A CRDS lung cancer molecular marker detection device

Abstract

The present invention discloses a CRDS lung cancer molecular marker detection device, comprising a base, a lifting device and a CRDS detection device, wherein the bottom of the lifting device is fixed to the surface of the base, and the top of the lifting device is fixed to the CRDS detection device. When collecting the fasting breathing gas of a patient, the present invention only requires holding a handle by hand and blowing at a mouthpiece, which is more convenient to hold than a traditional mouthpiece. After collecting the gas, the mouthpiece can be taken out and replaced with a new one by pressing buttons on both sides. Compared with the traditional method of directly inserting the mouthpiece into the trachea, the present invention has better sealing performance and can filter out saliva in the patient's breath, making it more convenient for the patient to blow, thereby increasing the efficiency of gas collection.

Description

Technical Field

[0001] The invention relates to the technical field of CRDS lung cancer molecular markers, and in particular to a CRDS lung cancer molecular marker detection device. Background Art

[0002] Cavity Ring-Down Spectroscopy (CRDS) is an absorption spectrum detection technology that has developed rapidly in recent years. Based on the introduction of the detection principle of cavity ring-down spectroscopy, the theoretical formulas of CRDS technology for reflectivity measurement and trace gas concentration detection are derived in detail. It is analyzed that due to the long actual absorption optical path, the detection accuracy of CRDS technology is not affected by the light source intensity and its changes, so it has the characteristics of low detection limit, high measurement accuracy and good reliability.

[0003] At present, when using CRDS technology to detect lung cancer molecules, it is necessary to collect the patient's fasting breathing gas. Since the current nozzle is directly inserted into the trachea, it is easy to leak when blowing, and it is inconvenient to hold. In addition, the height of the CRDS instrument cannot be adjusted, which is not convenient for medical staff to observe the test results. For this reason, we propose a CRDS lung cancer molecular marker detection device. Summary of the invention

[0004] The object of the present invention is to provide a CRDS lung cancer molecular marker detection device to solve the problems raised in the above background technology.

[0005] To achieve the above objectives, the present invention provides the following technical solutions: a CRDS lung cancer molecular marker detection device, comprising a base, a lifting device and a CRDS detection device, wherein the bottom of the lifting device is fixed to the surface of the base, and the top of the lifting device is fixed to the CRDS detection device.

[0006] Preferably, the lifting device consists of an outer sleeve, an inner moving column, a driving motor, a top plate, a moving block and a screw rod. The top of the inner moving column is fixed to the bottom of the CRDS detection device, the bottom of the outer sleeve is fixed to the surface of the base, and the top sliding sleeve is on the outside of one end of the inner moving column. A threaded hole is opened in the moving block, and the moving block is threadedly connected to the screw rod through the threaded hole. The moving block is fixed to the inner wall of the bottom of the inner moving column, and a track groove is engraved on the outside of the inner moving column. Two track plates are symmetrically fixed to the inner wall of the outer sleeve, and the outer side of the track plate is slidably connected to the inner wall of the track groove. The driving motor is fixed to the inner wall of the bottom of the outer sleeve, and the output end of the driving motor is fixed to one end of the screw rod. The end of the screw rod away from the driving motor is rotatably connected to the top plate through a bearing, and the outer side of the top plate is slidably connected to the inner wall of the inner moving column.

[0007] Preferably, the outer side of the top plate is symmetrically fixed with a limiting block, the inner wall of the inner movable column is symmetrically provided with a limiting groove, and the outer side of the limiting block is slidably connected with the inner wall of the limiting groove.

[0008] Preferably, the CRDS detection device consists of a support plate, a CRDS detection instrument, a gas connecting pipe, a blow nozzle and a connecting assembly. The CRDS detection instrument is installed on the support plate, and the bottom of the support plate is fixed to the top of the inner movable column. One end of the gas connecting pipe is connected to the gas interface on the CRDS detection instrument, and the other end of the gas connecting pipe is connected to the blow nozzle through the connecting assembly.

