area network, an alarming module, a fingerprint confirmation and storage module and a blood collecting needle, blood collecting bottle and reagent bottle holder for storing a blood collecting needle, a blood collecting bottle and a reagent bottle, blood is stirred and mixed to be uniform through the blood collecting bottle energy heating and reagent bottle energy refrigerating stirring arm, the blood detection unit comprises a CRP detection device, a red blood cell counting chamber, a hemoglobin detection device, a laser detection device and a blood reagent strip corresponding item detection position, and the remote display device is used for setting detection items including CRP detection, red cell counting, hemoglobin detection, laser detection and blood reagent strip corresponding item detection.

The invention belongs to the technical field of biochemical detection, and particularly relates to a G-6-PD detection kit free from anemia influences and a detection method thereof. The kit comprisesa sample detection device, hemolytic agent dry powder, hemoglobin test paper, a sample adding colorimetric card, G-6-PD test paper and a detection colorimetric card, wherein the sample detection device comprises a sample adding pipe, a first clamping groove and a second clamping groove. According to the kit and the detection method thereof provided by the invention, the anemia degree of a subjectcan be conveniently determined, the sample adding amount can be rapidly determined, the method is used for screening detection of erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, thesample adding amount can be compensated according to hemoglobin test results, the test method is small in blood consumption and flexible and convenient in test, and meanwhile, the accuracy of the detection results is improved.

The invention relates to a piece of test paper for stool examination. The test paper comprises a base plate, a calprotectin detection part, a lactoferrin detection part, a hemoglobin detection part, atransferring detection part, a vibrio cholera detection part, a pH detection part, and a lactose detection part. A plurality of chambers that are spaced and are not communicated are formed on the base plate. In addition, the invention also relates to a kit for stool examination. The kit includes a stool collection device, a stool transfer device, and a stool extraction buffer solution. The test paper and the kit have advantages of small size, light weight, high portability, and simple usage method. Multiple indicators of a sample can be detected once. The detection speed and sensitivity are high; the price is low. The test paper and the kit can be used in a communication hospital widely, thereby enhancing the capability of preliminary detection of diarrhea in a community hospital.

The invention provides a micro-fluidic chip for detecting glycosylated hemoglobin and a detection method thereof. The micro-fluidic chip is sequentially provided with a cover plate layer, a fluid layer with a hollow channel structure and a substrate layer from top to bottom, and the hollow channel structure and the substrate layer jointly form a sample detection unit. A sample injection through hole and a waste liquid leading-out through hole are respectively formed in the cover plate layer. The sample detection unit comprises one or more sample injection chambers, a dilution chamber, an affinity chromatography channel, a detection chamber and a waste liquid pool. The sample injection through hole is communicated with the sample injection chamber, and the waste liquid leading-out through hole is communicated with the waste liquid pool. Sample introduction, sample dilution and optical and electrical detection are integrated through the micro-fluidic chip; the operation process is greatly simplified, the consumption of samples and reagents is reduced, expensive equipment is not needed, the use cost is largely reduced, the on-site instant detection of glycosylated hemoglobin can be realized, and huge economic value and social value are created.

The invention discloses a noninvasive hemoglobin tester. The noninvasive hemoglobin tester comprises a detection circuit, a near-infrared light source module, an image acquisition module, a display screen and a power module, wherein the near-infrared light source module, the image acquisition module, the display screen and the power module are connected with the detection circuit respectively . The invention further discloses a detection method for the noninvasive hemoglobin tester. According to the tester, near-infrared light sources are adopted for irradiating palpebrae conjunctiva superficial layer arterial rete, reflected light is acquired to carry out blood vessel shape analysis and red depth analysis, quantity conversion is carried out on analysis results, the analysis results and standard values are compared, and hemoglobin values can be obtained quickly and accurately and directly displayed on the display screen. According to the detection method, the steps are simple, blood samples are not needed, and needed measurement values can be displayed visually and quickly in a noninvasive optical measurement mode; for the same measurement object, high-frequency multiple metering can be achieved, pains of patients are relieved, medical resources are saved, and good social value and economic value are achieved.

