Topical ointment for treating kinesia and producing method thereof

Abstract

The invention discloses a topical ointment for treating kinesia and a producing method thereof, and aims at providing a topical ointment which is fast to achieve the effect, convenient to apply, few in side effect and capable of increasing and decreasing the using amount at any time to adapt to the different individual needs and is used for treating the kinesia and a producing method thereof. The topical ointment for treating the kinesia is prepared from camphor, menthol, eucalyptus oil, scopolamine hydrobromide, a penetration enhancer and an ointment base, wherein at least one of azone and propylene glycol is adopted as the penetration enhancer, and at least one of wool fat and white vaseline is adopted as the ointment base. According to the topical ointment for treating the kinesia, ointment applying is convenient, the effects are achieved quickly, the medicine effect components can be absorbed quickly, and the effective plasma concentration can be reached; the topical ointment can be used 10 minutes before people ride a transportation vehicle, the effects are quickly achieved after about 10 minutes, and the medicine effect can maintain 5-6 hours.

Description

technical field

[0001] The invention relates to a medicine for treating motion sickness, in particular to a transdermal preparation for treating motion sickness and a production method thereof. Background technique

[0002] Motion sickness is a general term for motion sickness, seasickness, airsickness, and diseases caused by various reasons such as swinging, bumping, rotating, and accelerated motion. Scopolamine is an anti-M-cholinergic receptor drug. Because it easily penetrates the blood-brain barrier, it also has central anticholinergic effects, mainly manifesting inhibition and sedation; because it can selectively inhibit the motility of vestibular neurons or Spontaneous excitatory discharge has good anti-dizziness and antiemetic effects; however, oral anti-dizziness is often accompanied by side effects such as dry mouth, mydriasis, blurred vision, drowsiness and palpitations, which limits its application. Through research, using scopolamine as a raw material to make a...

Examples

Embodiment 1

[0030] (1) Precisely weigh 2.72g of scopolamine hydrobromide and dissolve it in 22.48g of azone to make phase A;

[0031] (2) Weigh 36.6g of camphor and 36.6g of menthol, grind and dissolve in 36.6g of eucalyptus oil to make phase B;

[0032] (3) Add 110g of lanolin and 755g of white petrolatum in turn to phase A, stir well while adding, and gradually heat and stir at a temperature lower than 60°C to melt the lanolin and white petrolatum, then add phase B to make 1000g, Stir well and serve.

Embodiment 2

[0034] (1) Precisely weigh 3.68g of scopolamine hydrobromide and dissolve it in 20.32g of azone to make phase A;

[0035] (2) Weigh 27.0g of camphor and 27.0g of menthol, grind and dissolve in 27.0g of eucalyptus oil to make phase B;

[0036] (3) Add 105g of lanolin and 790g of white petrolatum in sequence to phase A, stir evenly while adding, and gradually heat and stir at a temperature lower than 60°C to melt the lanolin and white petrolatum, then add phase B to make 1000g, Stir well and serve.

Embodiment 3

[0038] (1) Precisely weigh 3.0 g of scopolamine hydrobromide and dissolve it in 21.0 g of azone to make phase A;

[0039] (2) Weigh 32.0g of camphor and 32.0g of menthol, grind and dissolve in 32.0g of eucalyptus oil to make phase B;

[0040] (3) Add 100g of lanolin and 780g of white petrolatum in turn to phase A, stir evenly while adding, and gradually heat and stir at a temperature lower than 60°C to melt the lanolin and white petrolatum, then add phase B to make 1000g, Stir well and serve.

[0041] The shape of the external ointment for treating motion sickness made by embodiment 1-3 is light yellow ointment, gas fragrance, has cool and refreshing stimulation.

[0042] Using thin-layer chromatography, ether, absolute ethanol, and petroleum ether were used as solvents, ether-dilute ethanol (1:1), cyclohexane-ethyl acetate (19:1), toluene-ethyl acetate (19:1) :1) as a developing agent to identify scopolamine hydrobromide, eucalyptus oil and menthol in the ointment; in the c...

technical field

[0001] The invention relates to a medicine for treating motion sickness, in particular to a transdermal preparation for treating motion sickness and a production method thereof. Background technique

[0002] Motion sickness is a general term for motion sickness, seasickness, airsickness, and diseases caused by various reasons such as swinging, bumping, rotating, and accelerated motion. Scopolamine is an anti-M-cholinergic receptor drug. Because it easily penetrates the blood-brain barrier, it also has central anticholinergic effects, mainly manifesting inhibition and sedation; because it can selectively inhibit the motility of vestibular neurons or Spontaneous excitatory discharge has good anti-dizziness and antiemetic effects; however, oral anti-dizziness is often accompanied by side effects such as dry mouth, mydriasis, blurred vision, drowsiness and palpitations, which limits its application. Through research, using scopolamine as a raw material to make a...

Examples

Embodiment 1

[0030] (1) Precisely weigh 2.72g of scopolamine hydrobromide and dissolve it in 22.48g of azone to make phase A;

[0031] (2) Weigh 36.6g of camphor and 36.6g of menthol, grind and dissolve in 36.6g of eucalyptus oil to make phase B;

[0032] (3) Add 110g of lanolin and 755g of white petrolatum in turn to phase A, stir well while adding, and gradually heat and stir at a temperature lower than 60°C to melt the lanolin and white petrolatum, then add phase B to make 1000g, Stir well and serve.

Embodiment 2

[0034] (1) Precisely weigh 3.68g of scopolamine hydrobromide and dissolve it in 20.32g of azone to make phase A;

[0035] (2) Weigh 27.0g of camphor and 27.0g of menthol, grind and dissolve in 27.0g of eucalyptus oil to make phase B;

[0036] (3) Add 105g of lanolin and 790g of white petrolatum in sequence to phase A, stir evenly while adding, and gradually heat and stir at a temperature lower than 60°C to melt the lanolin and white petrolatum, then add phase B to make 1000g, Stir well and serve.

Embodiment 3

[0038] (1) Precisely weigh 3.0 g of scopolamine hydrobromide and dissolve it in 21.0 g of azone to make phase A;

[0039] (2) Weigh 32.0g of camphor and 32.0g of menthol, grind and dissolve in 32.0g of eucalyptus oil to make phase B;

[0040] (3) Add 100g of lanolin and 780g of white petrolatum in turn to phase A, stir evenly while adding, and gradually heat and stir at a temperature lower than 60°C to melt the lanolin and white petrolatum, then add phase B to make 1000g, Stir well and serve.

[0041] The shape of the external ointment for treating motion sickness made by embodiment 1-3 is light yellow ointment, gas fragrance, has cool and refreshing stimulation.

[0042] Using thin-layer chromatography, ether, absolute ethanol, and petroleum ether were used as solvents, ether-dilute ethanol (1:1), cyclohexane-ethyl acetate (19:1), toluene-ethyl acetate (19:1) :1) as a developing agent to identify scopolamine hydrobromide, eucalyptus oil and menthol in the ointment; in the c...