[0009] Preferably, the blowing nozzle is composed of a funnel-shaped shell, an air outlet pipe and a connecting claw. The funnel-shaped shell is fixedly sleeved on the outside of the air outlet pipe. One end of the connecting claw is a trapezoidal structure, and a groove is provided on the outside of the connecting claw. Two connecting claws are provided and are symmetrically distributed and fixed on one end of the funnel-shaped shell.

[0010] Preferably, a filter screen is provided at one end of the air outlet pipe close to the funnel shell.

[0011] Preferably, the connecting assembly consists of an air cylinder, a connecting column, a clamping piece and a handle, one end of the air cylinder is connected to one end of the gas connecting pipe, and the other end of the air cylinder is fixed to the connecting column, two openings are symmetrically opened on both sides of the connecting column, and two limit plates are symmetrically fixed to the top and bottom inner walls of the connecting column, one end of the air outlet pipe is inserted into the connecting column and connected to the air cylinder, and the outer side of the air outlet pipe is slidably connected to the inner wall of the limit plate, two clamping pieces are provided, and are symmetrically distributed and fixed in the two openings, and the handle is fixed at the bottom of the air cylinder.

[0012] Preferably, the clamping part is composed of a pressing plate, a clamping shaft, a fixing plate and a spring, the two ends of the clamping shaft are respectively fixed to the top and bottom inner walls of the opening through bearings, and the pressing plate is fixedly sleeved on the outside of the clamping shaft, one end of the pressing plate is a trapezoidal structure and is clamped with the clamping groove, the fixing plate is fixed on the inner wall of one side of the opening, a plurality of springs are provided, and the two ends of the plurality of springs are respectively fixed to the fixing plate and the inner wall of one end of the pressing plate.

[0013] Preferably, the bottom of the base is rectangularly distributed and fixed with four locking universal wheels.

[0014] Compared with the prior art, the present invention has the following beneficial effects:

[0015] 1. When collecting the fasting breathing gas of the patient, the present invention only needs to hold the handle and blow at the mouthpiece. Compared with the traditional mouthpiece, it is more convenient to hold. After collecting the gas, the mouthpiece can be taken out and replaced with a new one by pressing the buttons on both sides. Compared with the traditional method of directly inserting the mouthpiece into the trachea, it has better sealing performance and can filter out saliva in the patient's breath, which is more convenient for the patient to blow, thereby increasing the efficiency of gas collection.

[0016] 2. The present invention can adjust the height of the CRDS detection device through the lifting device, which is convenient for doctors and patients to read the detection data, and the locking universal wheels on the base facilitate the movement of the instrument. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0018] Figure 2 It is a structural schematic diagram of the CRDS detection device of the present invention;

[0019] Figure 3 It is a schematic diagram of a partial cross-sectional structure of a connection assembly of the present invention;

[0020] Figure 4 It is a partial cross-sectional structural schematic diagram of the lifting device of the present invention;

[0021] Figure 5 for Figure 2 Enlarged view of point A in the middle;

[0022] Figure 6 A schematic diagram of the connection between the top plate and the inner movable column of the present invention;

[0023] Figure 7 for Figure 3 Enlarged view of point B in the middle.