The invention belongs to the field of chemical analysis and testing, and particularly relates to an adenine-based cyanine probe, and a preparation method and application thereof. The method comprises the following steps: synthesizing a CY5.5 dye through a four-step reactionl and reacting the CY5.5 dye with adenine under the conditions of N, N'-dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP), and separating an obtained crude product through thin layer chromatography to obtain the final product. The cyanine probe obtained by the invention has excellent optical performance and hemoglobin recognition effect, and is beneficial to detection of hemoglobin.

The invention is applicable to the field of medical equipment, and discloses a blood cell analyzer. The device comprises a sampling part, an optical channel reaction tank, an optical detection unit, a hemoglobin detection unit, an impedance counting detection sample preparation unit, an impedance counting detection unit, a first reagent supply device, a second reagent supply device, a diluent supply device, a conveying pipeline assembly and a fluid power device, the sampling part, the optical detection unit, the optical channel reaction tank, the hemoglobin detection unit, the impedance counting detection sample preparation unit, the impedance counting detection unit, the first reagent supply device, the second reagent supply device, the diluent supply device and the fluid power device are connected through the conveying pipeline assembly to form a liquid path system; the average gas consumption of the liquid path system is less than or equal to 2.0 L/min in a detection period of completing hemoglobin detection, impedance counting detection and optical detection, so that the miniaturization and low-cost design of the instrument is realized.

The invention discloses a multichannel glycosylated hemoglobin detector. The detector comprises a detector body, and the detector body comprises a controller, a support, a detection mechanism and a liquid path system; the detection mechanism comprises a test disc and a driving assembly used for driving the test disc to rotate. The driving assembly is controlled by the controller; the test disc comprises a disc body, and a plurality of notches for bearing test cards are formed in the disc body; a pressing plate for pressing the test cards is arranged at the notches on the disc body; the plurality of notches are uniformly distributed in the circumferential direction; a detection plate for detecting the optical values of the test cards in the notches is fixedly arranged in the disc body; theliquid path system comprises a peristaltic pump, a liquid bottle and a liquid adding needle used for adding reaction liquid into the test cards in the notches, the peristaltic pump is electrically connected with the controller, a liquid outlet of the liquid bottle is connected with one end of the peristaltic pump, and the other end of the peristaltic pump is connected with the liquid adding needle. The detector can realize multi-channel detection, and has the characteristics of simple structure, low cost and high detection efficiency.

The invention discloses a urine dry chemical analysis quality control material for performing quality control on a urine analyzer and urine analysis test paper during urine analysis. The urine dry chemical analysis quality control material comprises esterase, sodium nitrite, anhydrous dextrose, a probile substitute, hemoglobin, a ketone substitute, bovine serum albumin, direct bilirubin, creatinine, anhydrous calcium chloride, urea, sodium chloride, a pigment, a preservative and the like. When urine analysis is carried out, quality control is carried out on the used test paper, and quality monitoring is carried out on a plurality of detection test paper such as leukocyte, nitrite, pro-urobiliary, protein, pH value, occult blood, urine specific gravity, ketone body, bilirubin, glucose, creatinine, urine calcium, pro-leukocyte and the like. The quality control material is simple in preparation method, and easy to operate, and is stable and safe.

Intact erythrocytes with selected and often elevated levels of hemoglobin A1c (HbA1c) for use as quality controls for HbA1c assays and assay instruments are prepared by hypotonic dialysis of erythrocytes from a healthy mammal to permeabilize the erythrocyte membranes, infusion of the permeabilized erythrocytes with hemoglobin A1c, and de-permeabilization of the infused erythrocytes. Quality controls of essentially any level of HbA1c can be prepared in this manner and once prepared will be useful for monitoring the entire assay procedure, including the lysis of the erythrocytes in a typical sample.