A high-activity nanoscale tricalcium phosphate production reactor and its use method

Abstract

The invention discloses a high-activity nanoscale tricalcium phosphate production reactor, which belongs to the technical field of nanoscale tricalcium phosphate preparation devices. It includes a frame body composed of a support plate, a support profile and a connector, and a reaction part composed of a first reaction container, a second reaction container and a third reaction container; the reactor has a rotation function, can achieve full reaction, and also has drainage, drying, temperature control and other functions to improve reaction accuracy; when two groups of reaction containers work at the same time, the output can be effectively increased, and when a single group of reaction containers is working, the other group of idle reaction containers can be maintained, maintained or repaired; when a single container is damaged, the reaction production of the other group of containers will not be affected.

Description

Technical Field

[0001] The invention relates to the field of production equipment and use methods thereof, and in particular to a high-activity nanoscale tricalcium phosphate production reactor and a use method thereof. Background Art

[0002] Tricalcium phosphate biomaterials have good bioactivity, biocompatibility and biodegradability, and have been widely used in medicine and hard tissue replacement materials. For example, α-tricalcium phosphate can be used to prepare bone cement, and porous β-tricalcium phosphate materials have been used as controlled drug sustained-release carriers for antibiotic treatment of bone infections. β-tricalcium phosphate tooth adhesives combined with antibacterial agents can treat various types of caries.

[0003] The preparation methods in the prior art often have complicated steps and processes, and the procedures are cumbersome, making it difficult to effectively improve production efficiency.

[0004] The present invention optimizes and integrates the reaction devices into one reaction equipment, and can mix two groups of raw materials at the same time, thereby improving the output and production efficiency. When a single reaction device needs to be cleaned, the other set of reaction devices can still be produced, which has good flexible production capacity. Summary of the invention

[0005] The purpose of the present invention is to solve the problems of low production efficiency and low integration in the prior art, and proposes a high-activity nanoscale tricalcium phosphate production reactor and a use method thereof.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] A high-activity nanoscale tricalcium phosphate production reactor, comprising a frame body composed of a support plate, a support profile and a connecting piece, a first reaction container, a second reaction container and a third reaction container; characterized in that there are two first reaction containers, two second reaction containers and one third reaction container, the containers are all arranged inside the frame body, a first fixing piece is fixedly connected to the side of the support plate facing the inside, and the first fixing piece is sequentially connected to the second fixing piece and a connecting sleeve; the connecting sleeve is a hollow tubular structure, and a first channel and a second channel are symmetrically opened on its side wall, and the discharge ports of the first reaction container and the second reaction container are respectively connected to the first and second channels; the bottom of the first and second reaction containers are also provided with an openable and closable bottom cover, and the bottom cover is used for filling during the preparation process ; Control switches for opening and closing the channels are provided at the first channel and the second channel; a drainage rod passing through the flow channel is provided in the flow channel inside the connecting sleeve, and a spiral blade for drainage is provided on the part of the drainage rod extending into the connecting sleeve; the other end of the connecting sleeve extends into the third reaction container; the third reaction container comprises an outer shell and a hollow reaction cavity; a heating device is provided between the reaction cavity and the outer shell for providing a reaction temperature to the reaction cavity of the third reaction container; the reaction cavity is sealed and connected to the connecting sleeve; two first reaction containers are symmetrically arranged on both sides of the third reaction container, and two second reaction containers are symmetrically arranged on both sides of the third reaction container; a rotating device is also connected to the frame portion, and the rotating device can drive the frame to rotate under the drive of the driving component connected thereto.

[0008] Preferably, the first and second fixing members are connected by bolts, and the second fixing member and the connecting sleeve are connected by bolts; further, to facilitate the connection, a protrusion perpendicular to the axial direction can be provided at the end of the connecting sleeve, and a threaded hole is opened on the protrusion corresponding to the threaded hole on the second fixing member, and the connection is established by bolts.

[0009] Preferably, the second fixing member and the connecting sleeve can be connected by interference fit.

[0010] Preferably, the second fixing member and the connecting sleeve can be welded or integrally formed.

[0011] Preferably, the portion of the drainage rod extending into the third reaction container also has an extension portion, and a plurality of groups of breaking rods perpendicular to the extension direction are arranged on the circumference of the extension portion; and a rotating motor capable of driving the drainage rod to rotate is arranged at the end of the drainage rod.

