A multi-brain region recording electrode, a manufacturing method and an implantation method

Abstract

The present invention discloses a multi-brain region recording electrode, a manufacturing method and an implantation method, and relates to the technical field of medical equipment. The multi-brain region recording electrode includes a needle row and a plurality of single brain region electrodes connected in parallel to each other, the plurality of single brain region electrodes respectively have a connection end and an implantation end arranged relatively, the connection ends of the plurality of single brain region electrodes are respectively electrically connected to the needle row, the plurality of single brain region electrodes all extend in the same direction, the implantation ends of any two single brain region electrodes are spaced apart in the extension direction of the single brain region electrodes, and the implantation ends of the plurality of single brain region electrodes are used to be respectively inserted into different target brain regions. The multi-brain region recording electrode provided by the present invention can be implanted into multiple target brain regions at the same time, which is convenient and fast, saves time and labor costs, and has wide applicability.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to a multi-brain region recording electrode, a manufacturing method and an implantation method. Background Art

[0002] Brain region recording electrodes are used to achieve synchronous recording of action potentials and local field potentials in multiple brain regions of experimental animals, thereby solving the problem of simultaneously recording the functional electrical activities of multiple brain regions in freely moving animals under a specific behavioral paradigm, in order to analyze the relevant circuit functions under this behavior, which is very helpful for the analysis of neural circuit functions.

[0003] At present, the single brain region electrodes on the market are used for signal recording in a single brain region. When performing multi-brain region signal recording, it is necessary to implant multiple single brain region electrodes in sequence for different target brain regions. This process will consume a lot of time and cost a lot. In addition, implanting multiple single brain region electrodes in different positions will require a large space, which will not be possible when the brain volume of the implanted object is small. Summary of the invention

[0004] The object of the present invention is to provide a multi-brain region recording electrode, which can be implanted into multiple different target brain regions at one time.

[0005] Another object of the present invention is to provide a method for producing a multi-brain region recording electrode, which can produce a multi-brain region recording electrode that can be implanted into multiple different target brain regions at one time.

[0006] Another object of the present invention is to provide a method for implanting multi-brain region recording electrodes, which can be implanted into multiple different target brain regions at one time.

[0007] The present invention provides a technical solution:

[0008] A multi-brain region recording electrode comprises a needle row and a plurality of single brain region electrodes connected in parallel to each other, wherein the plurality of single brain region electrodes respectively have a connecting end and an implanting end arranged opposite to each other, the connecting ends of the plurality of single brain region electrodes are respectively electrically connected to the needle row, the plurality of single brain region electrodes all extend in the same direction, the implanting ends of any two of the single brain region electrodes are spaced apart in the extending direction of the single brain region electrodes, and the implanting ends of the plurality of single brain region electrodes are used to be respectively inserted into different target brain regions.

[0009] Furthermore, a plurality of the single brain region electrodes are stacked in sequence.

[0010] Furthermore, the multi-brain region recording electrode also includes a glue layer, and any two adjacent single brain region electrodes are connected through the glue layer.

[0011] Furthermore, the single brain region electrode includes a plurality of electrode units, the plurality of electrode units are arranged in a row, and the plurality of electrode units extend in the same direction.

[0012] Furthermore, the plurality of electrode units are connected in sequence in an arrangement direction.

[0013] Furthermore, the electrode unit includes a sleeve and an electrode wire, the sleeve is sleeved on the electrode wire, the connecting end and the implantation end are respectively arranged at opposite ends of the electrode wire, the implantation end passes through the sleeve, the sleeves of two adjacent electrode units are arranged in a row and connected in sequence, and the sleeve is used to guide the electrode wire so that the implantation end is inserted into the target brain area.

[0014] Furthermore, the implantation ends of the plurality of electrode wires in the same single brain region electrode are flush.

[0015] Furthermore, the connection ends of the plurality of single brain region electrodes are flush.