[0024] In the figure: 1-base; 2-lifting device; 3-CRDS detection device; 4-outer sleeve; 5-inner moving column; 6-driving motor; 7-top plate; 8-moving block; 9-screw rod; 10-track groove; 11-track plate; 12-limiting block; 13-limiting groove; 14-support plate; 15-CRDS detection instrument; 16-gas connecting pipe; 17-blowing nozzle; 18-connecting assembly; 19-funnel-shaped shell; 20-exhaust pipe; 21-connecting claw; 22-slot; 23-filter; 24-air cylinder; 25-connecting column; 26-clamping piece; 27-handle; 28-opening; 29-limiting plate; 30-pressing plate; 31-clamping shaft; 32-fixing plate; 33-spring; 34-locking universal wheel. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0026] See also Figure 1-7The figure shows a CRDS lung cancer molecular marker detection device, which includes a base 1, a lifting device 2 and a CRDS detection device 3. The bottom of the lifting device 2 is fixed to the surface of the base 1, and the top of the lifting device 2 is fixed to the CRDS detection device 3. The height of the CRDS detection device 3 is adjusted by the lifting device 2, and the collected gas is detected by the CRDS detection device 3.

[0027] The lifting device 2 is composed of an outer sleeve 4, an inner moving column 5, a driving motor 6, a top plate 7, a moving block 8 and a screw rod 9. The top of the inner moving column 5 is fixed to the bottom of the CRDS detection device 3, the bottom of the outer sleeve 4 is fixed to the surface of the base 1, and the top is slidably sleeved on the outside of one end of the inner moving column 5. A threaded hole is opened in the moving block 8, and it is threadedly connected to the screw rod 9 through the threaded hole. The moving block 8 is fixed to the inner wall of the bottom of the inner moving column 5, and a track groove 10 is engraved on the outer side of the inner moving column 5. Two track plates 11 are symmetrically fixed to the inner wall of the outer sleeve 4, and the outer side of the track plate 11 is slidably connected to the inner wall of the track groove 10. The driving motor 6 is fixed to the inner wall of the bottom of the outer sleeve 4, and the output end of the driving motor 6 is fixed to one end of the screw rod 9. The end of the screw rod 9 away from the driving motor 6 is rotatably connected to the top plate 7 through a bearing, and the outer side of the top plate 7 is slidably connected to the inner wall of the inner moving column 5. The height adjustment of the CRDS detection device 3 is achieved through the lifting device 2.

[0028] In actual use, if the height of the CRDS detection device 3 is felt to be inconvenient for doctors and patients to observe, at this time, the driving motor 6 is rotated to drive the screw rod 9 to rotate, so that the moving block 8 threadedly connected to the screw rod 9 moves on the screw rod 9, driving the inner moving column 5 to rise and fall in the outer sleeve 4, thereby realizing the adjustment of the height of the CRDS detection device 3.

[0029] A limiting block 12 is symmetrically fixed on the outer side of the top plate 7, and a limiting groove 13 is symmetrically opened on the inner wall of the inner movable column 5, and the outer side of the limiting block 12 is slidably connected to the inner wall of the limiting groove 13, and one end of the screw rod 9 is rotatably connected to the top plate 7 through a bearing. When the inner movable column 5 is raised or lowered, the limiting block 12 fixed on the outer side of the top plate 7 is slidably connected to the limiting groove 13 symmetrically opened on the inner wall of the inner movable column 5, so that the inner movable column 5 can rise stably.

[0030] See also Figure 1-7 In the figure, the CRDS detection device 3 is composed of a support plate 14, a CRDS detection instrument 15, a gas connecting pipe 16, a nozzle 17 and a connecting component 18. The CRDS detection instrument 15 is installed on the support plate 14, and the bottom of the support plate 14 is fixed to the top of the inner moving column 5. One end of the gas connecting pipe 16 is connected to the gas interface on the CRDS detection instrument 15, and the other end of the gas connecting pipe 16 is connected to the nozzle 17 through the connecting component 18, and the detection of the collected gas is realized through the CRDS detection device 3.

[0031] In actual use, the patient puts the mouthpiece 17 against his mouth and then blows air. The gas is collected through the gas connecting tube 16, and the collected gas is compared with the respiratory symptom and the gas in the personal medical information metadata database. The markers are screened and identified and detected by the CRDS detection instrument 15 to diagnose whether he has lung cancer.