[0012] Preferably, the end of the breaking rod is also provided with a grinding ball with a smooth surface.

[0013] Preferably, the rotary motor can be replaced by a high-torque hydraulic motor to increase the driving torque.

[0014] Preferably, a material switch that can be opened and closed is provided on the side wall of the reaction chamber of the third reaction container.

[0015] Preferably, the reactor includes two working states: in the first working state, a first reaction container and its corresponding second reaction container are working; in the second working state, both first reaction containers and their corresponding second reaction containers are working. This can improve working efficiency and achieve mass production; when it is not necessary for two groups of containers to work at the same time, the cleaning and maintenance of the non-working container can be achieved.

[0016] Preferably, the first and second reaction containers are both designed to be detachable structures.

[0017] Preferably, the heating device is a nickel-chromium heating wire.

[0018] Preferably, the rotating device is a gear, which meshes with a gear fixedly connected to the rotating motor, thereby enabling the frame body to rotate under the drive of the rotating motor.

[0019] The specific operation methods of the above equipment are as follows:

[0020] Step 1: The reactor is placed horizontally as a whole, calcium salt particles and phosphorus pentoxide particles are added to the first reaction container, and ethanol is added to dissolve them; ammonia water is added to the second reaction container;

[0021] Step 2: After the reactants in the first container are completely dissolved, the control switches for opening and closing the first channel and the second channel are turned on to completely mix the dissolved liquid and the ammonia water.

[0022] Step 3: close the control switches for opening and closing the first channel and the second channel, so that the mixed liquid is completely enclosed in the second reaction container; turn on the rotating device to drive the frame part to rotate, and the second reaction container also rotates or swings accordingly; the mixed liquid in the second reaction container is fully mixed to achieve stable regulation of the pH value;

[0023] Step 4: Keep the frame in a vertical state, turn on the control switch for opening and closing the second channel, so that the sol with uniform and stable shaking flows into the third reaction container along the drainage rod 44; age and dry the sol through a heating device to obtain tricalcium phosphate dry gel.

[0024] Preferably, the above steps further include

[0025] Step 5: Open the material switch, take out the tricalcium phosphate dry gel, and further process it into nano-scale tricalcium phosphate powder.

[0026] Preferably, the above steps can also be designed as follows:

[0027] Step 5: Turn on the rotating motor to break the dry gel into powder;

[0028] Step 6: Further heat the crushed powder by a heating device to obtain nano-scale tricalcium phosphate powder.

[0029] Compared with the prior art, the present invention provides a high-activity nanoscale tricalcium phosphate production reactor and a method for using the same, which has the following beneficial effects:

[0030] The preparation methods in the prior art often have complicated steps and processes, and the procedures are cumbersome, making it difficult to effectively improve production efficiency.

[0031] The reactor has a rotation function, which can achieve full reaction. It also has drainage, drying, temperature control and other functions to improve reaction accuracy. When two groups of reaction vessels work at the same time, the output can be effectively increased. When a single group of reaction vessels is working, the other group of idle reaction vessels can be maintained, serviced or overhauled. When a single container is damaged, it will not affect the reaction production of the other group of containers.

[0032] The present invention optimizes the reaction device and integrates it into one reaction equipment, which can mix two groups of raw materials at the same time, thereby improving the output and production efficiency.

[0033] When a single reaction unit needs to be cleaned, another set of reaction units can still be produced, which has good flexible production capacity. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 This is a front view of a high-activity nanoscale tricalcium phosphate production reactor proposed by the present invention in a horizontally placed state;

[0035] Figure 2 It is a partial enlarged view of a high-activity nanoscale tricalcium phosphate production reactor proposed by the present invention;

[0036] Figure 3 This is a front view of a high-activity nanoscale tricalcium phosphate production reactor proposed by the present invention in a vertically placed state.