[0016] The present invention also provides a method for making a multi-brain region recording electrode, which is used to make the multi-brain region recording electrode, wherein the multi-brain region electrode includes a needle row and a plurality of single brain region electrodes connected in parallel to each other, wherein the plurality of single brain region electrodes respectively have a connection end and an implantation end arranged opposite to each other, wherein the connection ends of the plurality of single brain region electrodes are respectively electrically connected to the needle row, wherein the plurality of single brain region electrodes extend in the same direction, and the implantation ends of any two single brain region electrodes are spaced apart in the extension direction of the single brain region electrodes, and the implantation ends of the plurality of single brain region electrodes are used to be respectively inserted into different target brain regions. The method for making the multi-brain region recording electrode includes:

[0017] Measuring the distances between multiple target brain regions to obtain multiple preset distance values;

[0018] Connecting a plurality of single brain region electrodes in parallel, and making the extension directions of the plurality of single brain region electrodes consistent;

[0019] Cutting a plurality of the single brain region electrodes to obtain the implantation end and the connection end, and making the implantation ends of any two of the single brain region electrodes spaced apart by the preset distance value in the extension direction of the single brain region electrodes;

[0020] The connection ends of the plurality of single brain region electrodes are electrically connected to the pin headers respectively.

[0021] The present invention also provides a method for implanting a multi-brain region recording electrode, using the multi-brain region recording electrode, the multi-brain region recording electrode includes a needle row and a plurality of single brain region electrodes connected in parallel to each other, the plurality of single brain region electrodes respectively have a connection end and an implantation end that are relatively arranged, the connection ends of the plurality of single brain region electrodes are respectively electrically connected to the needle row, the plurality of single brain region electrodes all extend in the same direction, the implantation ends of any two of the single brain region electrodes are spaced apart in the extension direction of the single brain region electrodes, and the implantation ends of the plurality of single brain region electrodes are used to be respectively inserted into different target brain regions. The method for implanting a multi-brain region recording electrode includes:

[0022] Localize multiple target brain regions;

[0023] Pushing the multi-brain region recording electrode so that the plurality of single brain region electrodes simultaneously move toward the respective corresponding target brain regions, so that the respective implant ends of the single brain region electrodes are inserted into the respective corresponding target brain regions;

[0024] The multi-brain region recording electrodes are fixed on the skull.

[0025] Compared with the prior art, the multi-brain region recording electrode provided by the present invention has multiple single brain regions connected in parallel with each other, and all extend in the same direction, and the implant ends of any two single brain region electrodes are spaced apart in the extension direction of the single brain region electrodes. In practical applications, multiple single brain region electrodes connected together are implanted at the same time, and the implantation can be completed until the implant ends of each single brain region electrode reach their respective corresponding target brain regions. This is convenient and fast, occupies a small space, and is not affected by the brain volume of the implanted object. Therefore, the beneficial effects of the multi-brain region recording electrode provided by the present invention are: it can be implanted into multiple target brain regions at the same time, which is convenient and fast, saves time and labor costs, and has a wide range of applicability. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only illustrate certain embodiments of the present invention and should not be regarded as limiting the scope. For those of ordinary skill in the art, other related drawings can also be obtained based on these drawings without creative work.

[0027] Figure 1 A schematic diagram of the structure of a multi-brain region recording electrode provided by an embodiment of the present invention;

[0028] Figure 2 for Figure 1 Schematic diagram of the pin arrangement structure;

[0029] Figure 3 for Figure 1Schematic diagram of the structure of electrodes in a single brain region;

[0030] Figure 4 A schematic flow chart of a method for making multi-brain region recording electrodes provided in an embodiment of the present invention;

[0031] Figure 5 A schematic flowchart of a method for implanting multi-brain region recording electrodes provided in an embodiment of the present invention.

[0032] Icon: 100-multi-brain region recording electrode; 110-needle row; 111-main body; 113-pin; 130-single brain region electrode; 131-connecting end; 132-electrode unit; 1321-sleeve; 1323-electrode wire; 133-implantation end; 150-glue layer. DETAILED DESCRIPTION

[0033] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations.

[0034] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0036] In the description of the present invention, it should be understood that the directions or positions indicated by “upper” and the like are based on the directions or positions shown in the accompanying drawings, or are the directions or positions in which the product of the invention is usually placed when in use, or are directions or positions commonly understood by those skilled in the art. These directions or positions are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or component referred to must have a specific direction, be constructed and operated in a specific direction, and therefore should not be understood as a limitation on the present invention.