[0032] As an option, the structure of the CRDS detection instrument 15 includes a gas sample chamber, a pillar, a mounting plate, a reflector and an adjustment device, the bottom of the gas sample chamber is fixed to the mounting plate through a pillar, two reflectors are symmetrically arranged at both ends of the gas sample chamber, and the two reflectors are respectively fixed to the gas sample chamber through an adjustment device, the adjustment device includes a mounting block, a spherical gasket, a corrugated gasket, a support, an annular baffle, a sealing cylinder, a sealing cover, an O-ring, a driving member and a connecting member, the mounting block is located on the inner side of the gas sample chamber, and the diameter of the mounting block is smaller than the inner diameter of the gas sample chamber, a through hole is provided in the middle of the mounting block, and an annular groove communicating with the through hole is provided on the inner side of the mounting block, the reflector is located on the inner side of the annular groove, and the two sides of the reflector are respectively fixed to the side walls of the annular groove through a spherical gasket and a corrugated gasket, one side of the mounting block is fixed to the annular baffle through a support, and the annular baffle is fixed to the inner wall of the gas sample chamber;

[0033] The sealing cover is sleeved on the outer side of the gas sample chamber port, and the sealing cover is rotatably connected to the outer wall of the gas sample chamber through a connecting piece, an optical window is fixed in the middle of the sealing cover, and a sealing cylinder is fixed on the inner side of the sealing cover at a position corresponding to the optical window, an O-ring is fixed on the outer side of the sealing cylinder, and the O-ring abuts against the inner wall of the gas sample chamber, the driving member passes through the sealing cover and is fixedly connected to the sealing cover, and the output end of the driving member abuts against the mounting block.

[0034] Preferably, a plurality of the support members are provided, and the plurality of support members are distributed at equal angles between the mounting block and the annular baffle.

[0035] Preferably, the support member includes a support block, a return spring, a piston, a support rod and a support ball, one end of the support block is fixed to the annular baffle, the other end of the support block is provided with a mounting groove, one end of the return spring is fixed to the bottom of the mounting groove, and the other end of the return spring is fixed to the piston, the piston is slidingly matched with the side wall of the mounting groove, one end of the support rod is fixed to a side of the piston away from the return spring, and the other end is fixed to the support ball, a ball groove is provided on one side of the mounting block at a position corresponding to the support ball, and the support ball is slidingly matched in the ball groove.

[0036] Preferably, the connecting member includes a connecting bearing, a connecting tube and a fixing bolt, the inner ring of the connecting bearing is fixed to the outside of the gas sample chamber port, and the outer ring of the connecting bearing is fixed to the inner wall of the connecting tube, the inner wall of the sealing cover cooperates with the connecting tube, and the sealing cover and the connecting tube are both provided with threaded holes, and the sealing cover and the connecting tube are fixed by threaded connection of the threaded holes with fixing bolts.

[0037] Preferably, a plurality of O-rings are provided, and the plurality of O-rings are fixed at equal distances on the outside of the sealing cylinder.

[0038] Preferably, the driving member includes a threaded barrel, a screw rod, a knob, a fixed block and a driving ball, the threaded barrel passes through the sealing cover and is fixedly connected to the sealing cover, the screw rod passes through the threaded barrel and is threadedly connected to the threaded barrel, one end of the screw rod away from the mounting block is fixed to the knob, and the other end is fixed to the fixed block, a groove is provided on the side of the fixed block away from the screw rod, the driving ball is slidably fitted in the groove, and the outer side of the driving ball is slidably connected to the mounting block.

[0039] Preferably, an arc-shaped slide groove is provided at a position corresponding to the driving ball on a side of the mounting block away from the supporting ball, and the driving ball is slidably connected in the arc-shaped slide groove.

[0040] Preferably, an anti-slip protrusion is fixed on the outer side of the knob.