[0037] In the figure: 39. support plate, 40. support profile, 41. connecting piece, 47. first reaction container, 48. second reaction container, 30. third reaction container, 37. first fixing piece, 38 second fixing piece, 33. connecting sleeve; 49. first channel, 50. second channel, 44. drainage rod, 22. outer shell, 21. reaction chamber, 27. heating device, 53. sealing ring. DETAILED DESCRIPTION

[0038] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0039] In the description of the present invention, it is necessary to understand that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0040] Embodiment 1:

[0041] Reference Figure 1-3 , a high-activity nanoscale tricalcium phosphate production reactor, comprising a frame body composed of a support plate, a support profile and a connecting piece, a first reaction container, a second reaction container and a third reaction container; characterized in that there are two first reaction containers, two second reaction containers and one third reaction container, the containers are all arranged inside the frame body, a first fixing piece is fixedly connected to the side of the support plate facing the inside, and the first fixing piece is sequentially connected to the second fixing piece and a connecting sleeve; the connecting sleeve is a hollow tubular structure, a first channel and a second channel are symmetrically opened on its side wall, and the discharge ports of the first reaction container and the second reaction container are respectively connected to the first and second channels; the bottom of the first and second reaction containers are also provided with an openable and closable bottom cover, and the bottom cover is used for filling in the preparation process material; control switches for opening and closing the channels are provided at the first channel and the second channel; a drainage rod passing through the channel is provided in the flow channel inside the connecting sleeve, and a spiral blade for drainage is provided on the part of the drainage rod extending into the connecting sleeve; the other end of the connecting sleeve extends into the third reaction container; the third reaction container comprises an outer shell and a hollow reaction cavity; a heating device is provided between the reaction cavity and the outer shell for providing a reaction temperature to the reaction cavity of the third reaction container; the reaction cavity is sealed and connected to the connecting sleeve; two first reaction containers are symmetrically arranged on both sides of the third reaction container, and two second reaction containers are symmetrically arranged on both sides of the third reaction container; a rotating device is also connected to the frame portion, and the rotating device can drive the frame to rotate under the drive of the driving component connected thereto.

[0042] Preferably, the portion of the drainage rod extending into the third reaction container also has an extension portion, and a plurality of groups of breaking rods perpendicular to the extension direction are arranged on the circumference of the extension portion; and a rotating motor capable of driving the drainage rod to rotate is arranged at the end of the drainage rod.

[0043] Preferably, a material switch that can be opened and closed is provided on the side wall of the reaction chamber of the third reaction container.

[0044] Preferably, the reactor includes two working states: in the first working state, a first reaction container and its corresponding second reaction container are working; in the second working state, both first reaction containers and their corresponding second reaction containers are working. This can improve working efficiency and achieve mass production; when it is not necessary for two groups of containers to work at the same time, the cleaning and maintenance of the non-working container can be achieved.

[0045] Preferably, the first and second reaction containers are designed to be detachable structures.

[0046] Preferably, the heating device is a nickel-chromium heating wire.

[0047] Preferably, the rotating device is a gear, which meshes with a gear fixedly connected to the rotating motor, thereby enabling the frame body to rotate under the drive of the rotating motor.

[0048] Reference Figure 1-3 The specific operation method of a high-activity nanoscale tricalcium phosphate production reactor is as follows:

[0049] Step 1: The reactor is placed horizontally as a whole, calcium salt particles and phosphorus pentoxide particles are added to the first reaction container, and ethanol is added to dissolve them; ammonia water is added to the second reaction container;

[0050] Step 2: After the reactants in the first container are completely dissolved, the control switches for opening and closing the first channel and the second channel are turned on to completely mix the dissolved liquid and the ammonia water.

[0051] Step 3: close the control switches for opening and closing the first channel and the second channel, so that the mixed liquid is completely enclosed in the second reaction container; turn on the rotating device to drive the frame part to rotate, and the second reaction container also rotates or swings accordingly; the mixed liquid in the second reaction container is fully mixed to achieve stable regulation of the pH value;

[0052] Step 4: Keep the frame in a vertical state, turn on the control switch for opening and closing the second channel, so that the sol with uniform and stable shaking flows into the third reaction container along the drainage rod; age and dry the sol through a heating device to obtain tricalcium phosphate dry gel.

[0053] Preferably, the above steps further include

[0054] Step 5: Open the material switch, take out the tricalcium phosphate dry gel, and further process it into nano-scale tricalcium phosphate powder.

[0055] Preferably, the above steps can also be designed as follows:

[0056] Step 5: Turn on the rotating motor to break the dry gel into powder;

[0057] Step 6: Further heat the crushed powder by a heating device to obtain nano-scale tricalcium phosphate powder.