[0037] Furthermore, the terms “first”, “second”, etc. are merely used for distinguishing descriptions and should not be understood as indicating or implying relative importance.

[0038] In the description of the present invention, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms such as "setting" and "connection" should be understood in a broad sense. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be the internal communication of two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0039] The specific implementation modes of the present invention are described in detail below in conjunction with the accompanying drawings.

[0040] Please refer to Figure 1 As shown, the multi-brain region recording electrode 100 provided in the embodiment of the present invention is used to be implanted in the brain of an experimental animal to achieve synchronous recording of action potentials and local field potentials in multiple brain regions, thereby solving the problem of simultaneously recording the functional activity of multiple brain regions on freely moving animals under a specific behavioral paradigm, so as to analyze the relevant loop functions under this behavior. The multi-brain region recording electrode 100 provided in this embodiment can be implanted into multiple target brain regions at the same time, which is convenient and fast, saves time and labor costs, and has wide applicability.

[0041] The multi-brain region recording electrode 100 provided in this embodiment includes a needle row 110 and a plurality of single brain region electrodes 130 connected in parallel to each other. The plurality of single brain region electrodes 130 are used to be respectively inserted into different target brain regions. The plurality of single brain region electrodes 130 respectively have relatively arranged connection ends 131 and implantation ends 133. The connection ends 131 of the plurality of single brain region electrodes 130 are respectively electrically connected to the needle row 110, and the implantation ends 133 of the plurality of single brain region electrodes 130 are used to be inserted into the corresponding target brain regions. The plurality of single brain region electrodes 130 all extend in the same direction, that is, the plurality of single brain region electrodes 130 in the multi-brain region recording electrode 100 provided in this embodiment are all arranged in parallel. In the actual implantation process, the implantation direction angles of the plurality of single brain region electrodes 130 are also the same. The implantation ends 133 of any two single brain region electrodes 130 are spaced apart in the extension direction of the single brain region electrodes 130 , that is, among any two single brain region electrodes 130 , the implantation end 133 of one single brain region electrode 130 crosses the implantation end 133 of the other single brain region electrode 130 in the extension direction of the single brain region electrode 130 .

[0042] Please combine Figure 1 and Figure 2As shown, the pin header 110 can be connected to the electrophysiological recording instrument. The pin header 110 includes a main body 111 and multiple rows of pins 113 protruding from one side of the main body 111. The specific number of pins 113 and the number of distribution layers are determined according to the specific number of single brain region electrodes 130. In this embodiment, a 16-channel pin header 110 is used, that is, the number of pins 113 is 16, and they are distributed in two layers, 8 in each layer, so two single brain region electrodes 130 are connected correspondingly, that is, they are inserted into two brain regions.

[0043] In the actual production process, a matching pin header 110 is selected according to the required number of target brain regions, and then the corresponding single brain region electrode 130 is produced. For example, when corresponding to three brain regions, a pin header 110 with three rows of pins 113 is selected, and each row of pins 113 is connected to a single brain region electrode 130. When the experimental multi-brain region is four brain regions, a 32-channel pin header 110 can be directly used, on which the pins 113 are arranged in 4 layers, 8 in each layer, and each layer of pins 113 is connected to a single brain region electrode 130, and the 4 single brain region electrodes 130 are stacked and connected in sequence.

[0044] In the actual implantation process of the multi-brain region recording electrode 100 provided in this embodiment, since the implantation ends 133 of the multiple single brain region electrodes 130 are arranged at intervals in the extension direction of the single brain region electrodes 130, the implantation ends 133 of the multiple single brain region electrodes 130 can stay in different brain regions of the experimental animal's brain when the external force of the implantation stops. In actual application, the multi-brain region recording electrode 100 is selected according to the positioning of different brain regions of the experimental animal's brain. When the multi-brain region recording electrode 100 is implanted under the action of external force, the multiple single brain region electrodes 130 move toward their respective corresponding target brain regions simultaneously along the implantation direction, and stop when the respective implantation ends 133 of each single brain region electrode 130 reach their respective corresponding target brain regions, that is, the implantation of the multi-brain region recording electrode 100 is completed, and the multiple single brain region electrodes 130 are implanted into their respective corresponding target brain regions at the same time, so that the synchronous recording of the action potentials and local field potentials of multiple brain regions can be realized.