[0041] See also Figure 1-7 In the figure, the mouthpiece 17 is composed of a funnel-shaped shell 19, an air outlet pipe 20 and a connecting claw 21. The funnel-shaped shell 19 is fixedly sleeved on the outside of the air outlet pipe 20. One end of the connecting claw 21 is a trapezoidal structure, and a slot 22 is provided on the outside of the connecting claw 21. Two connecting claws 21 are provided and are symmetrically distributed and fixed at one end of the funnel-shaped shell 19. The connection between the mouthpiece 17 and the connecting assembly 18 is achieved through the connecting claw 21.

[0042] A filter screen 23 is provided at one end of the air outlet pipe 20 close to the funnel shell, which effectively prevents saliva in the blown air from entering the air connecting pipe 16 .

[0043] The connecting assembly 18 consists of an air cylinder 24, a connecting column 25, a clamping piece 26 and a handle 27. One end of the air cylinder 24 is connected to one end of the gas connecting pipe 16, and the other end of the air cylinder 24 is fixed to the connecting column 25. Two openings 28 are symmetrically opened on both sides of the connecting column 25, and two limit plates 29 are symmetrically fixed to the top and bottom inner walls of the connecting column 25. One end of the air outlet pipe 20 is inserted into the connecting column 25 and connected to the air cylinder 24, and the outer side of the air outlet pipe 20 is slidably connected to the inner wall of the limit plate 29. Two clamping pieces 26 are provided and are symmetrically distributed and fixed in the two openings 28. The handle 27 is fixed to the bottom of the air cylinder 24. Holding the gas by the handle 27 makes gas collection more labor-saving. The connection of the nozzle 17 to the connecting column 25 makes its sealing better.

[0044] The clamping member 26 is composed of a pressing plate 30, a clamping shaft 31, a fixing plate 32 and a spring 33. The two ends of the clamping shaft 31 are respectively fixed to the top and bottom inner walls of the opening 28 through bearings, and the pressing plate 30 is fixedly sleeved on the outside of the clamping shaft 31. One end of the pressing plate 30 is a trapezoidal structure and is clamped with the clamping groove 22. The fixing plate 32 is fixed on the inner wall of one side of the opening 28. There are multiple springs 33, and the two ends of the multiple springs 33 are respectively fixed to the fixing plate 32 and the inner wall of one end of the pressing plate 30. The clamping of the connecting claw 21 by the clamping member 26 makes it easier to replace the mouthpiece 17.

[0045] When the mouthpiece 17 is replaced, the patient can press the pressing plates 30 on both sides of the connecting column 25 to disengage one end of the pressing plates 30 from the card slot 22 and to replace the mouthpiece 17 with a new one. When replacing the mouthpiece 17, align one end of the mouthpiece 17 with the connecting column 25 and align the two connecting claws 21 with the two openings 28 to insert the new one.

[0046] The bottom of the base 1 is rectangularly distributed and fixed with four locking universal wheels 34 to facilitate the transportation and movement of the equipment.

[0047] In this solution, the driving motor 6 is preferably of model Y80M1-2, the motor operation circuit is a conventional motor forward and reverse control program, the circuit operation is an existing conventional circuit, and the circuits and controls involved in the present invention are all existing technologies and will not be elaborated on here.

