A microfluidic droplet generation device and method based on surface acoustic waves

A technology of droplet generation and surface acoustic wave, which is applied in the field of microfluidics, can solve the problems of limited experimental repeatability, product life cycle, device failure, and complicated production process, so as to achieve a firm PDMS flow channel structure and continuous Generating, generating the effect of uniform droplet

CN109012769BActive Publication Date: 2020-01-21XI AN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2020-01-21

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Abstract

The invention discloses a device and a method for generating micro-fluidic droplets based on surface acoustic waves. The device comprises a piezoelectric substrate, a set of curved interdigital transducers is arranged on the piezoelectric substrate, a closed PDMS micro-channel system is applied to the upper part of the piezoelectric substrate, and the closed PDMS micro-channel system is formed bytop PDMS and a PDMS sealing film. The method comprises the following steps: fixing the micro-fluidic droplet generating device on the objective table of a microscope, switching in the micro-fluidic droplet generating device, and setting the pressures of a dispersed phase inlet joint and a continuous phase inlet joint; and connecting a signal generator with the curved interdigital transducers, adjusting the output signal of the signal generator, turning on a syringe pump, adjusting and stabilizing the two-phase interface position of a dispersed phase and a continuous phase, and generating the micro-fluidic droplets. The device and the method realize the electric control of the formation rate and the size of the droplets; and the device has a small size and can be integrated with other devices, so the repeatability is enhanced, and cracks between channels, caused by overlarge pressure of an input fluid, are reduced.
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Description

technical field

[0001] The invention relates to the field of microfluidic technology, in particular to a device and method for generating microfluidic droplets based on surface acoustic waves. Background technique

[0002] The droplet microfluidic platform has become an important tool in the fields of biology, chemistry, and medicine. As an important technology in the droplet microfluidic platform, the method of microdroplet generation is very important. Different methods are in the control of droplet size and uniformity. In terms of gender, there is a big difference. At present, the generation methods of micro-droplets mainly include co-flow method, flow convergence method, T-channel method and derivative methods based on the above methods, which mainly rely on two incompatible fluids, one is the continuous phase and the other is the continuous phase. It is a dispersed phase. When the force applied to a certain part of the dispersed phase is greater than its interfacial te...

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Embodiment Construction

[0028] The present invention is described in detail below in conjunction with accompanying drawing.

[0029] refer to figure 1 , a microfluidic droplet generation device based on surface acoustic waves, including a piezoelectric substrate 1, a group of arc-shaped interdigital transducers 2 are arranged on the piezoelectric substrate 1, and a closed PDMS microstructure is attached to the upper part of the piezoelectric substrate 1. The channel system, the closed PDMS micro channel system is used to accommodate the dispersed phase solution and the continuous phase solution samples, provide an environment for the generation of droplets and transport the generated droplets to the droplet collection port.

[0030] The closed PDMS microchannel system is composed of the top PDMS 3 and the PDMS sealing film 6, wherein the top PDMS 3 includes a straight channel 7 and an arc-shaped channel 9, and the middle part of the straight channel 7 passes through the channel communication port 8 a...