[0045] In this embodiment, multiple single brain region electrodes 130 are stacked in sequence. In other embodiments, multiple single brain regions 130 can also be arranged side by side and spaced apart according to implantation requirements, and multiple single brain regions 130 can be connected together through other middleware. In addition, multiple single brain regions 130 can also be located in multiple different planes, and the planes they are located in intersect.

[0046] The multi-brain region recording electrode 100 further includes a glue layer 150, and any two adjacent single brain region electrodes 130 are connected by the glue layer 150. In the actual preparation process of the multi-brain region recording electrode 100 provided in this embodiment, two adjacent single brain region electrodes 130 are bonded by an adhesive such as glue to realize the sequential stacking of multiple single brain region electrodes 130, and the adhesive solidifies to form the glue layer 150. In other embodiments, two adjacent single brain region electrodes 130 can also be connected by other forms, such as bundling by a binding piece.

[0047] Please combine Figure 1 and Figure 3 As shown, the single brain region electrode 130 includes a plurality of electrode units 132 , which are arranged in rows and extend in the same direction, that is, the plurality of electrode units 132 are parallel to each other.

[0048] In this embodiment, the plurality of electrode units 132 are connected sequentially in the arrangement direction, and two adjacent electrode units 132 are directly bonded sequentially by an adhesive such as glue. In other embodiments, the plurality of electrode units 132 on the same single brain region electrode 130 can also be connected and fixed together in other forms, such as by bundling with a binding piece.

[0049] The electrode unit 132 includes a sleeve 1321 and an electrode wire 1323. The sleeve 1321 is sleeved on the electrode wire 1323. The connection end 131 and the implantation end 133 are respectively arranged at two opposite ends of the electrode wire 1323, and the implantation end 133 passes through the sleeve 1321. In the actual manufacturing process, since the metal wire used in the electrode wire 1323 is often relatively soft, it is difficult to insert it into the corresponding target brain area during the implantation process. Therefore, the sleeve 1321 is sleeved on the electrode wire 1323 to guide the electrode wire 1323 so that the implantation end 133 is inserted into the target brain area. In this embodiment, the sleeve 1321 is a silicon tube. In other embodiments, the sleeve 1321 can also be made of tubes of other materials according to actual implantation requirements.

[0050] Please continue to refer to Figure 1As shown, the multi-brain region recording electrode 100 provided in this embodiment has 16 channels, and the electrode wire 1323 in each sleeve 1321 is composed of two strands of metal wire twisted together, that is, each electrode wire 1323 is two channels, that is, the number of sleeves 1321 is 8. One layer of 4 sleeves 1321 is sleeved on 4 electrode wires 1323 to form 4 electrode units 132, and the 4 electrode units 132 are arranged to form a single brain region electrode 130. Another layer of 4 sleeves 1321 is sleeved on another 4 electrode wires 1323 to form 4 electrode units 132, and the 4 electrode units 132 are arranged to form another single brain region electrode 130. Two single brain region electrodes 130 are stacked, and a 16-channel pin header 110 is selected correspondingly. The pin header 110 is provided with 16 pins 113, and the 16 pins 113 are also arranged in two rows. Two metal wires of the four electrode wires 1323 in a single brain region electrode 130 are respectively welded to a row of eight pins 113. In other embodiments, the electrode wires 1323 can also be electrically connected to the pins 113 on the pin header 110 in other forms, such as through wires.

[0051] In other embodiments, according to other experimental requirements such as the actual number of actual target brain regions, the number of channels can be changed, such as 32 channels, and the corresponding pin header 110 can be selected.

