Bioprinted meniscus implant and methods of using same

Abstract

The present invention provide meniscus implant compositions, as well as method for making and using the same. The subject meniscus implants find use in repairing and / or replacing damaged or diseased meniscal tissue in a mammalian subject.

Description

[0001] Cross References to Related Applications

[0002] This application claims priority to the filing date of US Provisional Patent Application Serial No. 62 / 351,222, filed June 16, 2016, the disclosure of which is incorporated herein by reference in its entirety. technical field

[0003] The present invention provides synthetic tissue structures, including artificial meniscal implants comprising precisely patterned layers comprising variable synthetic tissue fibers dispensed from a bioprinter, and methods of making and using the same structure. Background technique

[0004] The meniscus is one of the most commonly injured areas of the knee joint, with an average injury incidence of 66 injuries per 100,000 people in the United States. Complete or partial removal of the meniscus relieves acute pain, but in the absence of an appropriate replacement, meniscus removal can lead to damage to the cartilage in the knee joint, leading to osteoarthritis (OA). The meniscus often ex...

Examples

Embodiment Construction

[0050] Aspects of the invention include synthetic tissue structures comprising one or more layers deposited by a bioprinter, wherein each layer comprises one or more synthetic tissue fibers comprising, optionally comprising cells, and A solidified biocompatible matrix optionally comprising one or more active agents, wherein at least one of matrix material, cell type, cell density, and / or amount of active agent varies in at least one direction within the layer. Preferably, at least one of said layers comprises a single continuous synthetic tissue fiber of variable composition dispensed from a bioprinter. The term "cured" as used herein refers to the solid or semi-solid state of a material that maintains its shape fidelity and structural integrity after deposition. The term "shape fidelity" as used herein means the ability of a material to maintain its three-dimensional shape. In some embodiments, the cured material is capable of maintaining its three-dimensional shape for a pe...

[0001] Cross References to Related Applications

[0002] This application claims priority to the filing date of US Provisional Patent Application Serial No. 62 / 351,222, filed June 16, 2016, the disclosure of which is incorporated herein by reference in its entirety. technical field

[0003] The present invention provides synthetic tissue structures, including artificial meniscal implants comprising precisely patterned layers comprising variable synthetic tissue fibers dispensed from a bioprinter, and methods of making and using the same structure. Background technique

[0004] The meniscus is one of the most commonly injured areas of the knee joint, with an average injury incidence of 66 injuries per 100,000 people in the United States. Complete or partial removal of the meniscus relieves acute pain, but in the absence of an appropriate replacement, meniscus removal can lead to damage to the cartilage in the knee joint, leading to osteoarthritis (OA). The meniscus often ex...

Examples

Embodiment Construction

[0050] Aspects of the invention include synthetic tissue structures comprising one or more layers deposited by a bioprinter, wherein each layer comprises one or more synthetic tissue fibers comprising, optionally comprising cells, and A solidified biocompatible matrix optionally comprising one or more active agents, wherein at least one of matrix material, cell type, cell density, and / or amount of active agent varies in at least one direction within the layer. Preferably, at least one of said layers comprises a single continuous synthetic tissue fiber of variable composition dispensed from a bioprinter. The term "cured" as used herein refers to the solid or semi-solid state of a material that maintains its shape fidelity and structural integrity after deposition. The term "shape fidelity" as used herein means the ability of a material to maintain its three-dimensional shape. In some embodiments, the cured material is capable of maintaining its three-dimensional shape for a pe...

Images