[0058] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A highly active nanoscale tricalcium phosphate production reactor, comprising a frame body composed of a support plate (39), a support profile (40) and a connecting piece (41), a first reaction container (47), a second reaction container (48) and a third reaction container (30); characterized in that: There are two first reaction containers (47), two second reaction containers (48), and one third reaction container (30), all of which are arranged inside the frame body. A first fixing member (37) is fixedly connected to the side of the support plate (39) facing the inside, and the first fixing member (37) is sequentially connected to the second fixing member (38) and the connecting sleeve (33); the connecting sleeve (33) is a hollow tubular structure, and a first channel (49) and a second channel (50) are symmetrically opened on its side wall, and the discharge ports of the first reaction container (47) and the second reaction container (48) are respectively connected to the first and second channels; the bottoms of the first and second reaction containers are also provided with openable and closable bottom covers, and the bottom covers are used for filling in the preparation process; control switches for opening and closing the channels are provided at the first channel (49) and the second channel (50); a control switch is provided in the flow channel in the connecting sleeve (33); A drainage rod (44) is provided which passes through the flow channel, and a portion of the drainage rod (44) which extends into the connecting sleeve (33) is provided with a spiral blade for drainage; the other end of the connecting sleeve (33) extends into the interior of the third reaction container (30); the third reaction container (30) comprises an outer shell (22) and a reaction cavity (21) which is arranged hollow; a heating device (27) is provided between the reaction cavity (21) and the outer shell (22) for providing a reaction temperature to the reaction cavity (21) of the third reaction container (30); the reaction cavity (21) is sealedly connected to the connecting sleeve (33); two first reaction containers (47) are symmetrically arranged on both sides of the third reaction container (30), and two second reaction containers (48) are symmetrically arranged on both sides of the third reaction container (30); a rotating device is also connected to the frame portion, and the rotating device can drive the frame to rotate under the drive of a driving component connected thereto; The portion of the drainage rod (44) extending into the third reaction container (30) further comprises an extension portion, and a plurality of groups of breaking rods perpendicular to the extension direction are arranged in the circumferential direction of the extension portion; a rotating motor capable of driving the drainage rod (44) to rotate is arranged at the end of the drainage rod (44); A material switch that can be opened and closed is provided on the side wall of the reaction chamber (21) of the third reaction container (30); The reactor comprises two working states. In the first working state, a first reaction container and its corresponding second reaction container are working; in the second working state, both the two first reaction containers and their corresponding second reaction containers are working.

2. The high-activity nanoscale tricalcium phosphate production reactor according to claim 1, characterized in that: The first and second reaction containers are both designed to be detachable structures.

3. The high-activity nanoscale tricalcium phosphate production reactor according to claim 1, characterized in that: The heating device (27) is a nickel-chromium heating wire.

4. The high-activity nanoscale tricalcium phosphate production reactor according to claim 1, characterized in that: The rotating device is a gear, which is meshed with a gear fixedly connected to the rotating motor, thereby enabling the frame body to rotate under the drive of the rotating motor.

5. A method for using a high-activity nanoscale tricalcium phosphate production reactor according to any one of claims 1 to 4, characterized in that: The use of the nanoscale tricalcium phosphate reactor includes the following steps: Step 1: The reactor is placed horizontally, calcium salt particles and phosphorus pentoxide particles are added to the first reaction container (47), and ethanol is added to dissolve them; ammonia water is added to the second reaction container (48); Step 2: After the reactants in the first reaction container (47) are completely dissolved, the control switches for opening and closing the first channel (49) and the second channel (50) are turned on to completely mix the dissolved liquid and the ammonia water; Step 3: closing the control switches for opening and closing the first channel (49) and the second channel (50), so that the mixed liquid is completely enclosed in the second reaction container (48); turning on the rotating device to drive the frame to rotate, and the second reaction container (48) also rotates or swings accordingly; the mixed liquid in the second reaction container is fully mixed to achieve stable regulation of the pH value; Step 4: Keep the frame in a vertical state, turn on the control switch for opening and closing the second channel (50), and allow the sol that shakes evenly and stably flows along the drainage rod (44) into the third reaction container (30); and age and dry the sol by the heating device (27) to obtain tricalcium phosphate dry gel.

6. A method for using the high-activity nanoscale tricalcium phosphate production reactor according to claim 5, characterized in that: Also includes Step 5: Open the material switch, take out the tricalcium phosphate dry gel, and further process it into nano-scale tricalcium phosphate powder.

7. A method for using the high-activity nanoscale tricalcium phosphate production reactor according to claim 6, characterized in that: Also includes Step 5: Turn on the rotating motor to break the dry gel into powder; Step 6: The crushed powder is further heated by a heating device (27) to obtain nanoscale tricalcium phosphate powder.

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