[0052] In this embodiment, the implantation ends 133 of the multiple electrode wires 1323 in the same single brain region electrode 130 are flush. Considering the uncertainties in actual processing, in other embodiments, the implantation ends 133 of the multiple electrode wires 1323 in the same single brain region electrode 130 may have a certain error, that is, they may be roughly flush. In addition, in this embodiment, the connection ends 131 of the multiple electrode wires 1323 in the same single brain region electrode 130 are also flush.

[0053] The multi-brain region recording electrode 100 provided in this embodiment, when the multi-brain region recording electrode 100 is implanted under the action of external force, multiple single brain region electrodes 130 move toward their respective corresponding target brain regions simultaneously along the implantation direction, and stop when the implantation end 133 of each single brain region electrode 130 reaches their respective corresponding target brain regions, that is, the implantation of the multi-brain region recording electrode 100 is completed, and multiple single brain region electrodes 130 are implanted into their respective corresponding target brain regions at the same time, thereby achieving synchronous recording of action potentials and local field potentials of multiple brain regions. As a result, the multi-brain region signal recording electrode style and the corresponding electrode implantation method are simplified. When the brain volume of the implanted object is small, since multiple single brain region electrodes do not need to be implanted in partitions, the implantation space occupied on the brain surface is extremely small, the implementation range is large, and the applicability is wide.

[0054] Therefore, the multi-brain region recording electrode provided by the present invention has a simple structure and can be implanted into multiple target brain regions at the same time, which is convenient and fast, saves time and labor costs, and has wide applicability.

[0055] The structure of the multi-brain region recording electrode 100 provided by the present invention is not limited to the recording of signals from multiple brain regions, and optical fibers can also be implanted in certain brain regions for light stimulation.

[0056] Please refer to Figure 4 As shown, the present invention also provides a method for manufacturing a multi-brain region recording electrode, which is used to manufacture the multi-brain region recording electrode 100 provided in the embodiment, comprising:

[0057] Step S101, measuring the distances between multiple target brain regions to obtain multiple preset distance values.

[0058] The preset distance value is the spacing distance between the implant ends 133 of any two single brain region electrodes 130 in the embodiment in the extension direction of the single brain region electrodes 130 .

[0059] Furthermore, the method for making the multi-brain region recording electrodes also includes:

[0060] Step S102 , connecting a plurality of single brain region electrodes 130 in parallel, and making the extension directions of the plurality of single brain region electrodes 130 consistent.

[0061] In this embodiment, one end of the electrode wire 1323 is passed through the sleeve 1321 to form an electrode unit 132, and then multiple electrode units 132 are arranged in a row and connected in sequence to form a single brain region electrode 130. The extension direction of the single brain region electrode 130 is the extension direction of the sleeve 1321.

[0062] Furthermore, the method for making the multi-brain region recording electrodes also includes:

[0063] Step S103 , cutting a plurality of single brain region electrodes 130 to obtain implantation ends 133 and connection ends 131 , and making the implantation ends 133 of any two single brain region electrodes 130 spaced apart by a preset distance in the extension direction of the single brain region electrodes 130 .

[0064] According to the multiple preset distance values ​​obtained in step S101, one end of the multiple electrode wires 1323 passing through the sleeve 1321 is cut, so that the interval between the electrode wires 1323 on any two single brain region electrodes 130 in the extension direction of the sleeve 1321 is equal to the preset distance value. One end of the cut electrode wire 1323 is the implantation end 133, and the other end opposite to the implantation end 133 is the connection end 131.

[0065] Furthermore, the method for making the multi-brain region recording electrodes also includes:

[0066] Step S104 , electrically connecting the connection ends 131 of the plurality of single brain region electrodes 130 to the pin headers 110 respectively.

[0067] After the multi-brain region recording electrode 100 is manufactured, it needs to be modified and tested. The multi-brain region recording electrode 100 provided in the embodiment can be manufactured by the manufacturing method of the multi-brain region recording electrode provided by the present invention.

[0068] Please refer to Figure 5 As shown, the present invention also provides a method for implanting a multi-brain region recording electrode, using the multi-brain region recording electrode 100 provided in the embodiment, the method for implanting a multi-brain region recording electrode includes:

[0069] Step S201, locating multiple target brain regions.

