The invention discloses a medicinal liquor for strengthening muscles and bones and resisting aging and a preparation method thereof. The medicinal liquor can regulate qi and blood, warm uterus, dredgeextra meridians and smooth blood vessels through ginseng, astragalus membranaceus, poria cocos, angelica sinensis and ligusticum wallichii. Radix rehmanniae preparata, bighead atractylodes rhizome, divaricate saposhnikovia root, dried rehmannia root and dwarf lilyturf tuber can improve physique and enhance immunity so as to delay aging and reduce wrinkles, the dried orange peel, wolfberry fruit,sweet potato pulp and Chinese magnoliavine fruit can tonify liver and kidney and enhance metabolism so as to further achieve the purpose of delaying aging, and notopterygium root, tortoise-plastron glue, cinnamon and cortex lycii radicis are matched to achieve the purposes of strengthening muscles and bones; and the medicinal effect can be exerted to the maximum extent by taking the liquor as a medium, honey is added to enable the medicinal liquor to be sweet and tasty, the direct effect of traditional Chinese medicines is enhanced to achieve the effects of maintaining beauty and keeping young, and therefore the effects of delaying senescence and reducing wrinkles are achieved by changing physique, enhancing immunity and metabolism, and clinical tests prove that the formula regulates qi and blood, strengthens the muscles and bones, smoothens the blood vessels, warms the uterus, dredges the extra meridians, moistens skin, pleases face and delays senescence.