[0048] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0049] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A CRDS lung cancer molecular marker detection device, comprising a base (1), a lifting device (2) and a CRDS detection device (3), characterized in that: The bottom of the lifting device (2) is fixed to the surface of the base (1), and the top of the lifting device (2) is fixed to the CRDS detection device (3); The lifting device (2) is composed of an outer sleeve (4), an inner moving column (5), a driving motor (6), a top plate (7), a moving block (8) and a screw rod (9). The top of the inner moving column (5) is fixed to the bottom of the CRDS detection device (3). The bottom of the outer sleeve (4) is fixed to the surface of the base (1), and the top sliding sleeve is sleeved on the outside of one end of the inner moving column (5). A threaded hole is opened in the moving block (8), and the moving block (8) is threadedly connected to the screw rod (9) through the threaded hole. The moving block (8) is connected to the inner wall of the bottom of the inner moving column (5). The outer wall of the outer sleeve (4) is symmetrically fixed with two track plates (11), and the outer side of the track plates (11) is slidably connected to the inner wall of the track groove (10). The drive motor (6) is fixed to the inner wall of the bottom of the outer sleeve (4), and the output end of the drive motor (6) is fixed to one end of the screw rod (9). The end of the screw rod (9) away from the drive motor (6) is rotatably connected to the top plate (7) through a bearing, and the outer side of the top plate (7) is slidably connected to the inner wall of the inner movable column (5); The outer side of the top plate (7) is symmetrically fixed with a limit block (12), the inner wall of the inner movable column (5) is symmetrically provided with a limit groove (13), and the outer side of the limit block (12) is slidably connected to the inner wall of the limit groove (13); The CRDS detection device (3) is composed of a support plate (14), a CRDS detection instrument (15), a gas connection pipe (16), a blowing nozzle (17) and a connecting assembly (18); the CRDS detection instrument (15) is mounted on the support plate (14), and the bottom of the support plate (14) is fixed to the top of the inner movable column (5); one end of the gas connection pipe (16) is connected to the gas interface on the CRDS detection instrument (15), and the other end of the gas connection pipe (16) is connected to the blowing nozzle (17) through the connecting assembly (18); The structure of the CRDS detection instrument (15) includes a gas sample chamber, a support, a mounting plate, a reflector and an adjustment device; The blowing nozzle (17) is composed of a funnel-shaped shell (19), an air outlet pipe (20) and a connecting claw (21); the funnel-shaped shell (19) is fixedly sleeved on the outside of the air outlet pipe (20); one end of the connecting claw (21) is a trapezoidal structure, and a slot (22) is provided on the outside of the connecting claw (21); two connecting claws (21) are provided and symmetrically distributed and fixed on one end of the funnel-shaped shell (19); The connection assembly (18) is composed of a gas cylinder (24), a connection column (25), a clamping piece (26) and a handle (27). One end of the gas cylinder (24) is connected to one end of the gas connection pipe (16), and the other end of the gas cylinder (24) is fixed to the connection column (25). Two openings (28) are symmetrically opened on both sides of the connection column (25), and two limit plates (29) are symmetrically fixed to the top and bottom inner walls of the connection column (25). One end of the gas outlet pipe (20) is inserted into the connection column (25) and connected to the gas cylinder (24), and the outer side of the gas outlet pipe (20) is slidably connected to the inner wall of the limit plate (29). Two clamping pieces (26) are provided and are symmetrically distributed and fixed in the two openings (28). The handle (27) is fixed to the bottom of the gas cylinder (24).

2. A CRDS lung cancer molecular marker detection device according to claim 1, characterized in that: The air outlet pipe (20) is provided with a filter screen (23) at one end close to the funnel shell.

3. A CRDS lung cancer molecular marker detection device according to claim 2, characterized in that: The clamping member (26) is composed of a pressing plate (30), a clamping shaft (31), a fixing plate (32) and a spring (33). The two ends of the clamping shaft (31) are respectively fixed to the top and bottom inner walls of the opening (28) through bearings, and the pressing plate (30) is fixedly sleeved on the outside of the clamping shaft (31). One end of the pressing plate (30) is a trapezoidal structure and is clamped to the clamping groove (22). The fixing plate (32) is fixed to the inner wall of one side of the opening (28). A plurality of springs (33) are provided, and the two ends of the plurality of springs (33) are respectively fixed to the fixing plate (32) and the inner wall of one end of the pressing plate (30).

4. A CRDS lung cancer molecular marker detection device according to claim 3, characterized in that: The bottom of the base (1) is arranged in a rectangular shape and is fixed with four locking universal wheels (34).

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