[0070] Through animal brain area positioning surgery and other methods, multiple target brain areas in the experimental subject's brain are located to determine the implantation direction.

[0071] Furthermore, the method for implanting the multi-brain region recording electrodes also includes:

[0072] Step S202 , pushing the multi-brain region recording electrode 100 , so that the respective implant ends 133 of the plurality of single brain region electrodes 130 are simultaneously inserted into the respective corresponding target brain regions.

[0073] The multi-brain region recording electrode 100 is implanted according to the implantation direction determined in step S201. During the implantation process, the multiple single brain region electrodes 130 on the multi-brain region recording electrode 100 all move toward their respective corresponding target brain regions. When each single brain region electrode 130 reaches its respective corresponding target brain region, the pushing is stopped and the multi-brain region recording electrode 100 is fixed by dental cement or other fixing methods.

[0074] Furthermore, the method for implanting the multi-brain region recording electrodes also includes:

[0075] Step S203, fixing the multi-brain region recording electrodes 100 on the skull.

[0076] The multi-brain region recording electrode 100 is fixed to the corresponding skull of the implanted subject's brain, and the implantation is completed.

[0077] The method for implanting multi-brain region recording electrodes provided by the present invention is used to implant the multi-brain region recording electrodes 100 provided in the embodiment into an experimental brain. In actual use, the method for implanting multi-brain region recording electrodes and the multi-brain region recording electrodes 100 provided in the embodiment do not necessarily have to be completely bound together.

[0078] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A multi-brain region recording electrode, characterized in that: It comprises a needle row and a plurality of single brain region electrodes connected in parallel to each other, wherein the plurality of single brain region electrodes respectively have connecting ends and implanting ends arranged opposite to each other, the connecting ends of the plurality of single brain region electrodes are respectively electrically connected to the needle row, the plurality of single brain region electrodes all extend in the same direction, the implanting ends of any two of the single brain region electrodes are spaced apart in the extending direction of the single brain region electrodes, and the implanting ends of the plurality of single brain region electrodes are used to be respectively inserted into different target brain regions; A plurality of the single brain region electrodes are stacked in sequence; The single brain region electrode comprises a plurality of electrode units, the plurality of electrode units are arranged in a row, and the plurality of electrode units extend in the same direction; The plurality of electrode units are connected in sequence in an arrangement direction; The electrode unit comprises a sleeve and an electrode wire, wherein the sleeve is sleeved on the electrode wire, and the sleeves of two adjacent electrode units are arranged in a row and connected in sequence; The multi-brain region recording electrode further comprises a glue layer, and any two adjacent single-brain region electrodes are connected via the glue layer.

2. The multi-brain region recording electrode according to claim 1, characterized in that: The connecting end and the implanting end are respectively arranged at two opposite ends of the electrode wire, and the implanting end passes through the sleeve, and the sleeve is used to guide the electrode wire so that the implanting end is inserted into the target brain area.

3. The multi-brain region recording electrode according to claim 2, characterized in that: The implantation ends of the plurality of electrode wires in the same single brain region electrode are flush.

4. The multi-brain region recording electrode according to claim 1, characterized in that: The connection ends of the plurality of single brain region electrodes are flush.

5. A method for making multi-brain region recording electrodes, characterized in that: Used to manufacture the multi-brain region recording electrode according to any one of claims 1 to 4, wherein the manufacturing method of the multi-brain region recording electrode comprises: Measuring the distances between multiple target brain regions to obtain multiple preset distance values; Connecting a plurality of single brain region electrodes in parallel, and making the extension directions of the plurality of single brain region electrodes consistent; Cutting a plurality of the single brain region electrodes to obtain the implantation end and the connection end, and making the implantation ends of any two of the single brain region electrodes spaced apart by the preset distance value in the extension direction of the single brain region electrodes; The connection ends of the plurality of single brain region electrodes are electrically connected to the pin headers respectively; In the actual preparation process, any two adjacent single brain region electrodes are bonded together by an adhesive to achieve sequential stacking of the plurality of single brain region electrodes, and the adhesive is solidified to form a glue layer.

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